Details for: BIN1

Gene ID: 274

Symbol: BIN1

Ensembl ID: ENSG00000136717

Description: bridging integrator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 252.9811
    Cell Significance Index: -39.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.8212
    Cell Significance Index: -28.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.9461
    Cell Significance Index: -36.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.1987
    Cell Significance Index: -39.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.0349
    Cell Significance Index: -40.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.1883
    Cell Significance Index: -36.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.8665
    Cell Significance Index: -39.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.4985
    Cell Significance Index: -41.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0658
    Cell Significance Index: -39.7200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.1666
    Cell Significance Index: 99.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.7323
    Cell Significance Index: 139.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6807
    Cell Significance Index: -9.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.6721
    Cell Significance Index: 94.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8428
    Cell Significance Index: 83.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3709
    Cell Significance Index: 276.3000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.2003
    Cell Significance Index: 16.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8268
    Cell Significance Index: 23.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.6811
    Cell Significance Index: 20.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6100
    Cell Significance Index: 322.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4327
    Cell Significance Index: 92.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2353
    Cell Significance Index: 74.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2174
    Cell Significance Index: 81.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2055
    Cell Significance Index: 34.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1316
    Cell Significance Index: 71.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9212
    Cell Significance Index: 126.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8325
    Cell Significance Index: 43.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7369
    Cell Significance Index: 264.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6898
    Cell Significance Index: 81.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6619
    Cell Significance Index: 23.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6300
    Cell Significance Index: 5.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5010
    Cell Significance Index: 452.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4371
    Cell Significance Index: 238.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4148
    Cell Significance Index: 11.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3350
    Cell Significance Index: 66.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3171
    Cell Significance Index: 9.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3139
    Cell Significance Index: 6.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2459
    Cell Significance Index: 111.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2447
    Cell Significance Index: 46.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1642
    Cell Significance Index: 11.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1145
    Cell Significance Index: 11.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0948
    Cell Significance Index: 4.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0689
    Cell Significance Index: 11.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0382
    Cell Significance Index: 4.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0179
    Cell Significance Index: 0.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0147
    Cell Significance Index: 27.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -3.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0096
    Cell Significance Index: -0.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0110
    Cell Significance Index: -0.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0193
    Cell Significance Index: -8.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0255
    Cell Significance Index: -34.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0331
    Cell Significance Index: -25.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0398
    Cell Significance Index: -25.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0408
    Cell Significance Index: -29.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0494
    Cell Significance Index: -36.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0554
    Cell Significance Index: -5.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0636
    Cell Significance Index: -1.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0653
    Cell Significance Index: -36.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0680
    Cell Significance Index: -42.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0863
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0898
    Cell Significance Index: -15.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0953
    Cell Significance Index: -2.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1199
    Cell Significance Index: -34.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1641
    Cell Significance Index: -7.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1717
    Cell Significance Index: -1.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1781
    Cell Significance Index: -21.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1814
    Cell Significance Index: -8.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1852
    Cell Significance Index: -8.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1928
    Cell Significance Index: -28.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1994
    Cell Significance Index: -41.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2067
    Cell Significance Index: -26.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2184
    Cell Significance Index: -5.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2304
    Cell Significance Index: -12.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2724
    Cell Significance Index: -31.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2782
    Cell Significance Index: -28.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3154
    Cell Significance Index: -8.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3168
    Cell Significance Index: -12.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3267
    Cell Significance Index: -8.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3443
    Cell Significance Index: -4.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3469
    Cell Significance Index: -11.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4020
    Cell Significance Index: -29.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4131
    Cell Significance Index: -11.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4477
    Cell Significance Index: -35.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4495
    Cell Significance Index: -13.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4631
    Cell Significance Index: -28.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4743
    Cell Significance Index: -36.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4753
    Cell Significance Index: -11.4000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4779
    Cell Significance Index: -4.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5083
    Cell Significance Index: -9.9200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5531
    Cell Significance Index: -5.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5920
    Cell Significance Index: -41.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6106
    Cell Significance Index: -12.9600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.6207
    Cell Significance Index: -3.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6229
    Cell Significance Index: -32.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6334
    Cell Significance Index: -17.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6369
    Cell Significance Index: -15.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7564
    Cell Significance Index: -13.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7572
    Cell Significance Index: -24.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** BIN1 is highly expressed in oligodendrocytes, microglial cells, T cells, and other immune cells, suggesting its involvement in immune responses and neuronal function. 2. **Molecular Weight:** The BIN1 protein has a molecular weight of approximately 70 kDa, with a predicted pI of 6.5. 3. **Cellular Localization:** BIN1 is primarily localized to the cytoskeleton, nucleus, and endosomes, indicating its involvement in cytoskeletal organization, nuclear regulation, and endocytic processes. 4. **Interactions:** BIN1 interacts with numerous proteins, including actin-binding proteins, GTPases, and transcription factors, to modulate signaling pathways and regulate cellular processes. **Pathways and Functions:** 1. **Actin Cytoskeleton:** BIN1 regulates actin filament polymerization and organization, which is essential for cell migration, endocytosis, and cytoskeletal dynamics. 2. **Endocytosis:** BIN1 modulates clathrin-mediated endocytosis and endosome-to-lysosome transport, influencing cellular uptake and degradation of proteins and lipids. 3. **Signaling Pathways:** BIN1 interacts with various signaling proteins to regulate cell survival, differentiation, and immune responses, including the regulation of amyloid-beta formation and negative regulation of amyloid precursor protein catabolic process. 4. **Transcriptional Regulation:** BIN1 regulates transcription by interacting with RNA polymerase II and influencing gene expression, including the regulation of neuron differentiation and astrocyte differentiation. 5. **Cell Cycle Regulation:** BIN1 modulates the cell cycle process, influencing cell proliferation and apoptosis. **Clinical Significance:** 1. **Neurological Disorders:** BIN1 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where its dysregulation is associated with disease progression. 2. **Cancer:** BIN1 has been identified as a potential oncogene in various cancers, including breast, lung, and colon cancer, where its overexpression is correlated with tumor progression and poor prognosis. 3. **Immunological Disorders:** BIN1 plays a critical role in immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cardiovascular Diseases:** BIN1 has been linked to cardiovascular diseases, including atherosclerosis and heart failure, where its dysregulation is associated with disease progression and poor prognosis. In conclusion, the BIN1 gene is a complex regulator of cellular processes, with implications for various diseases, including neurological disorders, cancer, immunological disorders, and cardiovascular diseases. Further research is necessary to fully understand the mechanisms by which BIN1 regulates cellular processes and to explore its potential as a therapeutic target for disease treatment.

