Details for: PSMB10

Gene ID: 5699

Symbol: PSMB10

Ensembl ID: ENSG00000205220

Description: proteasome 20S subunit beta 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 142.0809
    Cell Significance Index: -22.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.4890
    Cell Significance Index: -18.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.5165
    Cell Significance Index: -30.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.4562
    Cell Significance Index: -25.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9707
    Cell Significance Index: -23.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8437
    Cell Significance Index: -21.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9933
    Cell Significance Index: -23.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2191
    Cell Significance Index: 153.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.5264
    Cell Significance Index: 83.6600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.0703
    Cell Significance Index: 8.2300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.7092
    Cell Significance Index: 23.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.3945
    Cell Significance Index: 55.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.9447
    Cell Significance Index: 49.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8722
    Cell Significance Index: 220.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8593
    Cell Significance Index: 202.2400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.5516
    Cell Significance Index: 3.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2923
    Cell Significance Index: 11.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2679
    Cell Significance Index: 147.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0281
    Cell Significance Index: 71.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9984
    Cell Significance Index: 901.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9505
    Cell Significance Index: 171.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9011
    Cell Significance Index: 110.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8703
    Cell Significance Index: 56.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8415
    Cell Significance Index: 9.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6579
    Cell Significance Index: 65.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6542
    Cell Significance Index: 83.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5966
    Cell Significance Index: 8.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5469
    Cell Significance Index: 13.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5327
    Cell Significance Index: 11.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5118
    Cell Significance Index: 14.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4909
    Cell Significance Index: 25.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4247
    Cell Significance Index: 25.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4210
    Cell Significance Index: 71.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3903
    Cell Significance Index: 53.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3757
    Cell Significance Index: 5.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3226
    Cell Significance Index: 8.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2490
    Cell Significance Index: 11.7100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2220
    Cell Significance Index: 2.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2067
    Cell Significance Index: 39.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1765
    Cell Significance Index: 8.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1756
    Cell Significance Index: 77.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1401
    Cell Significance Index: 2.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1270
    Cell Significance Index: 16.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1210
    Cell Significance Index: 19.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1080
    Cell Significance Index: 2.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0952
    Cell Significance Index: 3.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0910
    Cell Significance Index: 49.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0836
    Cell Significance Index: 1.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0796
    Cell Significance Index: 3.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0479
    Cell Significance Index: 9.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0377
    Cell Significance Index: 4.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0169
    Cell Significance Index: 1.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0159
    Cell Significance Index: 5.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0109
    Cell Significance Index: 0.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0101
    Cell Significance Index: 0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0004
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0044
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0104
    Cell Significance Index: -0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0116
    Cell Significance Index: -21.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0131
    Cell Significance Index: -24.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0162
    Cell Significance Index: -24.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0182
    Cell Significance Index: -24.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0188
    Cell Significance Index: -10.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0370
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0373
    Cell Significance Index: -27.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0457
    Cell Significance Index: -29.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0533
    Cell Significance Index: -2.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0606
    Cell Significance Index: -27.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0726
    Cell Significance Index: -1.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0912
    Cell Significance Index: -26.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1077
    Cell Significance Index: -21.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1433
    Cell Significance Index: -16.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1632
    Cell Significance Index: -10.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1650
    Cell Significance Index: -2.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1839
    Cell Significance Index: -26.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2249
    Cell Significance Index: -2.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2274
    Cell Significance Index: -23.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2411
    Cell Significance Index: -3.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2519
    Cell Significance Index: -19.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2957
    Cell Significance Index: -18.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -0.3136
    Cell Significance Index: 0.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3281
    Cell Significance Index: -9.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3285
    Cell Significance Index: -17.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3424
    Cell Significance Index: -3.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3665
    Cell Significance Index: -29.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3677
    Cell Significance Index: -24.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3751
    Cell Significance Index: -21.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3769
    Cell Significance Index: -23.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3796
    Cell Significance Index: -2.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4533
    Cell Significance Index: -20.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4883
    Cell Significance Index: -2.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5435
    Cell Significance Index: -20.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5712
    Cell Significance Index: -20.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5843
    Cell Significance Index: -16.3300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.5854
    Cell Significance Index: -5.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6080
    Cell Significance Index: -22.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PSMB10 is a member of the beta subunit family of the 20S proteasome, which is a large protein complex consisting of 28 subunits arranged in a toroidal structure. The beta subunits are responsible for the degradation of proteins, and PSMB10 is one of the 10 beta subunits present in the 20S proteasome. The proteasome is a highly specific enzyme that recognizes and degrades damaged or misfolded proteins, playing a critical role in maintaining protein homeostasis and regulating cell growth and division. **Pathways and Functions** PSMB10 is involved in various cellular processes, including: 1. **Antigen processing and presentation**: The proteasome, including PSMB10, is essential for the degradation of proteins into peptides, which are then presented to T-cells by MHC class I molecules, triggering an immune response. 2. **Cell cycle regulation**: The proteasome degrades proteins that inhibit cell cycle progression, allowing cells to progress through the cell cycle and divide. 3. **Apoptosis**: The proteasome can also induce apoptosis (programmed cell death) by degrading pro-apoptotic proteins. 4. **Immune responses**: PSMB10 is expressed in immune cells, such as T-cells and monocytes, where it plays a role in the regulation of immune responses. 5. **Protein homeostasis**: The proteasome, including PSMB10, maintains protein homeostasis by degrading damaged or misfolded proteins. **Clinical Significance** Dysregulation of the proteasome, including PSMB10, has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Defects in the proteasome have been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: The proteasome is involved in the degradation of tumor suppressor proteins, allowing cancer cells to grow and proliferate unchecked. 3. **Neurodegenerative diseases**: Dysregulation of the proteasome has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Autoimmune disorders**: The proteasome plays a role in the regulation of immune responses, and dysregulation has been linked to autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. In summary, PSMB10 is a critical component of the 20S proteasome, involved in various cellular processes, including antigen processing and presentation, cell cycle regulation, apoptosis, and protein homeostasis. Dysregulation of PSMB10 has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis and regulating immune responses.

