Details for: ANK3

Gene ID: 288

Symbol: ANK3

Ensembl ID: ENSG00000151150

Description: ankyrin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 688.0314
    Cell Significance Index: -107.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 424.9667
    Cell Significance Index: -107.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 211.9576
    Cell Significance Index: -100.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 191.2828
    Cell Significance Index: -77.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 149.1456
    Cell Significance Index: -100.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 86.8077
    Cell Significance Index: -107.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.7393
    Cell Significance Index: -78.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.0560
    Cell Significance Index: -93.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.3970
    Cell Significance Index: -108.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.3654
    Cell Significance Index: -31.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 11.7780
    Cell Significance Index: 104.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 10.0828
    Cell Significance Index: 281.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 8.5245
    Cell Significance Index: 146.0900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.3278
    Cell Significance Index: 64.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 8.2193
    Cell Significance Index: 505.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 8.0208
    Cell Significance Index: 192.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 7.3612
    Cell Significance Index: 494.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.4788
    Cell Significance Index: 184.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 6.4518
    Cell Significance Index: 2314.1600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 6.4331
    Cell Significance Index: 39.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.0334
    Cell Significance Index: 266.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.8060
    Cell Significance Index: 219.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.3800
    Cell Significance Index: 412.8600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 5.0894
    Cell Significance Index: 53.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.7351
    Cell Significance Index: 2583.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.6657
    Cell Significance Index: 735.3400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.1094
    Cell Significance Index: 7.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.0745
    Cell Significance Index: 36.6500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.7613
    Cell Significance Index: 35.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.5234
    Cell Significance Index: 2071.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.4061
    Cell Significance Index: 2593.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3212
    Cell Significance Index: 33.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1287
    Cell Significance Index: 59.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0414
    Cell Significance Index: 65.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0205
    Cell Significance Index: 47.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.9692
    Cell Significance Index: 1492.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9601
    Cell Significance Index: 20.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8639
    Cell Significance Index: 48.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8379
    Cell Significance Index: 151.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7722
    Cell Significance Index: 11.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7440
    Cell Significance Index: 91.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7092
    Cell Significance Index: 115.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6573
    Cell Significance Index: 71.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5594
    Cell Significance Index: 355.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.4507
    Cell Significance Index: 5.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3888
    Cell Significance Index: 171.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3887
    Cell Significance Index: 11.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2882
    Cell Significance Index: 542.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2822
    Cell Significance Index: 56.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2805
    Cell Significance Index: 253.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0922
    Cell Significance Index: 50.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0586
    Cell Significance Index: 42.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0541
    Cell Significance Index: 1.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0329
    Cell Significance Index: 6.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0567
    Cell Significance Index: -8.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0667
    Cell Significance Index: -30.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0687
    Cell Significance Index: -50.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0823
    Cell Significance Index: -62.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0863
    Cell Significance Index: -53.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1010
    Cell Significance Index: -1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1191
    Cell Significance Index: -3.1800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1219
    Cell Significance Index: -1.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1275
    Cell Significance Index: -71.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1363
    Cell Significance Index: -13.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1977
    Cell Significance Index: -27.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2414
    Cell Significance Index: -50.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2489
    Cell Significance Index: -42.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3037
    Cell Significance Index: -87.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4214
    Cell Significance Index: -49.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4247
    Cell Significance Index: -5.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4567
    Cell Significance Index: -46.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4652
    Cell Significance Index: -59.6300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4772
    Cell Significance Index: -5.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4972
    Cell Significance Index: -25.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5241
    Cell Significance Index: -24.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5505
    Cell Significance Index: -71.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5544
    Cell Significance Index: -57.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5620
    Cell Significance Index: -38.8700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5945
    Cell Significance Index: -7.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6100
    Cell Significance Index: -27.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6118
    Cell Significance Index: -43.2700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.6157
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6752
    Cell Significance Index: -77.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6848
    Cell Significance Index: -22.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7018
    Cell Significance Index: -9.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7357
    Cell Significance Index: -15.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7700
    Cell Significance Index: -90.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7810
    Cell Significance Index: -15.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7983
    Cell Significance Index: -17.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8248
    Cell Significance Index: -26.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9196
    Cell Significance Index: -13.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9198
    Cell Significance Index: -8.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9595
    Cell Significance Index: -20.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9893
    Cell Significance Index: -112.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9894
    Cell Significance Index: -78.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0517
    Cell Significance Index: -64.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0518
    Cell Significance Index: -78.3900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.1416
    Cell Significance Index: -12.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2328
    Cell Significance Index: -30.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANK3 exhibits several key characteristics that enable it to perform its functions: 1. **Cytoskeletal binding**: ANK3 interacts with various cytoskeletal proteins, including spectrin and actin, to maintain the structural integrity of the plasma membrane. 2. **Membrane protein binding**: ANK3 binds to a wide range of membrane proteins, including ion channels, transporters, and receptors, to regulate their activity and localization. 3. **Protein localization**: ANK3 regulates the localization of proteins to the plasma membrane, ensuring their proper targeting and function. 4. **Signal transduction**: ANK3 modulates signal transduction pathways, influencing cell signaling and response to extracellular stimuli. **Pathways and Functions** ANK3 is involved in various cellular pathways, including: 1. **Axon guidance**: ANK3 regulates axon guidance and neuronal development, ensuring proper axonal targeting and connectivity. 2. **Neuromuscular junction formation**: ANK3 is essential for the formation and maintenance of neuromuscular junctions, which are critical for muscle function. 3. **Cardiac muscle cell function**: ANK3 regulates cardiac muscle cell function, including action potential propagation and contraction. 4. **Cell signaling**: ANK3 modulates cell signaling pathways, influencing cell growth, differentiation, and survival. ANK3's functions can be broadly categorized into: 1. **Structural maintenance**: ANK3 maintains the structural integrity of the plasma membrane, ensuring its proper functioning and organization. 2. **Protein regulation**: ANK3 regulates the activity and localization of membrane proteins, influencing cell signaling and response to extracellular stimuli. 3. **Cell development**: ANK3 is essential for neuronal development, axon guidance, and neuromuscular junction formation. **Clinical Significance** Dysregulation of ANK3 has been implicated in various neurological and cardiac disorders, including: 1. **Neurological disorders**: ANK3 mutations have been associated with conditions such as autism spectrum disorder, schizophrenia, and epilepsy. 2. **Cardiac disorders**: ANK3 mutations have been linked to cardiac arrhythmias, including long QT syndrome. 3. **Muscular dystrophy**: ANK3 mutations have been implicated in muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness. In conclusion, ANK3 is a multifunctional protein that plays a critical role in maintaining the structural integrity and function of the plasma membrane in various cell types. Its dysregulation has been associated with various neurological and cardiac disorders, highlighting the importance of ANK3 in maintaining cellular homeostasis and function.

