Details for: CAPZA2

Gene ID: 830

Symbol: CAPZA2

Ensembl ID: ENSG00000198898

Description: capping actin protein of muscle Z-line subunit alpha 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.41
    Marker Score: 4,932
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.94
    Marker Score: 3,547
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.8
    Marker Score: 7,108
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.76
    Marker Score: 2,379
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.62
    Marker Score: 1,642
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.5
    Marker Score: 4,984
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.49
    Marker Score: 2,850
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.44
    Marker Score: 4,578
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.43
    Marker Score: 136,103
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.42
    Marker Score: 3,522
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.38
    Marker Score: 60,990
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.37
    Marker Score: 5,780
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.33
    Marker Score: 3,033
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.31
    Marker Score: 78,597
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3
    Marker Score: 9,935
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.27
    Marker Score: 1,420
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.26
    Marker Score: 8,028
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.25
    Marker Score: 3,727
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.24
    Marker Score: 916
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.24
    Marker Score: 77,542
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.22
    Marker Score: 4,328
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.22
    Marker Score: 5,948
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.21
    Marker Score: 5,331
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.21
    Marker Score: 4,607
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.18
    Marker Score: 5,493
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.16
    Marker Score: 2,165
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.15
    Marker Score: 25,037
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.15
    Marker Score: 2,315
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.15
    Marker Score: 18,527
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.14
    Marker Score: 1,429
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.12
    Marker Score: 740
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.12
    Marker Score: 4,307
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.12
    Marker Score: 1,669
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.12
    Marker Score: 1,898
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.1
    Marker Score: 1,154
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.08
    Marker Score: 868
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.07
    Marker Score: 495
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.07
    Marker Score: 2,206
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.07
    Marker Score: 2,095
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.06
    Marker Score: 699
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.05
    Marker Score: 45,853
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.04
    Marker Score: 1,052
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.04
    Marker Score: 4,804
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.03
    Marker Score: 3,444
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.03
    Marker Score: 920
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.03
    Marker Score: 2,147
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2
    Marker Score: 3,401
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.97
    Marker Score: 12,567
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.97
    Marker Score: 816
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.96
    Marker Score: 1,846
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.96
    Marker Score: 797
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.95
    Marker Score: 2,359
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.95
    Marker Score: 7,503
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.94
    Marker Score: 736
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.94
    Marker Score: 4,265
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.94
    Marker Score: 4,833
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.91
    Marker Score: 3,489
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.91
    Marker Score: 1,255
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.9
    Marker Score: 2,136
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.9
    Marker Score: 1,985
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9
    Marker Score: 7,458
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.89
    Marker Score: 9,070
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.88
    Marker Score: 2,198
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.88
    Marker Score: 2,606
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.87
    Marker Score: 1,692
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.87
    Marker Score: 3,403
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.86
    Marker Score: 2,960
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.85
    Marker Score: 1,127
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.85
    Marker Score: 1,229
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.84
    Marker Score: 1,759
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.84
    Marker Score: 825
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.84
    Marker Score: 1,307
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.83
    Marker Score: 870
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.82
    Marker Score: 1,932
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.82
    Marker Score: 1,715
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.82
    Marker Score: 1,958
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.81
    Marker Score: 3,210
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2,664
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.81
    Marker Score: 2,117
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.79
    Marker Score: 945
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.79
    Marker Score: 576
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.79
    Marker Score: 2,538
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.79
    Marker Score: 507
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.77
    Marker Score: 1,055
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.75
    Marker Score: 5,509
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.75
    Marker Score: 410
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.75
    Marker Score: 869
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.74
    Marker Score: 642
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.73
    Marker Score: 699
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.73
    Marker Score: 1,674
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.73
    Marker Score: 570
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.73
    Marker Score: 2,080
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.73
    Marker Score: 701
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.73
    Marker Score: 1,179
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.73
    Marker Score: 10,493
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.73
    Marker Score: 2,131
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.73
    Marker Score: 367
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.72
    Marker Score: 841
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.72
    Marker Score: 4,758
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.72
    Marker Score: 3,898

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Capping Actin Protein**: CAPZA2 is a subunit of the capping actin protein, which regulates actin filament capping and maintains the integrity of the actin cytoskeleton. 2. **Muscle Z-line Subunit**: The alpha-2 subunit of the capping actin protein is specifically associated with the muscle Z-line, a critical structure in muscle cells that regulates muscle contraction and relaxation. 3. **Endothelial Cell Expression**: CAPZA2 is highly expressed in endothelial cells, including alveolar capillary type 2 endothelial cells, pulmonary artery endothelial cells, and endothelial cells of the vascular tree. 4. **Immune Cell Expression**: The gene is also expressed in myeloid leukocytes, including CD14-positive, CD16-negative classical monocytes, suggesting a role in immune responses. **Pathways and Functions** 1. **Actin Cytoskeleton Organization**: CAPZA2 regulates actin filament capping and organization, maintaining the integrity of the actin cytoskeleton and ensuring proper cellular structure and function. 2. **Adaptive Immune System**: The gene's expression in myeloid leukocytes suggests a role in immune responses, including antigen presentation and recognition. 3. **Cellular Stress Response**: CAPZA2 may participate in cellular stress responses, such as those triggered by oxidative stress or heat shock, by regulating actin dynamics and maintaining cellular homeostasis. 4. **Protein Modification**: The gene's involvement in asparagine n-linked glycosylation and post-translational protein modification suggests that CAPZA2 plays a role in regulating protein function and stability. **Clinical Significance** 1. **Muscle Disorders**: Alterations in CAPZA2 expression or function may contribute to muscle disorders, such as muscular dystrophy or myopathies. 2. **Endothelial Dysfunction**: Changes in CAPZA2 expression or function may lead to endothelial dysfunction, which is a hallmark of various cardiovascular diseases, including atherosclerosis and hypertension. 3. **Immune-Mediated Diseases**: The gene's role in immune responses suggests that alterations in CAPZA2 expression or function may contribute to immune-mediated diseases, such as autoimmune disorders or inflammatory conditions. 4. **Cancer**: CAPZA2's involvement in protein modification and cellular stress responses may also contribute to cancer development and progression, particularly in endothelial cells and immune cells. In conclusion, the CAPZA2 gene plays a critical role in regulating actin dynamics, maintaining cellular structure, and participating in immune responses. Further research on this gene is necessary to fully elucidate its functions and clinical significance, particularly in the context of muscle disorders, endothelial dysfunction, immune-mediated diseases, and cancer.

Genular Protein ID: 53438944

Symbol: CAZA2_HUMAN

Name: F-actin-capping protein subunit alpha-2

UniProtKB Accession Codes:

P47755 B4DG50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7665558

Title: Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.

PubMed ID: 7665558

DOI: 10.1074/jbc.270.37.21472

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9331217

Title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

PubMed ID: 9331217

DOI: 10.1002/(sici)1097-0169(1997)38:2<120::aid-cm2>3.0.co;2-b

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 15850461

Title: The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

PubMed ID: 15850461

DOI: 10.1042/bj20050387

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30361697

Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin.

PubMed ID: 30361697

DOI: 10.1038/s41556-018-0215-z

Sequence Information:

  • Length: 286
  • Mass: 32949
  • Checksum: B5E1B617A38E758B
  • Sequence:
    • MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD 
QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW 
RTSVETALRA YVKEHYPNGV CTVYGKKIDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT 
ITPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.