Details for: ARRB2

Gene ID: 409

Symbol: ARRB2

Ensembl ID: ENSG00000141480

Description: arrestin beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.2311
    Cell Significance Index: -22.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.6791
    Cell Significance Index: -29.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.6898
    Cell Significance Index: -17.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.3065
    Cell Significance Index: -27.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.3066
    Cell Significance Index: -28.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.5250
    Cell Significance Index: -29.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9033
    Cell Significance Index: -28.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.1629
    Cell Significance Index: -24.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9534
    Cell Significance Index: -27.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6826
    Cell Significance Index: -26.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.5867
    Cell Significance Index: 121.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6201
    Cell Significance Index: -12.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1169
    Cell Significance Index: 91.5400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.7131
    Cell Significance Index: 29.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5043
    Cell Significance Index: 78.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.4358
    Cell Significance Index: 36.6800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.4184
    Cell Significance Index: 9.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4165
    Cell Significance Index: 37.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3590
    Cell Significance Index: 87.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8388
    Cell Significance Index: 757.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8344
    Cell Significance Index: 50.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.7709
    Cell Significance Index: -2.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7019
    Cell Significance Index: 76.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6809
    Cell Significance Index: 136.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6564
    Cell Significance Index: 64.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3388
    Cell Significance Index: 39.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3239
    Cell Significance Index: 116.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2567
    Cell Significance Index: 50.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2391
    Cell Significance Index: 6.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2223
    Cell Significance Index: 42.3000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2006
    Cell Significance Index: 1.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1841
    Cell Significance Index: 127.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1776
    Cell Significance Index: 20.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1055
    Cell Significance Index: 7.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0887
    Cell Significance Index: 2.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0802
    Cell Significance Index: 43.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0753
    Cell Significance Index: 1.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0428
    Cell Significance Index: 4.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0364
    Cell Significance Index: 2.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0177
    Cell Significance Index: 7.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0133
    Cell Significance Index: 2.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0100
    Cell Significance Index: -18.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0128
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0141
    Cell Significance Index: -10.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0152
    Cell Significance Index: -2.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0157
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0209
    Cell Significance Index: -13.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0224
    Cell Significance Index: -30.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0242
    Cell Significance Index: -4.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0247
    Cell Significance Index: -13.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0357
    Cell Significance Index: -22.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0361
    Cell Significance Index: -26.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0568
    Cell Significance Index: -25.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0609
    Cell Significance Index: -2.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0712
    Cell Significance Index: -9.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0750
    Cell Significance Index: -4.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0754
    Cell Significance Index: -21.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0767
    Cell Significance Index: -16.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0862
    Cell Significance Index: -3.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0950
    Cell Significance Index: -12.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0991
    Cell Significance Index: -2.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1278
    Cell Significance Index: -4.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1495
    Cell Significance Index: -21.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1673
    Cell Significance Index: -19.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2014
    Cell Significance Index: -15.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2192
    Cell Significance Index: -25.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2309
    Cell Significance Index: -7.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2431
    Cell Significance Index: -25.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2573
    Cell Significance Index: -6.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2591
    Cell Significance Index: -19.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3113
    Cell Significance Index: -5.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3135
    Cell Significance Index: -16.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3165
    Cell Significance Index: -17.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3309
    Cell Significance Index: -20.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3313
    Cell Significance Index: -9.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3338
    Cell Significance Index: -23.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3379
    Cell Significance Index: -7.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3531
    Cell Significance Index: -18.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3551
    Cell Significance Index: -22.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3649
    Cell Significance Index: -28.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4635
    Cell Significance Index: -20.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4677
    Cell Significance Index: -10.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4728
    Cell Significance Index: -8.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4875
    Cell Significance Index: -22.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5325
    Cell Significance Index: -16.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5419
    Cell Significance Index: -20.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5470
    Cell Significance Index: -17.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5504
    Cell Significance Index: -13.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5641
    Cell Significance Index: -4.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5720
    Cell Significance Index: -20.0400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5800
    Cell Significance Index: -11.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5998
    Cell Significance Index: -12.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6267
    Cell Significance Index: -13.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6377
    Cell Significance Index: -7.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6617
    Cell Significance Index: -17.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6764
    Cell Significance Index: -18.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6953
    Cell Significance Index: -13.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: ARRB2 is a cytoplasmic protein that interacts with GPCRs and other signaling molecules, influencing their activity and downstream signaling. 2. **Expression**: The gene is highly expressed in immune cells, including classical and non-classical monocytes, macrophages, and T cells. 3. **Function**: ARRB2 regulates GPCR desensitization, internalization, and signaling, modulating immune responses, inflammation, and cellular differentiation. 4. **Interactions**: ARRB2 interacts with various signaling molecules, including GPCRs, MAP kinases, and transcription factors, to regulate signaling pathways. **Pathways and Functions** ARRB2 is involved in numerous signaling pathways, including: 1. **GPCR desensitization and internalization**: ARRB2 facilitates the desensitization and internalization of GPCRs, regulating their signaling output and preventing excessive signaling. 2. **Immune response regulation**: ARRB2 modulates immune cell activation, differentiation, and function, influencing the production of cytokines and chemokines. 3. **Inflammation regulation**: ARRB2 regulates inflammatory responses by modulating the activity of immune cells and the production of pro-inflammatory cytokines. 4. **Cellular differentiation**: ARRB2 influences the differentiation of immune cells, including T cells and macrophages, by regulating signaling pathways involved in their development. 5. **Signaling by GPCRs**: ARRB2 interacts with GPCRs, influencing their signaling and downstream effects. **Clinical Significance** Dysregulation of ARRB2 has been implicated in various diseases, including: 1. **Immune disorders**: ARRB2 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where immune cell dysregulation is a key feature. 2. **Inflammatory disorders**: ARRB2 dysregulation has been implicated in inflammatory disorders, such as atherosclerosis and inflammatory bowel disease, where inflammation plays a key role. 3. **Neurological disorders**: ARRB2 has been implicated in neurological disorders, such as Parkinson's disease and schizophrenia, where GPCR signaling dysregulation is a key feature. 4. **Cancer**: ARRB2 has been implicated in cancer development and progression, where GPCR signaling dysregulation contributes to tumor growth and metastasis. In conclusion, ARRB2 is a critical regulator of GPCR signaling, immune response, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis and overall health.