Genular Protein ID: 3599018716

Symbol: BIN1_HUMAN

Name: Myc box-dependent-interacting protein 1

UniProtKB Accession Codes:

O00499 O00297 O00545 O43867 O60552 O60553 O60554 O60555 O75514 O75515 O75516 O75517 O75518 Q659B7 Q92944 Q99688

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 11 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 27 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 1 RefSeq 15 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9195986

Title: Identification and characterization of a nerve terminal-enriched amphiphysin isoform.

PubMed ID: 9195986

DOI: 10.1074/jbc.272.26.16700

PubMed ID: 9182667

Title: Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle.

PubMed ID: 9182667

DOI: 10.1083/jcb.137.6.1355

PubMed ID: 8782822

Title: BIN1 is a novel Myc-interacting protein with features of a tumour suppressor.

PubMed ID: 8782822

DOI: 10.1038/ng0996-69

PubMed ID: 9603201

Title: Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.

PubMed ID: 9603201

DOI: 10.1046/j.1471-4159.1998.70062369.x

PubMed ID: 9223448

Title: cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants.

PubMed ID: 9223448

DOI: 10.1006/bbrc.1997.6927

PubMed ID: 9395479

Title: Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.

PubMed ID: 9395479

DOI: 10.1074/jbc.272.50.31453

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9418903

Title: A role for the putative tumor suppressor Bin1 in muscle cell differentiation.

PubMed ID: 9418903

DOI: 10.1128/mcb.18.1.566

PubMed ID: 10903846

Title: Bin2, a functionally nonredundant member of the BAR adaptor gene family.

PubMed ID: 10903846

DOI: 10.1006/geno.2000.6216

PubMed ID: 12668730

Title: Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.

PubMed ID: 12668730

DOI: 10.1242/jcs.00403

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16530520

Title: The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

PubMed ID: 16530520

DOI: 10.1053/j.gastro.2005.12.030

PubMed ID: 17676042

Title: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.

PubMed ID: 17676042

DOI: 10.1038/ng2086

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24755653

Title: Mutations in BIN1 associated with centronuclear myopathy disrupt membrane remodeling by affecting protein density and oligomerization.

PubMed ID: 24755653

DOI: 10.1371/journal.pone.0093060

PubMed ID: 27179792

Title: BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production.

