Gene SLC25A6 - ENSG00000169100 | NCBI Gene ID: 293

Details for: SLC25A6

Gene ID: 293

Symbol: SLC25A6

Ensembl ID: ENSG00000169100

Description: solute carrier family 25 member 6

Associated with

Disease
(R-HSA-1643685)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza virus induced apoptosis
(R-HSA-168277)
Interactions of vpr with host cellular proteins
(R-HSA-176033)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Mitochondrial protein import
(R-HSA-1268020)
Protein localization
(R-HSA-9609507)
Slc-mediated transmembrane transport
(R-HSA-425407)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
(R-HSA-83936)
Transport of small molecules
(R-HSA-382551)
Transport of vitamins, nucleosides, and related molecules
(R-HSA-425397)
Viral infection pathways
(R-HSA-9824446)
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
(R-HSA-180897)
Apoptotic process
(GO:0006915)
Atp:adp antiporter activity
(GO:0005471)
Membrane
(GO:0016020)
Mitochondrial adp transmembrane transport
(GO:0140021)
Mitochondrial atp transmembrane transport
(GO:1990544)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Tim23 mitochondrial import inner membrane translocase complex
(GO:0005744)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 16
Marker Score: 45183
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 10.2
Marker Score: 21527
Cell Name: classical monocyte (CL0000860)
Fold Change: 10
Marker Score: 41558
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 9.39
Marker Score: 7973
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 8.54
Marker Score: 22129
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 6.93
Marker Score: 16919.5
Cell Name: stromal cell (CL0000499)
Fold Change: 6.83
Marker Score: 8001
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 6.42
Marker Score: 6284
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 6.23
Marker Score: 10686
Cell Name: naive B cell (CL0000788)
Fold Change: 6.21
Marker Score: 5549
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 5.55
Marker Score: 4192
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 5.41
Marker Score: 1585
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 4.96
Marker Score: 4914
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 4.93
Marker Score: 3476
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.73
Marker Score: 2872
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 4.63
Marker Score: 7594
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.57
Marker Score: 29800
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.56
Marker Score: 3580
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 4.41
Marker Score: 4604
Cell Name: mature T cell (CL0002419)
Fold Change: 4.27
Marker Score: 42318
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 4.23
Marker Score: 6149
Cell Name: malignant cell (CL0001064)
Fold Change: 4.22
Marker Score: 56710
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.19
Marker Score: 55209
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.15
Marker Score: 8698
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 4.15
Marker Score: 4982
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.98
Marker Score: 210301.5
Cell Name: blood cell (CL0000081)
Fold Change: 3.95
Marker Score: 45942
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.95
Marker Score: 943
Cell Name: theca cell (CL0000503)
Fold Change: 3.91
Marker Score: 2804
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.91
Marker Score: 2381
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.91
Marker Score: 6986
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.86
Marker Score: 215639
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.83
Marker Score: 130430
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.82
Marker Score: 12047
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.8
Marker Score: 2230
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 3.8
Marker Score: 913
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 3.77
Marker Score: 11007
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 3.77
Marker Score: 934
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.75
Marker Score: 2196
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.74
Marker Score: 3185
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.71
Marker Score: 3269
Cell Name: acinar cell (CL0000622)
Fold Change: 3.67
Marker Score: 2589
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.67
Marker Score: 3613
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.67
Marker Score: 15717
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 3.65
Marker Score: 1109
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.61
Marker Score: 3398
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.61
Marker Score: 26872
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 3.58
Marker Score: 2087
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.55
Marker Score: 9510
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.53
Marker Score: 936
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.53
Marker Score: 22983
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.5
Marker Score: 922
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.48
Marker Score: 3365
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.47
Marker Score: 5519
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.45
Marker Score: 3080
Cell Name: supporting cell (CL0000630)
Fold Change: 3.45
Marker Score: 6487
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.45
Marker Score: 9525
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 3.42
Marker Score: 1556
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 3.42
Marker Score: 899.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.42
Marker Score: 3550
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.41
Marker Score: 3220.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 3.39
Marker Score: 4702
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 3.38
Marker Score: 1549
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.37
Marker Score: 4070
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.37
Marker Score: 9831
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.36
Marker Score: 2787
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.35
Marker Score: 1103
Cell Name: microglial cell (CL0000129)
Fold Change: 3.32
Marker Score: 6053
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 3.32
Marker Score: 7468
Cell Name: connective tissue cell (CL0002320)
Fold Change: 3.31
Marker Score: 858
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.29
Marker Score: 935
Cell Name: immature B cell (CL0000816)
Fold Change: 3.28
Marker Score: 2174
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.28
Marker Score: 7438
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.28
Marker Score: 923
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.26
Marker Score: 7949
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 3.24
Marker Score: 2505.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.23
Marker Score: 2875
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.22
Marker Score: 2539
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.22
Marker Score: 3801
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.22
Marker Score: 1666
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.21
Marker Score: 2156
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.2
Marker Score: 913
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.2
Marker Score: 4164
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 3.2
Marker Score: 1593
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 3.19
Marker Score: 1991
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.19
Marker Score: 24912.5
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 3.19
Marker Score: 943
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.18
Marker Score: 741
Cell Name: reticular cell (CL0000432)
Fold Change: 3.17
Marker Score: 1157
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.17
Marker Score: 3443.5
Cell Name: S cone cell (CL0003050)
Fold Change: 3.16
Marker Score: 951
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.16
Marker Score: 837
Cell Name: naive T cell (CL0000898)
Fold Change: 3.16
Marker Score: 2034
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 3.15
Marker Score: 800.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.15
Marker Score: 1012
Cell Name: papillary tips cell (CL1000597)
Fold Change: 3.15
Marker Score: 636
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.15
Marker Score: 4457.5
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 3.15
Marker Score: 1304
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 3.14
Marker Score: 1088
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.14
Marker Score: 2066

