Details for: FYB1

Gene ID: 2533

Symbol: FYB1

Ensembl ID: ENSG00000082074

Description: FYN binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.0169
    Cell Significance Index: -36.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.4165
    Cell Significance Index: -37.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.4190
    Cell Significance Index: -27.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3171
    Cell Significance Index: -34.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.9775
    Cell Significance Index: 184.4100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 6.9311
    Cell Significance Index: 69.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 5.0412
    Cell Significance Index: 228.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9219
    Cell Significance Index: -13.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.3693
    Cell Significance Index: 128.3200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.9899
    Cell Significance Index: 12.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.5833
    Cell Significance Index: 681.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4170
    Cell Significance Index: 239.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9194
    Cell Significance Index: 132.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7301
    Cell Significance Index: 46.2800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.5938
    Cell Significance Index: 13.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2308
    Cell Significance Index: 200.1900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0352
    Cell Significance Index: 10.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9908
    Cell Significance Index: 107.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3471
    Cell Significance Index: 10.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2177
    Cell Significance Index: 13.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1904
    Cell Significance Index: 4.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1611
    Cell Significance Index: 5.6600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1462
    Cell Significance Index: 0.9700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1431
    Cell Significance Index: 1.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0789
    Cell Significance Index: 0.4900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0622
    Cell Significance Index: 0.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0578
    Cell Significance Index: 1.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0176
    Cell Significance Index: 1.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0147
    Cell Significance Index: 0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0032
    Cell Significance Index: -0.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0084
    Cell Significance Index: -15.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0149
    Cell Significance Index: -23.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0208
    Cell Significance Index: -28.3200
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0220
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0367
    Cell Significance Index: -27.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0378
    Cell Significance Index: -26.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0417
    Cell Significance Index: -30.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0480
    Cell Significance Index: -35.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0499
    Cell Significance Index: -1.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0508
    Cell Significance Index: -14.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0538
    Cell Significance Index: -30.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0547
    Cell Significance Index: -34.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0573
    Cell Significance Index: -20.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0583
    Cell Significance Index: -11.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0704
    Cell Significance Index: -31.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0734
    Cell Significance Index: -33.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1009
    Cell Significance Index: -1.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1306
    Cell Significance Index: -15.4000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1444
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1487
    Cell Significance Index: -31.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1523
    Cell Significance Index: -26.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1583
    Cell Significance Index: -28.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2142
    Cell Significance Index: -31.1400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2179
    Cell Significance Index: -3.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2238
    Cell Significance Index: -30.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2399
    Cell Significance Index: -29.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2534
    Cell Significance Index: -32.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2646
    Cell Significance Index: -12.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2711
    Cell Significance Index: -31.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2724
    Cell Significance Index: -31.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2824
    Cell Significance Index: -29.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3253
    Cell Significance Index: -8.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3275
    Cell Significance Index: -25.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3320
    Cell Significance Index: -14.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3324
    Cell Significance Index: -42.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3361
    Cell Significance Index: -15.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3684
    Cell Significance Index: -23.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4195
    Cell Significance Index: -28.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4334
    Cell Significance Index: -32.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4480
    Cell Significance Index: -9.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4699
    Cell Significance Index: -15.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4763
    Cell Significance Index: -37.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4767
    Cell Significance Index: -9.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4943
    Cell Significance Index: -30.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4950
    Cell Significance Index: -35.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5135
    Cell Significance Index: -31.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5333
    Cell Significance Index: -9.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5507
    Cell Significance Index: -27.8300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5622
    Cell Significance Index: -6.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5785
    Cell Significance Index: -32.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.5964
    Cell Significance Index: -4.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6083
    Cell Significance Index: -38.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6166
    Cell Significance Index: -32.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.6232
    Cell Significance Index: -5.9900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.6393
    Cell Significance Index: -5.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6423
    Cell Significance Index: -17.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6561
    Cell Significance Index: -29.0200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6660
    Cell Significance Index: -8.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6782
    Cell Significance Index: -35.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6862
    Cell Significance Index: -24.0400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.7164
    Cell Significance Index: -5.3300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.7173
    Cell Significance Index: -5.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7452
    Cell Significance Index: -28.2200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.7617
    Cell Significance Index: -7.9000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.7641
    Cell Significance Index: -3.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7682
    Cell Significance Index: -25.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7911
    Cell Significance Index: -15.4400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.7951
    Cell Significance Index: -9.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FYB1 is a member of the FYB family of proteins, which are known for their ability to interact with various signaling molecules and adaptor proteins. The FYB1 protein is primarily localized to the plasma membrane, where it interacts with other proteins to regulate cell signaling pathways. Notably, FYB1 is highly expressed in cells of the immune system, including monocytes, T cells, and dendritic cells, suggesting its critical role in immune response and regulation. **Pathways and Functions:** FYB1 is involved in several key pathways, including: 1. **Integrin-mediated signaling pathway**: FYB1 interacts with integrins, which are transmembrane receptors that facilitate cell adhesion and migration. This interaction regulates signaling pathways that control cell migration, proliferation, and differentiation. 2. **T cell receptor signaling pathway**: FYB1 is essential for the proper functioning of T cell receptors, which recognize and respond to antigens. The interaction between FYB1 and TCR signaling molecules regulates T cell activation, proliferation, and differentiation. 3. **Adaptive immune system**: FYB1 is expressed in cells of the adaptive immune system, including T cells and dendritic cells, where it plays a role in regulating immune responses and cell signaling. 4. **Cell-cell communication**: FYB1 interacts with other proteins to regulate cell-cell communication, including the regulation of adhesion molecules and signaling pathways. **Clinical Significance:** FYB1 has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: FYB1 mutations have been associated with immunodeficiency disorders, such as X-linked lymphoproliferative disease. 2. **Autoimmune diseases**: FYB1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune responses and cell signaling. 3. **Cancer**: FYB1 has been linked to cancer, including leukemia and lymphoma, where it regulates cell proliferation, migration, and differentiation. In conclusion, FYB1 is a complex gene that plays a critical role in various cellular processes, including immune response, cell signaling, and cell-cell communication. Further research is needed to fully elucidate the functions of FYB1 and its implications in human disease. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which FYB1 regulates immune responses and cell signaling. 2. The development of therapeutic strategies targeting FYB1 may provide new avenues for treating immunodeficiency disorders and autoimmune diseases. 3. The study of FYB1's role in cancer may lead to the identification of new targets for cancer therapy. By continuing to explore the complexities of FYB1, we may uncover new insights into the regulation of immune responses and cell signaling, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1209605747

