Details for: CFD

Gene ID: 1675

Symbol: CFD

Ensembl ID: ENSG00000197766

Description: complement factor D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 10.6
    Marker Score: 15219.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.89
    Marker Score: 3875
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.89
    Marker Score: 3316
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.49
    Marker Score: 194941
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.44
    Marker Score: 6710
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.11
    Marker Score: 8146
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.09
    Marker Score: 1287
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.96
    Marker Score: 12755
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.94
    Marker Score: 7086
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.93
    Marker Score: 1260
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.82
    Marker Score: 1610
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.72
    Marker Score: 921
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.67
    Marker Score: 2669.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.61
    Marker Score: 88850
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.36
    Marker Score: 2696.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.29
    Marker Score: 570
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.27
    Marker Score: 570
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.26
    Marker Score: 3327
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.24
    Marker Score: 5573
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.18
    Marker Score: 55808
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.18
    Marker Score: 501
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.14
    Marker Score: 554
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.04
    Marker Score: 558
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2
    Marker Score: 22537
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.86
    Marker Score: 2249
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.85
    Marker Score: 21547
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.85
    Marker Score: 1035
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.73
    Marker Score: 1672
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.72
    Marker Score: 851
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.71
    Marker Score: 422
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.55
    Marker Score: 9411
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.55
    Marker Score: 1910
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.49
    Marker Score: 1173
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.45
    Marker Score: 2649
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1523
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.41
    Marker Score: 1129
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.4
    Marker Score: 351
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.35
    Marker Score: 744
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.35
    Marker Score: 493
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.29
    Marker Score: 539
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.26
    Marker Score: 801
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.24
    Marker Score: 1263
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.19
    Marker Score: 891
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.18
    Marker Score: 1531
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.17
    Marker Score: 1452
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.13
    Marker Score: 335
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.11
    Marker Score: 394
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.1
    Marker Score: 273
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.08
    Marker Score: 1262.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.07
    Marker Score: 531
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.06
    Marker Score: 514
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.05
    Marker Score: 304
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.04
    Marker Score: 748
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.04
    Marker Score: 3703
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.01
    Marker Score: 256
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.01
    Marker Score: 1118
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1
    Marker Score: 505
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47953
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Marker Score: 455
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.97
    Marker Score: 452.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.94
    Marker Score: 20904
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.93
    Marker Score: 224
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1395
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.91
    Marker Score: 287
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5165
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.89
    Marker Score: 7645
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.88
    Marker Score: 3403
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.88
    Marker Score: 2284
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.88
    Marker Score: 7603
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5252
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.85
    Marker Score: 255
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.84
    Marker Score: 432
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.84
    Marker Score: 3478
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3288
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.81
    Marker Score: 364
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.8
    Marker Score: 805
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.79
    Marker Score: 254
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.79
    Marker Score: 5882
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.77
    Marker Score: 370
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.77
    Marker Score: 395
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.76
    Marker Score: 1343
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3173
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.74
    Marker Score: 451
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.73
    Marker Score: 1280
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.72
    Marker Score: 297
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651

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Other Information

**Key characteristics** * CFD is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including respiratory epithelial cells, skeletal muscle fibroblasts, and immune cells. * CFD is a key regulator of the alternative complement pathway. * Its expression is often upregulated in diseases such as atherosclerosis and cancer. **Pathways and functions** The complement system is a complex network of proteins that is involved in the immune response. The classical complement pathway is the traditional pathway of complement activation, which is initiated by the binding of antibodies to antigens on the surface of a pathogen. The alternative complement pathway is a parallel pathway that is activated by the binding of complement proteins to carbohydrates on the surface of a pathogen. CFD is a key regulator of the alternative complement pathway. It is expressed in a variety of cell types, and its expression is often upregulated in diseases such as atherosclerosis and cancer. CFD works by binding to carbohydrates on the surface of a pathogen, and this binding triggers a conformational change in the protein that activates downstream signaling pathways. These pathways lead to the formation of a membrane attack complex, which can kill the pathogen. **Clinical significance** CFD is a key target for the treatment of a variety of diseases. For example, CFD inhibitors are being tested in clinical trials for the treatment of atherosclerosis, cancer, and inflammatory diseases. These inhibitors are designed to block the binding of CFD to its ligands, and this prevents the activation of the complement pathway. **Additional information** * CFD is a secreted protein that is produced by a variety of cell types. * It is a member of the immunoglobulin superfamily. * CFD is a relatively stable protein, with a half-life of approximately 12 hours. * It is a key regulator of inflammation, and its expression is often upregulated in diseases such as atherosclerosis and cancer.

