Gene FYB1 - ENSG00000082074 | NCBI Gene ID: 2533

Details for: FYB1

Gene ID: 2533

Symbol: FYB1

Ensembl ID: ENSG00000082074

Description: FYN binding protein 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Cell-cell communication
(R-HSA-1500931)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Signal regulatory protein family interactions
(R-HSA-391160)
Tcr signaling
(R-HSA-202403)
Actin cytoskeleton
(GO:0015629)
Anchoring junction
(GO:0070161)
Biological_process
(GO:0008150)
Cytosol
(GO:0005829)
Immune response
(GO:0006955)
Integrin-mediated signaling pathway
(GO:0007229)
Lipid binding
(GO:0008289)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Signaling receptor binding
(GO:0005102)
T cell receptor signaling pathway
(GO:0050852)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.24
Marker Score: 3697.5
Cell Name: classical monocyte (CL0000860)
Fold Change: 4.34
Marker Score: 18013
Cell Name: mature microglial cell (CL0002629)
Fold Change: 4.3
Marker Score: 1554
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4
Marker Score: 211661
Cell Name: mature T cell (CL0002419)
Fold Change: 3.85
Marker Score: 38126
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 3.84
Marker Score: 2328
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.75
Marker Score: 209786
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.64
Marker Score: 2754.5
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.63
Marker Score: 3085
Cell Name: naive T cell (CL0000898)
Fold Change: 3.63
Marker Score: 2340
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.56
Marker Score: 9973
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.45
Marker Score: 14784
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.34
Marker Score: 1659
Cell Name: blood cell (CL0000081)
Fold Change: 3.32
Marker Score: 38617
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.31
Marker Score: 6443
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.29
Marker Score: 3291
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.25
Marker Score: 5567.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.17
Marker Score: 7733
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.06
Marker Score: 1068
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.04
Marker Score: 5432.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.03
Marker Score: 1512
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.01
Marker Score: 2182
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.94
Marker Score: 1513
Cell Name: microglial cell (CL0000129)
Fold Change: 2.88
Marker Score: 5249
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.88
Marker Score: 2782
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.88
Marker Score: 2693
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.84
Marker Score: 8956
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.81
Marker Score: 2503.5
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.76
Marker Score: 2020
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.67
Marker Score: 5242
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.62
Marker Score: 1132
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.55
Marker Score: 2147
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.54
Marker Score: 787
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.48
Marker Score: 1428
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.44
Marker Score: 2699
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.43
Marker Score: 5482
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.4
Marker Score: 6618
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.37
Marker Score: 15125
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.32
Marker Score: 2801
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.31
Marker Score: 2497
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.31
Marker Score: 3397
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.3
Marker Score: 2022
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.29
Marker Score: 1905
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.25
Marker Score: 741
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.25
Marker Score: 3099
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.24
Marker Score: 679
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.23
Marker Score: 5391
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.18
Marker Score: 2421
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.18
Marker Score: 1338
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.13
Marker Score: 868
Cell Name: memory T cell (CL0000813)
Fold Change: 2.12
Marker Score: 912
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.11
Marker Score: 560
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.99
Marker Score: 4960
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.99
Marker Score: 1320
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.98
Marker Score: 1160
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.94
Marker Score: 2225
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.94
Marker Score: 1523
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.85
Marker Score: 953
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.84
Marker Score: 1326
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.83
Marker Score: 596
Cell Name: thymocyte (CL0000893)
Fold Change: 1.77
Marker Score: 1853.5
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.76
Marker Score: 447
Cell Name: Unknown (CL0000548)
Fold Change: 1.74
Marker Score: 1269
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.73
Marker Score: 598
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.72
Marker Score: 2433
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.72
Marker Score: 5012
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.64
Marker Score: 4251
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.63
Marker Score: 1339
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.63
Marker Score: 682
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.63
Marker Score: 1450.5
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.57
Marker Score: 864.5
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.55
Marker Score: 1129
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.55
Marker Score: 352
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.49
Marker Score: 620
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.48
Marker Score: 1511
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166807
Cell Name: neutrophil (CL0000775)
Fold Change: 1.45
Marker Score: 884
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.39
Marker Score: 773
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 1.38
Marker Score: 1220.5
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.38
Marker Score: 628
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.35
Marker Score: 8200
Cell Name: myelocyte (CL0002193)
Fold Change: 1.34
Marker Score: 578
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.32
Marker Score: 796
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.31
Marker Score: 883
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.31
Marker Score: 1422
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.2
Marker Score: 30676
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.18
Marker Score: 380
Cell Name: macrophage (CL0000235)
Fold Change: 1.13
Marker Score: 1262
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4723
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.12
Marker Score: 2275.5
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 1.08
Marker Score: 1757
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.05
Marker Score: 263
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.05
Marker Score: 275
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.04
Marker Score: 704
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.03
Marker Score: 425.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.02
Marker Score: 578
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71685
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47910
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.98
Marker Score: 2240
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30393

Hover over a box to see details here...

