Details for: BIN1
Gene ID: 274
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BIN1
Ensembl ID: ENSG00000136717
Description: bridging integrator 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 25.2rCSI 51.74%PRS 67.11
-
CSI 19.83rCSI 18.3%PRS 45.8
-
CSI 17.84rCSI 69.71%PRS 55.51
-
CSI 17.76rCSI 33.53%PRS 55.15
-
CSI 17.49rCSI 15.93%PRS 59.93
-
CSI 17.47rCSI 14.19%PRS 45.53
-
CSI 13.86rCSI 18.95%PRS 54.65
-
CSI 12.22rCSI 17.96%PRS 40.92
-
CSI 10.7rCSI 34.72%PRS 47.59
-
CSI 10.31rCSI 10.8%PRS 42.15
-
CSI 9.03rCSI 8.87%PRS 60.25
-
CSI 7.82rCSI 11.96%PRS 61.17
-
CSI 7.5rCSI 9.05%PRS 52.77
-
CSI 6.77rCSI 5.07%PRS 59.39
-
CSI 5.96rCSI 7.97%PRS 73.8
-
CSI 5.88rCSI 4.13%PRS 66.9
-
CSI 5.75rCSI 5%PRS 54.34
-
CSI 5.73rCSI 9.21%PRS 31.64
-
CSI 5.7rCSI 4.24%PRS 58.09
-
CSI 5.62rCSI 12.61%PRS 30.3
-
CSI 5.5rCSI 10.3%PRS 34.99
-
CSI 5.46rCSI 9.94%PRS 72.9
-
CSI 5.39rCSI 15.94%PRS 35.46
-
CSI 5.06rCSI 7.01%PRS 49.7
-
CSI 4.98rCSI 11.89%PRS 55.43
-
CSI 4.95rCSI 7.36%PRS 47.46
-
CSI 4.66rCSI 7.16%PRS 51.88
-
CSI 4.63rCSI 16.84%PRS 77.62
-
CSI 4.43rCSI 3.08%PRS 53.46
-
CSI 4.42rCSI 3.08%PRS 57.78
-
CSI 4.3rCSI 5.87%PRS 47.58
-
CSI 4.29rCSI 6.48%PRS 46.92
-
CSI 4.25rCSI 17.65%PRS 45.86
-
CSI 4.24rCSI 5.67%PRS 67.18
-
CSI 4.2rCSI 12.03%PRS 62.58
-
CSI 4.1rCSI 6.3%PRS 46.88
-
CSI 4.04rCSI 16.26%PRS 55.19
-
CSI 4.03rCSI 3.7%PRS 52.28
-
CSI 4rCSI 2.36%PRS 60.03
-
CSI 4rCSI 3.93%PRS 71.66
-
CSI 3.94rCSI 8.09%PRS 39.42
-
CSI 3.81rCSI 2.74%PRS 57.83
-
CSI 3.73rCSI 13.44%PRS 28.49
-
CSI 3.73rCSI 3.45%PRS 64.89
-
CSI 3.67rCSI 2.94%PRS 66.23
-
CSI 3.66rCSI 12.27%PRS 33.58
-
CSI 3.58rCSI 11.18%PRS 33.05
-
CSI 3.53rCSI 5.03%PRS 47.57
-
CSI 3.5rCSI 3.45%PRS 77.72
-
CSI 3.48rCSI 3.14%PRS 41.62
-
CSI 3.48rCSI 13.13%PRS 30.51
-
CSI 3.47rCSI 8.02%PRS 36.85
-
CSI 3.46rCSI 6.22%PRS 38.48
-
CSI 3.39rCSI 2.97%PRS 54.56
-
CSI 3.32rCSI 5.24%PRS 46.01
-
CSI 3.3rCSI 2.84%PRS 53.3
-
CSI 3.27rCSI 4.11%PRS 81.17
-
CSI 3.27rCSI 5.1%PRS 71.65
-
CSI 3.24rCSI 2.55%PRS 51.27
-
CSI 3.13rCSI 2.61%PRS 65.15
-
CSI 3.09rCSI 5.96%PRS 74.68
-
CSI 3.07rCSI 2.33%PRS 56.2
-
CSI 2.96rCSI 2.3%PRS 61.79
-
CSI 2.91rCSI 2.18%PRS 76.75
-
CSI 2.84rCSI 2.79%PRS 47.28
-
CSI 2.77rCSI 4.47%PRS 35.85
-
CSI 2.76rCSI 2.06%PRS 63.4
-
CSI 2.67rCSI 2.24%PRS 62.27
-
