Details for: CFD

Gene ID: 1675

Symbol: CFD

Ensembl ID: ENSG00000197766

Description: complement factor D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 207.5924
    Cell Significance Index: -32.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.0879
    Cell Significance Index: -32.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.7290
    Cell Significance Index: -34.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.2511
    Cell Significance Index: -28.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.9061
    Cell Significance Index: -32.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.4338
    Cell Significance Index: -32.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.2490
    Cell Significance Index: -28.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0999
    Cell Significance Index: -32.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 24.4158
    Cell Significance Index: 165.4300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 21.9838
    Cell Significance Index: 65.3800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 18.8745
    Cell Significance Index: 49.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 12.0269
    Cell Significance Index: 234.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9939
    Cell Significance Index: -32.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.3017
    Cell Significance Index: 237.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9295
    Cell Significance Index: -31.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.6439
    Cell Significance Index: 141.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6185
    Cell Significance Index: -23.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6618
    Cell Significance Index: -14.5800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.9409
    Cell Significance Index: 36.7600
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 5.8534
    Cell Significance Index: 59.0700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6111
    Cell Significance Index: 15.3400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.2238
    Cell Significance Index: 5.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8925
    Cell Significance Index: 360.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7883
    Cell Significance Index: 245.5800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.6260
    Cell Significance Index: 23.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5462
    Cell Significance Index: 152.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.4871
    Cell Significance Index: 31.6700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.4228
    Cell Significance Index: 15.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2613
    Cell Significance Index: 65.5200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1293
    Cell Significance Index: 14.2200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.0126
    Cell Significance Index: 11.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0023
    Cell Significance Index: 70.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8933
    Cell Significance Index: 806.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8349
    Cell Significance Index: 107.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7266
    Cell Significance Index: 54.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6645
    Cell Significance Index: 33.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6103
    Cell Significance Index: 99.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4188
    Cell Significance Index: 6.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2909
    Cell Significance Index: 128.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2648
    Cell Significance Index: 18.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1645
    Cell Significance Index: 12.6300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.1547
    Cell Significance Index: 0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1542
    Cell Significance Index: 18.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1523
    Cell Significance Index: 17.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1187
    Cell Significance Index: 64.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1020
    Cell Significance Index: 13.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0761
    Cell Significance Index: 13.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0710
    Cell Significance Index: 7.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0489
    Cell Significance Index: 0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0284
    Cell Significance Index: 53.4700
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.0273
    Cell Significance Index: 0.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0268
    Cell Significance Index: 1.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0159
    Cell Significance Index: -0.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0183
    Cell Significance Index: -33.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0202
    Cell Significance Index: -15.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0240
    Cell Significance Index: -36.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0281
    Cell Significance Index: -38.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0387
    Cell Significance Index: -28.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0442
    Cell Significance Index: -28.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0472
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0497
    Cell Significance Index: -36.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0606
    Cell Significance Index: -21.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0639
    Cell Significance Index: -36.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0685
    Cell Significance Index: -31.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0722
    Cell Significance Index: -45.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1006
    Cell Significance Index: -28.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1191
    Cell Significance Index: -23.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1418
    Cell Significance Index: -28.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1849
    Cell Significance Index: -38.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1982
    Cell Significance Index: -12.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2001
    Cell Significance Index: -29.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2162
    Cell Significance Index: -6.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2356
    Cell Significance Index: -10.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2454
    Cell Significance Index: -12.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2476
    Cell Significance Index: -29.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2520
    Cell Significance Index: -43.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2696
    Cell Significance Index: -28.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2752
    Cell Significance Index: -31.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3624
    Cell Significance Index: -2.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3634
    Cell Significance Index: -11.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3679
    Cell Significance Index: -5.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3726
    Cell Significance Index: -24.0400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3747
    Cell Significance Index: -4.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3765
    Cell Significance Index: -29.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4318
    Cell Significance Index: -6.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4403
    Cell Significance Index: -9.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4451
    Cell Significance Index: -11.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4480
    Cell Significance Index: -12.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4783
    Cell Significance Index: -22.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4865
    Cell Significance Index: -4.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4964
    Cell Significance Index: -26.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5276
    Cell Significance Index: -8.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5592
    Cell Significance Index: -35.2500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.5653
    Cell Significance Index: -5.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6307
    Cell Significance Index: -16.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6455
    Cell Significance Index: -12.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6510
    Cell Significance Index: -36.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6889
    Cell Significance Index: -14.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6933
    Cell Significance Index: -30.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6979
    Cell Significance Index: -25.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine-type peptidase activity**: CFD exhibits serine-type peptidase activity, which enables it to cleave and activate the complement system. 2. **Alternative complement pathway activation**: CFD is specifically involved in the activation of the alternative complement pathway, which is distinct from the classical and lectin pathways. 3. **Diverse expression patterns**: CFD is expressed in various cell types, including immune cells, fibroblasts, and decidual cells, suggesting its role in different physiological and pathological processes. 4. **Regulation of inflammation**: CFD plays a crucial role in regulating inflammation by modulating the complement cascade and preventing excessive tissue damage. **Pathways and Functions:** 1. **Alternative complement activation**: CFD facilitates the activation of the alternative complement pathway, which involves the cleavage of C3 convertase and the subsequent amplification of the complement cascade. 2. **Complement cascade regulation**: CFD helps regulate the complement cascade by modulating the activity of C3 convertase and preventing excessive activation. 3. **Innate immune system**: CFD is involved in the innate immune system, where it helps eliminate pathogens and regulate inflammation. 4. **Tissue homeostasis**: CFD maintains tissue homeostasis by regulating the complement cascade and preventing tissue damage. **Clinical Significance:** 1. **Complement dysregulation**: Dysregulation of the complement system, including CFD, has been implicated in various diseases, such as autoimmune disorders, cancer, and infectious diseases. 2. **Inflammatory disorders**: CFD has been linked to inflammatory disorders, such as atherosclerosis, arthritis, and multiple sclerosis. 3. **Cancer**: CFD has been shown to play a role in cancer progression and metastasis, highlighting its potential as a therapeutic target. 4. **Autoimmune diseases**: CFD has been implicated in autoimmune diseases, such as lupus and rheumatoid arthritis, where it may contribute to disease pathogenesis. In conclusion, complement factor D is a critical component of the innate immune system, playing a pivotal role in the activation of the alternative complement pathway. Its diverse expression patterns and regulation of inflammation suggest its importance in different physiological and pathological processes. Further research is needed to fully elucidate the complexities of CFD and its role in various diseases.

