Details for: CL0000623

Cell ID: CL0000623

Cell Name: natural killer cell

Description: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.

Synonyms: large granular lymphocyte, null cell, NK cell

Genes (max top 100)

(Fold Change: Indicates the ratio of the CSI Threshold for natural killer cell to Cell Significance Index of natural killer cell in specific gene. A fold change greater than 1 suggests significant gene expression.)

  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: N/A
    Ensembl ID: ENSG00000121410
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: N/A
    Ensembl ID: ENSG00000175899
  • Gene Symbol: A2MP1 (ENSG00000291190)
    Fold Change: N/A
    Ensembl ID: ENSG00000291190
  • Gene Symbol: NAT1 (ENSG00000171428)
    Fold Change: N/A
    Ensembl ID: ENSG00000171428
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: N/A
    Ensembl ID: ENSG00000156006
  • Gene Symbol: NATP (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: N/A
    Ensembl ID: ENSG00000196136
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: N/A
    Ensembl ID: ENSG00000114771
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: N/A
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: N/A
    Ensembl ID: ENSG00000129673
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: N/A
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AAVS1 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: N/A
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: N/A
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: N/A
    Ensembl ID: ENSG00000107331
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: N/A
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: N/A
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: N/A
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: N/A
    Ensembl ID: ENSG00000198691
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: N/A
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: N/A
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: N/A
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: N/A
    Ensembl ID: ENSG00000175164
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: N/A
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: N/A
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: N/A
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: N/A
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: N/A
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: N/A
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: N/A
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: N/A
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: N/A
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: N/A
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: N/A
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: N/A
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: N/A
    Ensembl ID: ENSG00000110881
  • Gene Symbol: ACHE (ENSG00000087085)
    Fold Change: N/A
    Ensembl ID: ENSG00000087085
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: N/A
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: N/A
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ACR (ENSG00000100312)
    Fold Change: N/A
    Ensembl ID: ENSG00000100312
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: N/A
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: N/A
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: N/A
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACP2 (ENSG00000134575)
    Fold Change: N/A
    Ensembl ID: ENSG00000134575
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: N/A
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: N/A
    Ensembl ID: ENSG00000014257
  • Gene Symbol: ACRV1 (ENSG00000134940)
    Fold Change: N/A
    Ensembl ID: ENSG00000134940
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: N/A
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: N/A
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: N/A
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTBP2 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP3 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP4 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP6 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP7 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP8 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP9 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: N/A
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: N/A
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: N/A
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ACTG1P1 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P2 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P3 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: N/A
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACTG1P9 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P10 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: N/A
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: N/A
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: N/A
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: N/A
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: N/A
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: N/A
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: N/A
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACVR2B (ENSG00000114739)
    Fold Change: N/A
    Ensembl ID: ENSG00000114739
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: N/A
    Ensembl ID: ENSG00000139567
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: N/A
    Ensembl ID: ENSG00000243989
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: N/A
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: N/A
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: N/A
    Ensembl ID: ENSG00000196839
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: N/A
    Ensembl ID: ENSG00000151651
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: N/A
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: N/A
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: N/A
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: N/A
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: N/A
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: N/A
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: N/A
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: N/A
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: N/A
    Ensembl ID: ENSG00000174233
  • Gene Symbol: ADCY7 (ENSG00000121281)
    Fold Change: N/A
    Ensembl ID: ENSG00000121281
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: N/A
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: N/A
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ADCYAP1 (ENSG00000141433)
    Fold Change: N/A
    Ensembl ID: ENSG00000141433
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: N/A
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: N/A
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: N/A
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: N/A
    Ensembl ID: ENSG00000148700
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: N/A
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: N/A
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: N/A
    Ensembl ID: ENSG00000196616

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the CSI Threshold for natural killer cell to Cell Significance Index of natural killer cell in specific gene. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the CSI Threshold for natural killer cell to Cell Significance Index of natural killer cell in specific gene. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * NK cells are a type of lymphocyte that can spontaneously kill target cells without prior antigenic activation. * They possess germline-encoded activation receptors that enable them to recognize and eliminate infected cells or tumor cells. * NK cells regulate immune responses via cytokine release and direct contact with other cells. * They are involved in various cellular processes such as transcription, translation, and cell differentiation. * NK cells are essential for the innate immune system, providing a first line of defense against pathogens and tumor cells. **Clinical Significance** * NK cells play a crucial role in the innate immune system, providing a first line of defense against pathogens and tumor cells. * Abnormalities in NK cell function have been linked to various diseases, including cancer, autoimmune disorders, and infectious diseases. * NK cells are being explored as a potential therapeutic target for cancer treatment, as they can recognize and eliminate tumor cells. * Understanding the function and regulation of NK cells is essential for the development of effective immunotherapies and vaccines. * NK cells are also being studied in the context of autoimmune disorders, such as multiple sclerosis and type 1 diabetes, where they may play a role in the pathogenesis of these diseases. **Pathways and Ontologies** * NK cells are involved in various cellular processes such as transcription, translation, and cell differentiation. * They are also involved in immune responses, including the regulation of cytokine release and the elimination of infected cells or tumor cells. * NK cells are essential for the innate immune system, providing a first line of defense against pathogens and tumor cells. * Abnormalities in NK cell function have been linked to various diseases, including cancer, autoimmune disorders, and infectious diseases. * Understanding the function and regulation of NK cells is essential for the development of effective immunotherapies and vaccines. **Genes Associated with NK Cells** * DLX5: involved in the regulation of transcription and cell differentiation. * RPL13: involved in the regulation of translation and cell differentiation. * RPL11: involved in the regulation of translation and cell differentiation. **Conclusion** NK cells are a type of lymphocyte that plays a crucial role in the innate immune system. They possess germline-encoded activation receptors that enable them to recognize and eliminate infected cells or tumor cells. NK cells regulate immune responses via cytokine release and direct contact with other cells. Understanding the function and regulation of NK cells is essential for the development of effective immunotherapies and vaccines. Abnormalities in NK cell function have been linked to various diseases, including cancer, autoimmune disorders, and infectious diseases.