Details for: ANXA1

Gene ID: 301

Symbol: ANXA1

Ensembl ID: ENSG00000135046

Description: annexin A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.21
    Marker Score: 3297
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.18
    Marker Score: 13198
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.04
    Marker Score: 225876.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.93
    Marker Score: 5695
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.71
    Marker Score: 9426
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.65
    Marker Score: 124286
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.61
    Marker Score: 8811
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.6
    Marker Score: 35604
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.57
    Marker Score: 3133
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.56
    Marker Score: 27819
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.55
    Marker Score: 10374.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.55
    Marker Score: 30866
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.54
    Marker Score: 1684
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.51
    Marker Score: 2391
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.51
    Marker Score: 4721
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.47
    Marker Score: 14860
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.45
    Marker Score: 6289
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.44
    Marker Score: 3677.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.43
    Marker Score: 2011
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.42
    Marker Score: 25429
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.4
    Marker Score: 39565
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.39
    Marker Score: 3883
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 3.38
    Marker Score: 11609
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.36
    Marker Score: 2247
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.34
    Marker Score: 2632.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.32
    Marker Score: 3997
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.27
    Marker Score: 2754
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.22
    Marker Score: 27732
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.19
    Marker Score: 15680
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.19
    Marker Score: 4696
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.17
    Marker Score: 8296
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.16
    Marker Score: 2289
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.13
    Marker Score: 4043
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.12
    Marker Score: 3282
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.12
    Marker Score: 3013
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.09
    Marker Score: 989
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.04
    Marker Score: 2703
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.99
    Marker Score: 7435
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.94
    Marker Score: 8110
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.93
    Marker Score: 1615
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.9
    Marker Score: 1246
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.89
    Marker Score: 8113
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.89
    Marker Score: 979
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.88
    Marker Score: 1478
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.86
    Marker Score: 73293
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.83
    Marker Score: 3300.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.79
    Marker Score: 674
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.77
    Marker Score: 6757
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.76
    Marker Score: 95695
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.76
    Marker Score: 5375
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.75
    Marker Score: 871
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.71
    Marker Score: 2533
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.7
    Marker Score: 142902
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.7
    Marker Score: 14186
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.68
    Marker Score: 6458
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.67
    Marker Score: 5084
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.66
    Marker Score: 3212
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.64
    Marker Score: 1305
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.64
    Marker Score: 1625
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.63
    Marker Score: 1693
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.62
    Marker Score: 1920
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.62
    Marker Score: 10885
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.6
    Marker Score: 4395
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.59
    Marker Score: 921
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.59
    Marker Score: 803
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.56
    Marker Score: 3528
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.53
    Marker Score: 1136
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.53
    Marker Score: 1833
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.52
    Marker Score: 921
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.52
    Marker Score: 4937
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.51
    Marker Score: 5653
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.51
    Marker Score: 3640
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.49
    Marker Score: 3671
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.48
    Marker Score: 15049
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.48
    Marker Score: 2131
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.46
    Marker Score: 6384
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.46
    Marker Score: 2656
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.45
    Marker Score: 1534
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.44
    Marker Score: 39119
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.43
    Marker Score: 779
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.42
    Marker Score: 1046
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.42
    Marker Score: 15783
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.39
    Marker Score: 1027
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.37
    Marker Score: 10230.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.36
    Marker Score: 680
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.34
    Marker Score: 1111
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.33
    Marker Score: 1913
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.33
    Marker Score: 1355
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.32
    Marker Score: 9133.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.31
    Marker Score: 1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.31
    Marker Score: 531
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.29
    Marker Score: 4573
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.28
    Marker Score: 1154
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.26
    Marker Score: 2741
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.22
    Marker Score: 1618
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.22
    Marker Score: 3633
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.2
    Marker Score: 3018
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.19
    Marker Score: 3765
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.18
    Marker Score: 1784.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.18
    Marker Score: 1818

