Details for: IL3RA

Gene ID: 3563

Symbol: IL3RA

Ensembl ID: ENSG00000185291

Description: interleukin 3 receptor subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.4124
    Cell Significance Index: -18.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7356
    Cell Significance Index: -16.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.2573
    Cell Significance Index: 93.7600
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 4.9521
    Cell Significance Index: 34.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2831
    Cell Significance Index: 40.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0721
    Cell Significance Index: 127.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9286
    Cell Significance Index: 21.9100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7307
    Cell Significance Index: 12.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1648
    Cell Significance Index: 29.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1584
    Cell Significance Index: 24.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7654
    Cell Significance Index: 49.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6802
    Cell Significance Index: 9.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6501
    Cell Significance Index: 11.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5953
    Cell Significance Index: 26.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5913
    Cell Significance Index: 112.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5348
    Cell Significance Index: 15.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5182
    Cell Significance Index: 29.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5001
    Cell Significance Index: 10.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3996
    Cell Significance Index: 58.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3695
    Cell Significance Index: 74.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3416
    Cell Significance Index: 15.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3383
    Cell Significance Index: 121.3600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3154
    Cell Significance Index: 2.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3109
    Cell Significance Index: 280.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3093
    Cell Significance Index: 23.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3092
    Cell Significance Index: 30.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3066
    Cell Significance Index: 11.6100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.2695
    Cell Significance Index: 4.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2393
    Cell Significance Index: 368.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2344
    Cell Significance Index: 38.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1941
    Cell Significance Index: 365.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1921
    Cell Significance Index: 2.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1875
    Cell Significance Index: 2.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1874
    Cell Significance Index: 53.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1762
    Cell Significance Index: 6.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1678
    Cell Significance Index: 309.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1571
    Cell Significance Index: 2.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1472
    Cell Significance Index: 29.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1445
    Cell Significance Index: 3.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1297
    Cell Significance Index: 176.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0784
    Cell Significance Index: 8.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0745
    Cell Significance Index: 0.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0596
    Cell Significance Index: 1.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0564
    Cell Significance Index: 6.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0532
    Cell Significance Index: 0.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0531
    Cell Significance Index: 2.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0259
    Cell Significance Index: 16.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0142
    Cell Significance Index: 0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0057
    Cell Significance Index: 2.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0029
    Cell Significance Index: 0.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0015
    Cell Significance Index: 0.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0184
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0220
    Cell Significance Index: -16.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0239
    Cell Significance Index: -17.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0306
    Cell Significance Index: -17.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0336
    Cell Significance Index: -14.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0487
    Cell Significance Index: -1.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0607
    Cell Significance Index: -3.6500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0767
    Cell Significance Index: -0.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0817
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0835
    Cell Significance Index: -17.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0945
    Cell Significance Index: -12.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0982
    Cell Significance Index: -13.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0983
    Cell Significance Index: -10.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1016
    Cell Significance Index: -17.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1278
    Cell Significance Index: -13.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1352
    Cell Significance Index: -17.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1395
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1533
    Cell Significance Index: -17.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1662
    Cell Significance Index: -19.6000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1748
    Cell Significance Index: -2.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1760
    Cell Significance Index: -5.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1808
    Cell Significance Index: -5.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1884
    Cell Significance Index: -8.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1988
    Cell Significance Index: -4.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2179
    Cell Significance Index: -15.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2237
    Cell Significance Index: -17.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2265
    Cell Significance Index: -6.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2330
    Cell Significance Index: -7.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2368
    Cell Significance Index: -17.6500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2424
    Cell Significance Index: -3.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2459
    Cell Significance Index: -3.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2535
    Cell Significance Index: -5.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2709
    Cell Significance Index: -4.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2757
    Cell Significance Index: -8.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2794
    Cell Significance Index: -5.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2849
    Cell Significance Index: -9.9800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2857
    Cell Significance Index: -2.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2865
    Cell Significance Index: -6.9900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2940
    Cell Significance Index: -3.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3103
    Cell Significance Index: -16.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3147
    Cell Significance Index: -7.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3217
    Cell Significance Index: -6.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3352
    Cell Significance Index: -6.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3362
    Cell Significance Index: -6.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3530
    Cell Significance Index: -16.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3531
    Cell Significance Index: -10.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3641
    Cell Significance Index: -7.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3791
    Cell Significance Index: -9.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL3RA is a type I transmembrane protein, consisting of four immunoglobulin-like domains and a short cytoplasmic tail. The extracellular domain of IL3RA is responsible for ligand binding, while the cytoplasmic domain interacts with downstream signaling molecules. IL3RA is a heterodimeric receptor, requiring the presence of the interleukin-3 receptor subunit beta (IL3RB) for full signaling activity. **Pathways and Functions** IL3RA is involved in the regulation of several cellular processes, including: 1. **Immune response**: IL3RA plays a critical role in the development and function of various immune cells, such as granulocytes, monocytes, and lymphocytes. 2. **Cell growth and differentiation**: IL3RA is involved in the regulation of cell growth and differentiation in response to IL-3. 3. **Survival**: IL3RA is essential for the survival of hematopoietic cells, including stem cells and progenitor cells. 4. **Angiogenesis**: IL3RA has been shown to be involved in the regulation of angiogenesis, the process of new blood vessel formation. IL3RA signaling is mediated through the JAK/STAT pathway, which involves the phosphorylation and activation of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins. This pathway is essential for the transcriptional regulation of target genes involved in immune response, cell growth, and differentiation. **Clinical Significance** Dysregulation of IL3RA has been implicated in various diseases, including: 1. **Blood disorders**: Mutations in the IL3RA gene have been associated with certain blood disorders, such as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). 2. **Immunodeficiency**: IL3RA deficiency has been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 3. **Cancer**: IL3RA has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer. 4. **Inflammatory disorders**: IL3RA has been implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, IL3RA is a critical component of the immune system, playing a pivotal role in the regulation of immune response, cell growth, and differentiation. Dysregulation of IL3RA has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms of IL3RA signaling and its role in disease pathogenesis.

Genular Protein ID: 2707533972

Symbol: IL3RA_HUMAN

Name: Interleukin-3 receptor subunit alpha

UniProtKB Accession Codes:

P26951 A8K3F3 B9VI81 Q5HYQ7 Q5HYQ8 Q9UEH7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 12 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1833064

Title: Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors.

PubMed ID: 1833064

DOI: 10.1016/0092-8674(91)90039-2

PubMed ID: 7887951

Title: Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor.

PubMed ID: 7887951

DOI: 10.1006/bbrc.1995.1346

PubMed ID: 19109256

Title: A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode.

PubMed ID: 19109256

DOI: 10.1074/jbc.m808197200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10527461

Title: Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues.

PubMed ID: 10527461

DOI: 10.1002/stem.170265

PubMed ID: 25043189

Title: Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.

PubMed ID: 25043189

DOI: 10.1016/j.celrep.2014.06.038

PubMed ID: 29374162

Title: A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

PubMed ID: 29374162

DOI: 10.1038/s41467-017-02633-7

Sequence Information:

  • Length: 378
  • Mass: 43330
  • Checksum: 716CE1803F2E5FC0
  • Sequence:
    • MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI ECVKDADYSM 
PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS GKPWAGAENL TCWIHDVDFL 
SCSWAVGPGA PADVQYDLYL NVANRRQQYE CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS 
HILVRGRSAA FGIPCTDKFV VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL 
QIQKRMQPVI TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN 
TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ NDKLVVWEAG 
KAGLEECLVT EVQVVQKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.