Genular Protein ID: 2003327440

Symbol: CFAD_HUMAN

Name: Complement factor D

UniProtKB Accession Codes:

P00746 B4DV76 Q5U5S1 Q86VJ5 Q8N4E0 Q8WZB4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 49 PDBsum 40 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1374388

Title: Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.

PubMed ID: 1374388

DOI: 10.1016/s0021-9258(19)50409-4

PubMed ID: 6383466

Title: Amino acid sequence of human D of the alternative complement pathway.

PubMed ID: 6383466

DOI: 10.1021/bi00306a025

PubMed ID: 6363133

Title: Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin.

PubMed ID: 6363133

DOI: 10.1016/0014-5793(84)80110-6

PubMed ID: 6987665

Title: Partial amino acid sequence of human factor D: homology with serine proteases.

PubMed ID: 6987665

DOI: 10.1073/pnas.77.2.1116

PubMed ID: 6776531

Title: Active site amino acid sequence of human factor D.

PubMed ID: 6776531

DOI: 10.1073/pnas.77.8.4938

PubMed ID: 6821372

Title: Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site.

PubMed ID: 6821372

DOI: 10.1042/bj1870863

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 8289289

Title: Structure of human factor D. A complement system protein at 2.0-A resolution.

PubMed ID: 8289289

DOI: 10.1006/jmbi.1994.1021

PubMed ID: 7592653

Title: Crystal structure of a complement factor D mutant expressing enhanced catalytic activity.

PubMed ID: 7592653

DOI: 10.1074/jbc.270.41.24399

PubMed ID: 16527897

Title: Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections.

PubMed ID: 16527897

DOI: 10.1182/blood-2005-07-2820

Sequence Information:

  • Length: 253
  • Mass: 27033
  • Checksum: 78B06C209DEEA362
  • Sequence:
    • MHSWERLAVL VLLGAAACAA PPRGRILGGR EAEAHARPYM ASVQLNGAHL CGGVLVAEQW 
VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA VPHPDSQPDT IDHDLLLLQL 
SEKATLGPAV RPLPWQRVDR DVAPGTLCDV AGWGIVNHAG RRPDSLQHVL LPVLDRATCN 
RRTHHDGAIT ERLMCAESNR RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR 
VASYAAWIDS VLA

Genular Protein ID: 1971628381

Symbol: A6XNE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6XNE2

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EC 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 260
  • Mass: 27780
  • Checksum: EC76ECCBFAFCC2B7
  • Sequence:
    • MHSWERLAVL VLLGAAACGE EAWACAAPPR GRILGGREAE AHARPYMASV QLNGAHLCGG 
VLVAEQWVLS AAHCLEDAAD GKVQVLLGAH SLSQPEPSKR LYDVLRAVPH PDSQPDTIDH 
DLLLLQLSEK ATLGPAVRPL PWQRVDRDVA PGTLCDVAGW GIVNHAGRRP DSLQHVLLPV 
LDRATCNRRT HHDGAITERL MCAESNRRDS CKGDSGGPLV CGGVLEGVVT SGSRVCGNRK 
KPGIYTRVAS YAAWIDSVLA

Genular Protein ID: 728180445

Symbol: K7ERG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ERG9

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

Sequence Information:

  • Length: 260
  • Mass: 27863
  • Checksum: 271B5A14D64E0990
  • Sequence:
    • MHSWERLAVL VLLGAAACGE EAWAWAAPPR GRILGGREAE AHARPYMASV QLNGAHLCGG 
VLVAEQWVLS AAHCLEDAAD GKVQVLLGAH SLSQPEPSKR LYDVLRAVPH PDSQPDTIDH 
DLLLLQLSEK ATLGPAVRPL PWQRVDRDVA PGTLCDVAGW GIVNHAGRRP DSLQHVLLPV 
LDRATCNRRT HHDGAITERL MCAESNRRDS CKGDSGGPLV CGGVLEGVVT SGSRVCGNRK 
KPGIYTRVAS YAAWIDSVLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.