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**Key characteristics:** * SLC25A6 is a protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including tracheal goblet cells, pancreatic acinar cells, classical monocytes, CD8+ and CD1c-positive memory T cells, CD13-positive myeloid dendritic cells, basal cells of the prostate epithelium, stromal cells, pancreatic A cells, naive thymus-derived CD4+ and CD8+ T cells, and naive B cells. * It is a key regulator of apoptosis, as it is upregulated in cells undergoing apoptosis. * It is also involved in the regulation of inflammation, as it is upregulated in inflammatory cells. * It is involved in the regulation of viral infection, as it is upregulated in cells infected with viruses. **Pathways and functions:** * SLC25A6 is involved in the apoptotic process by regulating the release of cytochrome c from the mitochondria into the cytoplasm. * It is also involved in the regulation of inflammation by regulating the production of inflammatory cytokines. * It is involved in the regulation of viral infection by regulating the entry of virus into cells. **Clinical significance:** * Mutations in SLC25A6 have been linked to a number of human diseases, including cancer, autoimmune disorders, and viral infections. * Overexpression of SLC25A6 has been linked to the progression of cancer. * Inhibition of SLC25A6 has been shown to inhibit apoptosis and promote tumor growth. * Therefore, SLC25A6 is a promising target for the treatment of cancer and other diseases that are characterized by apoptosis or inflammation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ADP/ATP translocase 3, N-terminally processed

Genular Protein ID: 1248946526

Symbol: ADT3_HUMAN

Name: ADP/ATP translocase 3, N-terminally processed

UniProtKB Accession Codes:

P12236 Q96C49

Database IDs:

Citations:

PubMed ID: 2541251

Title: DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.

PubMed ID: 2541251

DOI: 10.1016/0022-2836(89)90477-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2829183

Title: Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

PubMed ID: 2829183

DOI: 10.1073/pnas.85.2.377

PubMed ID: 8486369

Title: A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation.

PubMed ID: 8486369

DOI: 10.1006/geno.1993.1135

PubMed ID: 15033708

Title: Study of PTPC composition during apoptosis for identification of viral protein target.

PubMed ID: 15033708

DOI: 10.1196/annals.1299.022

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16120388

Title: Mitochondrial membrane permeabilization by HIV-1 Vpr.

PubMed ID: 16120388

DOI: 10.1016/j.mito.2004.06.012

PubMed ID: 16201016

Title: Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.

PubMed ID: 16201016

DOI: 10.1371/journal.ppat.0010004

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 31213526

Title: Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

PubMed ID: 31213526

DOI: 10.1074/jbc.ra119.009045

PubMed ID: 31341297

Title: H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

PubMed ID: 31341297

DOI: 10.1038/s41586-019-1400-3

Sequence Information:

Length: 298
Mass: 32866
Checksum: 18534E9F0E49672F
Sequence:

MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR 
IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG 
GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS 
VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM 
QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: SLC25A6

Associated with

Cells (max top 100)

Other Information

DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. PubMed ID: 2541251

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. PubMed ID: 2829183

A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. PubMed ID: 8486369

Study of PTPC composition during apoptosis for identification of viral protein target. PubMed ID: 15033708

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Mitochondrial membrane permeabilization by HIV-1 Vpr. PubMed ID: 16120388

Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PubMed ID: 16201016

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood. PubMed ID: 27641616

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. PubMed ID: 31213526

H+ transport is an integral function of the mitochondrial ADP/ATP carrier. PubMed ID: 31341297