PubMed ID: 27179792

DOI: 10.1093/hmg/ddw146

PubMed ID: 27488240

Title: Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.

PubMed ID: 27488240

DOI: 10.1186/s13024-016-0124-1

PubMed ID: 28893863

Title: Bin1 directly remodels actin dynamics through its BAR domain.

PubMed ID: 28893863

DOI: 10.15252/embr.201744137

PubMed ID: 20142620

Title: Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation.

PubMed ID: 20142620

DOI: 10.1212/wnl.0b013e3181cef7f9

PubMed ID: 25260562

Title: Adult-onset autosomal dominant centronuclear myopathy due to BIN1 mutations.

PubMed ID: 25260562

DOI: 10.1093/brain/awu272

PubMed ID: 29950440

Title: A Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine.

PubMed ID: 29950440

DOI: 10.1212/wnl.0000000000005862

Sequence Information:

  • Length: 593
  • Mass: 64699
  • Checksum: 0FF1956F0C7E3B50
  • Sequence:
    • MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 
LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD 
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK 
AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN 
TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP 
DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQLRKGPP VPPPPKHTPS KEVKQEQILS 
LFEDTFVPEI SVTTPSQFEA PGPFSEQASL LDLDFDPLPP VTSPVKAPTP SGQSIPWDLW 
EPTESPAGSL PSGEPSAAEG TFAVSWPSQT AEPGPAQPAE ASEVAGGTQP AAGAQEPGET 
AASEAASSSL PAVVVETFPA TVNGTVEGGS GAGRLDLPPG FMFKVQAQHD YTATDTDELQ 
LKAGDVVLVI PFQNPEEQDE GWLMGVKESD WNQHKELEKC RGVFPENFTE RVP

Genular Protein ID: 2427542689

Symbol: Q9BTH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BTH3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 5 Gene3D 2 IntAct 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 6 SAM 2 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 439
  • Mass: 48286
  • Checksum: 350E428C8E198136
  • Sequence:
    • MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 
LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD 
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKAEEELIK 
AQKVFEEMNV DLQEELPSLW NSRVGFYVNT FQSIAGLEEN FHKEMSKLNQ NLNDVLVGLE 
KQHGSNTFTV KAQPSDNAPA KGNKSPSPPD GSPAATPEIR VNHEPEPAGG ATPGATLPKS 
PSQPAEASEV AGGTQPAAGA QEPGETAASE AASSSLPAVV VETFPATVNG TVEGGSGAGR 
LDLPPGFMFK VQAQHDYTAT DTDELQLRAG DVVLVIPFQN PEEQDEGWLM GVKESDWNQH 
KELEKCRGVF PENFTERVP

Genular Protein ID: 3497018245

Symbol: B7Z2Z2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2Z2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 470
  • Mass: 51711
  • Checksum: DC211F88681AC56B
  • Sequence:
    • MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 
LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD 
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK 
AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN 
TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAR AKGNKSPSPP 
DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQPAEASE VAGGTQPAAG AQEPGETAAS 
EAASSSLPAV VVETFPATVN GTVEGGSGAG RLDLPPGFMF KVQAQHDYTA TDTDELQLRA 
GDVVLVIPFQ NPEEQDEGWL MGVKESDWNQ HKELEKCRGV FPENFTGRVP

Genular Protein ID: 3353487358

Symbol: B7Z6Y2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6Y2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 385
  • Mass: 43165
  • Checksum: 291A5612A0829A4A
  • Sequence:
    • MMRKVLQKLG KADETKDEQF EQCVQNFNKQ LTEGTRLQKD LRTYLASVKA MHEASKKLNE 
CLQEVYEPDW PGRDEANKIA ENNDLLWMDY HQKLVDQALL TMDTYLGQFP DIKSRIAKRG 
RKLVDYDSAR HHYESLQTAK KKDEAKIAKA EEELIKAQKV FEEMNVDLQE ELPSLWNSRV 
GFYVNTFQSI AGLEENFHKE MSKLNQNLND VLVGLEKQHG SNTFTVKAQP SDNAPAKGNK 
SPSPPDGSPA ATPEIRVNHE PEPAGGATPG ATLPKSPSQS SLPAVVVETF PATVNGTVEG 
GSGAGRLDLP PGFMFKVQAQ HDYTATDTDE LQLKAGDVVL VIPFQNPEEQ DEGWLMGVKE 
SDWNQHKELE KCRGVFPENF TERVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.