CSI 2.64rCSI 2.19%PRS 45.85
-
CSI 2.64rCSI 3.16%PRS 64.05
-
CSI 2.62rCSI 3.58%PRS 49.85
-
CSI 2.55rCSI 1.93%PRS 57.17
-
CSI 2.51rCSI 5.05%PRS 35.03
-
CSI 2.51rCSI 10.66%PRS 42.04
-
CSI 2.45rCSI 1.63%PRS 70.47
-
CSI 2.41rCSI 2.24%PRS 44.66
-
CSI 2.4rCSI 3.3%PRS 65.59
-
CSI 2.39rCSI 1.89%PRS 32.97
-
CSI 2.36rCSI 2.66%PRS 61.31
-
CSI 2.29rCSI 2.73%PRS 65.27
-
CSI 2.28rCSI 3.82%PRS 29.6
-
CSI 2.26rCSI 2.62%PRS 65.57
-
CSI 2.23rCSI 2.84%PRS 50.23
-
CSI 2.22rCSI 1.55%PRS 46.67
-
CSI 2.19rCSI 2.99%PRS 38.39
-
CSI 2.17rCSI 1.91%PRS 49.81
-
CSI 2.15rCSI 1.43%PRS 48.64
-
CSI 2.15rCSI 1.78%PRS 43.47
-
CSI 2.14rCSI 7.75%PRS 64
-
CSI 2.11rCSI 2.54%PRS 43.07
-
CSI 2.06rCSI 1.39%PRS 55.24
-
CSI 2.06rCSI 5.38%PRS 43.97
-
CSI 2.05rCSI 1.98%PRS 35.82
-
CSI 1.98rCSI 2.8%PRS 41.96
-
CSI 1.93rCSI 3.3%PRS 65.5
-
CSI 1.92rCSI 6.35%PRS 46.82
-
CSI 1.91rCSI 3.47%PRS 38.68
-
CSI 1.89rCSI 7.72%PRS 42.34
-
CSI 1.88rCSI 1.49%PRS 66.84
-
CSI 1.84rCSI 3.26%PRS 28.61
-
CSI 0.2rCSI 4.2%PRS 83.5%
-
CSI 0.2rCSI 5.2%PRS 29.1%
-
CSI 0.2rCSI 3.2%PRS 77.6%
-
CSI 0.3rCSI 3.1%PRS 70.0%
-
CSI 0.3rCSI 4.1%PRS 67.5%
-
CSI 0.4rCSI 0.9%PRS 34.6%
-
CSI 0.4rCSI 2.1%PRS 79.5%
-
CSI 0.4rCSI 0.6%PRS 53.6%
-
CSI 0.5rCSI 1.8%PRS 65.3%
-
CSI 0.5rCSI 6.5%PRS 37.4%
-
CSI 0.5rCSI 5.2%PRS 78.9%
-
CSI 0.5rCSI 11.9%PRS 29.9%
-
CSI 0.5rCSI 2.5%PRS 56.8%
-
CSI 0.6rCSI 1.6%PRS 60.3%
-
CSI 0.6rCSI 3.5%PRS 57.0%
-
CSI 0.6rCSI 7.0%PRS 61.3%
-
CSI 0.7rCSI 3.9%PRS 70.8%
-
CSI 0.7rCSI 2.0%PRS 36.5%
-
CSI 0.8rCSI 2.5%PRS 34.2%
-
CSI 0.8rCSI 4.5%PRS 31.7%
-
CSI 0.8rCSI 3.5%PRS 66.2%
-
CSI 0.9rCSI 5.0%PRS 31.0%
-
CSI 0.9rCSI 2.3%PRS 44.6%
-
CSI 0.9rCSI 2.8%PRS 30.8%
-
CSI 0.9rCSI 5.0%PRS 76.2%
-
CSI 0.9rCSI 6.6%PRS 33.3%
-
CSI 0.9rCSI 4.5%PRS 55.8%
-
CSI 0.9rCSI 2.7%PRS 67.4%
-
CSI 1.0rCSI 2.8%PRS 44.9%
-
CSI 1.0rCSI 1.8%PRS 71.0%
-
CSI 1.1rCSI 1.5%PRS 61.1%
-
CSI 1.1rCSI 2.4%PRS 33.6%
-
CSI 1.1rCSI 2.4%PRS 35.6%
-
CSI 1.1rCSI 2.7%PRS 63.0%
-
CSI 1.1rCSI 1.4%PRS 29.5%
-
CSI 1.2rCSI 2.4%PRS 62.6%
-
CSI 1.2rCSI 18.1%PRS 66.5%
-
CSI 1.3rCSI 2.8%PRS 51.4%
-
CSI 1.3rCSI 1.9%PRS 62.1%
-
CSI 1.3rCSI 2.3%PRS 37.5%
-
CSI 1.3rCSI 3.6%PRS 81.7%
-
CSI 1.3rCSI 1.7%PRS 30.5%
-
CSI 1.4rCSI 18.0%PRS 68.1%
-
CSI 1.4rCSI 1.1%PRS 45.5%
-
CSI 1.4rCSI 2.4%PRS 43.4%
-
CSI 1.4rCSI 1.1%PRS 48.3%