Genular Protein ID: 1701047670

Symbol: ARRB2_HUMAN

Name: Beta-arrestin-2

UniProtKB Accession Codes:

P32121 B4DLW0 B5B0C0 B7WPL3 D3DTK2 H0Y688 Q0Z8D3 Q2PP19 Q6ICT3 Q8N7Y2 Q9UEQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 4 ExpressionAtlas 1 GO 49 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 16 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1587386

Title: Cloning of a member of the arrestin family from a human thyroid cDNA library.

PubMed ID: 1587386

DOI: 10.1016/0303-7207(92)90038-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9346876

Title: A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.

PubMed ID: 9346876

DOI: 10.1074/jbc.272.44.27497

PubMed ID: 10644702

Title: beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.

PubMed ID: 10644702

DOI: 10.1074/jbc.275.4.2479

PubMed ID: 10748214

Title: Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.

PubMed ID: 10748214

DOI: 10.1074/jbc.m910348199

PubMed ID: 10973280

Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

PubMed ID: 10973280

DOI: 10.1038/79767

PubMed ID: 11279203

Title: Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.

PubMed ID: 11279203

DOI: 10.1074/jbc.m101450200

PubMed ID: 11877451

Title: Regulation of arrestin-3 phosphorylation by casein kinase II.

PubMed ID: 11877451

DOI: 10.1074/jbc.m201379200

PubMed ID: 12488444

Title: Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2.

PubMed ID: 12488444

DOI: 10.1074/jbc.m210350200

PubMed ID: 12582207

Title: Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.

PubMed ID: 12582207

DOI: 10.1073/pnas.262789099

PubMed ID: 12949261

Title: Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

PubMed ID: 12949261

DOI: 10.1073/pnas.1834556100

PubMed ID: 12958365

Title: Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.

PubMed ID: 12958365

DOI: 10.1126/science.1083195

PubMed ID: 14711824

Title: Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

PubMed ID: 14711824

DOI: 10.1074/jbc.c300443200

PubMed ID: 15054093

Title: Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.

PubMed ID: 15054093

DOI: 10.1074/jbc.m402125200

PubMed ID: 15205453

Title: Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.

PubMed ID: 15205453

DOI: 10.1074/jbc.m405878200

PubMed ID: 15125834

Title: Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.

PubMed ID: 15125834

DOI: 10.1016/s1097-2765(04)00216-3

PubMed ID: 15618519

Title: Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

PubMed ID: 15618519

DOI: 10.1126/science.1104135

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 15888437

Title: Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2.

PubMed ID: 15888437

DOI: 10.1074/jbc.m501926200

PubMed ID: 16144840

Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

PubMed ID: 16144840

DOI: 10.1074/jbc.m500535200

PubMed ID: 15475570

Title: Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.

PubMed ID: 15475570

DOI: 10.1124/mol.104.006072

PubMed ID: 15635042

Title: Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.

PubMed ID: 15635042

DOI: 10.1124/mol.104.006270

PubMed ID: 15671180

Title: Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

PubMed ID: 15671180

DOI: 10.1073/pnas.0409534102

PubMed ID: 15699339

Title: beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.

PubMed ID: 15699339

DOI: 10.1073/pnas.0407444102

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16280323

Title: beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

PubMed ID: 16280323

DOI: 10.1074/jbc.m506576200

PubMed ID: 16319069

Title: A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.

PubMed ID: 16319069

DOI: 10.1074/jbc.m508074200

PubMed ID: 16492667

Title: Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

PubMed ID: 16492667

DOI: 10.1074/jbc.m513380200

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 16378096

Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.

PubMed ID: 16378096

DOI: 10.1038/ni1294

PubMed ID: 16524428

Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.