Genular Protein ID: 2003327440

Symbol: CFAD_HUMAN

Name: Complement factor D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1374388

Title: Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.

PubMed ID: 1374388

DOI: 10.1016/s0021-9258(19)50409-4

PubMed ID: 6383466

Title: Amino acid sequence of human D of the alternative complement pathway.

PubMed ID: 6383466

DOI: 10.1021/bi00306a025

PubMed ID: 6363133

Title: Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin.

PubMed ID: 6363133

DOI: 10.1016/0014-5793(84)80110-6

PubMed ID: 6987665

Title: Partial amino acid sequence of human factor D: homology with serine proteases.

PubMed ID: 6987665

DOI: 10.1073/pnas.77.2.1116

PubMed ID: 6776531

Title: Active site amino acid sequence of human factor D.

PubMed ID: 6776531

DOI: 10.1073/pnas.77.8.4938

PubMed ID: 6821372

Title: Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site.

PubMed ID: 6821372

DOI: 10.1042/bj1870863

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 8289289

Title: Structure of human factor D. A complement system protein at 2.0-A resolution.

PubMed ID: 8289289

DOI: 10.1006/jmbi.1994.1021

PubMed ID: 7592653

Title: Crystal structure of a complement factor D mutant expressing enhanced catalytic activity.

PubMed ID: 7592653

DOI: 10.1074/jbc.270.41.24399

PubMed ID: 16527897

Title: Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections.

PubMed ID: 16527897

DOI: 10.1182/blood-2005-07-2820

Sequence Information:

  • Length: 253
  • Mass: 27033
  • Checksum: 78B06C209DEEA362
  • Sequence:
  • MHSWERLAVL VLLGAAACAA PPRGRILGGR EAEAHARPYM ASVQLNGAHL CGGVLVAEQW 
    VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA VPHPDSQPDT IDHDLLLLQL 
    SEKATLGPAV RPLPWQRVDR DVAPGTLCDV AGWGIVNHAG RRPDSLQHVL LPVLDRATCN 
    RRTHHDGAIT ERLMCAESNR RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR 
    VASYAAWIDS VLA

Genular Protein ID: 728180445

Symbol: K7ERG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

Sequence Information:

  • Length: 260
  • Mass: 27863
  • Checksum: 271B5A14D64E0990
  • Sequence:
  • MHSWERLAVL VLLGAAACGE EAWAWAAPPR GRILGGREAE AHARPYMASV QLNGAHLCGG 
    VLVAEQWVLS AAHCLEDAAD GKVQVLLGAH SLSQPEPSKR LYDVLRAVPH PDSQPDTIDH 
    DLLLLQLSEK ATLGPAVRPL PWQRVDRDVA PGTLCDVAGW GIVNHAGRRP DSLQHVLLPV 
    LDRATCNRRT HHDGAITERL MCAESNRRDS CKGDSGGPLV CGGVLEGVVT SGSRVCGNRK 
    KPGIYTRVAS YAAWIDSVLA

Genular Protein ID: 1971628381

Symbol: A6XNE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 260
  • Mass: 27780
  • Checksum: EC76ECCBFAFCC2B7
  • Sequence:
  • MHSWERLAVL VLLGAAACGE EAWACAAPPR GRILGGREAE AHARPYMASV QLNGAHLCGG 
    VLVAEQWVLS AAHCLEDAAD GKVQVLLGAH SLSQPEPSKR LYDVLRAVPH PDSQPDTIDH 
    DLLLLQLSEK ATLGPAVRPL PWQRVDRDVA PGTLCDVAGW GIVNHAGRRP DSLQHVLLPV 
    LDRATCNRRT HHDGAITERL MCAESNRRDS CKGDSGGPLV CGGVLEGVVT SGSRVCGNRK 
    KPGIYTRVAS YAAWIDSVLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.