Details for: RND3

Gene ID: 390

Symbol: RND3

Ensembl ID: ENSG00000115963

Description: Rho family GTPase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.4
    Marker Score: 149705
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.19
    Marker Score: 2719
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.97
    Marker Score: 1007
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.78
    Marker Score: 1158
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.61
    Marker Score: 1491
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.55
    Marker Score: 2719
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.45
    Marker Score: 3609
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.35
    Marker Score: 1009
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.24
    Marker Score: 1867
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.22
    Marker Score: 2341
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.16
    Marker Score: 539
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.15
    Marker Score: 539
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.13
    Marker Score: 1454
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.12
    Marker Score: 1674
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.06
    Marker Score: 10131
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.99
    Marker Score: 753
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.99
    Marker Score: 22414
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.93
    Marker Score: 2491
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.91
    Marker Score: 7069
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.89
    Marker Score: 8153
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.86
    Marker Score: 4543
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.86
    Marker Score: 1853.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.86
    Marker Score: 64313
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.79
    Marker Score: 1128
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.76
    Marker Score: 406
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.75
    Marker Score: 3100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.74
    Marker Score: 3174
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7
    Marker Score: 1878
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.7
    Marker Score: 4440
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.66
    Marker Score: 373
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.62
    Marker Score: 13932
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.6
    Marker Score: 462
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.59
    Marker Score: 785
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.58
    Marker Score: 1059
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.58
    Marker Score: 1525
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.57
    Marker Score: 1829
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.55
    Marker Score: 972.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.53
    Marker Score: 4790
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.5
    Marker Score: 20212
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.49
    Marker Score: 369
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.48
    Marker Score: 1707
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.47
    Marker Score: 968
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.47
    Marker Score: 416.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167468
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.38
    Marker Score: 1896
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.37
    Marker Score: 10684
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.35
    Marker Score: 713
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.35
    Marker Score: 1348
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 849
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.31
    Marker Score: 454
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3
    Marker Score: 373
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.28
    Marker Score: 1574
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.27
    Marker Score: 1957.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.26
    Marker Score: 1478.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.25
    Marker Score: 644
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.25
    Marker Score: 1509
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.24
    Marker Score: 5973
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.24
    Marker Score: 1316
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.24
    Marker Score: 31719
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.23
    Marker Score: 450.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.23
    Marker Score: 312
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.22
    Marker Score: 284
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.21
    Marker Score: 1978
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.21
    Marker Score: 382
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.19
    Marker Score: 698
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18401
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.17
    Marker Score: 15480
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.16
    Marker Score: 544
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.15
    Marker Score: 409
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.11
    Marker Score: 348
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1
    Marker Score: 7177
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1
    Marker Score: 2071
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.1
    Marker Score: 1435
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.09
    Marker Score: 1686
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.09
    Marker Score: 2575
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.08
    Marker Score: 1459
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.08
    Marker Score: 497
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.07
    Marker Score: 4206.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.06
    Marker Score: 9221
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.06
    Marker Score: 1322
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.06
    Marker Score: 2016
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2152
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.05
    Marker Score: 2095
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.05
    Marker Score: 690
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.04
    Marker Score: 1170
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251691
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.03
    Marker Score: 3967
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.02
    Marker Score: 6491
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.02
    Marker Score: 258
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.02
    Marker Score: 251
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71713
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47937.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.99
    Marker Score: 479
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.95
    Marker Score: 1026
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.95
    Marker Score: 1822
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.94
    Marker Score: 16626

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Other Information

**Key characteristics:** * RND3 is a large protein with a molecular weight of approximately 120 kDa. * It is a member of the Rho GTPase family of proteins, which are involved in a variety of cellular processes, including cell adhesion, migration, and signaling. * RND3 is a key regulator of the actin cytoskeleton, and its expression is regulated by a variety of factors, including growth factors, cytokines, and mechanical signals. **Pathways and functions:** * RND3 is involved in the regulation of cell adhesion by binding to the integrins of the cell surface and facilitating their interaction with each other. * It is also involved in the organization of the actin cytoskeleton, and its expression is upregulated in cells that are migrating or dividing. * RND3 has been shown to play a role in the regulation of cell migration by binding to the cytoskeletal protein actin and facilitating its interaction with the cell membrane. * It is also involved in the regulation of cell adhesion by binding to the extracellular matrix protein fibronectin and facilitating its interaction with the cell membrane. **Clinical significance:** * Mutations in the RND3 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * These mutations can lead to the loss of function of the RND3 protein, which can result in the disruption of cell adhesion, migration, and signaling. * As a result, mutations in the RND3 gene are associated with a number of diseases that are characterized by abnormal cell behavior. **Additional information:** * RND3 is a relatively recently identified gene, and there is still much that is unknown about its function. * However, the research that has been conducted to date suggests that RND3 is a critical protein for cell adhesion, migration, and signaling.

Genular Protein ID: 3991818285

Symbol: RND3_HUMAN

Name: Rho-related GTP-binding protein RhoE

UniProtKB Accession Codes:

P61587 D3DP95 P52199

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 7 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9531558

Title: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.

PubMed ID: 9531558

DOI: 10.1083/jcb.141.1.187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8649376

Title: Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.

PubMed ID: 8649376

DOI: 10.1128/mcb.16.6.2689

PubMed ID: 11940653

Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.

PubMed ID: 11940653

DOI: 10.1128/mcb.22.9.2952-2964.2002

PubMed ID: 12163169

Title: Crystal structure of Rnd3/RhoE: functional implications.

PubMed ID: 12163169

DOI: 10.1016/s0014-5793(02)03094-6

Sequence Information:

  • Length: 244
  • Mass: 27368
  • Checksum: DD2D4021CD42BACC
  • Sequence:
    • MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY 
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE 
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL 
QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS 
CTVM

Genular Protein ID: 1870712514

Symbol: B2R838_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R838

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 3 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 244
  • Mass: 27341
  • Checksum: 241D4021CD5930E4
  • Sequence:
    • MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY 
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE 
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL 
QSENSVRDIF HVATLACVSK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS 
CTVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.