ANXA1 | ENSG00000135046 | NCBI 301

Details for: ANXA1

Gene ID: 301

Symbol: ANXA1

Ensembl ID: ENSG00000135046

Description: annexin A1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
Formyl peptide receptors bind formyl peptides and many other ligands
(R-HSA-444473)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Muscle contraction
(R-HSA-397014)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Smooth muscle contraction
(R-HSA-445355)
Actin cytoskeleton organization
(GO:0030036)
Actin filament
(GO:0005884)
Adaptive immune response
(GO:0002250)
Adherens junction
(GO:0005912)
Alpha-beta t cell differentiation
(GO:0046632)
Apical plasma membrane
(GO:0016324)
Arachidonate secretion
(GO:0050482)
Basolateral plasma membrane
(GO:0016323)
Cadherin binding involved in cell-cell adhesion
(GO:0098641)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Cell-cell adhesion
(GO:0098609)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Collagen-containing extracellular matrix
(GO:0062023)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome membrane
(GO:0031901)
Endosome
(GO:0005768)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Granulocyte chemotaxis
(GO:0071621)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Keratinocyte differentiation
(GO:0030216)
Lateral plasma membrane
(GO:0016328)
Lipid binding
(GO:0008289)
Monocyte chemotaxis
(GO:0002548)
Motile cilium
(GO:0031514)
Myoblast migration involved in skeletal muscle regeneration
(GO:0014839)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of exocytosis
(GO:0045920)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of t-helper 2 cell differentiation
(GO:0045629)
Neutrophil activation
(GO:0042119)
Neutrophil clearance
(GO:0097350)
Neutrophil homeostasis
(GO:0001780)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptide cross-linking
(GO:0018149)
Phagocytic cup
(GO:0001891)
Phagocytosis
(GO:0006909)
Phosphatidylserine binding
(GO:0001786)
Phospholipase a2 inhibitor activity
(GO:0019834)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of neutrophil apoptotic process
(GO:0033031)
Positive regulation of t-helper 1 cell differentiation
(GO:0045627)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of vesicle fusion
(GO:0031340)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Regulation of cell shape
(GO:0008360)
Regulation of hormone secretion
(GO:0046883)
Regulation of inflammatory response
(GO:0050727)
Regulation of interleukin-1 production
(GO:0032652)
Regulation of leukocyte migration
(GO:0002685)
Sarcolemma
(GO:0042383)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Vesicle
(GO:0031982)
Vesicle membrane
(GO:0012506)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 608.0547
Cell Significance Index: -94.5800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 253.4546
Cell Significance Index: -104.4100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 252.7959
Cell Significance Index: -64.1200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 206.2241
Cell Significance Index: -83.7800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 203.6123
Cell Significance Index: -96.1300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 179.7291
Cell Significance Index: -92.4500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 90.0138
Cell Significance Index: -85.9400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 76.7911
Cell Significance Index: -94.6800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.8639
Cell Significance Index: -100.9400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 26.5742
Cell Significance Index: -58.1600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.6398
Cell Significance Index: -97.2300
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 14.9215
Cell Significance Index: 128.2200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.7405
Cell Significance Index: -34.1300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 12.1263
Cell Significance Index: 323.7900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 9.5755
Cell Significance Index: 176.9800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 7.9913
Cell Significance Index: 229.0800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.8603
Cell Significance Index: 369.4300
Cell Name: peg cell (CL4033014)
Fold Change: 6.2411
Cell Significance Index: 144.1900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.0649
Cell Significance Index: 107.1800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.0174
Cell Significance Index: 136.5700
Cell Name: lactocyte (CL0002325)
Fold Change: 4.9950
Cell Significance Index: 645.3200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.1926
Cell Significance Index: 47.6300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 4.0955
Cell Significance Index: 185.6400
Cell Name: odontoblast (CL0000060)
Fold Change: 3.6632
Cell Significance Index: 469.6000
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.5357
Cell Significance Index: 1930.9100
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.2494
Cell Significance Index: 20.1900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.0552
Cell Significance Index: 375.6600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 3.0298
Cell Significance Index: 576.5900
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 2.9618
Cell Significance Index: 37.3000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.9522
Cell Significance Index: 1305.2400
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.4900
Cell Significance Index: 15.4100
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.2091
Cell Significance Index: 6.5700
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.0485
Cell Significance Index: 39.9800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.0239
Cell Significance Index: 56.5600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.8076
Cell Significance Index: 178.8200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7654
Cell Significance Index: 91.7100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.6846
Cell Significance Index: 231.3400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.6661
Cell Significance Index: 15.3400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.3625
Cell Significance Index: 96.3600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9340
Cell Significance Index: 168.3700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7776
Cell Significance Index: 126.4700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.7704
Cell Significance Index: 1420.7200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5659
Cell Significance Index: 16.6200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.5346
Cell Significance Index: 3.2300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.4831
Cell Significance Index: 24.4200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3001
Cell Significance Index: 15.6300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2978
Cell Significance Index: 458.4400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2826
Cell Significance Index: 30.7400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2207
Cell Significance Index: 167.0500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0051
Cell Significance Index: 0.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0019
Cell Significance Index: 0.1200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0064
