Details for: ARRB2

Gene ID: 409

Symbol: ARRB2

Ensembl ID: ENSG00000141480

Description: arrestin beta 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.28
    Marker Score: 183205
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.16
    Marker Score: 6149
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.53
    Marker Score: 29408
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.51
    Marker Score: 6242
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.47
    Marker Score: 5958
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.46
    Marker Score: 2970
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.39
    Marker Score: 2729.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.17
    Marker Score: 6838
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.1
    Marker Score: 857
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.09
    Marker Score: 1149
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.08
    Marker Score: 53230
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.04
    Marker Score: 13059
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.03
    Marker Score: 1787
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.98
    Marker Score: 1976
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.87
    Marker Score: 2752
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.86
    Marker Score: 7964
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.85
    Marker Score: 18349
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.79
    Marker Score: 4377
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.78
    Marker Score: 1722
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.76
    Marker Score: 3441
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.73
    Marker Score: 10514.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.71
    Marker Score: 4438
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.66
    Marker Score: 2964
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.64
    Marker Score: 86479
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.62
    Marker Score: 804
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.57
    Marker Score: 1144
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.55
    Marker Score: 2139
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.52
    Marker Score: 633
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.51
    Marker Score: 1521
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166937
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.44
    Marker Score: 1466
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.44
    Marker Score: 14586
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.44
    Marker Score: 4191
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.42
    Marker Score: 3970
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.41
    Marker Score: 1036
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.4
    Marker Score: 1248
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.38
    Marker Score: 597
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.36
    Marker Score: 1272
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.36
    Marker Score: 490
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.34
    Marker Score: 656
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.33
    Marker Score: 1602.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.31
    Marker Score: 950
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.27
    Marker Score: 1201
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.26
    Marker Score: 599
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.24
    Marker Score: 727
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.24
    Marker Score: 762
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.24
    Marker Score: 5137
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.23
    Marker Score: 843
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.23
    Marker Score: 633
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.22
    Marker Score: 954
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.19
    Marker Score: 1329
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.19
    Marker Score: 820
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.18
    Marker Score: 259
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.17
    Marker Score: 985
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.17
    Marker Score: 956
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.17
    Marker Score: 775
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.16
    Marker Score: 1365.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.14
    Marker Score: 286
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.14
    Marker Score: 491
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.14
    Marker Score: 4650
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.13
    Marker Score: 390
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.13
    Marker Score: 395
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.13
    Marker Score: 3110
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.12
    Marker Score: 617
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.11
    Marker Score: 383
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.1
    Marker Score: 1894
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.09
    Marker Score: 339
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.09
    Marker Score: 790
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.08
    Marker Score: 917
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.07
    Marker Score: 272
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.06
    Marker Score: 709
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.04
    Marker Score: 1900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.03
    Marker Score: 705
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 328
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.02
    Marker Score: 503.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.01
    Marker Score: 1313
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.01
    Marker Score: 2046
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1
    Marker Score: 1081
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1
    Marker Score: 607
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71645
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.99
    Marker Score: 669
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47871
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.99
    Marker Score: 569
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.98
    Marker Score: 788
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.96
    Marker Score: 1047
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.95
    Marker Score: 289
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.95
    Marker Score: 1056
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.94
    Marker Score: 309
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.93
    Marker Score: 878
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.93
    Marker Score: 188
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.93
    Marker Score: 57161
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.93
    Marker Score: 893
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.92
    Marker Score: 2497.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.92
    Marker Score: 180
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.91
    Marker Score: 193
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.9
    Marker Score: 7763

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Other Information

**Key characteristics:** * ARRB2 is a transmembrane protein with a predicted molecular weight of approximately 150 kDa. * It is highly expressed in a variety of cell types, including monocyte, macrophage, and endothelial cells. * It is a key regulator of the WNT signaling pathway, which is a major signaling pathway involved in various cellular processes. * It also regulates the MAPK and ERK signaling pathways. **Pathways and functions:** * The main pathway activated by ARRB2 is the beta-catenin independent wnt signaling pathway. * In this pathway, ARRB2 acts as a co-receptor for beta-catenin, a key regulator of the wnt pathway. * When ARRB2 binds to beta-catenin, it recruits beta-catenin to the plasma membrane, where it forms a complex with other wnt proteins. * This complex activates the wnt signaling pathway, which promotes cell migration, proliferation, and survival. **Clinical significance:** * Mutations in ARRB2 have been linked to various human diseases, including cancer and developmental disorders. * In cancer, ARRB2 mutations can lead to the activation of the wnt pathway, which can promote tumor growth and metastasis. * Therefore, ARRB2 is a promising target for cancer therapy. **Additional information:** * ARRB2 is also involved in the regulation of cell adhesion, migration, and signaling in non-lymphoid tissues. * It is a key regulator of wound healing and tissue development. * It is also involved in the regulation of inflammation and angiogenesis.