Genular Protein ID: 994654996

Symbol: PSB10_HUMAN

Name: Proteasome subunit beta type-10

UniProtKB Accession Codes:

P40306 B2R5J4 Q5U098

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 8 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 59 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268911

Title: A tight cluster of five unrelated human genes on chromosome 16q22.1.

PubMed ID: 8268911

DOI: 10.1093/hmg/2.10.1589

PubMed ID: 9551082

Title: Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1.

PubMed ID: 9551082

DOI: 10.1016/s0167-4889(97)00152-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8666937

Title: Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

PubMed ID: 8666937

DOI: 10.1084/jem.183.4.1807

PubMed ID: 10575004

Title: Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1.

PubMed ID: 10575004

DOI: 10.1074/jbc.274.49.35196

PubMed ID: 11493458

Title: Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface.

PubMed ID: 11493458

DOI: 10.1182/blood.v98.4.1108

PubMed ID: 11717192

Title: Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation.

PubMed ID: 11717192

DOI: 10.1093/intimm/13.12.1515

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15501285

Title: Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach.

PubMed ID: 15501285

DOI: 10.1016/j.toxicon.2004.07.018

PubMed ID: 15907481

Title: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.

PubMed ID: 15907481

DOI: 10.1016/j.febslet.2005.04.012

PubMed ID: 17262812

Title: Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.

PubMed ID: 17262812

DOI: 10.1002/ibd.20110

PubMed ID: 18694960

Title: CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1.

PubMed ID: 18694960

DOI: 10.1128/mcb.00611-08

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31783057

Title: PSMB10, the last immunoproteasome gene missing for PRAAS.

PubMed ID: 31783057

DOI: 10.1016/j.jaci.2019.11.024

Sequence Information:

  • Length: 273
  • Mass: 28936
  • Checksum: D6728E50513A45B9
  • Sequence:
    • MLKPALEPRG GFSFENCQRN ASLERVLPGL KVPHARKTGT TIAGLVFQDG VILGADTRAT 
NDSVVADKSC EKIHFIAPKI YCCGAGVAAD AEMTTRMVAS KMELHALSTG REPRVATVTR 
ILRQTLFRYQ GHVGASLIVG GVDLTGPQLY GVHPHGSYSR LPFTALGSGQ DAALAVLEDR 
FQPNMTLEAA QGLLVEAVTA GILGDLGSGG NVDACVITKT GAKLLRTLSS PTEPVKRSGR 
YHFVPGTTAV LTQTVKPLTL ELVEETVQAM EVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.