-
CSI 1.4rCSI 1.5%PRS 59.8%
-
CSI 1.5rCSI 1.8%PRS 40.0%
-
CSI 1.5rCSI 4.9%PRS 76.7%
-
CSI 1.5rCSI 1.4%PRS 45.4%
-
CSI 1.5rCSI 3.7%PRS 28.7%
-
CSI 1.5rCSI 3.9%PRS 40.9%
-
CSI 1.6rCSI 2.0%PRS 58.4%
-
CSI 1.6rCSI 1.6%PRS 44.4%
-
CSI 1.6rCSI 2.1%PRS 72.5%
-
CSI 1.6rCSI 2.0%PRS 54.6%
-
CSI 1.6rCSI 1.6%PRS 58.0%
-
CSI 1.6rCSI 2.0%PRS 28.1%
-
CSI 1.6rCSI 41.7%PRS 84.2%
-
CSI 1.6rCSI 1.4%PRS 48.6%
-
CSI 1.7rCSI 7.4%PRS 31.8%
-
CSI 1.7rCSI 2.7%PRS 48.7%
-
CSI 1.7rCSI 2.0%PRS 48.6%
-
CSI 1.7rCSI 1.9%PRS 67.5%
-
CSI 1.7rCSI 4.5%PRS 38.0%
-
CSI 1.7rCSI 3.7%PRS 48.8%
-
CSI 1.7rCSI 2.4%PRS 58.3%
-
CSI 1.7rCSI 4.1%PRS 41.0%
-
CSI 1.7rCSI 3.6%PRS 51.0%
-
CSI 1.8rCSI 2.6%PRS 56.1%
-
CSI 1.8rCSI 3.2%PRS 35.9%
-
CSI 1.8rCSI 2.8%PRS 41.6%
-
CSI 1.8rCSI 3.3%PRS 28.6%
-
CSI 1.9rCSI 1.5%PRS 66.8%
-
CSI 1.9rCSI 7.7%PRS 42.3%
-
CSI 1.9rCSI 3.5%PRS 38.7%
-
CSI 1.9rCSI 6.4%PRS 46.8%
-
CSI 1.9rCSI 3.3%PRS 65.5%
-
CSI 2.0rCSI 2.8%PRS 42.0%
-
CSI 2.1rCSI 2.0%PRS 35.8%
-
CSI 2.1rCSI 5.4%PRS 44.0%
-
CSI 2.1rCSI 1.4%PRS 55.2%
-
CSI 2.1rCSI 2.5%PRS 43.1%
-
CSI 2.1rCSI 7.8%PRS 64.0%
-
CSI 2.2rCSI 1.8%PRS 43.5%
-
CSI 2.2rCSI 1.4%PRS 48.6%
-
CSI 2.2rCSI 1.9%PRS 49.8%
-
CSI 2.2rCSI 3.0%PRS 38.4%
-
CSI 2.2rCSI 1.6%PRS 46.7%
-
CSI 2.2rCSI 2.8%PRS 50.2%
-
CSI 2.3rCSI 2.6%PRS 65.6%
-
CSI 2.3rCSI 3.8%PRS 29.6%
-
CSI 2.3rCSI 2.7%PRS 65.3%
-
CSI 2.4rCSI 2.7%PRS 61.3%
-
CSI 2.4rCSI 1.9%PRS 33.0%
-
CSI 2.4rCSI 3.3%PRS 65.6%
-
CSI 2.4rCSI 2.2%PRS 44.7%
-
CSI 2.5rCSI 1.6%PRS 70.5%
-
CSI 2.5rCSI 10.7%PRS 42.0%
-
CSI 2.5rCSI 5.1%PRS 35.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3599018716
Symbol: BIN1_HUMAN
Name: Myc box-dependent-interacting protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9195986
Title: Identification and characterization of a nerve terminal-enriched amphiphysin isoform.
PubMed ID: 9195986
PubMed ID: 9182667
Title: Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle.
PubMed ID: 9182667
PubMed ID: 8782822
Title: BIN1 is a novel Myc-interacting protein with features of a tumour suppressor.
PubMed ID: 8782822
DOI: 10.1038/ng0996-69
PubMed ID: 9603201
Title: Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.
PubMed ID: 9603201
PubMed ID: 9223448
Title: cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants.
