Details for: NCF2

Gene ID: 4688

Symbol: NCF2

Ensembl ID: ENSG00000116701

Description: neutrophil cytosolic factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.6629
    Cell Significance Index: -13.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.6974
    Cell Significance Index: -13.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.7440
    Cell Significance Index: -14.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.9192
    Cell Significance Index: -15.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.8439
    Cell Significance Index: -13.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.5872
    Cell Significance Index: 158.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.3377
    Cell Significance Index: 51.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4856
    Cell Significance Index: -5.4400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.5546
    Cell Significance Index: 19.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4970
    Cell Significance Index: 8.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2333
    Cell Significance Index: 44.3900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1839
    Cell Significance Index: 1.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1478
    Cell Significance Index: 102.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0931
    Cell Significance Index: 84.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0882
    Cell Significance Index: 2.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0611
    Cell Significance Index: 12.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0500
    Cell Significance Index: 4.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0483
    Cell Significance Index: 30.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0329
    Cell Significance Index: 0.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0229
    Cell Significance Index: 3.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0215
    Cell Significance Index: 0.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0148
    Cell Significance Index: 0.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0119
    Cell Significance Index: 6.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0028
    Cell Significance Index: -0.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0051
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -13.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0164
    Cell Significance Index: -7.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0184
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0200
    Cell Significance Index: -14.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0222
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0244
    Cell Significance Index: -2.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0245
    Cell Significance Index: -1.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0249
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0258
    Cell Significance Index: -4.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0301
    Cell Significance Index: -3.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0330
    Cell Significance Index: -0.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0354
    Cell Significance Index: -7.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0354
    Cell Significance Index: -12.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0458
    Cell Significance Index: -13.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0506
    Cell Significance Index: -9.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0644
    Cell Significance Index: -2.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0766
    Cell Significance Index: -9.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0800
    Cell Significance Index: -10.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0932
    Cell Significance Index: -12.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0969
    Cell Significance Index: -11.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0971
    Cell Significance Index: -5.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1005
    Cell Significance Index: -6.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1033
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1069
    Cell Significance Index: -12.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1135
    Cell Significance Index: -2.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1210
    Cell Significance Index: -15.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1236
    Cell Significance Index: -9.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1263
    Cell Significance Index: -4.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1275
    Cell Significance Index: -1.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1280
    Cell Significance Index: -6.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1297
    Cell Significance Index: -13.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1437
    Cell Significance Index: -2.9800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1475
    Cell Significance Index: -1.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1570
    Cell Significance Index: -10.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1678
    Cell Significance Index: -4.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1737
    Cell Significance Index: -7.5600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1782
    Cell Significance Index: -1.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1792
    Cell Significance Index: -2.7000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1922
    Cell Significance Index: -1.6800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1949
    Cell Significance Index: -2.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2088
    Cell Significance Index: -15.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2180
    Cell Significance Index: -5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2215
    Cell Significance Index: -10.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2256
    Cell Significance Index: -15.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2292
    Cell Significance Index: -12.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2352
    Cell Significance Index: -12.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2460
    Cell Significance Index: -15.1200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2481
    Cell Significance Index: -2.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2676
    Cell Significance Index: -13.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2777
    Cell Significance Index: -11.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2994
    Cell Significance Index: -15.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3165
    Cell Significance Index: -14.0000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3212
    Cell Significance Index: -2.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3226
    Cell Significance Index: -8.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3468
    Cell Significance Index: -12.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3516
    Cell Significance Index: -7.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3626
    Cell Significance Index: -13.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3691
    Cell Significance Index: -13.5500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3723
    Cell Significance Index: -2.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3724
    Cell Significance Index: -23.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3742
    Cell Significance Index: -7.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3790
    Cell Significance Index: -17.6700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3908
    Cell Significance Index: -3.9900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4031
    Cell Significance Index: -4.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4038
    Cell Significance Index: -13.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4129
    Cell Significance Index: -13.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NCF2 is a cytosolic protein that is specifically expressed in myeloid cells, including classical and non-classical monocytes, alveolar macrophages, and lung macrophages. It belongs to the p47phox family of proteins, which are essential components of the NADPH oxidase complex. NCF2 is characterized by its ability to bind to other subunits of the complex, including p22phox, and facilitate the assembly of the active enzyme. The protein is also known for its role in regulating the activity of NADPH oxidase, which is crucial for the production of ROS. **Pathways and Functions** NCF2 is involved in several key pathways, including: 1. **Respiratory Burst**: NCF2 plays a central role in the activation of NADPH oxidase, which generates superoxide anions through the transfer of electrons from NADPH to oxygen. 2. **Antigen Processing and Presentation**: NCF2 is involved in the regulation of the NADPH oxidase complex, which helps to activate macrophages and other myeloid cells in response to pathogens and foreign substances. 3. **Innate Immune Response**: NCF2 is essential for the production of ROS, which helps to eliminate pathogens and foreign substances from the body. 4. **Electron Transfer Activity**: NCF2 is involved in the transfer of electrons from NADPH to oxygen, generating superoxide anions. **Clinical Significance** Dysregulation of NCF2 has been implicated in several diseases, including: 1. **Chronic Inflammatory Disorders**: Mutations in the NCF2 gene have been associated with chronic inflammatory disorders, such as chronic granulomatous disease (CGD). 2. **Cancer**: NCF2 has been shown to play a role in the development and progression of cancer, particularly in solid tumors. 3. **Respiratory Diseases**: NCF2 is involved in the regulation of the NADPH oxidase complex, which helps to protect against oxidative stress and inflammation in the lungs. 4. **Neurodegenerative Diseases**: NCF2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, NCF2 is a critical protein component of the NADPH oxidase complex, which plays a central role in the production of ROS and the regulation of the innate immune response. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 2143487864

