ANXA1 | ENSG00000135046 | NCBI 301

Details for: ANXA1

Gene ID: 301

Symbol: ANXA1

Ensembl ID: ENSG00000135046

Description: annexin A1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
Formyl peptide receptors bind formyl peptides and many other ligands
(R-HSA-444473)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Muscle contraction
(R-HSA-397014)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Smooth muscle contraction
(R-HSA-445355)
Actin cytoskeleton organization
(GO:0030036)
Actin filament
(GO:0005884)
Adaptive immune response
(GO:0002250)
Adherens junction
(GO:0005912)
Alpha-beta t cell differentiation
(GO:0046632)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Cadherin binding involved in cell-cell adhesion
(GO:0098641)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Cell-cell adhesion
(GO:0098609)
Cell surface
(GO:0009986)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Collagen-containing extracellular matrix
(GO:0062023)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome membrane
(GO:0031901)
Endosome
(GO:0005768)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Granulocyte chemotaxis
(GO:0071621)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Keratinocyte differentiation
(GO:0030216)
Lateral plasma membrane
(GO:0016328)
Lipid binding
(GO:0008289)
Localization
(GO:0051179)
Monocyte chemotaxis
(GO:0002548)
Motile cilium
(GO:0031514)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of exocytosis
(GO:0045920)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of t-helper 2 cell differentiation
(GO:0045629)
Neutrophil activation
(GO:0042119)
Neutrophil clearance
(GO:0097350)
Neutrophil homeostasis
(GO:0001780)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptide cross-linking
(GO:0018149)
Phagocytic cup
(GO:0001891)
Phagocytosis
(GO:0006909)
Phosphatidylserine binding
(GO:0001786)
Phospholipase a2 inhibitor activity
(GO:0019834)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of t-helper 1 cell differentiation
(GO:0045627)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of vesicle fusion
(GO:0031340)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Regulation of cell shape
(GO:0008360)
Regulation of hormone secretion
(GO:0046883)
Regulation of inflammatory response
(GO:0050727)
Regulation of interleukin-1 production
(GO:0032652)
Regulation of leukocyte migration
(GO:0002685)
Sarcolemma
(GO:0042383)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Vesicle
(GO:0031982)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.21
Marker Score: 3,297
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.18
Marker Score: 13,198
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.04
Marker Score: 225,877
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.93
Marker Score: 5,695
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.71
Marker Score: 9,426
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.65
Marker Score: 124,286
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.61
Marker Score: 8,811
Cell Name: mature T cell (CL0002419)
Fold Change: 3.6
Marker Score: 35,604
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.57
Marker Score: 3,133
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.56
Marker Score: 27,819
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.55
Marker Score: 10,375
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.55
Marker Score: 30,866
Cell Name: basophil (CL0000767)
Fold Change: 3.54
Marker Score: 1,684
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 3.51
Marker Score: 2,391
Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.51
Marker Score: 4,721
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.47
Marker Score: 14,860
Cell Name: secretory cell (CL0000151)
Fold Change: 3.45
Marker Score: 6,289
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.44
Marker Score: 3,678
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.43
Marker Score: 2,011
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.42
Marker Score: 25,429
Cell Name: blood cell (CL0000081)
Fold Change: 3.4
Marker Score: 39,565
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.39
Marker Score: 3,883
Cell Name: ciliated cell (CL0000064)
Fold Change: 3.38
Marker Score: 11,609
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 3.36
Marker Score: 2,247
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.34
Marker Score: 2,633
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.32
Marker Score: 3,997
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.27
Marker Score: 2,754
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.22
Marker Score: 27,732
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.19
Marker Score: 15,680
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.19
Marker Score: 4,696
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.17
Marker Score: 8,296
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.16
Marker Score: 2,289
Cell Name: basal cell (CL0000646)
Fold Change: 3.13
Marker Score: 4,043
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.12
Marker Score: 3,282
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.12
Marker Score: 3,013
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.09
Marker Score: 989
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.04
Marker Score: 2,703
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.99
Marker Score: 7,435
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.94
Marker Score: 8,110
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.93
Marker Score: 1,615
Cell Name: memory T cell (CL0000813)
Fold Change: 2.9
Marker Score: 1,246
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.89
Marker Score: 8,113
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.89
Marker Score: 979
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.88
Marker Score: 1,478
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.86
Marker Score: 73,293
Cell Name: club cell (CL0000158)
Fold Change: 2.83
Marker Score: 3,301
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.79
Marker Score: 674
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.77
Marker Score: 6,757
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.76
Marker Score: 95,695
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.76
Marker Score: 5,375
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.75
Marker Score: 871
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.71
Marker Score: 2,533
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.7
Marker Score: 142,902
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.7
Marker Score: 14,186
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.68
Marker Score: 6,458
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.67
Marker Score: 5,084
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.66
Marker Score: 3,212
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.64
Marker Score: 1,305
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.64
Marker Score: 1,625
Cell Name: naive T cell (CL0000898)
Fold Change: 2.63
Marker Score: 1,693
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.62
Marker Score: 1,920
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.62
Marker Score: 10,885
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.6
Marker Score: 4,395
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.59
Marker Score: 921
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.59
Marker Score: 803
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.56
Marker Score: 3,528
Cell Name: granulocyte (CL0000094)
Fold Change: 2.53
Marker Score: 1,136
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.53
Marker Score: 1,833
Cell Name: reticular cell (CL0000432)
Fold Change: 2.52
Marker Score: 921
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.52
Marker Score: 4,937
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.51
Marker Score: 5,653
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.51
Marker Score: 3,640
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.49
Marker Score: 3,671
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.48
Marker Score: 15,049
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.48
Marker Score: 2,131
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.46
Marker Score: 6,384
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.46
Marker Score: 2,656
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.45
Marker Score: 1,534
Cell Name: lactocyte (CL0002325)
Fold Change: 2.44
Marker Score: 39,119
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.43
Marker Score: 779
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.42
Marker Score: 1,046
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.42
Marker Score: 15,783
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.39
Marker Score: 1,027
Cell Name: decidual cell (CL2000002)
Fold Change: 2.37
Marker Score: 10,231
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.36
Marker Score: 680
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.34
Marker Score: 1,111
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.33
Marker Score: 1,913
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.33
Marker Score: 1,355
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.32
Marker Score: 9,134
Cell Name: myelocyte (CL0002193)
Fold Change: 2.31
Marker Score: 1,000
Cell Name: keratocyte (CL0002363)
Fold Change: 2.31
Marker Score: 531
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.29
Marker Score: 4,573
Cell Name: lymphocyte (CL0000542)
Fold Change: 2.28
Marker Score: 1,154
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.26
Marker Score: 2,741
Cell Name: Unknown (CL0000548)
Fold Change: 2.22
Marker Score: 1,618
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.22
Marker Score: 3,633
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.2
Marker Score: 3,018
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.19
Marker Score: 3,765
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.18
Marker Score: 1,785
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.18
Marker Score: 1,818

