Details for: SLC25A6

Gene ID: 293

Symbol: SLC25A6

Ensembl ID: ENSG00000169100

Description: solute carrier family 25 member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 316.6422
    Cell Significance Index: -130.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 271.5863
    Cell Significance Index: -139.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 270.4594
    Cell Significance Index: -127.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 190.6793
    Cell Significance Index: -127.9500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 52.1939
    Cell Significance Index: 137.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.9337
    Cell Significance Index: -91.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 27.5381
    Cell Significance Index: 749.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.7577
    Cell Significance Index: -45.4300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 17.8331
    Cell Significance Index: 104.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4216
    Cell Significance Index: -46.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 15.3837
    Cell Significance Index: 129.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 13.0313
    Cell Significance Index: 104.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.4842
    Cell Significance Index: 275.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 9.7109
    Cell Significance Index: 105.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.4618
    Cell Significance Index: 198.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.6965
    Cell Significance Index: 302.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.6922
    Cell Significance Index: 405.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.3859
    Cell Significance Index: 107.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.1947
    Cell Significance Index: 287.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 7.7455
    Cell Significance Index: 42.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.1413
    Cell Significance Index: 126.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.7991
    Cell Significance Index: 878.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.9612
    Cell Significance Index: 818.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.9489
    Cell Significance Index: 137.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.7525
    Cell Significance Index: 371.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.6735
    Cell Significance Index: 163.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.5307
    Cell Significance Index: 997.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.4341
    Cell Significance Index: 668.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 5.3913
    Cell Significance Index: 381.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.3852
    Cell Significance Index: 253.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.2661
    Cell Significance Index: 899.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.0458
    Cell Significance Index: 148.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.9167
    Cell Significance Index: 366.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.7602
    Cell Significance Index: 561.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.3961
    Cell Significance Index: 230.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.3443
    Cell Significance Index: 40.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.1194
    Cell Significance Index: 2249.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.8119
    Cell Significance Index: 1685.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.7437
    Cell Significance Index: 42.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6064
    Cell Significance Index: 103.3800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.3257
    Cell Significance Index: 34.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.8286
    Cell Significance Index: 195.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.7799
    Cell Significance Index: 356.3700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3951
    Cell Significance Index: 14.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.9041
    Cell Significance Index: 13.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7384
    Cell Significance Index: 32.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7246
    Cell Significance Index: 1557.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6019
    Cell Significance Index: 158.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5763
    Cell Significance Index: 256.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5553
    Cell Significance Index: 308.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5186
    Cell Significance Index: 40.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0998
    Cell Significance Index: 16.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0545
    Cell Significance Index: 200.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.7900
    Cell Significance Index: 597.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4548
    Cell Significance Index: 333.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4271
    Cell Significance Index: 13.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2953
    Cell Significance Index: 3.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2628
    Cell Significance Index: 52.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1592
    Cell Significance Index: 12.6100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1538
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1164
    Cell Significance Index: 86.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0770
    Cell Significance Index: 27.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0070
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0197
    Cell Significance Index: -37.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0484
    Cell Significance Index: -89.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0601
    Cell Significance Index: -92.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0826
    Cell Significance Index: -4.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0831
    Cell Significance Index: -112.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1034
    Cell Significance Index: -58.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1579
    Cell Significance Index: -100.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1587
    Cell Significance Index: -6.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1693
    Cell Significance Index: -117.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2093
    Cell Significance Index: -130.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2278
    Cell Significance Index: -103.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2389
    Cell Significance Index: -27.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2740
    Cell Significance Index: -78.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3848
    Cell Significance Index: -55.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4682
    Cell Significance Index: -11.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5075
    Cell Significance Index: -106.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5452
    Cell Significance Index: -30.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5509
    Cell Significance Index: -9.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7482
    Cell Significance Index: -20.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7583
    Cell Significance Index: -20.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0314
    Cell Significance Index: -79.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1249
    Cell Significance Index: -24.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1408
    Cell Significance Index: -118.7800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -1.2362
    Cell Significance Index: -6.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2365
    Cell Significance Index: -21.1900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.5286
    Cell Significance Index: -9.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.6571
    Cell Significance Index: -34.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7687
    Cell Significance Index: -108.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.9119
    Cell Significance Index: -19.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.9299
    Cell Significance Index: -115.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.9807
    Cell Significance Index: -13.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.0592
    Cell Significance Index: -52.9300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -2.1274
    Cell Significance Index: -18.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2672
    Cell Significance Index: -66.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -2.3902
    Cell Significance Index: -36.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.4653
    Cell Significance Index: -109.0500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -2.4841
    Cell Significance Index: -14.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial Function:** SLC25A6 is involved in mitochondrial ADP/ATP translocase activity, which is essential for energy metabolism and regulating mitochondrial membrane potential. 2. **Protein Metabolism:** This gene is involved in the transport of small molecules, including nucleosides, vitamins, and related molecules, across the plasma membrane. 3. **Immune Response:** SLC25A6 is expressed in immune cells, such as classical monocytes, CD8-positive T cells, and myeloid dendritic cells, and plays a role in regulating immune responses, including apoptosis and viral infection pathways. 4. **Cellular Localization:** SLC25A6 is primarily localized to the mitochondrial inner membrane, where it regulates mitochondrial function and protein import. **Pathways and Functions:** 1. **Apoptotic Process:** SLC25A6 is involved in regulating mitochondrial outer membrane permeabilization, which is a critical step in the apoptotic process. 2. **ATP:ADP Antiporter Activity:** This gene regulates the transport of ADP and ATP across the mitochondrial membrane, which is essential for energy metabolism. 3. **Disease:** SLC25A6 has been implicated in various diseases, including HIV infection, influenza, and cancer, highlighting its importance in human health and disease. 4. **Viral Infection Pathways:** This gene plays a role in regulating viral infection pathways, including HIV and influenza, by modulating immune responses and mitochondrial function. **Clinical Significance:** 1. **HIV Infection:** SLC25A6 has been shown to play a role in regulating HIV-induced apoptosis and immune responses, highlighting its potential as a therapeutic target for HIV treatment. 2. **Influenza Infection:** This gene is involved in regulating influenza-induced apoptosis and immune responses, highlighting its potential as a therapeutic target for influenza treatment. 3. **Cancer:** SLC25A6 has been implicated in various cancers, including prostate cancer, highlighting its potential as a biomarker or therapeutic target. 4. **Immune Response:** This gene plays a critical role in regulating immune responses, including apoptosis and viral infection pathways, highlighting its importance in maintaining immune homeostasis. In conclusion, SLC25A6 is a multifaceted gene involved in various cellular processes, including mitochondrial function, protein metabolism, and immune response. Its implications in human health and disease highlight its potential as a therapeutic target or biomarker for various diseases, including HIV infection, influenza, and cancer. Further research is needed to fully elucidate the roles of SLC25A6 in human health and disease.