Genular Protein ID: 439672573

Symbol: ANK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7836469

Title: AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier.

PubMed ID: 7836469

DOI: 10.1074/jbc.270.5.2352

PubMed ID: 8666667

Title: Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus.

PubMed ID: 8666667

DOI: 10.1083/jcb.133.4.819

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15579534

Title: Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.

PubMed ID: 15579534

DOI: 10.1073/pnas.0403711101

PubMed ID: 15611082

Title: The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.

PubMed ID: 15611082

DOI: 10.1074/jbc.m413351200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21223964

Title: Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.

PubMed ID: 21223964

DOI: 10.1016/j.yexcr.2011.01.002

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23903368

Title: Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling.

PubMed ID: 23903368

DOI: 10.1038/ki.2013.280

PubMed ID: 25950943

Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

PubMed ID: 25950943

DOI: 10.1111/jnc.13158

PubMed ID: 25966638

Title: A novel phenotype in N-glycosylation disorders: Gillessen-Kaesbach-Nishimura skeletal dysplasia due to pathogenic variants in ALG9.

PubMed ID: 25966638

DOI: 10.1038/ejhg.2015.91

PubMed ID: 25307106

Title: Crystal structure of human Ankyrin G death domain.

PubMed ID: 25307106

DOI: 10.1002/prot.24702

PubMed ID: 22865819

Title: Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility.

PubMed ID: 22865819

DOI: 10.1002/humu.22174

PubMed ID: 23390136

Title: Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders.

PubMed ID: 23390136

DOI: 10.1093/hmg/ddt043

Sequence Information:

  • Length: 4377
  • Mass: 480410
  • Checksum: F6F9FABD09F15C13
  • Sequence:
  • MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY 
    IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA 
    EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVKFLL DNGASQSLAT EDGFTPLAVA 
    LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH 
    IAAHYGNINV ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD 
    GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV QLLLQHNVPV 
    DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG FTPLHIACKK NRIKVMELLL 
    KHGASIQAVT ESGLTPIHVA AFMGHVNIVS QLMHHGASPN TTNVRGETAL HMAARSGQAE 
    VVRYLVQDGA QVEAKAKDDQ TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA 
    REGHEDVAAF LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT 
    PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL LEYGADANAV 
    TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP LHLAAQEDRV NVAEVLVNQG 
    AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN 
    VLLQNNASPN ELTVNGNTAL GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM 
    NEVLDMSDDE VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE 
    GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT FTREFDSDSL 
    RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS RHHGMRIIIP PRKCTAPTRI 
    TCRLVKRHKL ANPPPMVEGE GLASRLVEMG PAGAQFLGPV IVEIPHFGSM RGKERELIVL 
    RSENGETWKE HQFDSKNEDL TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI 
    KQESNQIGPE GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS 
    PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG GTSPAQWEDI 
    TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ LYRELICVPY MAKFVVFAKM 
    NDPVESSLRC FCMTDDKVDK TLEQQENFEE VARSKDIEVL EGKPIYVDCY GNLAPLTKGG 
    QQLVFNFYSF KENRLPFSIK IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK 
    KETESDQDDE IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST 
    RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK STLGASTTSS 
    VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA RAPAVTEATP LKGLASNSTF 
    SSRTSPVTTA GSLLERSSIT MTPPASPKSN INMYSSSLPF KSIITSAAPL ISSPLKSVVS 
    PVKSAVDVIS SAKITMASSL SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT 
    LQEKISSATN SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL 
    YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA ALLSPIKTLT 
    TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE ILKDVAEMKE DLMRMTAILQ 
    TDVPEEKPFQ PELPKEGRID DEEPFKIVEK VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD 
    KGHSPEDDWI EFSSEEIREA RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND 
    IGSSSLTNLK YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD 
    SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK PLFHEVPIPP 
    VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF MELEPKPTTS SIKEKVKAFQ 
    MKASSEEDDH NRVLSKGMRV KEETHITTTT RMVYHSPPGG EGASERIEET MSVHDIMKAF 
    QSGRDPSKEL AGLFEHKSAV SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA 
    EPTEVIIRET KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE 
    ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD DELSELRGES 
    YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK RSREKIATAP KKEILSKIYK 
    DVSENGVGKV SKDEHFDKVT VLHYSGNVSS PKHAMWMRFT EDRLDRGREK LIYEDRVDRT 
    VKEAEEKLTE VSQFFRDKTE KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL 
    ASNDEWVKAR QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA 
    PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK IQESKLPVYQ 
    VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV VNDSGSDNVK KQRTEMSSKA 
    MPDSFSEQQA KDLACHITSD LATRGPWDKK VFRTWESSGA TNNKSQKEKL SHVLVHDVRE 
    NHIGHPESKS VDQKNEFMSV TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH 
    PGGLLDQPSR RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS 
    KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD SLEFSPGKES 
    PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ VGKQYEKEIQ QGGVKKIISQ 
    ECKTVQETRG TFYTTRQQKQ PPSPQGSPED DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE 
    FTSKTPDSLI AYIPGKPSPI PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS 
    NQRPKNNRVA YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI 
    RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS AEKASNQKEL 
    ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT AEFSHDTDAT EIDSLDGYDL 
    QDEDDGLTES DSKLPIQAME IKKDIWNTEG ILKPADRSFS QSKLEVIEEE GKVGPDEDKP 
    PSKSSSSEKT PDKTDQKSGA QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL 
    DFDPWSNNRG DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP 
    FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD KSMVTATPQP 
    QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG SLEKSAAATN TSKVDPKLRT 
    PIKMGISAST MTMKKEGPGE ITDKIEAVMT SCQGLENETI TMISNTANSQ MGVRPHEKHD 
    FQKDNFNNNN NLDSSTIQTD NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV 
    RDKQKVLGEQ QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA 
    LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL PVKVRSTCVT 
    TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF KGISGETLKL VDRLSEEEKK 
    MQSELSDEEE STSRNTSLSE TSRGGQPSVT TKSARDKKTE AAPLKSKSEK AGSEKRSSRR 
    TGPQSPCERT DIRMAIVADH LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK 
    WVTRDGKNAT TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW 
    QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA NGSHTEITPE 
    AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL AAYQKSLEET SKLIIEETKP 
    CVPVSMKKMS RTSPADGKPR LSLHEEEGSS GSEQKQGEGF KVKTKKEIRH VEKKSHS

Genular Protein ID: 452926691

Symbol: Q8NAK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 549
  • Mass: 61169
  • Checksum: ACA0A5B7643AB5EB
  • Sequence:
  • MALPQSEDAM TGDTDKYLGP QDLKELGDDS LPAEGYMGFS LGARSASLRS FSSDRSYTLN 
    RSSYARDSMM IEELLVPSKE QHLTFTREFD SDSLRHYSWA ADTLDNVNLV SSPIHSGFLV 
    SFMVDARGGS MRGSRHHGMR IIIPPRKCTA PTRITCRLVK RHKLANPPPM VEGEGLASRL 
    VEMGPAGAQF LGPVIVEIPH FGSMRGKERE LIVLRSENGE TWKEHQFDSK NEDLTELLNG 
    MDEELDSPEE LGKKRICRII TKDFPQYFAV VSRIKQESNQ IGPEGGILSS TTVPLVQASF 
    PEGALTKRIR VGLQAQPVPD EIVKKILGNK ATFSPIVTVE PRRRKFHKPI TMTIPVPPPS 
    GEGVSNGYKG DTTPNLRLLC SITGGTSPAQ WEDITGTTPL TFIKDCVSFT TNVSARFWLA 
    DCHQVLETVG LATQLYRELI CVPYMAKFVV FAKMNDPVES SLRCFCMTDD KVDKTLEQQE 
    NFEEVARSKD IEVLEGKPIY VDCYGNLAPL TKGGQQLVFN FYSFKENRLP FSIKIRDTSL 
    VLIKLSCII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.