Details for: RND3

Gene ID: 390

Symbol: RND3

Ensembl ID: ENSG00000115963

Description: Rho family GTPase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.4348
    Cell Significance Index: -56.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.7856
    Cell Significance Index: -48.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 84.7066
    Cell Significance Index: -56.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.5267
    Cell Significance Index: -48.2400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 24.3240
    Cell Significance Index: 72.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.2734
    Cell Significance Index: 323.1600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.8689
    Cell Significance Index: 23.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.8113
    Cell Significance Index: 197.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0930
    Cell Significance Index: 84.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8571
    Cell Significance Index: 31.0600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.5991
    Cell Significance Index: 17.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2550
    Cell Significance Index: 47.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2194
    Cell Significance Index: 284.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2124
    Cell Significance Index: 272.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0362
    Cell Significance Index: 900.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9001
    Cell Significance Index: 86.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8815
    Cell Significance Index: 133.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4928
    Cell Significance Index: 815.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4870
    Cell Significance Index: 268.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4087
    Cell Significance Index: 30.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3594
    Cell Significance Index: 20.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3201
    Cell Significance Index: 62.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.2216
    Cell Significance Index: 17.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0931
    Cell Significance Index: 987.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0827
    Cell Significance Index: 9.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0338
    Cell Significance Index: 168.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9137
    Cell Significance Index: 26.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7127
    Cell Significance Index: 12.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5530
    Cell Significance Index: 60.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5255
    Cell Significance Index: 72.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3918
    Cell Significance Index: 50.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3406
    Cell Significance Index: 67.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3311
    Cell Significance Index: 8.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3248
    Cell Significance Index: 24.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2173
    Cell Significance Index: 15.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1966
    Cell Significance Index: 19.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1911
    Cell Significance Index: 6.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1821
    Cell Significance Index: 4.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1644
    Cell Significance Index: 113.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1058
    Cell Significance Index: 20.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0635
    Cell Significance Index: 3.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0526
    Cell Significance Index: 97.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0493
    Cell Significance Index: 0.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0422
    Cell Significance Index: 1.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0407
    Cell Significance Index: 62.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0138
    Cell Significance Index: -25.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0322
    Cell Significance Index: -23.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0413
    Cell Significance Index: -56.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0436
    Cell Significance Index: -27.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0525
    Cell Significance Index: -39.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0537
    Cell Significance Index: -34.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0637
    Cell Significance Index: -46.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0808
    Cell Significance Index: -45.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0836
    Cell Significance Index: -1.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1006
    Cell Significance Index: -45.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1268
    Cell Significance Index: -45.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1550
    Cell Significance Index: -11.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1554
    Cell Significance Index: -26.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1643
    Cell Significance Index: -16.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1709
    Cell Significance Index: -49.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2162
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2206
    Cell Significance Index: -46.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2255
    Cell Significance Index: -25.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2284
    Cell Significance Index: -26.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2428
    Cell Significance Index: -48.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2474
    Cell Significance Index: -28.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2614
    Cell Significance Index: -6.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3048
    Cell Significance Index: -44.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3242
    Cell Significance Index: -15.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4840
    Cell Significance Index: -57.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5327
    Cell Significance Index: -18.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5404
    Cell Significance Index: -11.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5609
    Cell Significance Index: -58.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5630