**Key characteristics**: - FYB1 is a protein of the immunoglobulin superfamily. - It is expressed in a variety of cell types, including monocytes, macrophages, dendritic cells, and lymphocytes. - FYB1 is a key regulator of the actin cytoskeleton. - Its overexpression has been linked to the development of cancer. **Pathways and functions**: - FYB1 is involved in the regulation of the actin cytoskeleton. - It is a key regulator of cell migration, adhesion, and signaling. - FYB1 is also involved in the regulation of the immune response. **Clinical significance**: - FYB1 is a potential therapeutic target for cancer. - Inhibition of FYB1 has been shown to inhibit cancer cell growth and migration. - Clinical trials are currently underway to develop new drugs that target FYB1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adhesion and degranulation promoting adaptor protein

Genular Protein ID: 1209605747

Symbol: FYB1_HUMAN

Name: Adhesion and degranulation promoting adaptor protein

UniProtKB Accession Codes:

O15117 A8K2Y8 B4DLN2 E9PBV9 O00359 Q9NZI9

Database IDs:

Citations:

PubMed ID: 9207119

Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

PubMed ID: 9207119

DOI: 10.1073/pnas.94.14.7493

PubMed ID: 9115214

Title: Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases.

PubMed ID: 9115214

DOI: 10.1074/jbc.272.18.11674

PubMed ID: 10747096

Title: Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.

PubMed ID: 10747096

DOI: 10.1083/jcb.149.1.181

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9755858

Title: SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55.

PubMed ID: 9755858

DOI: 10.1016/s0014-5793(98)01040-0

PubMed ID: 9748251

Title: Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.

PubMed ID: 9748251

DOI: 10.1074/jbc.273.40.25789

PubMed ID: 9671755

Title: FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.

PubMed ID: 9671755

DOI: 10.1073/pnas.95.15.8779

PubMed ID: 10942756

Title: Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

PubMed ID: 10942756

DOI: 10.1074/jbc.m001439200

PubMed ID: 10856234

Title: SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.

PubMed ID: 10856234

DOI: 10.1093/emboj/19.12.2889

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15849195

Title: Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.

PubMed ID: 15849195

DOI: 10.1074/jbc.m413201200

PubMed ID: 16461356

Title: Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.

PubMed ID: 16461356

DOI: 10.1074/jbc.m508774200

PubMed ID: 16980616

Title: The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.

PubMed ID: 16980616

DOI: 10.1128/mcb.00331-06

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25516138

Title: Recessive thrombocytopenia likely due to a homozygous pathogenic variant in the FYB gene: case report.

PubMed ID: 25516138

DOI: 10.1186/s12881-014-0135-0

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25876182

Title: Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.

PubMed ID: 25876182

DOI: 10.1111/jth.12966

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 15062083

Title: Structure of a helically extended SH3 domain of the T cell adapter protein ADAP.

PubMed ID: 15062083

DOI: 10.1016/j.str.2004.02.021

Sequence Information:

Length: 783
Mass: 85387
Checksum: 4EE28EF12AA0E457
Sequence:

MAKYNTGGNP TEDVSVNSRP FRVTGPNSSS GIQARKNLFN NQGNASPPAG PSNVPKFGSP 
KPPVAVKPSS EEKPDKEPKP PFLKPTGAGQ RFGTPASLTT RDPEAKVGFL KPVGPKPINL 
PKEDSKPTFP WPPGNKPSLH SVNQDHDLKP LGPKSGPTPP TSENEQKQAF PKLTGVKGKF 
MSASQDLEPK PLFPKPAFGQ KPPLSTENSH EDESPMKNVS SSKGSPAPLG VRSKSGPLKP 
AREDSENKDH AGEISSLPFP GVVLKPAASR GGPGLSKNGE EKKEDRKIDA AKNTFQSKIN 
QEELASGTPP ARFPKAPSKL TVGGPWGQSQ EKEKGDKNSA TPKQKPLPPL FTLGPPPPKP 
NRPPNVDLTK FHKTSSGNST SKGQTSYSTT SLPPPPPSHP ASQPPLPASH PSQPPVPSLP 
PRNIKPPFDL KSPVNEDNQD GVTHSDGAGN LDEEQDSEGE TYEDIEASKE REKKREKEEK 
KRLELEKKEQ KEKEKKEQEI KKKFKLTGPI QVIHLAKACC DVKGGKNELS FKQGEQIEII 
RITDNPEGKW LGRTARGSYG YIKTTAVEID YDSLKLKKDS LGAPSRPIED DQEVYDDVAE 
QDDISSHSQS GSGGIFPPPP DDDIYDGIEE EDADDGFPAP PKQLDMGDEV YDDVDTSDFP 
VSSAEMSQGT NVGKAKTEEK DLKKLKKQEK EEKDFRKKFK YDGEIRVLYS TKVTTSITSK 
KWGTRDLQVK PGESLEVIQT TDDTKVLCRN EEGKYGYVLR SYLADNDGEI YDDIADGCIY 
DND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FYB1

Associated with

Cells (max top 100)

Other Information

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. PubMed ID: 9207119

Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. PubMed ID: 9115214

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. PubMed ID: 10747096

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. PubMed ID: 9755858

Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. PubMed ID: 9748251

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. PubMed ID: 9671755

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. PubMed ID: 10942756

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. PubMed ID: 10856234

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. PubMed ID: 15849195

Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. PubMed ID: 16461356

The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. PubMed ID: 16980616

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Recessive thrombocytopenia likely due to a homozygous pathogenic variant in the FYB gene: case report. PubMed ID: 25516138

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. PubMed ID: 25876182

ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion. PubMed ID: 27335501

Structure of a helically extended SH3 domain of the T cell adapter protein ADAP. PubMed ID: 15062083