Symbol: NCF2_HUMAN

Name: Neutrophil cytosol factor 2

UniProtKB Accession Codes:

P19878 B2R6Q1 B4DKQ7 B4DQA7 E9PHJ2 E9PHX3 Q2PP06 Q8NFC7 Q9BV51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 23 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 8 RefSeq 6 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1692159

Title: Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

PubMed ID: 1692159

DOI: 10.1126/science.1692159

PubMed ID: 7903171

Title: Characterization of the p67phox gene: genomic organization and restriction fragment length polymorphism analysis for prenatal diagnosis in chronic granulomatous disease.

PubMed ID: 7903171

PubMed ID: 12207919

Title: Expression of a p67(phox) homolog in Caco-2 cells giving O(2)(-)-reconstituting ability to cytochrome b(558) together with recombinant p47(phox).

PubMed ID: 12207919

DOI: 10.1016/s0006-291x(02)02059-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278853

Title: JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.

PubMed ID: 11278853

DOI: 10.1074/jbc.m011167200

PubMed ID: 12716910

Title: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.

PubMed ID: 12716910

DOI: 10.1074/jbc.m212856200

PubMed ID: 15642721

Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.

PubMed ID: 15642721

DOI: 10.1096/fj.04-2377fje

PubMed ID: 17290225

Title: Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding.

PubMed ID: 17290225

DOI: 10.1038/sj.emboj.7601561

PubMed ID: 11090627

Title: Structure of the TPR domain of p67phox in complex with Rac.GTP.

PubMed ID: 11090627

DOI: 10.1016/s1097-2765(05)00091-2

PubMed ID: 12169629

Title: Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.

PubMed ID: 12169629

DOI: 10.1093/emboj/cdf428

PubMed ID: 12887891

Title: PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.

PubMed ID: 12887891

DOI: 10.1016/s1097-2765(03)00246-6

PubMed ID: 8286749

Title: Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers.

PubMed ID: 8286749

PubMed ID: 9070911

Title: Identification of a double mutation (D160V-K161E) (sic) in the p67phox gene of a chronic granulomatous disease patient.

