Details for: CL0000623

Cell ID: CL0000623

Cell Name: natural killer cell

Marker Score Threshold: 1296
(Derived using integrated single-cell and genomic data)

Description: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.

Synonyms: large granular lymphocyte, null cell, NK cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.24
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.24
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.65
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.6
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.29
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.28
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.16
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.11
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.1
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.03
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.03
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.01
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.97
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.89
    Ensembl ID: ENSG00000149925
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.83
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.82
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.81
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.79
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.75
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.66
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.63
    Ensembl ID: ENSG00000143933
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.62
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.62
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.6
    Ensembl ID: ENSG00000112576
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.58
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.57
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.55
    Ensembl ID: ENSG00000124172
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.52
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.51
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.48
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.46
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.45
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.44
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.43
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.41
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.38
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.38
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.38
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.38
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.37
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.36
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.33
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.31
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.29
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.27
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.24
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.23
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.23
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.22
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.21
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.21
    Ensembl ID: ENSG00000132965
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.21
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.21
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.2
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.18
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.17
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.16
    Ensembl ID: ENSG00000110651
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.15
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.14
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.14
    Ensembl ID: ENSG00000109321
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.12
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.11
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143727
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.11
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.09
    Ensembl ID: ENSG00000020633
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.08
    Ensembl ID: ENSG00000172216
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.08
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.07
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.05
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.05
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.05
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.03
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.01
    Ensembl ID: ENSG00000111276
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104765
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1
    Ensembl ID: ENSG00000118971
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Germline-encoded activation receptors**: NK cells possess a set of germline-encoded activation receptors that recognize specific ligands on target cells, leading to the activation of immune responses. 2. **Cytotoxic granules**: NK cells contain cytotoxic granules that contain enzymes and proteins that can induce cell death in target cells. 3. **Cytokine release**: NK cells release cytokines that regulate immune responses, including the activation of T cells and the production of antibodies. 4. **Direct contact with other cells**: NK cells can interact with other immune cells, such as T cells and dendritic cells, to regulate immune responses. 5. **Lack of antigenic activation**: NK cells can recognize and destroy target cells without prior antigenic activation, making them a key component of the innate immune system. **Clinical Significance** 1. **Cancer immunotherapy**: NK cells have been explored as a potential therapeutic tool for cancer treatment, as they can recognize and destroy cancer cells without prior antigenic activation. 2. **Viral infections**: NK cells play a crucial role in controlling viral infections, particularly in the early stages of infection. 3. **Autoimmune diseases**: NK cells have been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Immunodeficiency diseases**: NK cells are essential for the regulation of immune responses, and deficiencies in NK cell function can lead to increased susceptibility to infections. 5. **Transplantation**: NK cells have been explored as a potential tool for graft rejection in transplantation, as they can recognize and destroy alloantigen-expressing cells. In conclusion, NK cells are a crucial component of the innate immune system, and their dysfunction has significant implications for human health. Further research is needed to fully understand the role of NK cells in immune function and disease, and to develop effective therapeutic strategies for the treatment of immune-related disorders.