Details for: TRBC1

Gene ID: 28639

Symbol: TRBC1

Ensembl ID: ENSG00000211751

Description: T cell receptor beta constant 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.1229
    Cell Significance Index: -27.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.2923
    Cell Significance Index: -19.0700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 12.4492
    Cell Significance Index: 33.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 10.2846
    Cell Significance Index: 213.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.3525
    Cell Significance Index: 328.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7395
    Cell Significance Index: -20.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.9128
    Cell Significance Index: 91.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.9092
    Cell Significance Index: 97.7200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.6826
    Cell Significance Index: 29.8300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.5644
    Cell Significance Index: 35.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.5581
    Cell Significance Index: 113.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.4411
    Cell Significance Index: 99.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4110
    Cell Significance Index: 30.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3515
    Cell Significance Index: 61.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9827
    Cell Significance Index: 187.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8515
    Cell Significance Index: 84.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6979
    Cell Significance Index: 630.1100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5825
    Cell Significance Index: 6.0400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4035
    Cell Significance Index: 2.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3688
    Cell Significance Index: 9.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3264
    Cell Significance Index: 53.0800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.1923
    Cell Significance Index: 1.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1861
    Cell Significance Index: 20.2500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1737
    Cell Significance Index: 1.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0215
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0107
    Cell Significance Index: -20.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0148
    Cell Significance Index: -0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0188
    Cell Significance Index: -14.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0268
    Cell Significance Index: -1.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0286
    Cell Significance Index: -1.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0344
    Cell Significance Index: -0.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0379
    Cell Significance Index: -16.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0383
    Cell Significance Index: -28.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0405
    Cell Significance Index: -29.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0438
    Cell Significance Index: -27.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0491
    Cell Significance Index: -1.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0587
    Cell Significance Index: -26.6600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0759
    Cell Significance Index: -0.7100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0772
    Cell Significance Index: -1.0500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0773
    Cell Significance Index: -1.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0812
    Cell Significance Index: -4.9800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0919
    Cell Significance Index: -1.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0933
    Cell Significance Index: -11.0000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0936
    Cell Significance Index: -0.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0966
    Cell Significance Index: -19.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1039
    Cell Significance Index: -4.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1160
    Cell Significance Index: -23.2600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1203
    Cell Significance Index: -1.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1334
    Cell Significance Index: -24.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1384
    Cell Significance Index: -19.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1596
    Cell Significance Index: -27.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1604
    Cell Significance Index: -20.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1786
    Cell Significance Index: -8.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1827
    Cell Significance Index: -22.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1885
    Cell Significance Index: -19.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1910
    Cell Significance Index: -27.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2023
    Cell Significance Index: -26.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2390
    Cell Significance Index: -27.3800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2476
    Cell Significance Index: -2.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2622
    Cell Significance Index: -20.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2972
    Cell Significance Index: -18.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3127
    Cell Significance Index: -18.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3420
    Cell Significance Index: -19.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3523
    Cell Significance Index: -26.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3577
    Cell Significance Index: -5.3900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3783
    Cell Significance Index: -4.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3806
    Cell Significance Index: -19.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3918
    Cell Significance Index: -25.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4318
    Cell Significance Index: -19.1000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.4649
    Cell Significance Index: -3.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5058
    Cell Significance Index: -19.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5102
    Cell Significance Index: -23.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5150
    Cell Significance Index: -18.9100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.5478
    Cell Significance Index: -2.2800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5515
    Cell Significance Index: -4.9100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6155
    Cell Significance Index: -6.5400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6226
    Cell Significance Index: -6.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6397
    Cell Significance Index: -22.4100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.6746
    Cell Significance Index: -7.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.7044
    Cell Significance Index: -6.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7367
    Cell Significance Index: -19.6700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7386
    Cell Significance Index: -8.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7667
    Cell Significance Index: -20.1600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.7786
    Cell Significance Index: -6.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7796
    Cell Significance Index: -21.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8144
    Cell Significance Index: -20.3100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.8203
    Cell Significance Index: -2.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8577
    Cell Significance Index: -28.0800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.8728
    Cell Significance Index: -6.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8767
    Cell Significance Index: -21.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.8919
    Cell Significance Index: -9.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.9016
    Cell Significance Index: -22.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9058
    Cell Significance Index: -26.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9215
    Cell Significance Index: -23.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9218
    Cell Significance Index: -26.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9402
    Cell Significance Index: -22.9400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.9972
    Cell Significance Index: -9.7200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -1.0127
    Cell Significance Index: -8.2000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0393
    Cell Significance Index: -20.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBC1 is a gene that belongs to the T cell receptor beta (TRBC) gene family, which comprises genes that encode the constant regions of the alpha-beta T cell receptor chains. The TRBC1 gene is characterized by its high degree of conservation across species, indicating its fundamental importance in the immune system. The gene is expressed in a wide range of immune cells, including mature T cells, naive thymus-derived CD4-positive T cells, and innate lymphoid cells. Notably, TRBC1 is also expressed in certain subsets of human NK cells, highlighting its role in the regulation of innate immune responses. **Pathways and Functions:** The TRBC1 gene is intricately involved in the adaptive immune response, particularly in the activation and signaling of alpha-beta T cells. The proper assembly of T cell receptors, which involves the association of TRBC1 with other alpha-beta chains, is crucial for the recognition of antigens and the initiation of an immune response. TRBC1 also plays a role in the regulation of T cell activation, proliferation, and differentiation. Furthermore, the gene is implicated in the development of various immune-related disorders, including autoimmune diseases and cancer. **Clinical Significance:** The TRBC1 gene has significant implications for our understanding of immune-related disorders and the development of novel therapeutic strategies. Dysregulation of TRBC1 has been implicated in various diseases, including multiple sclerosis, type 1 diabetes, and certain types of cancer. Furthermore, the gene's role in the regulation of innate immune responses makes it an attractive target for the development of immunotherapies aimed at modulating the innate immune system. Overall, the study of TRBC1 has the potential to reveal new insights into the complex mechanisms underlying immune responses and to inform the development of novel therapeutic interventions. **Implications for Immunology and Medicine:** The elucidation of TRBC1's role in the adaptive immune response has significant implications for our understanding of immune-related disorders and the development of novel therapeutic strategies. The gene's involvement in the regulation of T cell activation, proliferation, and differentiation highlights its potential as a target for the development of immunotherapies aimed at modulating the adaptive immune response. Additionally, the gene's role in the regulation of innate immune responses makes it an attractive target for the development of immunotherapies aimed at modulating the innate immune system. Further research into TRBC1 is warranted to fully elucidate its role in the immune system and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.