Details for: CL0000113

Cell ID: CL0000113

Cell Name: mononuclear phagocyte

Marker Score Threshold: 1004
(Derived using integrated single-cell and genomic data)

Description: A vertebrate phagocyte with a single nucleus.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.42
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.21
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.88
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.6
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.57
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.53
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.44
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.31
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.26
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.25
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.23
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.15
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.15
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.1
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.99
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.96
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.96
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.9
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.9
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.88
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.86
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.85
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.79
    Ensembl ID: ENSG00000085224
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.78
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.77
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.77
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.71
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.7
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.68
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.68
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.66
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.65
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.65
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.6
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.57
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.56
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.53
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.51
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.5
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.5
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.49
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.48
    Ensembl ID: ENSG00000142192
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.48
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.47
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.45
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.45
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.45
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.44
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.44
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.43
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.43
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.42
    Ensembl ID: ENSG00000241837
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.41
    Ensembl ID: ENSG00000183255
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.37
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.37
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.34
    Ensembl ID: ENSG00000162909
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143878
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.33
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.32
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.29
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.27
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.26
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.25
    Ensembl ID: ENSG00000137845
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.23
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.22
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.21
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.2
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.2
    Ensembl ID: ENSG00000087088
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.19
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.14
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.14
    Ensembl ID: ENSG00000156110
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.13
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 1.13
    Ensembl ID: ENSG00000248098
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.13
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.12
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.12
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.11
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.08
    Ensembl ID: ENSG00000173372
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.08
    Ensembl ID: ENSG00000109321
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.06
    Ensembl ID: ENSG00000004455
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.04
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.03
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADRA2B (ENSG00000274286)
    Fold Change: 1.03
    Ensembl ID: ENSG00000274286
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.03
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110330
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1
    Ensembl ID: ENSG00000101966
Hovered Details

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Hovered Details

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**Key Characteristics** The mononuclear phagocyte exhibits several key characteristics, including: 1. **Single nucleus**: The cell has a single nucleus, which is a characteristic feature of mononuclear phagocytes. 2. **Phagocytic activity**: The cell is capable of phagocytosing pathogens and other foreign particles, which is essential for the innate immune response. 3. **Antigen presentation**: The cell presents antigens to T-cells, which is crucial for the adaptive immune response. 4. **Regulation of cellular processes**: The cell regulates various cellular processes, including cell proliferation, differentiation, and survival. 5. **Expression of key genes**: The cell expresses several key genes, including ACTB and B2M, which are involved in various cellular processes. **Clinical Significance** The mononuclear phagocyte plays a critical role in the immune system, and its dysfunction can lead to various diseases, including: 1. **Immunodeficiency disorders**: Defects in the mononuclear phagocyte can lead to immunodeficiency disorders, such as chronic granulomatous disease (CGD). 2. **Autoimmune diseases**: The cell's ability to present antigens to T-cells can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases**: The cell's phagocytic activity is essential for the clearance of pathogens, and its dysfunction can lead to increased susceptibility to infections. 4. **Cancer**: The cell's ability to regulate cellular processes can contribute to cancer development and progression. Overall, the mononuclear phagocyte is a critical component of the immune system, and its dysfunction can have significant clinical implications.