Cell Significance Index: -0.6500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0381
Cell Significance Index: -51.7800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0509
Cell Significance Index: -95.8600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0798
Cell Significance Index: -59.1300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0984
Cell Significance Index: -2.4600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1104
Cell Significance Index: -62.2700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1142
Cell Significance Index: -83.7200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1224
Cell Significance Index: -76.4100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1351
Cell Significance Index: -85.7900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1520
Cell Significance Index: -11.3300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1974
Cell Significance Index: -89.6100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2152
Cell Significance Index: -14.8800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2379
Cell Significance Index: -68.4600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2411
Cell Significance Index: -3.2900
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2536
Cell Significance Index: -3.6100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2548
Cell Significance Index: -7.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2563
Cell Significance Index: -51.4200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2761
Cell Significance Index: -99.0400
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.3898
Cell Significance Index: -77.3500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4224
Cell Significance Index: -88.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4286
Cell Significance Index: -19.9900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4308
Cell Significance Index: -49.1700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.4426
Cell Significance Index: -7.6300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4597
Cell Significance Index: -9.9600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4868
Cell Significance Index: -83.1200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5401
Cell Significance Index: -62.9400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6354
Cell Significance Index: -92.3700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.7610
Cell Significance Index: -89.7500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7982
Cell Significance Index: -91.4500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8327
Cell Significance Index: -49.9900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9373
Cell Significance Index: -97.6000
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -1.0191
Cell Significance Index: -9.6800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1468
Cell Significance Index: -90.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.3078
Cell Significance Index: -100.3600
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.3409
Cell Significance Index: -34.2600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4311
Cell Significance Index: -87.9600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.5125
Cell Significance Index: -95.3300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.5186
Cell Significance Index: -102.1100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.5488
Cell Significance Index: -63.4600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5533
Cell Significance Index: -95.2300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.5890
Cell Significance Index: -42.5100
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.6643
Cell Significance Index: -13.9800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.8970
Cell Significance Index: -106.4500
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -1.9243
Cell Significance Index: -13.8200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.9725
Cell Significance Index: -63.1800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.9957
Cell Significance Index: -73.2600
Cell Name: late promyelocyte (CL0002151)
Fold Change: -2.0003
Cell Significance Index: -13.2700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -2.0941
Cell Significance Index: -109.9500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.3223
Cell Significance Index: -102.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Phospholipid-binding protein**: ANXA1 binds to phospholipids, particularly phosphatidylserine, and modulates their interactions with other molecules. 2. **Cell surface localization**: ANXA1 is primarily localized to the cell surface, where it interacts with other proteins and lipids to regulate cell signaling and migration. 3. **Immune system regulation**: ANXA1 plays a crucial role in regulating immune responses, including the activation and function of immune cells, such as neutrophils and T cells. 4. **Anti-inflammatory effects**: ANXA1 has been shown to have anti-inflammatory properties, inhibiting the production of pro-inflammatory cytokines and promoting the resolution of inflammation. 5. **Regulation of cell migration**: ANXA1 modulates cell migration, influencing the behavior of immune cells and endothelial cells during inflammation and tissue repair. **Pathways and Functions** ANXA1 is involved in numerous signaling pathways that regulate cell behavior and immune responses, including: 1. **G protein-coupled receptor (GPCR) signaling**: ANXA1 interacts with GPCRs to modulate their signaling and regulate immune responses. 2. **Cytokine signaling**: ANXA1 regulates cytokine production and signaling, influencing the immune response and inflammation. 3. **Cell migration**: ANXA1 modulates cell migration, influencing the behavior of immune cells and endothelial cells during inflammation and tissue repair. 4. **Apoptosis regulation**: ANXA1 has anti-apoptotic properties, inhibiting the activation of pro-apoptotic pathways and promoting cell survival. 5. **Wound healing**: ANXA1 regulates wound healing by modulating cell migration, inflammation, and tissue repair. **Clinical Significance** ANXA1 has been implicated in various diseases and disorders, including: 1. **Inflammatory disorders**: ANXA1 has anti-inflammatory properties, making it a potential therapeutic target for inflammatory diseases, such as rheumatoid arthritis and asthma. 2. **Immune-mediated disorders**: ANXA1 regulates immune responses, making it a potential therapeutic target for immune-mediated disorders, such as multiple sclerosis and autoimmune diseases. 3. **Cancer**: ANXA1 has been implicated in cancer progression and metastasis, highlighting its potential as a therapeutic target for cancer treatment. 4. **Neurological disorders**: ANXA1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential as a therapeutic target for these conditions. In conclusion, ANXA1 is a multifunctional protein that plays a crucial role in regulating immune responses, cell migration, and inflammation. Its anti-inflammatory properties and ability to modulate cell signaling make it a potential therapeutic target for various diseases and disorders. Further research is needed to fully understand the mechanisms of ANXA1 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Annexin A1