PubMed ID: 9223448
PubMed ID: 9395479
Title: Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
PubMed ID: 9395479
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 9418903
Title: A role for the putative tumor suppressor Bin1 in muscle cell differentiation.
PubMed ID: 9418903
DOI: 10.1128/mcb.18.1.566
PubMed ID: 10903846
Title: Bin2, a functionally nonredundant member of the BAR adaptor gene family.
PubMed ID: 10903846
PubMed ID: 12668730
Title: Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
PubMed ID: 12668730
DOI: 10.1242/jcs.00403
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16530520
Title: The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.
PubMed ID: 16530520
PubMed ID: 17676042
Title: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
PubMed ID: 17676042
DOI: 10.1038/ng2086
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24755653
Title: Mutations in BIN1 associated with centronuclear myopathy disrupt membrane remodeling by affecting protein density and oligomerization.
PubMed ID: 24755653
PubMed ID: 27179792
Title: BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production.
PubMed ID: 27179792
DOI: 10.1093/hmg/ddw146
PubMed ID: 27488240
Title: Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
PubMed ID: 27488240
PubMed ID: 28893863
Title: Bin1 directly remodels actin dynamics through its BAR domain.
PubMed ID: 28893863
PubMed ID: 20142620
Title: Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation.
PubMed ID: 20142620
PubMed ID: 25260562
Title: Adult-onset autosomal dominant centronuclear myopathy due to BIN1 mutations.
PubMed ID: 25260562
DOI: 10.1093/brain/awu272
PubMed ID: 29950440
Title: A Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine.
PubMed ID: 29950440
Sequence Information:
- Length: 593
- Mass: 64699
- Checksum: 0FF1956F0C7E3B50
- Sequence:
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQLRKGPP VPPPPKHTPS KEVKQEQILS LFEDTFVPEI SVTTPSQFEA PGPFSEQASL LDLDFDPLPP VTSPVKAPTP SGQSIPWDLW EPTESPAGSL PSGEPSAAEG TFAVSWPSQT AEPGPAQPAE ASEVAGGTQP AAGAQEPGET AASEAASSSL PAVVVETFPA TVNGTVEGGS GAGRLDLPPG FMFKVQAQHD YTATDTDELQ LKAGDVVLVI PFQNPEEQDE GWLMGVKESD WNQHKELEKC RGVFPENFTE RVP
Genular Protein ID: 2427542689
Symbol: Q9BTH3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 439
- Mass: 48286
- Checksum: 350E428C8E198136
- Sequence:
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKAEEELIK AQKVFEEMNV DLQEELPSLW NSRVGFYVNT FQSIAGLEEN FHKEMSKLNQ NLNDVLVGLE KQHGSNTFTV KAQPSDNAPA KGNKSPSPPD GSPAATPEIR VNHEPEPAGG ATPGATLPKS PSQPAEASEV AGGTQPAAGA QEPGETAASE AASSSLPAVV VETFPATVNG TVEGGSGAGR LDLPPGFMFK VQAQHDYTAT DTDELQLRAG DVVLVIPFQN PEEQDEGWLM GVKESDWNQH KELEKCRGVF PENFTERVP
Genular Protein ID: 3497018245
Symbol: B7Z2Z2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 470
- Mass: 51711
- Checksum: DC211F88681AC56B
- Sequence:
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAR AKGNKSPSPP DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQPAEASE VAGGTQPAAG AQEPGETAAS EAASSSLPAV VVETFPATVN GTVEGGSGAG RLDLPPGFMF KVQAQHDYTA TDTDELQLRA GDVVLVIPFQ NPEEQDEGWL MGVKESDWNQ HKELEKCRGV FPENFTGRVP
Genular Protein ID: 3353487358
Symbol: B7Z6Y2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 385
- Mass: 43165
- Checksum: 291A5612A0829A4A
- Sequence:
MMRKVLQKLG KADETKDEQF EQCVQNFNKQ LTEGTRLQKD LRTYLASVKA MHEASKKLNE CLQEVYEPDW PGRDEANKIA ENNDLLWMDY HQKLVDQALL TMDTYLGQFP DIKSRIAKRG RKLVDYDSAR HHYESLQTAK KKDEAKIAKA EEELIKAQKV FEEMNVDLQE ELPSLWNSRV GFYVNTFQSI AGLEENFHKE MSKLNQNLND VLVGLEKQHG SNTFTVKAQP SDNAPAKGNK SPSPPDGSPA ATPEIRVNHE PEPAGGATPG ATLPKSPSQS SLPAVVVETF PATVNGTVEG GSGAGRLDLP PGFMFKVQAQ HDYTATDTDE LQLKAGDVVL VIPFQNPEEQ DEGWLMGVKE SDWNQHKELE KCRGVFPENF TERVP