Details for: CL0000860

Cell ID: CL0000860

Cell Name: classical monocyte

Marker Score Threshold: 4154
(Derived using integrated single-cell and genomic data)

Description: A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.

Synonyms: inflammatory monocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 10
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.63
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.12
    Ensembl ID: ENSG00000143933
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 3.89
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.82
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.79
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.79
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 3.46
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.37
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 3.22
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 3.03
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.99
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.8
    Ensembl ID: ENSG00000100300
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.62
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.6
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.54
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.53
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.51
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.46
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.45
    Ensembl ID: ENSG00000104763
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 2.42
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.35
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 2.26
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 2.25
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.12
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.1
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.06
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.06
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.06
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.04
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.03
    Ensembl ID: ENSG00000077549
  • Gene Symbol: C5AR1 (ENSG00000197405)
    Fold Change: 2
    Ensembl ID: ENSG00000197405
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.97
    Ensembl ID: ENSG00000089820
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.96
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.92
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.92
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.9
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.83
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.83
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.81
    Ensembl ID: ENSG00000042493
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.76
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.72
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.7
    Ensembl ID: ENSG00000134287
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.65
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.64
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.61
    Ensembl ID: ENSG00000069849
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.61
    Ensembl ID: ENSG00000100077
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.54
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.54
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.53
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.51
    Ensembl ID: ENSG00000112297
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.48
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.48
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.48
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.47
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.43
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.42
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.41
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130303
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.39
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.37
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.36
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.35
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.35
    Ensembl ID: ENSG00000132965
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.34
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.33
    Ensembl ID: ENSG00000165527
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.27
    Ensembl ID: ENSG00000147872
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.25
    Ensembl ID: ENSG00000103569
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.24
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.24
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.22
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 1.21
    Ensembl ID: ENSG00000141505
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.2
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.19
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.18
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.17
    Ensembl ID: ENSG00000095139
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.17
    Ensembl ID: ENSG00000090013
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.15
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196954
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.11
    Ensembl ID: ENSG00000147416
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183255
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.07
    Ensembl ID: ENSG00000184922
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.03
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.03
    Ensembl ID: ENSG00000131473
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **High Expression of CCR2**: Classical monocytes exhibit high expression of CCR2, a chemokine receptor that plays a crucial role in the recruitment of monocytes to sites of inflammation. 2. **Negative Lineage Markers**: Classical monocytes are negative for lineage markers CD3, CD19, and CD20, indicating that they are not T cells, B cells, or natural killer cells. 3. **Larger Size**: Classical monocytes are larger in size compared to non-classical monocytes, making them more easily identifiable. 4. **Rapid Response to Microbial Stimuli**: Classical monocytes respond rapidly to microbial stimuli by secreting cytokines and antimicrobial factors, which helps to initiate an inflammatory response. **Clinical Significance** 1. **Inflammation**: Classical monocytes play a key role in the initiation and maintenance of inflammation, which is a complex biological response to harmful stimuli, such as pathogens, damaged cells, or irritants. 2. **Autoimmune Diseases**: Classical monocytes are involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, where the immune system mistakenly attacks healthy tissues. 3. **Cancer**: Classical monocytes can contribute to cancer progression by promoting tumor growth, invasion, and metastasis. 4. **Infectious Diseases**: Classical monocytes are essential for the defense against infections, particularly those caused by bacteria, viruses, and fungi. 5. **Immunotherapy**: Classical monocytes can be targeted for immunotherapy, which involves using antibodies or other agents to modulate the immune response and treat diseases such as cancer and autoimmune disorders. **Genes and Pathways** 1. **Gene Symbol: SLC25A6**: The gene symbol SLC25A6 encodes a protein involved in the transport of ATP across the mitochondrial inner membrane. 2. **Gene Symbol: ATP5MC2**: The gene symbol ATP5MC2 encodes a subunit of the ATP synthase complex, which is responsible for generating ATP through chemiosmotic coupling. 3. **Gene Symbol: CALM2**: The gene symbol CALM2 encodes a protein involved in the regulation of calcium-dependent signaling pathways. 4. **Gene Symbol: AIF1**: The gene symbol AIF1 encodes a protein involved in the regulation of actin dynamics and the formation of actin filaments. 5. **Gene Symbol: ACTG1**: The gene symbol ACTG1 encodes a protein involved in the regulation of actin dynamics and the formation of actin filaments. **Pathways and Ontologies** 1. **Apoptotic Process**: Classical monocytes are involved in the regulation of apoptosis, a process of programmed cell death. 2. **Atp:adp Antiporter Activity**: Classical monocytes are involved in the transport of ATP across the mitochondrial inner membrane. 3. **Disease**: Classical monocytes are involved in the pathogenesis of various diseases, including autoimmune disorders, cancer, and infectious diseases. 4. **Hiv Infection**: Classical monocytes are involved in the defense against HIV infection. 5. **Host Interactions of Hiv Factors**: Classical monocytes interact with HIV factors, which can influence the progression of HIV infection. In conclusion, classical monocytes are rapidly responding inflammatory cells that play a crucial role in the initiation and maintenance of inflammation, as well as the defense against infections. Their involvement in various diseases, including autoimmune disorders, cancer, and infectious diseases, highlights the importance of understanding their biology and function.