Details for: CAPZA2

Gene ID: 830

Symbol: CAPZA2

Ensembl ID: ENSG00000198898

Description: capping actin protein of muscle Z-line subunit alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 477.4174
    Cell Significance Index: -74.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 329.0052
    Cell Significance Index: -83.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 231.5586
    Cell Significance Index: -95.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.0831
    Cell Significance Index: -99.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 197.2396
    Cell Significance Index: -80.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 177.9211
    Cell Significance Index: -91.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 148.6166
    Cell Significance Index: -99.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 85.0281
    Cell Significance Index: -81.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 73.6523
    Cell Significance Index: -90.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.0240
    Cell Significance Index: -80.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.6474
    Cell Significance Index: -97.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.0324
    Cell Significance Index: -64.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.5720
    Cell Significance Index: -42.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7530
    Cell Significance Index: 351.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6574
    Cell Significance Index: 905.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5715
    Cell Significance Index: 283.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5657
    Cell Significance Index: 310.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5136
    Cell Significance Index: 186.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2925
    Cell Significance Index: 67.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2808
    Cell Significance Index: 175.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2709
    Cell Significance Index: 23.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1105
    Cell Significance Index: 85.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0209
    Cell Significance Index: 76.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0162
    Cell Significance Index: 52.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0146
    Cell Significance Index: 165.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9558
    Cell Significance Index: 16.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8721
    Cell Significance Index: 385.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8355
    Cell Significance Index: 39.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8086
    Cell Significance Index: 103.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7425
    Cell Significance Index: 25.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7297
    Cell Significance Index: 94.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6802
    Cell Significance Index: 80.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6730
    Cell Significance Index: 241.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4906
    Cell Significance Index: 339.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4115
    Cell Significance Index: 10.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3570
    Cell Significance Index: 2.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3548
    Cell Significance Index: 10.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3453
    Cell Significance Index: 24.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1996
    Cell Significance Index: 5.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1734
    Cell Significance Index: 9.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1598
    Cell Significance Index: 9.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1497
    Cell Significance Index: 25.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0887
    Cell Significance Index: 4.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0834
    Cell Significance Index: 15.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0820
    Cell Significance Index: 1.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0788
    Cell Significance Index: 5.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0661
    Cell Significance Index: 124.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0456
    Cell Significance Index: 20.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0320
    Cell Significance Index: 0.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0187
    Cell Significance Index: 0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0037
    Cell Significance Index: 2.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0009
    Cell Significance Index: 0.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0019
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0172
    Cell Significance Index: -31.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0211
    Cell Significance Index: -15.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0241
    Cell Significance Index: -37.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0353
    Cell Significance Index: -47.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0403
    Cell Significance Index: -29.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0498
    Cell Significance Index: -5.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0520
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0545
    Cell Significance Index: -34.0200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0904
    Cell Significance Index: -0.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1031
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1189
    Cell Significance Index: -67.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1287
    Cell Significance Index: -12.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1631
    Cell Significance Index: -8.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1987
    Cell Significance Index: -4.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2020
    Cell Significance Index: -12.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2149
    Cell Significance Index: -45.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2695
    Cell Significance Index: -31.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2700
    Cell Significance Index: -12.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2794