PubMed ID: 9070911

DOI: 10.1006/bbrc.1997.6204

PubMed ID: 10498624

Title: Molecular characterization of autosomal recessive chronic granulomatous disease caused by a defect of the nicotinamide adenine dinucleotide phosphate (reduced form) oxidase component p67-phox.

PubMed ID: 10498624

PubMed ID: 10598813

Title: Autosomal recessive chronic granulomatous disease caused by novel mutations in NCF-2, the gene encoding the p67-phox component of phagocyte NADPH oxidase.

PubMed ID: 10598813

DOI: 10.1007/s004390051131

PubMed ID: 11112388

Title: Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (first update).

PubMed ID: 11112388

DOI: 10.1006/bcmd.2000.0333

PubMed ID: 16937026

Title: Genetic and mutational heterogeneity of autosomal recessive chronic granulomatous disease in Tunisia.

PubMed ID: 16937026

DOI: 10.1007/s10038-006-0039-8

PubMed ID: 18625437

Title: Focus on FOCIS: the continuing diagnostic challenge of autosomal recessive chronic granulomatous disease.

PubMed ID: 18625437

DOI: 10.1016/j.clim.2008.05.008

PubMed ID: 19624736

Title: Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutations.

PubMed ID: 19624736

DOI: 10.1111/j.1365-2362.2009.02195.x

PubMed ID: 20167518

Title: Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update).

PubMed ID: 20167518

DOI: 10.1016/j.bcmd.2010.01.009

PubMed ID: 23910690

Title: Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients.

PubMed ID: 23910690

DOI: 10.1016/j.jaci.2013.05.039

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 526
  • Mass: 59762
  • Checksum: EC136766E1915376
  • Sequence:
    • MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL KNMTEAEKAF 
TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ LRGNQLIDYK ILGLQFKLFA 
CEVLYNIAFM YAKKEEWKKA EEQLALATSM KSEPRHSKID KAMECVWKQK LYEPVVIPVG 
KLFRPNERQV AQLAKKDYLG KATVVASVVD QDSFSGFAPL QPQAAEPPPR PKTPEIFRAL 
EGEAHRVLFG FVPETKEELQ VMPGNIVFVL KKGNDNWATV MFNGQKGLVP CNYLEPVELR 
IHPQQQPQEE SSPQSDIPAP PSSKAPGRPQ LSPGQKQKEE PKEVKLSVPM PYTLKVHYKY 
TVVMKTQPGL PYSQVRDMVS KKLELRLEHT KLSYRPRDSN ELVPLSEDSM KDAWGQVKNY 
CLTLWCENTV GDQGFPDEPK ESEKADANNQ TTEPQLKKGS QVEALFSYEA TQPEDLEFQE 
GDIILVLSKV NEEWLEGECK GKVGIFPKVF VEDCATTDLE STRREV

Genular Protein ID: 1770991100

Symbol: A0A8V8TMB9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TMB9

Database IDs:

ARBA 3 CDD 3 CTD 1 EMBL 1 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 5 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 490
  • Mass: 55653
  • Checksum: 35A09739FEE7E402
  • Sequence:
    • MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL KNMTEAEKAF 
TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ LRGNQLIDYK ILGLQFKLFA 
CEVLYNIAFM YAKKEEWKKA EEQLALATSM KSEPRHSKID KAMECVWVVA SVVDQDSFSG 
FAPLQPQAAE PPPRPKTPEI FRALEGEAHR VLFGFVPETK EELQVMPGNI VFVLKKGNDN 
WATVMFNGQK GLVPCNYLEP VELRIHPQQQ PQEESSPQSD IPAPPSSKAP GRPQLSPGQK 
QKEEPKEVKL SVPMPYTLKV HYKYTVVMKT QPGLPYSQVR DMVSKKLELR LEHTKLSYRP 
RDSNELVPLS EDSMKDAWGQ VKNYCLTLWC ENTVGDQGFP DEPKESEKAD ANNQTTEPQL 
KKGSQVEALF SYEATQPEDL EFQEGDIILV LSKVNEEWLE GECKGKVGIF PKVFVEDCAT 
TDLESTRREV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.