Details for: LGALS2

Gene ID: 3957

Symbol: LGALS2

Ensembl ID: ENSG00000100079

Description: galectin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.3104
    Cell Significance Index: -7.6700
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 40.8593
    Cell Significance Index: 20.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.1317
    Cell Significance Index: -8.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.1648
    Cell Significance Index: -12.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0667
    Cell Significance Index: -7.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4982
    Cell Significance Index: -12.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3259
    Cell Significance Index: 26.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3111
    Cell Significance Index: 150.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.0093
    Cell Significance Index: 180.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.3681
    Cell Significance Index: 257.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.2881
    Cell Significance Index: 65.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9756
    Cell Significance Index: 1783.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6351
    Cell Significance Index: 265.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5687
    Cell Significance Index: 25.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5254
    Cell Significance Index: 260.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3407
    Cell Significance Index: 24.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2302
    Cell Significance Index: 85.0800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.1982
    Cell Significance Index: 7.1800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.9278
    Cell Significance Index: 9.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9139
    Cell Significance Index: 14.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5659
    Cell Significance Index: 107.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4164
    Cell Significance Index: 10.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3247
    Cell Significance Index: 10.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2714
    Cell Significance Index: 5.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2080
    Cell Significance Index: 7.3100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1971
    Cell Significance Index: 0.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1786
    Cell Significance Index: 17.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1519
    Cell Significance Index: 3.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0879
    Cell Significance Index: 54.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0731
    Cell Significance Index: 8.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0606
    Cell Significance Index: 12.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0132
    Cell Significance Index: 0.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0116
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0031
    Cell Significance Index: -2.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0050
    Cell Significance Index: -2.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0057
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0099
    Cell Significance Index: -4.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0117
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0125
    Cell Significance Index: -1.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0142
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0155
    Cell Significance Index: -3.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0174
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0175
    Cell Significance Index: -2.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0200
    Cell Significance Index: -7.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0222
    Cell Significance Index: -10.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0314
    Cell Significance Index: -0.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0321
    Cell Significance Index: -4.1100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0338
    Cell Significance Index: -0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0359
    Cell Significance Index: -7.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0380
    Cell Significance Index: -10.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0423
    Cell Significance Index: -7.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0476
    Cell Significance Index: -4.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0560
    Cell Significance Index: -2.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0592
    Cell Significance Index: -2.4300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0595
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0595
    Cell Significance Index: -8.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0701
    Cell Significance Index: -10.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0730
    Cell Significance Index: -8.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0777
    Cell Significance Index: -8.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0792
    Cell Significance Index: -1.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0797
    Cell Significance Index: -5.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0823
    Cell Significance Index: -1.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0826
    Cell Significance Index: -2.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0963
    Cell Significance Index: -11.3600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1009
    Cell Significance Index: -0.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1065
    Cell Significance Index: -6.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1081
    Cell Significance Index: -3.0200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1111
    Cell Significance Index: -0.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1242
    Cell Significance Index: -9.5300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1327
    Cell Significance Index: -2.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1469
    Cell Significance Index: -9.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1587
    Cell Significance Index: -11.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1618
    Cell Significance Index: -10.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1647
    Cell Significance Index: -2.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1675
    Cell Significance Index: -7.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1731
    Cell Significance Index: -10.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1742
    Cell Significance Index: -4.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1811
    Cell Significance Index: -10.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1816
    Cell Significance Index: -3.5500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1871
    Cell Significance Index: -1.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1892
    Cell Significance Index: -8.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1996
    Cell Significance Index: -10.3700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2088
    Cell Significance Index: -2.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2089
    Cell Significance Index: -5.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2202
    Cell Significance Index: -8.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2389
    Cell Significance Index: -8.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2458
    Cell Significance Index: -3.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2659
    Cell Significance Index: -6.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2663
    Cell Significance Index: -8.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2664
    Cell Significance Index: -5.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2704
    Cell Significance Index: -4.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2716
    Cell Significance Index: -8.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Carbohydrate-binding protein**: Galectin-2 possesses a carbohydrate-binding domain, allowing it to interact with various glycoproteins and glycolipids. 2. **Multifunctional protein**: Galectin-2 has been implicated in multiple biological processes, including inflammation, apoptosis, cell proliferation, and cell adhesion. 3. **Tissue-specific expression**: Galectin-2 is expressed in various tissues, including epithelial cells, immune cells, and stem cells, highlighting its role in tissue homeostasis and immune regulation. 4. **Regulation of immune responses**: Galectin-2 has been shown to modulate immune responses, including the regulation of T cell homeostasis and the promotion of anti-inflammatory responses. **Pathways and Functions:** 1. **Inflammation**: Galectin-2 has been shown to regulate inflammatory responses by modulating the activity of immune cells, such as dendritic cells and monocytes. 2. **Apoptosis**: Galectin-2 can induce apoptosis in various cell types, including cancer cells, by interacting with specific glycoproteins and inducing the activation of pro-apoptotic signaling pathways. 3. **Cell adhesion**: Galectin-2 can facilitate cell adhesion by interacting with specific glycolipids and glycoproteins, which is essential for the proper functioning of immune cells and epithelial cells. 4. **T cell homeostasis**: Galectin-2 has been shown to regulate T cell homeostasis by modulating the activity of T cell receptors and the activation of signaling pathways involved in T cell proliferation and differentiation. **Clinical Significance:** 1. **Cancer**: Galectin-2 has been implicated in cancer progression, where it can promote tumor growth, invasion, and metastasis by inducing apoptosis in cancer cells and facilitating angiogenesis. 2. **Autoimmune diseases**: Galectin-2 has been shown to play a role in autoimmune diseases, such as rheumatoid arthritis, where it can modulate immune responses and promote inflammation. 3. **Inflammatory bowel disease**: Galectin-2 has been implicated in inflammatory bowel disease, where it can regulate inflammatory responses and promote tissue repair. 4. **Vaccine development**: Galectin-2 has been explored as a potential adjuvant in vaccine development, where it can enhance immune responses and promote tolerance to antigens. In conclusion, galectin-2 is a multifaceted gene with a wide range of biological functions, including inflammation, apoptosis, and cell homeostasis. Its clinical significance extends to various diseases, including cancer, autoimmune diseases, and inflammatory bowel disease. Further research is needed to fully elucidate the mechanisms by which galectin-2 regulates biological processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2235279406

Symbol: LEG2_HUMAN

Name: Galectin-2

UniProtKB Accession Codes:

P05162 Q6FGY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1375225

Title: Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin.

PubMed ID: 1375225

DOI: 10.1016/s0021-9258(19)50059-x

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1988031

Title: Genomic sequence and organization of two members of a human lectin gene family.

PubMed ID: 1988031

DOI: 10.1021/bi00215a013

PubMed ID: 3020551

Title: Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.

PubMed ID: 3020551

DOI: 10.1073/pnas.83.20.7603

PubMed ID: 8262940

Title: X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

PubMed ID: 8262940

DOI: 10.2210/pdb1hlc/pdb

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 132
  • Mass: 14644
  • Checksum: E30B8768630A2ACB
  • Sequence:
    • MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF SESTIVCNSL 
DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG HELTFPNRLG HSHLSYLSVR 
GGFNMSSFKL KE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.