Details for: CAPZA2
Gene ID: 830
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CAPZA2
Ensembl ID: ENSG00000198898
Description: capping actin protein of muscle Z-line subunit alpha 2
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 83.16rCSI 64.07%PRS 14.66
-
CSI 50.6rCSI 95.53%PRS 20.02
-
CSI 50.06rCSI 45.21%PRS 14.29
-
CSI 42.22rCSI 57.45%PRS 24.36
-
CSI 38.23rCSI 39.95%PRS 16.76
-
CSI 32.69rCSI 63.58%PRS 16.4
-
CSI 29.18rCSI 19.39%PRS 19.21
-
CSI 28.19rCSI 25.88%PRS 18.51
-
CSI 28.09rCSI 25.92%PRS 16.39
-
CSI 24.11rCSI 25.26%PRS 17.11
-
CSI 23.63rCSI 68.42%PRS 18.15
-
CSI 22.01rCSI 70.62%PRS 23.17
-
CSI 21.06rCSI 22.06%PRS 14.89
-
CSI 20.91rCSI 29.84%PRS 18.03
-
CSI 20.75rCSI 30.4%PRS 64.28
-
CSI 20.25rCSI 19.49%PRS 16.57
-
CSI 20.22rCSI 30.5%PRS 15.97
-
CSI 16.93rCSI 22.5%PRS 17.51
-
CSI 16.66rCSI 22.78%PRS 25.54
-
CSI 14.73rCSI 72.63%PRS 21.72
-
CSI 14.62rCSI 23.58%PRS 25.19
-
CSI 12.31rCSI 56.87%PRS 33.09
-
CSI 11.73rCSI 46.69%PRS 27.86
-
CSI 11.4rCSI 14.1%PRS 14.02
-
CSI 11.23rCSI 18.5%PRS 18.78
-
CSI 11.2rCSI 76.9%PRS 31.16
-
CSI 10.58rCSI 38.08%PRS 8.8
-
CSI 10.19rCSI 17.45%PRS 21.64
-
CSI 10.12rCSI 35.49%PRS 28.55
-
CSI 9.97rCSI 21.22%PRS 25.67
-
CSI 9.9rCSI 42.93%PRS 28.24
-
CSI 9.76rCSI 52.68%PRS 29.28
-
CSI 9.62rCSI 58.22%PRS 35.49
-
CSI 9.3rCSI 100%PRS 28.67
-
CSI 9.03rCSI 12.3%PRS 14.19
-
CSI 8.93rCSI 17.05%PRS 36.17
-
CSI 8.66rCSI 8.35%PRS 11.38
-
CSI 7.81rCSI 45.46%PRS 23.99
-
CSI 7.8rCSI 18.97%PRS 9.21
-
CSI 7.73rCSI 39.9%PRS 31.17
-
CSI 7.33rCSI 9.2%PRS 20.58
-
CSI 7.16rCSI 11%PRS 18.89
-
CSI 6.48rCSI 6.38%PRS 17.39
-
CSI 6.38rCSI 50.01%PRS 33.19
-
CSI 6.35rCSI 13.98%PRS 24.4
-
CSI 6.16rCSI 11.88%PRS 35.76
-
CSI 6.16rCSI 8.88%PRS 25.53
-
CSI 6.04rCSI 10.98%PRS 56.77
-
CSI 5.84rCSI 42.7%PRS 42.59
-
CSI 5.76rCSI 43.28%PRS 29.08
-
CSI 5.6rCSI 8.54%PRS 14.83
-
CSI 5.16rCSI 30.37%PRS 9.88
-
CSI 5.04rCSI 11.17%PRS 14.84
-
CSI 4.88rCSI 3.25%PRS 40.06
-
CSI 4.52rCSI 10%PRS 11.44
-
CSI 4.41rCSI 6.77%PRS 22.41
-
CSI 4.4rCSI 8.07%PRS 55.75
-
CSI 4.12rCSI 32.87%PRS 58.29
-
CSI 4.12rCSI 3.62%PRS 11.61
-
CSI 4.07rCSI 3.41%PRS 19.15
-
CSI 4.04rCSI 11.92%PRS 19.33
-
CSI 3.53rCSI 10.33%PRS 47.72
-
CSI 3.45rCSI 2.88%PRS 44.06
-
CSI 3.38rCSI 12.76%PRS 9.66
-
CSI 3.31rCSI 5.29%PRS 17.56
-
CSI 3.31rCSI 79.17%PRS 7.65
-
CSI 3.26rCSI 63%PRS 47.2
-
CSI 3.18rCSI 8.57%PRS 20.68
-
CSI 3.15rCSI 34.23%PRS 30.62
-
CSI 3.07rCSI 7.29%PRS 23.97
-
CSI 3.07rCSI 73.97%PRS 8.63
-
CSI 3.05rCSI 4.89%PRS 46.18
