IGKV1 5 | ENSG00000243466 | NCBI 28299

Details for: IGKV1 5

Gene ID: 28299

Symbol: IGKV1 5

Ensembl ID: ENSG00000243466

Description: immunoglobulin kappa variable 1-5

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 11.0988
Cell Significance Index: -5.2400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5316
Cell Significance Index: 8.2300
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.4800
Cell Significance Index: 5.3700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0381
Cell Significance Index: 0.5600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0071
Cell Significance Index: -5.4000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0237
Cell Significance Index: -0.5900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0298
Cell Significance Index: -5.3700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0473
Cell Significance Index: -5.8100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0555
Cell Significance Index: -7.1100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0588
Cell Significance Index: -6.0100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0781
Cell Significance Index: -10.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0892
Cell Significance Index: -5.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1045
Cell Significance Index: -5.4300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1076
Cell Significance Index: -18.3800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1175
Cell Significance Index: -16.1300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1408
Cell Significance Index: -10.4900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1411
Cell Significance Index: -6.5800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1465
Cell Significance Index: -3.9200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1611
Cell Significance Index: -7.3000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1647
Cell Significance Index: -18.8700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1683
Cell Significance Index: -1.8800
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1882
Cell Significance Index: -2.5600
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1978
Cell Significance Index: -3.3600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2006
Cell Significance Index: -4.8600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2018
Cell Significance Index: -2.9300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2177
Cell Significance Index: -5.4300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2182
Cell Significance Index: -8.0100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2257
Cell Significance Index: -5.7500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2372
Cell Significance Index: -6.0600
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2433
Cell Significance Index: -1.6200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2635
Cell Significance Index: -4.8700
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2639
Cell Significance Index: -3.8600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2706
Cell Significance Index: -5.2900
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2840
Cell Significance Index: -2.9900
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2869
Cell Significance Index: -1.7800
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2931
Cell Significance Index: -3.6300
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.2937
Cell Significance Index: -3.0300
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.3070
Cell Significance Index: -3.2600
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3137
Cell Significance Index: -4.6300
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3146
Cell Significance Index: -2.9200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3146
Cell Significance Index: -5.3000
Cell Name: blood cell (CL0000081)
Fold Change: -0.3379
Cell Significance Index: -2.8800
Cell Name: peg cell (CL4033014)
Fold Change: -0.3398
Cell Significance Index: -7.8500
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3410
Cell Significance Index: -3.7300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3428
Cell Significance Index: -5.8600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3445
Cell Significance Index: -5.5800
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.3472
Cell Significance Index: -2.7900
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.3475
Cell Significance Index: -3.1800
Cell Name: B cell (CL0000236)
Fold Change: -0.3597
Cell Significance Index: -4.2500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3614
Cell Significance Index: -10.3600
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3628
Cell Significance Index: -3.8600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3734
Cell Significance Index: -8.0900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3786
Cell Significance Index: -5.3100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.3799
Cell Significance Index: -4.4900
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3836
Cell Significance Index: -5.3200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3839
Cell Significance Index: -5.2700
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3868
Cell Significance Index: -3.4500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3893
Cell Significance Index: -3.2700
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3915
Cell Significance Index: -3.5800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3931
Cell Significance Index: -4.4700
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.3960
Cell Significance Index: -5.0100
Cell Name: monocyte (CL0000576)
Fold Change: -0.3972
Cell Significance Index: -4.5700
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4026
Cell Significance Index: -5.2100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.4037
Cell Significance Index: -5.2800
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.4079