Genular Protein ID: 1248946526

Symbol: ADT3_HUMAN

Name: ADP/ATP translocase 3, N-terminally processed

UniProtKB Accession Codes:

P12236 Q96C49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2541251

Title: DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.

PubMed ID: 2541251

DOI: 10.1016/0022-2836(89)90477-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2829183

Title: Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

PubMed ID: 2829183

DOI: 10.1073/pnas.85.2.377

PubMed ID: 8486369

Title: A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation.

PubMed ID: 8486369

DOI: 10.1006/geno.1993.1135

PubMed ID: 15033708

Title: Study of PTPC composition during apoptosis for identification of viral protein target.

PubMed ID: 15033708

DOI: 10.1196/annals.1299.022

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16120388

Title: Mitochondrial membrane permeabilization by HIV-1 Vpr.

PubMed ID: 16120388

DOI: 10.1016/j.mito.2004.06.012

PubMed ID: 16201016

Title: Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.

PubMed ID: 16201016

DOI: 10.1371/journal.ppat.0010004

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 31213526

Title: Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

PubMed ID: 31213526

DOI: 10.1074/jbc.ra119.009045

PubMed ID: 31341297

Title: H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

PubMed ID: 31341297

DOI: 10.1038/s41586-019-1400-3

Sequence Information:

  • Length: 298
  • Mass: 32866
  • Checksum: 18534E9F0E49672F
  • Sequence:
    • MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR 
IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG 
GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS 
VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM 
QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.