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** 1. **Phospholipid-binding protein**: ANXA1 binds to phospholipids, particularly phosphatidylserine, and modulates their interactions with other molecules. 2. **Cell surface localization**: ANXA1 is primarily localized to the cell surface, where it interacts with other proteins and lipids to regulate cell signaling and migration. 3. **Immune system regulation**: ANXA1 plays a crucial role in regulating immune responses, including the activation and function of immune cells, such as neutrophils and T cells. 4. **Anti-inflammatory effects**: ANXA1 has been shown to have anti-inflammatory properties, inhibiting the production of pro-inflammatory cytokines and promoting the resolution of inflammation. 5. **Regulation of cell migration**: ANXA1 modulates cell migration, influencing the behavior of immune cells and endothelial cells during inflammation and tissue repair. **Pathways and Functions** ANXA1 is involved in numerous signaling pathways that regulate cell behavior and immune responses, including: 1. **G protein-coupled receptor (GPCR) signaling**: ANXA1 interacts with GPCRs to modulate their signaling and regulate immune responses. 2. **Cytokine signaling**: ANXA1 regulates cytokine production and signaling, influencing the immune response and inflammation. 3. **Cell migration**: ANXA1 modulates cell migration, influencing the behavior of immune cells and endothelial cells during inflammation and tissue repair. 4. **Apoptosis regulation**: ANXA1 has anti-apoptotic properties, inhibiting the activation of pro-apoptotic pathways and promoting cell survival. 5. **Wound healing**: ANXA1 regulates wound healing by modulating cell migration, inflammation, and tissue repair. **Clinical Significance** ANXA1 has been implicated in various diseases and disorders, including: 1. **Inflammatory disorders**: ANXA1 has anti-inflammatory properties, making it a potential therapeutic target for inflammatory diseases, such as rheumatoid arthritis and asthma. 2. **Immune-mediated disorders**: ANXA1 regulates immune responses, making it a potential therapeutic target for immune-mediated disorders, such as multiple sclerosis and autoimmune diseases. 3. **Cancer**: ANXA1 has been implicated in cancer progression and metastasis, highlighting its potential as a therapeutic target for cancer treatment. 4. **Neurological disorders**: ANXA1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential as a therapeutic target for these conditions. In conclusion, ANXA1 is a multifunctional protein that plays a crucial role in regulating immune responses, cell migration, and inflammation. Its anti-inflammatory properties and ability to modulate cell signaling make it a potential therapeutic target for various diseases and disorders. Further research is needed to fully understand the mechanisms of ANXA1 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Annexin A1

