Details for: LGALS2

Gene ID: 3957

Symbol: LGALS2

Ensembl ID: ENSG00000100079

Description: galectin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.17
    Marker Score: 11272
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.72
    Marker Score: 4198
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.43
    Marker Score: 135957
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.31
    Marker Score: 668
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.13
    Marker Score: 4497
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.94
    Marker Score: 6081
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.87
    Marker Score: 703
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.85
    Marker Score: 1883
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.85
    Marker Score: 8866
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.81
    Marker Score: 3522
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.7
    Marker Score: 1169
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.59
    Marker Score: 3786
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.51
    Marker Score: 853
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.31
    Marker Score: 3272.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2
    Marker Score: 1196.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.19
    Marker Score: 3096
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.18
    Marker Score: 1132
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.09
    Marker Score: 12715
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.09
    Marker Score: 1098
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.96
    Marker Score: 232
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.95
    Marker Score: 636
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1541
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1767
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1872
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.92
    Marker Score: 274
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.91
    Marker Score: 1098
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.87
    Marker Score: 3626.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.82
    Marker Score: 1924
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.78
    Marker Score: 536
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.75
    Marker Score: 240
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.71
    Marker Score: 493.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.71
    Marker Score: 184
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2960.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.68
    Marker Score: 148
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.66
    Marker Score: 1605
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.66
    Marker Score: 189
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.65
    Marker Score: 839
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.62
    Marker Score: 168
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.61
    Marker Score: 386
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6
    Marker Score: 625
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.59
    Marker Score: 269
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.57
    Marker Score: 198
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.57
    Marker Score: 141
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.56
    Marker Score: 1172
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.56
    Marker Score: 224
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 132
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.49
    Marker Score: 151
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1282
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.47
    Marker Score: 284
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 740
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.45
    Marker Score: 156
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.44
    Marker Score: 276
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.42
    Marker Score: 297
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6522
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.39
    Marker Score: 280
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.37
    Marker Score: 102
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 209
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.34
    Marker Score: 379
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.34
    Marker Score: 764
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.33
    Marker Score: 173
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.33
    Marker Score: 3313
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.32
    Marker Score: 74
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.31
    Marker Score: 312
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.3
    Marker Score: 287
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 304
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.3
    Marker Score: 295
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.29
    Marker Score: 106
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1637
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 118
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.26
    Marker Score: 164
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.26
    Marker Score: 201
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.26
    Marker Score: 74
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.25
    Marker Score: 128

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Other Information

**Key characteristics** - Type: Protein - Ensembl ID: ENSG00000100079 - Molecular weight: 120 kDa - Subcellular localization: Cell surface - Expression: Epithelial cells of the proximal tubule, enterocytes of the colon, CD14-positive and CD16-negative classical monocytes, enterocytes of the epithelium proper of ileum, pancreatic acinar cell, colon epithelial cell, intestinal crypt stem cell, dendritic cell **Pathways and functions** - **Cell-cell adhesion:** LGALS2 is a key molecule in cell-cell adhesion, facilitating the formation of cell contacts and the maintenance of tissue integrity. - **Galactoside binding:** It binds to galactoproteins, which are components of the extracellular matrix and cell adhesion molecules. - **Galectin complex:** LGALS2 forms a complex with galectin-9, which is expressed in endothelial cells and immune cells. This complex is involved in cell migration and inflammation. - **Positive regulation of apoptotic process:** LGALS2 positively regulates the apoptotic process by interacting with the Fas receptor and other apoptotic regulators. - **Positive regulation of inflammatory response:** It promotes the production of inflammatory cytokines and chemokines, contributing to the inflammatory response. - **Protein binding:** LGALS2 can bind to various proteins, including complement proteins, cadherins, and syndecans, influencing cell adhesion, migration, and signaling pathways. **Clinical significance** - LGALS2 is implicated in various human diseases, including inflammatory bowel disease, cancer, and cardiovascular diseases. - It is a potential therapeutic target for cancer immunotherapy, as it can inhibit tumor cell growth and angiogenesis. - Anti-LGALS2 antibodies have shown promise in preclinical models of cancer and inflammatory diseases. Overall, LGALS2 is a critical protein with diverse functions in cell adhesion, inflammation, and apoptosis. Its dysregulation has been linked to various human diseases, making it an important target for therapeutic interventions.

Genular Protein ID: 2235279406

Symbol: LEG2_HUMAN

Name: Galectin-2

UniProtKB Accession Codes:

P05162 Q6FGY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1375225

Title: Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin.

PubMed ID: 1375225

DOI: 10.1016/s0021-9258(19)50059-x

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1988031

Title: Genomic sequence and organization of two members of a human lectin gene family.

PubMed ID: 1988031

DOI: 10.1021/bi00215a013

PubMed ID: 3020551

Title: Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.

PubMed ID: 3020551

DOI: 10.1073/pnas.83.20.7603

PubMed ID: 8262940

Title: X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

PubMed ID: 8262940

DOI: 10.2210/pdb1hlc/pdb

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 132
  • Mass: 14644
  • Checksum: E30B8768630A2ACB
  • Sequence:
    • MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF SESTIVCNSL 
DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG HELTFPNRLG HSHLSYLSVR 
GGFNMSSFKL KE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.