Genular Protein ID: 1212786809

Symbol: ANXA1_HUMAN

Name: Annexin A1

UniProtKB Accession Codes:

P04083 B5BU38

Database IDs:

Citations:

PubMed ID: 2936963

Title: Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.

PubMed ID: 2936963

DOI: 10.1038/320077a0

PubMed ID: 1832554

Title: Correlation of gene and protein structure of rat and human lipocortin I.

PubMed ID: 1832554

DOI: 10.1021/bi00101a015

PubMed ID: 8425544

Title: Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.

PubMed ID: 8425544

DOI: 10.1111/j.1432-1033.1993.tb19904.x

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2457390

Title: Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.

PubMed ID: 2457390

DOI: 10.1021/bi00410a024

PubMed ID: 3303336

Title: Characterization by tandem mass spectrometry of structural modifications in proteins.

PubMed ID: 3303336

DOI: 10.1126/science.3303336

PubMed ID: 2532504

Title: A dimeric form of lipocortin-1 in human placenta.

PubMed ID: 2532504

DOI: 10.1042/bj2630097

PubMed ID: 8557678

Title: Calcium-dependent binding of S100C to the N-terminal domain of annexin I.

PubMed ID: 8557678

DOI: 10.1074/jbc.271.2.719

PubMed ID: 10772777

Title: Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis.

PubMed ID: 10772777

DOI: 10.1006/cbir.1999.0468

PubMed ID: 15485879

Title: Phosphorylation of annexin I by TRPM7 channel-kinase.

PubMed ID: 15485879

DOI: 10.1074/jbc.c400441200

PubMed ID: 15187149

Title: An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.

PubMed ID: 15187149

DOI: 10.4049/jimmunol.172.12.7669

PubMed ID: 17008549

Title: Annexin-1 modulates T-cell activation and differentiation.

PubMed ID: 17008549

DOI: 10.1182/blood-2006-05-022798

PubMed ID: 18641677

Title: Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.

PubMed ID: 18641677

DOI: 10.1038/bjp.2008.252

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19625660

Title: Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.

PubMed ID: 19625660

DOI: 10.1096/fj.09-131391

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22879591

Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

PubMed ID: 22879591

DOI: 10.1074/jbc.m112.394452

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25664854

Title: Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

PubMed ID: 25664854

DOI: 10.1172/jci76693

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8453382

Title: Crystal structure of human annexin I at 2.5-A resolution.

PubMed ID: 8453382

DOI: 10.1002/pro.5560020317

PubMed ID: 9915835

Title: NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit.

PubMed ID: 9915835

DOI: 10.1074/jbc.274.5.2971

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 10673436

Title: Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.

PubMed ID: 10673436

DOI: 10.1016/s0969-2126(00)00093-9

Sequence Information:

Length: 346
Mass: 38714
Checksum: 14B42E1FA4178EC0
Sequence:

MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV 
DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA 
DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL 
LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY 
TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM 
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANXA1

Associated with

Cells (max top 100)

Other Information

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. PubMed ID: 2936963

Correlation of gene and protein structure of rat and human lipocortin I. PubMed ID: 1832554

Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. PubMed ID: 8425544

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. PubMed ID: 2457390

Characterization by tandem mass spectrometry of structural modifications in proteins. PubMed ID: 3303336

A dimeric form of lipocortin-1 in human placenta. PubMed ID: 2532504

Calcium-dependent binding of S100C to the N-terminal domain of annexin I. PubMed ID: 8557678

Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. PubMed ID: 10772777

Phosphorylation of annexin I by TRPM7 channel-kinase. PubMed ID: 15485879

An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. PubMed ID: 15187149

Annexin-1 modulates T-cell activation and differentiation. PubMed ID: 17008549

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. PubMed ID: 18641677

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. PubMed ID: 19625660

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions. PubMed ID: 22879591

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. PubMed ID: 25664854

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of human annexin I at 2.5-A resolution. PubMed ID: 8453382

NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. PubMed ID: 9915835

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I. PubMed ID: 10673436