Details for: TGFBI
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.31
Marker Score: 3531 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2.92
Marker Score: 3341 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.76
Marker Score: 3330 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.17
Marker Score: 121462 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.13
Marker Score: 2128 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.99
Marker Score: 447 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.98
Marker Score: 3860 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.98
Marker Score: 2186 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.96
Marker Score: 12777 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.88
Marker Score: 1098 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.71
Marker Score: 745 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.67
Marker Score: 4338 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.67
Marker Score: 1760 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.66
Marker Score: 3377 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.64
Marker Score: 2259 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.59
Marker Score: 449 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.58
Marker Score: 17806.5 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.56
Marker Score: 649 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.55
Marker Score: 39731 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.53
Marker Score: 3592 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.5
Marker Score: 9131 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168587 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.44
Marker Score: 18928 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.43
Marker Score: 2208 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.26
Marker Score: 2389 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.26
Marker Score: 1156 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.22
Marker Score: 3032.5 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.21
Marker Score: 1236 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.19
Marker Score: 5141 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.18
Marker Score: 2837 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.15
Marker Score: 4265 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4771 - Cell Name: macrophage (CL0000235)
Fold Change: 1.11
Marker Score: 1238 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.1
Marker Score: 371 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.07
Marker Score: 3506 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.07
Marker Score: 1755 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.07
Marker Score: 737 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.06
Marker Score: 4089.5 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71770 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47996 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1
Marker Score: 377 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.95
Marker Score: 598.5 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 447.5 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.94
Marker Score: 518 - Cell Name: blood cell (CL0000081)
Fold Change: 0.92
Marker Score: 10717 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 363 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.89
Marker Score: 13928 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5031 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.88
Marker Score: 583 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.83
Marker Score: 266 - Cell Name: basal cell (CL0000646)
Fold Change: 0.82
Marker Score: 1063 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.82
Marker Score: 1014 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.82
Marker Score: 782 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.82
Marker Score: 695 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 621 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.81
Marker Score: 4874 - Cell Name: muscle cell (CL0000187)
Fold Change: 0.81
Marker Score: 229 - Cell Name: pericyte (CL0000669)
Fold Change: 0.8
Marker Score: 467 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.79
Marker Score: 561 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.78
Marker Score: 374 - Cell Name: supporting cell (CL0000630)
Fold Change: 0.78
Marker Score: 1464 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260 - Cell Name: monocyte (CL0000576)
Fold Change: 0.77
Marker Score: 999 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.76
Marker Score: 912 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1200 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.75
Marker Score: 721 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 385 - Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 665 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.72
Marker Score: 3004 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.72
Marker Score: 358 - Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.71
Marker Score: 187 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.7
Marker Score: 361 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.7
Marker Score: 360 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.69
Marker Score: 239 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.69
Marker Score: 288 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.68
Marker Score: 684 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.67
Marker Score: 230 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.66
Marker Score: 1266.5 - Cell Name: colon macrophage (CL0009038)
Fold Change: 0.66
Marker Score: 181 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.63
Marker Score: 159 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.63
Marker Score: 261 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.62
Marker Score: 138 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.61
Marker Score: 404 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.6
Marker Score: 323.5 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.6
Marker Score: 158 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6
Marker Score: 20369.5 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.59
Marker Score: 339 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.56
Marker Score: 135 - Cell Name: Unknown (CL0002371)
Fold Change: 0.56
Marker Score: 591 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443 - Cell Name: contractile cell (CL0000183)
Fold Change: 0.55
Marker Score: 298 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.55
Marker Score: 537 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.55
Marker Score: 294
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Other Information
Genular Protein ID: 3277490035
Symbol: BGH3_HUMAN
Name: Transforming growth factor-beta-induced protein ig-h3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1388724
Title: cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta.
PubMed ID: 1388724
PubMed ID: 9054935
Title: Kerato-epithelin mutations in four 5q31-linked corneal dystrophies.
PubMed ID: 9054935
DOI: 10.1038/ng0397-247
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8024701
Title: Beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice.
PubMed ID: 8024701
PubMed ID: 27609313
Title: Disulfide bond pattern of transforming growth factor beta-induced protein.
PubMed ID: 27609313
PubMed ID: 8077289
Title: cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epithelium.
PubMed ID: 8077289
PubMed ID: 11501939
PubMed ID: 18450759
Title: Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.
PubMed ID: 18450759
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26273833
Title: Absence of vitamin K-dependent gamma-carboxylation in human periostin extracted from fibrotic lung or secreted from a cell line engineered to optimize gamma-carboxylation.
PubMed ID: 26273833
PubMed ID: 9463327
Title: Mutation hot spots in 5q31-linked corneal dystrophies.
PubMed ID: 9463327
DOI: 10.1086/301720
PubMed ID: 9497262
Title: A kerato-epithelin (beta-ig-h3) mutation in lattice corneal dystrophy type IIIA.