Genular Protein ID: 1701047670

Symbol: ARRB2_HUMAN

Name: Beta-arrestin-2

UniProtKB Accession Codes:

P32121 B4DLW0 B5B0C0 B7WPL3 D3DTK2 H0Y688 Q0Z8D3 Q2PP19 Q6ICT3 Q8N7Y2 Q9UEQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 49 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 15 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1587386

Title: Cloning of a member of the arrestin family from a human thyroid cDNA library.

PubMed ID: 1587386

DOI: 10.1016/0303-7207(92)90038-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9346876

Title: A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.

PubMed ID: 9346876

DOI: 10.1074/jbc.272.44.27497

PubMed ID: 10644702

Title: beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.

PubMed ID: 10644702

DOI: 10.1074/jbc.275.4.2479

PubMed ID: 10748214

Title: Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.

PubMed ID: 10748214

DOI: 10.1074/jbc.m910348199

PubMed ID: 10973280

Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

PubMed ID: 10973280

DOI: 10.1038/79767

PubMed ID: 11279203

Title: Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.

PubMed ID: 11279203

DOI: 10.1074/jbc.m101450200

PubMed ID: 11877451

Title: Regulation of arrestin-3 phosphorylation by casein kinase II.

PubMed ID: 11877451

DOI: 10.1074/jbc.m201379200

PubMed ID: 12488444

Title: Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2.

PubMed ID: 12488444

DOI: 10.1074/jbc.m210350200

PubMed ID: 12582207

Title: Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.

PubMed ID: 12582207

DOI: 10.1073/pnas.262789099

PubMed ID: 12949261

Title: Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

PubMed ID: 12949261

DOI: 10.1073/pnas.1834556100

PubMed ID: 12958365

Title: Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.

PubMed ID: 12958365

DOI: 10.1126/science.1083195

PubMed ID: 14711824

Title: Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

PubMed ID: 14711824

DOI: 10.1074/jbc.c300443200

PubMed ID: 15054093

Title: Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.

PubMed ID: 15054093

DOI: 10.1074/jbc.m402125200

PubMed ID: 15205453

Title: Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.

PubMed ID: 15205453

DOI: 10.1074/jbc.m405878200

PubMed ID: 15125834

Title: Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.

PubMed ID: 15125834

DOI: 10.1016/s1097-2765(04)00216-3

PubMed ID: 15618519

Title: Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

PubMed ID: 15618519

DOI: 10.1126/science.1104135

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 15888437

Title: Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2.

PubMed ID: 15888437

DOI: 10.1074/jbc.m501926200

PubMed ID: 16144840

Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

PubMed ID: 16144840

DOI: 10.1074/jbc.m500535200

PubMed ID: 15475570

Title: Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.

PubMed ID: 15475570

DOI: 10.1124/mol.104.006072

PubMed ID: 15635042

Title: Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.

PubMed ID: 15635042

DOI: 10.1124/mol.104.006270

PubMed ID: 15671180

Title: Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

PubMed ID: 15671180

DOI: 10.1073/pnas.0409534102

PubMed ID: 15699339

Title: beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.

PubMed ID: 15699339

DOI: 10.1073/pnas.0407444102

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16280323

Title: beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

PubMed ID: 16280323

DOI: 10.1074/jbc.m506576200

PubMed ID: 16319069

Title: A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.

PubMed ID: 16319069

DOI: 10.1074/jbc.m508074200

PubMed ID: 16492667

Title: Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

PubMed ID: 16492667

DOI: 10.1074/jbc.m513380200

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 16378096

Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.

PubMed ID: 16378096

DOI: 10.1038/ni1294

PubMed ID: 16524428

Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.

PubMed ID: 16524428

DOI: 10.1111/j.1600-0749.2006.00292.x

PubMed ID: 17540773

Title: The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.

PubMed ID: 17540773

DOI: 10.1074/jbc.m700176200

PubMed ID: 18419762

Title: Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.

PubMed ID: 18419762

DOI: 10.1111/j.1471-4159.2008.05431.x

PubMed ID: 18604210

Title: An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

PubMed ID: 18604210

DOI: 10.1038/ni.1635

PubMed ID: 19325136

Title: The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.