Genular Protein ID: 1212786809

Symbol: ANXA1_HUMAN

Name: Annexin A1

UniProtKB Accession Codes:

P04083 B5BU38

Database IDs:

Citations:

PubMed ID: 2936963

Title: Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.

PubMed ID: 2936963

DOI: 10.1038/320077a0

PubMed ID: 1832554

Title: Correlation of gene and protein structure of rat and human lipocortin I.

PubMed ID: 1832554

DOI: 10.1021/bi00101a015

PubMed ID: 8425544

Title: Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.

PubMed ID: 8425544

DOI: 10.1111/j.1432-1033.1993.tb19904.x

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2457390

Title: Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.

PubMed ID: 2457390

DOI: 10.1021/bi00410a024

PubMed ID: 3303336

Title: Characterization by tandem mass spectrometry of structural modifications in proteins.

PubMed ID: 3303336

DOI: 10.1126/science.3303336

PubMed ID: 2532504

Title: A dimeric form of lipocortin-1 in human placenta.

PubMed ID: 2532504

DOI: 10.1042/bj2630097

PubMed ID: 8557678

Title: Calcium-dependent binding of S100C to the N-terminal domain of annexin I.

PubMed ID: 8557678

DOI: 10.1074/jbc.271.2.719

PubMed ID: 10772777

Title: Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis.

PubMed ID: 10772777

DOI: 10.1006/cbir.1999.0468

PubMed ID: 15485879

Title: Phosphorylation of annexin I by TRPM7 channel-kinase.

PubMed ID: 15485879

DOI: 10.1074/jbc.c400441200

PubMed ID: 15187149

Title: An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.

PubMed ID: 15187149

DOI: 10.4049/jimmunol.172.12.7669

PubMed ID: 17008549

Title: Annexin-1 modulates T-cell activation and differentiation.

PubMed ID: 17008549

DOI: 10.1182/blood-2006-05-022798

PubMed ID: 18641677

Title: Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.

PubMed ID: 18641677

DOI: 10.1038/bjp.2008.252

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19625660

Title: Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.

PubMed ID: 19625660

DOI: 10.1096/fj.09-131391

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22879591

Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

PubMed ID: 22879591

DOI: 10.1074/jbc.m112.394452

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25664854

Title: Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

PubMed ID: 25664854

DOI: 10.1172/jci76693

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8453382

Title: Crystal structure of human annexin I at 2.5-A resolution.

PubMed ID: 8453382

DOI: 10.1002/pro.5560020317

PubMed ID: 9915835

Title: NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit.

PubMed ID: 9915835

DOI: 10.1074/jbc.274.5.2971

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 10673436

Title: Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.

PubMed ID: 10673436

DOI: 10.1016/s0969-2126(00)00093-9

Sequence Information:

Length: 346
Mass: 38714
Checksum: 14B42E1FA4178EC0
Sequence:

MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV 
DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA 
DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL 
LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY 
TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM 
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANXA1

Associated with

Cells (max top 100)

Other Information

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. PubMed ID: 2936963

Correlation of gene and protein structure of rat and human lipocortin I. PubMed ID: 1832554

Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. PubMed ID: 8425544

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. PubMed ID: 2457390

Characterization by tandem mass spectrometry of structural modifications in proteins. PubMed ID: 3303336

A dimeric form of lipocortin-1 in human placenta. PubMed ID: 2532504

Calcium-dependent binding of S100C to the N-terminal domain of annexin I. PubMed ID: 8557678

Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. PubMed ID: 10772777

Phosphorylation of annexin I by TRPM7 channel-kinase. PubMed ID: 15485879

An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. PubMed ID: 15187149

Annexin-1 modulates T-cell activation and differentiation. PubMed ID: 17008549

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. PubMed ID: 18641677

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. PubMed ID: 19625660

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions. PubMed ID: 22879591

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. PubMed ID: 25664854

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of human annexin I at 2.5-A resolution. PubMed ID: 8453382

NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. PubMed ID: 9915835

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I. PubMed ID: 10673436