TRBC1 | ENSG00000211751 | NCBI 28639

Details for: TRBC1

Gene ID: 28639

Symbol: TRBC1

Ensembl ID: ENSG00000211751

Description: T cell receptor beta constant 1

Associated with

Adaptive immune response
(GO:0002250)
Alpha-beta t cell activation
(GO:0046631)
Alpha-beta t cell receptor complex
(GO:0042105)
Immune response
(GO:0006955)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
T cell receptor signaling pathway
(GO:0050852)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.6
Marker Score: 11,368
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.3
Marker Score: 9,618
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.27
Marker Score: 5,607
Cell Name: mature T cell (CL0002419)
Fold Change: 2.72
Marker Score: 26,888
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.61
Marker Score: 575
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.54
Marker Score: 1,270
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.5
Marker Score: 1,284
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.5
Marker Score: 1,812
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.48
Marker Score: 6,966
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.36
Marker Score: 1,987
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.35
Marker Score: 2,060
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.24
Marker Score: 2,161
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.21
Marker Score: 3,134
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 2.2
Marker Score: 497
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.15
Marker Score: 572
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.13
Marker Score: 919
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.1
Marker Score: 3,751
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.08
Marker Score: 644
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.02
Marker Score: 1,717
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2
Marker Score: 699
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2
Marker Score: 1,874
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.99
Marker Score: 1,438
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.97
Marker Score: 1,969
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.95
Marker Score: 103,095
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.82
Marker Score: 591
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.76
Marker Score: 2,590
Cell Name: memory T cell (CL0000813)
Fold Change: 1.74
Marker Score: 750
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.69
Marker Score: 4,132
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.64
Marker Score: 415
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 1.62
Marker Score: 1,348
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.62
Marker Score: 931
Cell Name: thymocyte (CL0000893)
Fold Change: 1.59
Marker Score: 1,662
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1,151
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.56
Marker Score: 6,679
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.54
Marker Score: 1,666
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.52
Marker Score: 345
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.39
Marker Score: 423
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.39
Marker Score: 776
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.39
Marker Score: 457
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.37
Marker Score: 2,684
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.35
Marker Score: 3,743
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.31
Marker Score: 1,166
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.25
Marker Score: 946
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.21
Marker Score: 711
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 1.19
Marker Score: 2,675
Cell Name: blood cell (CL0000081)
Fold Change: 1.15
Marker Score: 13,333
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.14
Marker Score: 770
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,780
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7,576
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.11
Marker Score: 1,232
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.07
Marker Score: 493
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.06
Marker Score: 820
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.06
Marker Score: 4,325
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 1.02
Marker Score: 281
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.02
Marker Score: 428
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.01
Marker Score: 741
Cell Name: Unknown (CL0000548)
Fold Change: 1.01
Marker Score: 737
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1
Marker Score: 677
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.99
Marker Score: 409
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.97
Marker Score: 759
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,409
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.94
Marker Score: 427
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,316
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,730
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.89
Marker Score: 307
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,282
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.87
Marker Score: 533
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.84
Marker Score: 689
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.83
Marker Score: 300
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.82
Marker Score: 413
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.81
Marker Score: 877
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 613
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,265
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 698
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: 0.74
Marker Score: 202
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.73
Marker Score: 404
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.73
Marker Score: 945
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 454
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.7
Marker Score: 1,134
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.64
Marker Score: 328
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.63
Marker Score: 683
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.62
Marker Score: 287
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.54
Marker Score: 211
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.53
Marker Score: 465
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.53
Marker Score: 172
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.48
Marker Score: 313
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.46
Marker Score: 122
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.46
Marker Score: 144
Cell Name: naive T cell (CL0000898)
Fold Change: 0.45
Marker Score: 292
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.44
Marker Score: 151
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 245
Cell Name: B cell (CL0000236)
Fold Change: 0.41
Marker Score: 391
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.4
Marker Score: 197

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** TRBC1 is a gene that belongs to the T cell receptor beta (TRBC) gene family, which comprises genes that encode the constant regions of the alpha-beta T cell receptor chains. The TRBC1 gene is characterized by its high degree of conservation across species, indicating its fundamental importance in the immune system. The gene is expressed in a wide range of immune cells, including mature T cells, naive thymus-derived CD4-positive T cells, and innate lymphoid cells. Notably, TRBC1 is also expressed in certain subsets of human NK cells, highlighting its role in the regulation of innate immune responses. **Pathways and Functions:** The TRBC1 gene is intricately involved in the adaptive immune response, particularly in the activation and signaling of alpha-beta T cells. The proper assembly of T cell receptors, which involves the association of TRBC1 with other alpha-beta chains, is crucial for the recognition of antigens and the initiation of an immune response. TRBC1 also plays a role in the regulation of T cell activation, proliferation, and differentiation. Furthermore, the gene is implicated in the development of various immune-related disorders, including autoimmune diseases and cancer. **Clinical Significance:** The TRBC1 gene has significant implications for our understanding of immune-related disorders and the development of novel therapeutic strategies. Dysregulation of TRBC1 has been implicated in various diseases, including multiple sclerosis, type 1 diabetes, and certain types of cancer. Furthermore, the gene's role in the regulation of innate immune responses makes it an attractive target for the development of immunotherapies aimed at modulating the innate immune system. Overall, the study of TRBC1 has the potential to reveal new insights into the complex mechanisms underlying immune responses and to inform the development of novel therapeutic interventions. **Implications for Immunology and Medicine:** The elucidation of TRBC1's role in the adaptive immune response has significant implications for our understanding of immune-related disorders and the development of novel therapeutic strategies. The gene's involvement in the regulation of T cell activation, proliferation, and differentiation highlights its potential as a target for the development of immunotherapies aimed at modulating the adaptive immune response. Additionally, the gene's role in the regulation of innate immune responses makes it an attractive target for the development of immunotherapies aimed at modulating the innate immune system. Further research into TRBC1 is warranted to fully elucidate its role in the immune system and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.