PubMed ID: 19325136

DOI: 10.1093/carcin/bgp071

PubMed ID: 19643177

Title: Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.

PubMed ID: 19643177

DOI: 10.1016/j.cellsig.2009.07.010

PubMed ID: 19782076

Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

PubMed ID: 19782076

DOI: 10.1016/j.febslet.2009.09.035

PubMed ID: 19620252

Title: An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.

PubMed ID: 19620252

DOI: 10.1189/jlb.0908551

PubMed ID: 19363159

Title: Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

PubMed ID: 19363159

DOI: 10.1073/pnas.0901083106

PubMed ID: 20048153

Title: Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

PubMed ID: 20048153

DOI: 10.1074/jbc.m109.091173

PubMed ID: 21255264

Title: Prolyl hydroxylase 2: a novel regulator of beta2 -adrenoceptor internalization.

PubMed ID: 21255264

DOI: 10.1111/j.1582-4934.2011.01268.x

PubMed ID: 22300987

Title: Carboxy-terminus of CXCR7 regulates receptor localization and function.

PubMed ID: 22300987

DOI: 10.1016/j.biocel.2012.01.007

PubMed ID: 22282525

Title: Differential signaling by splice variants of the human free fatty acid receptor GPR120.

PubMed ID: 22282525

DOI: 10.1124/mol.111.077388

PubMed ID: 22457824

Title: Ubiquitination of CXCR7 controls receptor trafficking.

PubMed ID: 22457824

DOI: 10.1371/journal.pone.0034192

PubMed ID: 23809162

Title: Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

PubMed ID: 23809162

DOI: 10.1016/j.immuni.2013.05.015

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 26839314

Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of beta-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor kappaB (NFkappaB) Activation.

PubMed ID: 26839314

DOI: 10.1074/jbc.m115.687129

PubMed ID: 28827538

Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

PubMed ID: 28827538

DOI: 10.1038/s41598-017-08996-7

PubMed ID: 35427647

Title: Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.

PubMed ID: 35427647

DOI: 10.1016/j.jbc.2022.101932

PubMed ID: 37660910

Title: G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.

PubMed ID: 37660910

DOI: 10.1016/j.jbc.2023.105218

Sequence Information:

  • Length: 409
  • Mass: 46106
  • Checksum: DEEC507D4A7B84FF
  • Sequence:
    • MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 
AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI 
PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG 
PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA 
DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN 
LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS 
AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC

Genular Protein ID: 4004153168

Symbol: K7ENA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ENA6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 330
  • Mass: 36587
  • Checksum: E45A1B0614D113AF
  • Sequence:
    • MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 
AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI 
PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG 
PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA 
DICLFSTAQY KCPVAQLEQD DQREGGCQQG GAGNPGVLQG QGEAGGVSRR GCLCGAAFCS 
YAPQAPRPHP PPQTPVSRSG DRCPCGHQPH

Genular Protein ID: 2121738329

Symbol: Q59EM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EM5 E7EMN1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 410
  • Mass: 46029
  • Checksum: 519868DA4FDA4E92
  • Sequence:
    • AANRAGGGRA HHGGETRDQL TVYLGKRDFV DHLDKVDPVD GVVLVDPDYL KDRKVFVTLT 
CAFRYGREDL DVLGLSFRKD LFIATYQAFP PVPNPPRPPT RLQDRLLRKL GQHAHPFFFT 
IPQNLPCSVT LQPGPEDTGK ACGVDFEIRA FCAKSLEEKS HKRNSVRLVI RKVQFAPEKP 
GPQPSAETTR HFLMSDRSLH LEASLDKELY YHGEPLNVNV HVTNNSTKTV KKIKVSVRQY 
ADICLFSTAQ YKCPVAQLEQ DDQVSPSSTF CKVYTITPLL SDNREKRGLA LDGKLKHEDT 
NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ 
SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDYDDQLC

Genular Protein ID: 4280323449

Symbol: Q68DZ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68DZ5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 4 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 217
  • Mass: 24363
  • Checksum: 61653F5BABCBB0FD
  • Sequence:
    • MSDRSLHLEA SLDKELYYHG EPLNVNVHVT NNSTKTVKKI KVSVRQYADI CLFSTAQYKC 
PVAQLEQDDQ VSPSSTFCKV YTITPLLSDN REKRGLALDG KLKHEDTNLA SSTIVKEGAN 
KEVLGILVSY RVKVKLVVSR GGDVSVELPF VLMHPKPHDH IPLPRPQSAA PETDVPVDTN 
LIEFDTNYAT DDDIVFEDFA RLRLKGMKDD DYDDQLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.