Symbol: FYB1_HUMAN

Name: Adhesion and degranulation promoting adaptor protein

UniProtKB Accession Codes:

O15117 A8K2Y8 B4DLN2 E9PBV9 O00359 Q9NZI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9207119

Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

PubMed ID: 9207119

DOI: 10.1073/pnas.94.14.7493

PubMed ID: 9115214

Title: Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases.

PubMed ID: 9115214

DOI: 10.1074/jbc.272.18.11674

PubMed ID: 10747096

Title: Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.

PubMed ID: 10747096

DOI: 10.1083/jcb.149.1.181

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9755858

Title: SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55.

PubMed ID: 9755858

DOI: 10.1016/s0014-5793(98)01040-0

PubMed ID: 9748251

Title: Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.

PubMed ID: 9748251

DOI: 10.1074/jbc.273.40.25789

PubMed ID: 9671755

Title: FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.

PubMed ID: 9671755

DOI: 10.1073/pnas.95.15.8779

PubMed ID: 10942756

Title: Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

PubMed ID: 10942756

DOI: 10.1074/jbc.m001439200

PubMed ID: 10856234

Title: SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.

PubMed ID: 10856234

DOI: 10.1093/emboj/19.12.2889

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15849195

Title: Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.

PubMed ID: 15849195

DOI: 10.1074/jbc.m413201200

PubMed ID: 16461356

Title: Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.

PubMed ID: 16461356

DOI: 10.1074/jbc.m508774200

PubMed ID: 16980616

Title: The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.

PubMed ID: 16980616

DOI: 10.1128/mcb.00331-06

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25516138

Title: Recessive thrombocytopenia likely due to a homozygous pathogenic variant in the FYB gene: case report.

PubMed ID: 25516138

DOI: 10.1186/s12881-014-0135-0

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25876182

Title: Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.

PubMed ID: 25876182

DOI: 10.1111/jth.12966

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 15062083

Title: Structure of a helically extended SH3 domain of the T cell adapter protein ADAP.

PubMed ID: 15062083

DOI: 10.1016/j.str.2004.02.021

Sequence Information:

  • Length: 783
  • Mass: 85387
  • Checksum: 4EE28EF12AA0E457
  • Sequence:
    • MAKYNTGGNP TEDVSVNSRP FRVTGPNSSS GIQARKNLFN NQGNASPPAG PSNVPKFGSP 
KPPVAVKPSS EEKPDKEPKP PFLKPTGAGQ RFGTPASLTT RDPEAKVGFL KPVGPKPINL 
PKEDSKPTFP WPPGNKPSLH SVNQDHDLKP LGPKSGPTPP TSENEQKQAF PKLTGVKGKF 
MSASQDLEPK PLFPKPAFGQ KPPLSTENSH EDESPMKNVS SSKGSPAPLG VRSKSGPLKP 
AREDSENKDH AGEISSLPFP GVVLKPAASR GGPGLSKNGE EKKEDRKIDA AKNTFQSKIN 
QEELASGTPP ARFPKAPSKL TVGGPWGQSQ EKEKGDKNSA TPKQKPLPPL FTLGPPPPKP 
NRPPNVDLTK FHKTSSGNST SKGQTSYSTT SLPPPPPSHP ASQPPLPASH PSQPPVPSLP 
PRNIKPPFDL KSPVNEDNQD GVTHSDGAGN LDEEQDSEGE TYEDIEASKE REKKREKEEK 
KRLELEKKEQ KEKEKKEQEI KKKFKLTGPI QVIHLAKACC DVKGGKNELS FKQGEQIEII 
RITDNPEGKW LGRTARGSYG YIKTTAVEID YDSLKLKKDS LGAPSRPIED DQEVYDDVAE 
QDDISSHSQS GSGGIFPPPP DDDIYDGIEE EDADDGFPAP PKQLDMGDEV YDDVDTSDFP 
VSSAEMSQGT NVGKAKTEEK DLKKLKKQEK EEKDFRKKFK YDGEIRVLYS TKVTTSITSK 
KWGTRDLQVK PGESLEVIQT TDDTKVLCRN EEGKYGYVLR SYLADNDGEI YDDIADGCIY 
DND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.