-
CSI 3.03rCSI 2.55%PRS 25.57
-
CSI 2.92rCSI 9.12%PRS 10.05
-
CSI 2.89rCSI 15.75%PRS 38.45
-
CSI 2.88rCSI 4.15%PRS 22.34
-
CSI 2.82rCSI 2.44%PRS 17.99
-
CSI 2.77rCSI 7.29%PRS 31.18
-
CSI 2.75rCSI 2.22%PRS 15.95
-
CSI 2.64rCSI 12.09%PRS 40.79
-
CSI 2.59rCSI 38.9%PRS 46.78
-
CSI 2.5rCSI 1.85%PRS 14.11
-
CSI 2.49rCSI 5.11%PRS 35.93
-
CSI 2.47rCSI 3.15%PRS 18.58
-
CSI 2.45rCSI 1.71%PRS 22.67
-
CSI 2.45rCSI 7.01%PRS 28.13
-
CSI 2.42rCSI 11.33%PRS 32.61
-
CSI 2.34rCSI 2.49%PRS 28
-
CSI 2.24rCSI 2.07%PRS 28.91
-
CSI 2.2rCSI 9.77%PRS 15.72
-
CSI 2.2rCSI 5.83%PRS 25.98
-
CSI 2.19rCSI 2.99%PRS 17.74
-
CSI 2.19rCSI 7.76%PRS 26.09
-
CSI 2.18rCSI 23.11%PRS 21.51
-
CSI 2.16rCSI 39.57%PRS 45.96
-
CSI 2.09rCSI 1.67%PRS 28.74
-
CSI 2.06rCSI 49.33%PRS 50.36
-
CSI 2.06rCSI 2.39%PRS 23.57
-
CSI 2.01rCSI 10.1%PRS 21.04
-
CSI 1.99rCSI 1.51%PRS 21.06
-
CSI -4.1rCSI -11.0%PRS 13.2%
-
CSI -3.9rCSI -2.9%PRS 27.0%
-
CSI -3.8rCSI -3.7%PRS 25.1%
-
CSI -3.7rCSI -9.3%PRS 44.7%
-
CSI -2.3rCSI -4.3%PRS 11.5%
-
CSI -2.2rCSI -1.8%PRS 16.9%
-
CSI -1.9rCSI -2.3%PRS 8.8%
-
CSI -1.3rCSI -1.2%PRS 24.2%
-
CSI -1.1rCSI -3.2%PRS 23.5%
-
CSI -1.1rCSI -0.7%PRS 19.3%
-
CSI -0.9rCSI -1.3%PRS 18.4%
-
CSI -0.8rCSI -3.9%PRS 17.0%
-
CSI -0.6rCSI -1.4%PRS 19.9%
-
CSI -0.5rCSI -0.9%PRS 31.9%
-
CSI -0.5rCSI -0.6%PRS 21.4%
-
CSI -0.5rCSI -2.9%PRS 55.3%
-
CSI -0.4rCSI -1.1%PRS 25.0%
-
CSI -0.4rCSI -1.7%PRS 19.6%
-
CSI -0.4rCSI -1.0%PRS 14.8%
-
CSI -0.4rCSI -0.3%PRS 18.9%
-
CSI -0.4rCSI -1.7%PRS 11.5%
-
CSI -0.3rCSI -0.7%PRS 9.4%
-
CSI -0.2rCSI -0.5%PRS 9.9%
-
CSI -0.2rCSI -0.4%PRS 21.5%
-
CSI -0.1rCSI -0.5%PRS 26.2%
-
CSI 0.0rCSI -0.9%PRS 64.7%
-
CSI 0.0rCSI 0.5%PRS 69.0%
-
CSI 0.1rCSI 0.2%PRS 13.8%
-
CSI 0.1rCSI 0.4%PRS 15.9%
-
CSI 0.1rCSI 0.9%PRS 51.7%
-
CSI 0.1rCSI 0.4%PRS 23.4%
-
CSI 0.1rCSI 0.7%PRS 16.4%
-
CSI 0.1rCSI 0.6%PRS 15.7%
-
CSI 0.1rCSI 0.1%PRS 20.7%
-
CSI 0.1rCSI 0.1%PRS 10.3%
-
CSI 0.1rCSI 0.2%PRS 31.8%
-
CSI 0.1rCSI 0.4%PRS 34.3%
-
CSI 0.1rCSI 0.4%PRS 39.8%
-
CSI 0.1rCSI 0.2%PRS 12.3%
-
CSI 0.1rCSI 0.2%PRS 24.1%
-
CSI 0.1rCSI 0.7%PRS 12.5%
-
CSI 0.1rCSI 2.3%PRS 76.9%
-
CSI 0.1rCSI 0.2%PRS 9.4%
-
CSI 0.1rCSI 1.3%PRS 43.3%
-
CSI 0.1rCSI 0.3%PRS 32.2%
-
CSI 0.1rCSI 0.3%PRS 25.4%
-
CSI 0.1rCSI 1.2%PRS 6.5%
-
CSI 0.2rCSI 0.3%PRS 21.1%
-
CSI 0.2rCSI 2.0%PRS 49.2%
-
CSI 0.2rCSI 2.4%PRS 65.6%
-
CSI 0.2rCSI 1.7%PRS 56.7%
-
CSI 0.2rCSI 1.2%PRS 16.4%
-
CSI 0.2rCSI 0.8%PRS 51.5%
-
CSI 0.2rCSI 0.3%PRS 31.3%
-
CSI 0.2rCSI 0.4%PRS 12.1%
-
CSI 0.2rCSI 0.2%PRS 16.0%