PubMed ID: 9497262
DOI: 10.1086/301765
PubMed ID: 9780098
Title: Two distinct kerato-epithelin mutations in Reis-Bucklers corneal dystrophy.
PubMed ID: 9780098
PubMed ID: 9799082
Title: A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities.
PubMed ID: 9799082
PubMed ID: 10660331
Title: A common beta ig-h3 gene mutation (delta F540) in a large cohort of Sardinian Reis Buecklers' corneal dystrophy patients.
PubMed ID: 10660331
PubMed ID: 10425035
Title: Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesis.
PubMed ID: 10425035
DOI: 10.1002/(sici)1098-1004(1999)14:2<126::aid-humu4>3.0.co;2-w
PubMed ID: 10328397
Title: A mutation within exon 14 of the TGFBI (BIGH3) gene on chromosome 5q31 causes an asymmetric, late-onset form of lattice corneal dystrophy.
PubMed ID: 10328397
PubMed ID: 11024425
Title: Association of autosomal dominantly inherited corneal dystrophies with BIGH3 gene mutations in Japan.
PubMed ID: 11024425
PubMed ID: 10865320
Title: A novel variant of granular corneal dystrophy caused by association of 2 mutations in the TGFBI gene-R124L and deltaT125-deltaE126.
PubMed ID: 10865320
PubMed ID: 10837380
Title: Corneal amyloidosis caused by Leu518Pro mutation of betaig-h3 gene.
PubMed ID: 10837380
DOI: 10.1136/bjo.84.6.583
PubMed ID: 11413411
Title: Late-onset form of lattice corneal dystrophy caused by Leu527Arg mutation of the TGFBI gene.
PubMed ID: 11413411
PubMed ID: 11297504
Title: Histologic phenotype-genotype correlation of corneal dystrophies associated with eight distinct mutations in the TGFBI gene.
PubMed ID: 11297504
PubMed ID: 11923233
Title: BIGH3 mutation spectrum in corneal dystrophies.
PubMed ID: 11923233
PubMed ID: 14597039
Title: A new mutation (Leu569Arg) within exon 13 of the TGFBI (BIGH3) gene causes lattice corneal dystrophy type I.
PubMed ID: 14597039
PubMed ID: 12782158
Title: A novel mutation of the TGFBI gene found in a Vietnamese family with atypical granular corneal dystrophy.
PubMed ID: 12782158
PubMed ID: 15531312
Title: Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI gene.
PubMed ID: 15531312
PubMed ID: 15623763
Title: TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients.
PubMed ID: 15623763
DOI: 10.1167/iovs.04-0440
PubMed ID: 15790870
Title: Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin.
PubMed ID: 15790870
DOI: 10.1167/iovs.04-1319
PubMed ID: 15838722
Title: Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type I.
PubMed ID: 15838722
PubMed ID: 16652336
Title: A subset of patients with epithelial basement membrane corneal dystrophy have mutations in TGFBI/BIGH3.
PubMed ID: 16652336
DOI: 10.1002/humu.20331
PubMed ID: 17013691
Title: A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type I.
PubMed ID: 17013691
PubMed ID: 16541014
Title: Unilateral lattice corneal dystrophy associated with the novel His572del mutation in the TGFBI gene.
PubMed ID: 16541014
PubMed ID: 16636649
Title: Expanding the mutational spectrum in TGFBI-linked corneal dystrophies: identification of a novel and unusual mutation (Val113Ile) in a family with granular dystrophy.
PubMed ID: 16636649
Sequence Information:
- Length: 683
- Mass: 74681
- Checksum: 40FDC8A71EBB3D00
- Sequence:
MALFVRLLAL ALALALGPAA TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA VQKVIGTNRK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA LPLSNLYETL GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWAS LPAEVLDSLV SNVNIELLNA LRYHMVGRRV LTDELKHGMT LTSMYQNSNI QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE DTFETLRAAV AASGLNTMLE GNGQYTLLAP TNEAFEKIPS ETLNRILGDP EALRDLLNNH ILKSAMCAEA IVAGLSVETL EGTTLEVGCS GDMLTINGKA IISNKDILAT NGVIHYIDEL LIPDSAKTLF ELAAESDVST AIDLFRQAGL GNHLSGSERL TLLAPLNSVF KDGTPPIDAH TRNLLRNHII KDQLASKYLY HGQTLETLGG KKLRVFVYRN SLCIENSCIA AHDKRGRYGT LFTMDRVLTP PMGTVMDVLK GDNRFSMLVA AIQSAGLTET LNREGVYTVF APTNEAFRAL PPRERSRLLG DAKELANILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS LKNNVVSVNK EPVAEPDIMA TNGVVHVITN VLQPPANRPQ ERGDELADSA LEIFKQASAF SRASQRSVRL APVYQKLLER MKH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.