Cell Significance Index: -3.2200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.4245
Cell Significance Index: -5.0000
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.4428
Cell Significance Index: -5.3500
Cell Name: mature B cell (CL0000785)
Fold Change: -0.4486
Cell Significance Index: -2.9200
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.4519
Cell Significance Index: -3.7300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.4530
Cell Significance Index: -5.7400
Cell Name: stromal cell (CL0000499)
Fold Change: -0.4551
Cell Significance Index: -4.6500
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.4598
Cell Significance Index: -5.2100
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4647
Cell Significance Index: -5.9700
Cell Name: neutrophil (CL0000775)
Fold Change: -0.4703
Cell Significance Index: -5.8800
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.4758
Cell Significance Index: -5.5300
Cell Name: glial cell (CL0000125)
Fold Change: -0.4874
Cell Significance Index: -5.3400
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.4911
Cell Significance Index: -5.8300
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.4917
Cell Significance Index: -4.7200
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.4948
Cell Significance Index: -10.3200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4953
Cell Significance Index: -5.3400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4976
Cell Significance Index: -6.5300
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4982
Cell Significance Index: -6.0100
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4985
Cell Significance Index: -6.0600
Cell Name: mast cell (CL0000097)
Fold Change: -0.5000
Cell Significance Index: -6.5800
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.5079
Cell Significance Index: -6.6300
Cell Name: immature B cell (CL0000816)
Fold Change: -0.5083
Cell Significance Index: -4.8100
Cell Name: acinar cell (CL0000622)
Fold Change: -0.5087
Cell Significance Index: -6.3900
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.5102
Cell Significance Index: -5.4100
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.5111
Cell Significance Index: -6.0400
Cell Name: erythroblast (CL0000765)
Fold Change: -0.5185
Cell Significance Index: -6.1800
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.5209
Cell Significance Index: -5.4900
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.5242
Cell Significance Index: -6.0800
Cell Name: podocyte (CL0000653)
Fold Change: -0.5266
Cell Significance Index: -6.0400
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.5284
Cell Significance Index: -1.9900
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.5302
Cell Significance Index: -6.4500
Cell Name: fibroblast (CL0000057)
Fold Change: -0.5304
Cell Significance Index: -4.9800
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.5308
Cell Significance Index: -4.9700
Cell Name: T cell (CL0000084)
Fold Change: -0.5311
Cell Significance Index: -6.2700
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5311
Cell Significance Index: -5.8800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5343
Cell Significance Index: -25.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Immunoglobulin kappa variable region:** The IGKV1-5 gene encodes for the variable region of the kappa light chain, which is a critical component of the immunoglobulin molecule. 2. **Significant expression:** The IGKV1-5 gene is significantly expressed in various cell types, including CD16-positive natural killer cells, CD56-dim natural killer cells, and central memory CD4-positive T cells. 3. **Multiple pathways:** The IGKV1-5 gene is involved in multiple pathways, including the adaptive immune response, anti-inflammatory response, and cellular interactions at the vascular wall. **Pathways and Functions:** 1. **Adaptive immune response:** The IGKV1-5 gene plays a crucial role in the adaptive immune response by encoding for the variable region of the kappa light chain, which is essential for antigen recognition and binding. 2. **Anti-inflammatory response:** The IGKV1-5 gene is involved in the anti-inflammatory response, particularly in the context of Leishmania parasite infection, where it helps to modulate the immune response and prevent excessive inflammation. 3. **Cellular interactions at the vascular wall:** The IGKV1-5 gene is involved in cellular interactions at the vascular wall, including the binding and uptake of ligands by scavenger receptors and the regulation of actin dynamics for phagocytic cup formation. 4. **Complement cascade:** The IGKV1-5 gene is involved in the complement cascade, particularly in the context of classical antibody-mediated complement activation. 5. **Innate immune system:** The IGKV1-5 gene is also involved in the innate immune system, particularly in the context of Leishmania parasite growth and survival. **Clinical Significance:** 1. **Leishmania infection:** The IGKV1-5 gene has been implicated in the pathogenesis of Leishmania infection, where it helps to modulate the immune response and prevent excessive inflammation. 2. **SARS-CoV infections:** The IGKV1-5 gene has been identified as a potential target for therapeutic intervention in SARS-CoV infections. 3. **Cancer immunotherapy:** The IGKV1-5 gene has been implicated in cancer immunotherapy, where it helps to modulate the immune response and enhance anti-tumor activity. 4. **Autoimmune diseases:** The IGKV1-5 gene has been implicated in autoimmune diseases, where it helps to modulate the immune response and prevent excessive inflammation. In conclusion, the IGKV1-5 gene plays a crucial role in the adaptive immune response, anti-inflammatory response, and cellular interactions at the vascular wall. Its clinical significance extends to Leishmania infection, SARS-CoV infections, cancer immunotherapy, and autoimmune diseases. Further research is needed to fully understand the complexities of the IGKV1-5 gene and its role in the immune system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.