PubMed ID: 16524428

DOI: 10.1111/j.1600-0749.2006.00292.x

PubMed ID: 17540773

Title: The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.

PubMed ID: 17540773

DOI: 10.1074/jbc.m700176200

PubMed ID: 18419762

Title: Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.

PubMed ID: 18419762

DOI: 10.1111/j.1471-4159.2008.05431.x

PubMed ID: 18604210

Title: An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

PubMed ID: 18604210

DOI: 10.1038/ni.1635

PubMed ID: 19325136

Title: The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.

PubMed ID: 19325136

DOI: 10.1093/carcin/bgp071

PubMed ID: 19643177

Title: Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.

PubMed ID: 19643177

DOI: 10.1016/j.cellsig.2009.07.010

PubMed ID: 19782076

Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

PubMed ID: 19782076

DOI: 10.1016/j.febslet.2009.09.035

PubMed ID: 19620252

Title: An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.

PubMed ID: 19620252

DOI: 10.1189/jlb.0908551

PubMed ID: 19363159

Title: Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

PubMed ID: 19363159

DOI: 10.1073/pnas.0901083106

PubMed ID: 20048153

Title: Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

PubMed ID: 20048153

DOI: 10.1074/jbc.m109.091173

PubMed ID: 21255264

Title: Prolyl hydroxylase 2: a novel regulator of beta2 -adrenoceptor internalization.

PubMed ID: 21255264

DOI: 10.1111/j.1582-4934.2011.01268.x

PubMed ID: 22300987

Title: Carboxy-terminus of CXCR7 regulates receptor localization and function.

PubMed ID: 22300987

DOI: 10.1016/j.biocel.2012.01.007

PubMed ID: 22282525

Title: Differential signaling by splice variants of the human free fatty acid receptor GPR120.

PubMed ID: 22282525

DOI: 10.1124/mol.111.077388

PubMed ID: 22457824

Title: Ubiquitination of CXCR7 controls receptor trafficking.

PubMed ID: 22457824

DOI: 10.1371/journal.pone.0034192

PubMed ID: 23809162

Title: Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

PubMed ID: 23809162

DOI: 10.1016/j.immuni.2013.05.015

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 26839314

Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of beta-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor kappaB (NFkappaB) Activation.

PubMed ID: 26839314

DOI: 10.1074/jbc.m115.687129

PubMed ID: 28827538

Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

PubMed ID: 28827538

DOI: 10.1038/s41598-017-08996-7

PubMed ID: 35427647

Title: Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.

PubMed ID: 35427647

DOI: 10.1016/j.jbc.2022.101932

PubMed ID: 37660910

Title: G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.

PubMed ID: 37660910

DOI: 10.1016/j.jbc.2023.105218

Sequence Information:

  • Length: 409
  • Mass: 46106
  • Checksum: DEEC507D4A7B84FF
  • Sequence:
    • MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 
AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI 
PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG 
PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA 
DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN 
LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS 
AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC

Genular Protein ID: 2121738329

Symbol: Q59EM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EM5 E7EMN1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 410
  • Mass: 46029
  • Checksum: 519868DA4FDA4E92
  • Sequence:
    • AANRAGGGRA HHGGETRDQL TVYLGKRDFV DHLDKVDPVD GVVLVDPDYL KDRKVFVTLT 
CAFRYGREDL DVLGLSFRKD LFIATYQAFP PVPNPPRPPT RLQDRLLRKL GQHAHPFFFT 
IPQNLPCSVT LQPGPEDTGK ACGVDFEIRA FCAKSLEEKS HKRNSVRLVI RKVQFAPEKP 
GPQPSAETTR HFLMSDRSLH LEASLDKELY YHGEPLNVNV HVTNNSTKTV KKIKVSVRQY 
ADICLFSTAQ YKCPVAQLEQ DDQVSPSSTF CKVYTITPLL SDNREKRGLA LDGKLKHEDT 
NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ 
SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDYDDQLC

Genular Protein ID: 4280323449

Symbol: Q68DZ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68DZ5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 217
  • Mass: 24363
  • Checksum: 61653F5BABCBB0FD
  • Sequence:
    • MSDRSLHLEA SLDKELYYHG EPLNVNVHVT NNSTKTVKKI KVSVRQYADI CLFSTAQYKC 
PVAQLEQDDQ VSPSSTFCKV YTITPLLSDN REKRGLALDG KLKHEDTNLA SSTIVKEGAN 
KEVLGILVSY RVKVKLVVSR GGDVSVELPF VLMHPKPHDH IPLPRPQSAA PETDVPVDTN 
LIEFDTNYAT DDDIVFEDFA RLRLKGMKDD DYDDQLC

Genular Protein ID: 4004153168

Symbol: K7ENA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ENA6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 330
  • Mass: 36587
  • Checksum: E45A1B0614D113AF
  • Sequence:
    • MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 
AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI 
PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG 
PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA 
DICLFSTAQY KCPVAQLEQD DQREGGCQQG GAGNPGVLQG QGEAGGVSRR GCLCGAAFCS 
YAPQAPRPHP PPQTPVSRSG DRCPCGHQPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.