    Cell Significance Index: -80.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3354
    Cell Significance Index: -48.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3417
    Cell Significance Index: -39.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4098
    Cell Significance Index: -6.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4658
    Cell Significance Index: -13.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5210
    Cell Significance Index: -59.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7499
    Cell Significance Index: -59.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7580
    Cell Significance Index: -6.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7894
    Cell Significance Index: -22.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8361
    Cell Significance Index: -87.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8372
    Cell Significance Index: -23.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8904
    Cell Significance Index: -10.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8917
    Cell Significance Index: -39.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9447
    Cell Significance Index: -10.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9738
    Cell Significance Index: -20.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9765
    Cell Significance Index: -5.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0819
    Cell Significance Index: -40.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2666
    Cell Significance Index: -33.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3253
    Cell Significance Index: -30.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3317
    Cell Significance Index: -28.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3411
    Cell Significance Index: -34.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3642
    Cell Significance Index: -94.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3938
    Cell Significance Index: -44.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4388
    Cell Significance Index: -19.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.5000
    Cell Significance Index: -36.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5580
    Cell Significance Index: -95.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.7675
    Cell Significance Index: -21.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8816
    Cell Significance Index: -55.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9561
    Cell Significance Index: -29.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Capping Actin Protein**: CAPZA2 is a subunit of the capping actin protein, which regulates actin filament capping and maintains the integrity of the actin cytoskeleton. 2. **Muscle Z-line Subunit**: The alpha-2 subunit of the capping actin protein is specifically associated with the muscle Z-line, a critical structure in muscle cells that regulates muscle contraction and relaxation. 3. **Endothelial Cell Expression**: CAPZA2 is highly expressed in endothelial cells, including alveolar capillary type 2 endothelial cells, pulmonary artery endothelial cells, and endothelial cells of the vascular tree. 4. **Immune Cell Expression**: The gene is also expressed in myeloid leukocytes, including CD14-positive, CD16-negative classical monocytes, suggesting a role in immune responses. **Pathways and Functions** 1. **Actin Cytoskeleton Organization**: CAPZA2 regulates actin filament capping and organization, maintaining the integrity of the actin cytoskeleton and ensuring proper cellular structure and function. 2. **Adaptive Immune System**: The gene's expression in myeloid leukocytes suggests a role in immune responses, including antigen presentation and recognition. 3. **Cellular Stress Response**: CAPZA2 may participate in cellular stress responses, such as those triggered by oxidative stress or heat shock, by regulating actin dynamics and maintaining cellular homeostasis. 4. **Protein Modification**: The gene's involvement in asparagine n-linked glycosylation and post-translational protein modification suggests that CAPZA2 plays a role in regulating protein function and stability. **Clinical Significance** 1. **Muscle Disorders**: Alterations in CAPZA2 expression or function may contribute to muscle disorders, such as muscular dystrophy or myopathies. 2. **Endothelial Dysfunction**: Changes in CAPZA2 expression or function may lead to endothelial dysfunction, which is a hallmark of various cardiovascular diseases, including atherosclerosis and hypertension. 3. **Immune-Mediated Diseases**: The gene's role in immune responses suggests that alterations in CAPZA2 expression or function may contribute to immune-mediated diseases, such as autoimmune disorders or inflammatory conditions. 4. **Cancer**: CAPZA2's involvement in protein modification and cellular stress responses may also contribute to cancer development and progression, particularly in endothelial cells and immune cells. In conclusion, the CAPZA2 gene plays a critical role in regulating actin dynamics, maintaining cellular structure, and participating in immune responses. Further research on this gene is necessary to fully elucidate its functions and clinical significance, particularly in the context of muscle disorders, endothelial dysfunction, immune-mediated diseases, and cancer.

Genular Protein ID: 53438944

Symbol: CAZA2_HUMAN

Name: F-actin-capping protein subunit alpha-2

UniProtKB Accession Codes:

P47755 B4DG50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7665558

Title: Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.

PubMed ID: 7665558

DOI: 10.1074/jbc.270.37.21472

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9331217

Title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

PubMed ID: 9331217

DOI: 10.1002/(sici)1097-0169(1997)38:2<120::aid-cm2>3.0.co;2-b

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 15850461

Title: The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

PubMed ID: 15850461

DOI: 10.1042/bj20050387

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30361697

Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin.

PubMed ID: 30361697

DOI: 10.1038/s41556-018-0215-z

Sequence Information:

  • Length: 286
  • Mass: 32949
  • Checksum: B5E1B617A38E758B
  • Sequence:
    • MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD 
QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW 
RTSVETALRA YVKEHYPNGV CTVYGKKIDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT 
ITPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.