    Cell Significance Index: -31.5900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5864
    Cell Significance Index: -8.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6720
    Cell Significance Index: -53.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7647
    Cell Significance Index: -18.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7675
    Cell Significance Index: -39.9800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.8070
    Cell Significance Index: -5.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8108
    Cell Significance Index: -25.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8420
    Cell Significance Index: -56.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9207
    Cell Significance Index: -10.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9234
    Cell Significance Index: -56.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9321
    Cell Significance Index: -48.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0368
    Cell Significance Index: -26.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0713
    Cell Significance Index: -11.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.1086
    Cell Significance Index: -9.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1550
    Cell Significance Index: -17.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1755
    Cell Significance Index: -30.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.1931
    Cell Significance Index: -7.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2343
    Cell Significance Index: -45.3100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.2410
    Cell Significance Index: -5.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2846
    Cell Significance Index: -56.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3465
    Cell Significance Index: -39.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4868
    Cell Significance Index: -39.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4913
    Cell Significance Index: -56.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.5154
    Cell Significance Index: -37.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.5273
    Cell Significance Index: -40.1600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.5350
    Cell Significance Index: -13.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6434
    Cell Significance Index: -57.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTPase activity:** RND3 is a GTPase, meaning it hydrolyzes GTP to GDP, regulating its activity and thereby controlling its interactions with downstream effectors. 2. **Rho GTPase cycle:** RND3 is part of the Rho GTPase cycle, which involves the exchange of GDP for GTP, leading to the activation of downstream effectors. 3. **Cellular localization:** RND3 is primarily localized to the plasma membrane, where it interacts with various proteins to regulate cellular processes. 4. **Protein binding:** RND3 interacts with numerous proteins, including actin-binding proteins, kinases, and other GTPases, to regulate its activity and downstream effects. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** RND3 regulates the organization of the actin cytoskeleton, which is essential for cell migration, shape changes, and intracellular transport. 2. **Cell adhesion:** RND3 modulates cell adhesion by regulating the interaction between cells and the extracellular matrix, which is crucial for tissue development and repair. 3. **Cell migration:** RND3 is involved in regulating cell migration, which is essential for development, wound healing, and immune responses. 4. **Signaling by Rho GTPases:** RND3 interacts with other Rho GTPases to regulate signaling pathways, including those involved in cell proliferation, differentiation, and survival. 5. **Regulation of the actin cytoskeleton organization:** RND3 regulates the activity of actin-binding proteins, such as actin-myosin interactins, to modulate the organization of the actin cytoskeleton. **Clinical Significance:** Dysregulation of RND3 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of RND3 has been observed in several types of cancer, including breast, prostate, and bladder cancer, suggesting its role in tumorigenesis and metastasis. 2. **Inflammatory diseases:** RND3 is involved in regulating inflammatory responses, and its dysregulation has been implicated in diseases such as arthritis and atherosclerosis. 3. **Neurological disorders:** RND3 has been implicated in the regulation of axonal growth and regeneration, and its dysregulation has been observed in neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease:** RND3 is involved in regulating vascular smooth muscle cell migration and proliferation, and its dysregulation has been implicated in cardiovascular disease. In conclusion, RND3 is a complex gene with multiple functions in regulating cellular processes, including actin cytoskeleton organization, cell adhesion, migration, and signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of RND3 in human disease.

Genular Protein ID: 3991818285

Symbol: RND3_HUMAN

Name: Rho-related GTP-binding protein RhoE

UniProtKB Accession Codes:

P61587 D3DP95 P52199

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9531558

Title: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.

PubMed ID: 9531558

DOI: 10.1083/jcb.141.1.187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8649376

Title: Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.

PubMed ID: 8649376

DOI: 10.1128/mcb.16.6.2689

PubMed ID: 11940653

Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.

PubMed ID: 11940653

DOI: 10.1128/mcb.22.9.2952-2964.2002

PubMed ID: 12163169

Title: Crystal structure of Rnd3/RhoE: functional implications.

PubMed ID: 12163169

DOI: 10.1016/s0014-5793(02)03094-6

Sequence Information:

  • Length: 244
  • Mass: 27368
  • Checksum: DD2D4021CD42BACC
  • Sequence:
    • MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY 
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE 
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL 
QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS 
CTVM

Genular Protein ID: 1870712514

Symbol: B2R838_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R838

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 3 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 244
  • Mass: 27341
  • Checksum: 241D4021CD5930E4
  • Sequence:
    • MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY 
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE 
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL 
QSENSVRDIF HVATLACVSK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS 
CTVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.