Details for: CL0000784

Cell ID: CL0000784

Cell Name: plasmacytoid dendritic cell

Marker Score Threshold: 538
(Derived using integrated single-cell and genomic data)

Description: A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection.

Synonyms: DC2, IPC, T-associated plasma cell, interferon-producing cell, lymphoid dendritic cell, pDC, plasmacytoid T cell, plasmacytoid monocyte, type 2 DC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.39
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.27
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.8
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.74
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.68
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.48
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.4
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.4
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.37
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.29
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.25
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.13
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.05
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.97
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.96
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.96
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.95
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.92
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.86
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.84
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.82
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.81
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.8
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.76
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.74
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.7
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.69
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.6
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.59
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.57
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.56
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.56
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.56
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.5
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.47
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.47
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.47
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.46
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.46
    Ensembl ID: ENSG00000042753
  • Gene Symbol: BOK (ENSG00000176720)
    Fold Change: 1.46
    Ensembl ID: ENSG00000176720
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.44
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.44
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.42
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.39
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.39
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.38
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.35
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.33
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.32
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.3
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.26
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.25
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.22
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.21
    Ensembl ID: ENSG00000146731
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.2
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.19
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.18
    Ensembl ID: ENSG00000074201
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.16
    Ensembl ID: ENSG00000173575
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.16
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.16
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.15
    Ensembl ID: ENSG00000104765
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.14
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.11
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.1
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.09
    Ensembl ID: ENSG00000175416
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.07
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.07
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.07
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110651
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.05
    Ensembl ID: ENSG00000084234
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.05
    Ensembl ID: ENSG00000053254
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134480
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.04
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.03
    Ensembl ID: ENSG00000132965
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.03
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.02
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149311
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Morphology**: PDCs exhibit a distinctive morphology, characterized by a large, pale nucleus, and abundant cytoplasm with numerous azurophilic granules. 2. **Localization**: PDCs are found in various tissues, including lymphoid organs, skin, and mucosa, where they interact with T cells and other immune cells. 3. **Surface markers**: PDCs express specific surface markers, including CD123, CD1a, and CD86, which distinguish them from other dendritic cell types. 4. **Interferon production**: PDCs are uniquely capable of producing type I interferons in response to infection, which plays a critical role in initiating antiviral immune responses. 5. **Antigen presentation**: PDCs recognize, process, and present antigens to T cells, which is essential for triggering immune responses. **Clinical Significance** 1. **Autoimmune disorders**: Dysregulation of PDCs has been implicated in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Cancer**: PDCs have been shown to contribute to tumor immune evasion and cancer progression. 3. **Viral infections**: PDCs play a crucial role in recognizing and responding to viral infections, particularly those caused by herpesviruses, influenza, and HIV. 4. **Infectious diseases**: PDCs are involved in the recognition and clearance of pathogens, including bacteria, viruses, and parasites. 5. **Immunotherapy**: PDCs have been explored as a target for immunotherapeutic strategies, including cancer vaccination and antiviral therapies. In summary, plasmacytoid dendritic cells are a unique subset of dendritic cells that play a critical role in early-stage immune responses, particularly the release of type I interferons in response to infection. Their dysregulation has been implicated in various diseases, including autoimmune disorders and cancer, highlighting the importance of understanding their biology and function in the context of human health and disease.