Details for: RNASE6

Gene ID: 6039

Symbol: RNASE6

Ensembl ID: ENSG00000169413

Description: ribonuclease A family member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.2397
    Cell Significance Index: -9.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.4147
    Cell Significance Index: -9.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.2610
    Cell Significance Index: -12.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.7504
    Cell Significance Index: -13.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.5429
    Cell Significance Index: -12.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5510
    Cell Significance Index: -9.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.5263
    Cell Significance Index: 85.5000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.5670
    Cell Significance Index: 17.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4658
    Cell Significance Index: -9.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3944
    Cell Significance Index: 51.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.3233
    Cell Significance Index: 42.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2709
    Cell Significance Index: -4.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.8053
    Cell Significance Index: 46.1200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.3514
    Cell Significance Index: 3.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9316
    Cell Significance Index: 24.9200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.8482
    Cell Significance Index: 3.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7688
    Cell Significance Index: 146.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4952
    Cell Significance Index: 48.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4019
    Cell Significance Index: 8.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3673
    Cell Significance Index: 331.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2830
    Cell Significance Index: 59.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2678
    Cell Significance Index: 29.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2625
    Cell Significance Index: 42.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1089
    Cell Significance Index: 7.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0868
    Cell Significance Index: 6.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0568
    Cell Significance Index: 35.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0408
    Cell Significance Index: 4.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0216
    Cell Significance Index: 15.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0016
    Cell Significance Index: 0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0003
    Cell Significance Index: 0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0099
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0107
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0112
    Cell Significance Index: -6.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0138
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0176
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -13.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0205
    Cell Significance Index: -13.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0206
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0253
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0284
    Cell Significance Index: -12.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0289
    Cell Significance Index: -10.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0316
    Cell Significance Index: -0.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0362
    Cell Significance Index: -7.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0408
    Cell Significance Index: -8.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0439
    Cell Significance Index: -7.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0519
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0601
    Cell Significance Index: -6.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0652
    Cell Significance Index: -7.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0654
    Cell Significance Index: -8.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0664
    Cell Significance Index: -9.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0757
    Cell Significance Index: -9.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0800
    Cell Significance Index: -1.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0815
    Cell Significance Index: -2.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0867
    Cell Significance Index: -12.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0909
    Cell Significance Index: -9.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1026
    Cell Significance Index: -13.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1158
    Cell Significance Index: -5.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1210
    Cell Significance Index: -5.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1268
    Cell Significance Index: -5.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1418
    Cell Significance Index: -10.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1552
    Cell Significance Index: -8.0600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1568
    Cell Significance Index: -2.2000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1610
    Cell Significance Index: -2.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1618
    Cell Significance Index: -10.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1670
    Cell Significance Index: -13.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1688
    Cell Significance Index: -3.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1690
    Cell Significance Index: -2.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1697
    Cell Significance Index: -12.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1788
    Cell Significance Index: -9.3200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1815
    Cell Significance Index: -1.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1950
    Cell Significance Index: -6.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2013
    Cell Significance Index: -12.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2077
    Cell Significance Index: -13.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2142
    Cell Significance Index: -12.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2251
    Cell Significance Index: -6.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2317
    Cell Significance Index: -7.5900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2319
    Cell Significance Index: -1.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2349
    Cell Significance Index: -7.4800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2419
    Cell Significance Index: -2.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2724
    Cell Significance Index: -12.0500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2734
    Cell Significance Index: -3.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2736
    Cell Significance Index: -4.1000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2838
    Cell Significance Index: -2.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2884
    Cell Significance Index: -4.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2904
    Cell Significance Index: -7.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2941
    Cell Significance Index: -7.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3010
    Cell Significance Index: -11.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3039
    Cell Significance Index: -4.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3077
    Cell Significance Index: -8.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3189
    Cell Significance Index: -6.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3190
    Cell Significance Index: -12.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3288
    Cell Significance Index: -6.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3317
    Cell Significance Index: -5.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3468
    Cell Significance Index: -10.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3482
    Cell Significance Index: -9.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Degradation:** RNASE6 is an endonuclease that cleaves RNA molecules, which is essential for the regulation of gene expression and the elimination of viral and bacterial RNA. 2. **Immune Cell Expression:** RNASE6 is expressed in various immune cells, including myeloid leukocytes, macrophages, and dendritic cells, indicating its involvement in the innate immune response. 3. **Antibacterial and Antiviral Activity:** RNASE6 has been shown to have antimicrobial properties, making it a potential target for the development of novel antibacterial and antiviral therapies. 4. **Cytokine Regulation:** RNASE6 may also play a role in the regulation of cytokine production, which is essential for the coordination of immune responses. **Pathways and Functions:** 1. **Antibacterial Humoral Response:** RNASE6 is involved in the recognition and elimination of bacterial pathogens, particularly gram-negative bacteria, through its RNA-degrading activity. 2. **Antimicrobial Humoral Immune Response Mediated by Antimicrobial Peptide:** RNASE6 may interact with antimicrobial peptides, such as cathelicidins, to enhance their antimicrobial activity. 3. **Cytoplasmic Vesicle:** RNASE6 is localized to cytoplasmic vesicles, where it can be released to target bacterial and viral RNA molecules. 4. **Defense Response to Gram-Negative and Gram-Positive Bacteria:** RNASE6 is expressed in cells that recognize and respond to gram-negative and gram-positive bacteria, highlighting its role in the innate immune response. **Clinical Significance:** RNASE6's involvement in the innate immune response makes it an attractive target for the development of novel therapies against bacterial and viral infections. Its ability to regulate cytokine production and interact with antimicrobial peptides also suggests potential applications in immunotherapy. Furthermore, RNASE6's expression in various immune cells highlights its potential as a biomarker for immune system dysregulation. In conclusion, RNASE6 is a multifaceted gene that plays a crucial role in the innate immune system, particularly in the defense against bacterial and viral infections. Its expression in various immune cells, RNA-degrading activity, and interaction with antimicrobial peptides make it an attractive target for the development of novel therapies.

Genular Protein ID: 1833421720

Symbol: RNAS6_HUMAN

Name: Ribonuclease K6

UniProtKB Accession Codes:

Q93091

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8836175

Title: Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family.

PubMed ID: 8836175

DOI: 10.1093/nar/24.18.3507

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25075772

Title: Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.

PubMed ID: 25075772

DOI: 10.1038/ki.2014.268

PubMed ID: 27089320

Title: Insights into the antimicrobial mechanism of action of human RNase6: structural determinants for bacterial cell agglutination and membrane permeation.

PubMed ID: 27089320

DOI: 10.3390/ijms17040552

PubMed ID: 27013146

Title: The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement.

PubMed ID: 27013146

DOI: 10.1042/bcj20160245

Sequence Information:

  • Length: 150
  • Mass: 17196
  • Checksum: 4C1F722066BCC13A
  • Sequence:
    • MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM SGINNYTQHC 
KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN MTDCRLTSGK YPQCRYSAAA 
QYKFFIVACD PPQKSDPPYK LVPVHLDSIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.