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - Annexin A1 is a protein of the annexin family of proteins. - It is a calcium-binding protein that is expressed in high levels in immune cells. - It is involved in a variety of signaling pathways, including the calcium ion binding pathway, the class a/1 (rhodopsin-like receptors) pathway, the cytokine signaling pathway, and the G protein-coupled receptor pathway. - It is a key regulator of immune responses. **Pathways and functions:** - Annexin A1 is involved in the regulation of the immune response through the calcium ion binding pathway. - It binds to calcium ions and activates the protein, leading to the activation of various signaling pathways. - It is involved in the regulation of inflammation, cell migration, and differentiation. - It is also involved in the regulation of cell growth and survival. **Clinical significance:** - Mutations in the ANXA1 gene have been linked to a number of diseases, including cancer, autoimmune diseases, and inflammatory diseases. - Annexin A1 is a potential target for the treatment of these diseases. **Additional information:** - ANXA1 is a highly conserved protein that is found in all vertebrates. - It is expressed in high levels in immune cells, including T cells, B cells, and macrophages. - It is also expressed in a variety of non-immune cells, including muscle cells, endothelial cells, and fibroblasts.

Genular Protein ID: 1212786809

Symbol: ANXA1_HUMAN

Name: Annexin A1

UniProtKB Accession Codes:

P04083 B5BU38

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 10 CPTC 1 CTD 1 ChEBI 26 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 DrugBank 18 DrugCentral 1 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 81 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2936963

Title: Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.

PubMed ID: 2936963

DOI: 10.1038/320077a0

PubMed ID: 1832554

Title: Correlation of gene and protein structure of rat and human lipocortin I.

PubMed ID: 1832554

DOI: 10.1021/bi00101a015

PubMed ID: 8425544

Title: Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.

PubMed ID: 8425544

DOI: 10.1111/j.1432-1033.1993.tb19904.x

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2457390

Title: Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.

PubMed ID: 2457390

DOI: 10.1021/bi00410a024

PubMed ID: 3303336

Title: Characterization by tandem mass spectrometry of structural modifications in proteins.

PubMed ID: 3303336

DOI: 10.1126/science.3303336

PubMed ID: 2532504

Title: A dimeric form of lipocortin-1 in human placenta.

PubMed ID: 2532504

DOI: 10.1042/bj2630097

PubMed ID: 8557678

Title: Calcium-dependent binding of S100C to the N-terminal domain of annexin I.

PubMed ID: 8557678

DOI: 10.1074/jbc.271.2.719

PubMed ID: 10772777

Title: Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis.

PubMed ID: 10772777

DOI: 10.1006/cbir.1999.0468

PubMed ID: 15485879

Title: Phosphorylation of annexin I by TRPM7 channel-kinase.

PubMed ID: 15485879

DOI: 10.1074/jbc.c400441200

PubMed ID: 15187149

Title: An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.

PubMed ID: 15187149

DOI: 10.4049/jimmunol.172.12.7669

PubMed ID: 17008549

Title: Annexin-1 modulates T-cell activation and differentiation.

PubMed ID: 17008549

DOI: 10.1182/blood-2006-05-022798

PubMed ID: 18641677

Title: Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.

PubMed ID: 18641677

DOI: 10.1038/bjp.2008.252

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19625660

Title: Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.

PubMed ID: 19625660

DOI: 10.1096/fj.09-131391

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22879591

Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

PubMed ID: 22879591

DOI: 10.1074/jbc.m112.394452

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25664854

Title: Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

PubMed ID: 25664854

DOI: 10.1172/jci76693

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8453382

Title: Crystal structure of human annexin I at 2.5-A resolution.

PubMed ID: 8453382

DOI: 10.1002/pro.5560020317

PubMed ID: 9915835

Title: NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit.

PubMed ID: 9915835

DOI: 10.1074/jbc.274.5.2971

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 10673436

Title: Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.

PubMed ID: 10673436

DOI: 10.1016/s0969-2126(00)00093-9

Sequence Information:

  • Length: 346
  • Mass: 38714
  • Checksum: 14B42E1FA4178EC0
  • Sequence:
    • MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV 
DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA 
DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL 
LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY 
TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM 
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.