-
CSI 0.2rCSI 0.3%PRS 13.6%
-
CSI 0.2rCSI 1.0%PRS 50.8%
-
CSI 0.2rCSI 0.3%PRS 14.9%
-
CSI 0.2rCSI 1.7%PRS 80.4%
-
CSI 0.2rCSI 0.9%PRS 41.1%
-
CSI 0.2rCSI 1.9%PRS 43.0%
-
CSI 0.2rCSI 0.8%PRS 26.2%
-
CSI 0.2rCSI 0.2%PRS 27.7%
-
CSI 0.2rCSI 0.3%PRS 16.9%
-
CSI 0.2rCSI 1.5%PRS 46.5%
-
CSI 0.2rCSI 1.0%PRS 43.0%
-
CSI 0.2rCSI 1.7%PRS 14.9%
-
CSI 0.2rCSI 0.3%PRS 27.9%
-
CSI 0.3rCSI 0.2%PRS 19.9%
-
CSI 0.3rCSI 3.8%PRS 11.5%
-
CSI 0.3rCSI 0.5%PRS 40.8%
-
CSI 0.3rCSI 0.8%PRS 12.3%
-
CSI 0.3rCSI 0.8%PRS 18.7%
-
CSI 0.3rCSI 1.7%PRS 49.0%
-
CSI 0.3rCSI 1.6%PRS 55.5%
-
CSI 0.3rCSI 2.0%PRS 40.7%
-
CSI 0.3rCSI 0.9%PRS 24.8%
-
CSI 0.3rCSI 1.2%PRS 22.0%
-
CSI 0.3rCSI 3.5%PRS 39.1%
-
CSI 0.3rCSI 1.4%PRS 52.4%
-
CSI 0.3rCSI 2.2%PRS 17.8%
-
CSI 0.3rCSI 1.2%PRS 27.4%
-
CSI 0.3rCSI 0.5%PRS 15.0%
-
CSI 0.3rCSI 0.2%PRS 23.7%
-
CSI 0.3rCSI 0.2%PRS 22.1%
-
CSI 0.3rCSI 0.9%PRS 15.7%
-
CSI 0.3rCSI 2.0%PRS 16.6%
-
CSI 0.3rCSI 0.3%PRS 28.4%
-
CSI 0.4rCSI 0.8%PRS 32.7%
-
CSI 0.4rCSI 1.9%PRS 28.6%
-
CSI 0.4rCSI 0.4%PRS 15.8%
-
CSI 0.4rCSI 3.3%PRS 56.3%
-
CSI 0.4rCSI 2.8%PRS 8.8%
-
CSI 0.4rCSI 0.7%PRS 9.4%
-
CSI 0.4rCSI 1.3%PRS 11.0%
-
CSI 0.4rCSI 0.9%PRS 24.6%
-
CSI 0.4rCSI 0.4%PRS 32.7%
-
CSI 0.4rCSI 2.2%PRS 44.3%
-
CSI 0.4rCSI 0.8%PRS 7.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 53438944
Symbol: CAZA2_HUMAN
Name: F-actin-capping protein subunit alpha-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7665558
Title: Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.
PubMed ID: 7665558
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9331217
Title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.
PubMed ID: 9331217
DOI: 10.1002/(sici)1097-0169(1997)38:2<120::aid-cm2>3.0.co;2-b
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 15850461
Title: The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
PubMed ID: 15850461
DOI: 10.1042/bj20050387
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19922875
Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.
PubMed ID: 19922875
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30361697
Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin.
PubMed ID: 30361697
Sequence Information:
- Length: 286
- Mass: 32949
- Checksum: B5E1B617A38E758B
- Sequence:
MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW RTSVETALRA YVKEHYPNGV CTVYGKKIDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT ITPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA