Details for: CL0002629

Cell ID: CL0002629

Cell Name: mature microglial cell

Marker Score Threshold: 361
(Derived using integrated single-cell and genomic data)

Description: A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation.

Synonyms: activated microglia, mature microglia, reactive microglia

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 5.38
    Ensembl ID: ENSG00000168675
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 4.63
    Ensembl ID: ENSG00000159216
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.11
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 4.01
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.96
    Ensembl ID: ENSG00000075624
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 3.71
    Ensembl ID: ENSG00000125730
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 3.12
    Ensembl ID: ENSG00000136250
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 3.12
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.03
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 3
    Ensembl ID: ENSG00000149311
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.98
    Ensembl ID: ENSG00000130203
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.89
    Ensembl ID: ENSG00000175899
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.73
    Ensembl ID: ENSG00000142599
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.71
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 2.52
    Ensembl ID: ENSG00000236824
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.48
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.41
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 2.39
    Ensembl ID: ENSG00000012779
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 2.35
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.26
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.24
    Ensembl ID: ENSG00000152518
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 2.19
    Ensembl ID: ENSG00000173369
  • Gene Symbol: C1QC (ENSG00000159189)
    Fold Change: 2.16
    Ensembl ID: ENSG00000159189
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.08
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ENTPD1 (ENSG00000138185)
    Fold Change: 2.07
    Ensembl ID: ENSG00000138185
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.05
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.04
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135298
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.96
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.95
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CD14 (ENSG00000170458)
    Fold Change: 1.93
    Ensembl ID: ENSG00000170458
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.93
    Ensembl ID: ENSG00000112576
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.83
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143153
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.8
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.78
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198668
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.71
    Ensembl ID: ENSG00000100280
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.68
    Ensembl ID: ENSG00000143119
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.68
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.63
    Ensembl ID: ENSG00000170017
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.61
    Ensembl ID: ENSG00000167601
  • Gene Symbol: CD86 (ENSG00000114013)
    Fold Change: 1.59
    Ensembl ID: ENSG00000114013
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.57
    Ensembl ID: ENSG00000173372
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.54
    Ensembl ID: ENSG00000047648
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.54
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.54
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.53
    Ensembl ID: ENSG00000182389
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.53
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.5
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.49
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 1.49
    Ensembl ID: ENSG00000124813
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.46
    Ensembl ID: ENSG00000184009
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.42
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.37
    Ensembl ID: ENSG00000100077
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.37
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.36
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.33
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.33
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.32
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.3
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.29
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.28
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.28
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.26
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.2
    Ensembl ID: ENSG00000097007
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.17
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143322
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.11
    Ensembl ID: ENSG00000179218
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.1
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.09
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.09
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.08
    Ensembl ID: ENSG00000278540
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.08
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.07
    Ensembl ID: ENSG00000067955
  • Gene Symbol: CBL (ENSG00000110395)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110395
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.07
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.07
    Ensembl ID: ENSG00000033627
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198363
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.04
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.04
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.04
    Ensembl ID: ENSG00000157388
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.03
    Ensembl ID: ENSG00000115307
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.02
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.02
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.02
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.01
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174437
Hovered Details

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Hovered Details

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**Key Characteristics** Mature microglial cells are characterized by: 1. **Amoeboid morphology**: A transformed morphology, allowing for increased mobility and interaction with the surrounding environment. 2. **Cytokine production**: The ability to produce cytokines, which regulate the immune response and inflammation. 3. **Antigen presentation**: The capacity to present antigens to T-cells, facilitating the activation of immune responses. 4. **Regulation of inflammation**: Mature microglial cells play a key role in regulating inflammation in the central nervous system (CNS). 5. **Cellular differentiation**: These cells can differentiate into various cell types, including macrophages and dendritic cells. **Clinical Significance** Mature microglial cells have significant clinical implications in various neurological disorders, including: 1. **Neurodegenerative diseases**: Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where mature microglial cells are involved in the progression of these diseases. 2. **Infectious diseases**: The ability of mature microglial cells to produce cytokines and present antigens makes them important in the defense against viral and bacterial infections in the CNS. 3. **Traumatic brain injury**: Mature microglial cells play a crucial role in the response to traumatic brain injury, regulating inflammation and promoting repair. **Regulatory Pathways** Mature microglial cells are regulated by various signaling pathways, including: 1. **RUNX1**: A transcription factor involved in the regulation of immune responses, cellular differentiation, and inflammation. 2. **B2M**: A major histocompatibility complex (MHC) class I molecule involved in antigen presentation and regulation of immune responses. 3. **ABR**: A guanylate-binding protein involved in the regulation of cellular signaling and immune responses. 4. **RUNX3**: A transcription factor involved in the regulation of immune responses, cellular differentiation, and inflammation. These regulatory pathways highlight the complex interactions between mature microglial cells and the surrounding environment, emphasizing the importance of these cells in the regulation of immune responses and inflammation in the CNS.