Details for: LCP1

Gene ID: 3936

Symbol: LCP1

Ensembl ID: ENSG00000136167

Description: lymphocyte cytosolic protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.96
    Marker Score: 12487
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.95
    Marker Score: 221127
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.92
    Marker Score: 38809
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.75
    Marker Score: 43644
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.66
    Marker Score: 4414
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.55
    Marker Score: 9958
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.41
    Marker Score: 9414
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.4
    Marker Score: 3287
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.34
    Marker Score: 6515
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.25
    Marker Score: 4781
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.24
    Marker Score: 3599
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.23
    Marker Score: 9425
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.19
    Marker Score: 1375
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.16
    Marker Score: 7709
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.13
    Marker Score: 2752.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.06
    Marker Score: 3501
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.01
    Marker Score: 8925
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.96
    Marker Score: 2326
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.95
    Marker Score: 2624
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.94
    Marker Score: 7332
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.88
    Marker Score: 3974
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.88
    Marker Score: 5015
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.84
    Marker Score: 6856
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.77
    Marker Score: 11884
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.73
    Marker Score: 1343
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.71
    Marker Score: 1664
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.7
    Marker Score: 142881.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.7
    Marker Score: 3816
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.69
    Marker Score: 5262
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.63
    Marker Score: 4704
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.59
    Marker Score: 1519
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.57
    Marker Score: 798
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.53
    Marker Score: 2528
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.51
    Marker Score: 2364
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.5
    Marker Score: 1524
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5
    Marker Score: 15985
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.5
    Marker Score: 1891
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.49
    Marker Score: 2099
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.49
    Marker Score: 1244
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.46
    Marker Score: 1782
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.45
    Marker Score: 62740
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.44
    Marker Score: 2287
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.35
    Marker Score: 1516
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.35
    Marker Score: 6080.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.34
    Marker Score: 1711
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.32
    Marker Score: 811
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.31
    Marker Score: 550
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.3
    Marker Score: 1182
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.27
    Marker Score: 1643
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.27
    Marker Score: 1251
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.26
    Marker Score: 1301
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.21
    Marker Score: 487
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.19
    Marker Score: 554
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8779
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.13
    Marker Score: 588
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.11
    Marker Score: 694
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.09
    Marker Score: 4371
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.08
    Marker Score: 3561
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.07
    Marker Score: 21007
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.07
    Marker Score: 12584
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.07
    Marker Score: 8003
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.05
    Marker Score: 1677
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.99
    Marker Score: 1449
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.94
    Marker Score: 1468
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.92
    Marker Score: 1154
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.89
    Marker Score: 1041
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.87
    Marker Score: 1589
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.86
    Marker Score: 1661
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.84
    Marker Score: 769
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.84
    Marker Score: 424
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.84
    Marker Score: 1388
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.83
    Marker Score: 1247.5
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.8
    Marker Score: 409
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.8
    Marker Score: 1938
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.79
    Marker Score: 4865.5
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.77
    Marker Score: 466
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.77
    Marker Score: 3980
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.77
    Marker Score: 574
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.76
    Marker Score: 1216
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.75
    Marker Score: 858
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.74
    Marker Score: 1756
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.74
    Marker Score: 1013
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.74
    Marker Score: 747
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.73
    Marker Score: 526
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.72
    Marker Score: 1247
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.72
    Marker Score: 609
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.71
    Marker Score: 698
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.7
    Marker Score: 7080
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.7
    Marker Score: 1733
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.68
    Marker Score: 1862
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.66
    Marker Score: 580
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.65
    Marker Score: 785
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.65
    Marker Score: 1369
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.65
    Marker Score: 821
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.63
    Marker Score: 957
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.61
    Marker Score: 2147
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.61
    Marker Score: 1069
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.6
    Marker Score: 1096
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.6
    Marker Score: 690
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.59
    Marker Score: 1912

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Other Information

## Summary LCP1 is a protein involved in various cellular and physiological processes. It is a cytoskeletal protein that plays a crucial role in cell migration, tissue remodeling, and immune responses. ## Key characteristics * LCP1 is a transmembrane protein with a predicted molecular weight of approximately 120 kDa. * It is highly expressed in various cell types, including immune cells, endothelial cells, and tumor cells. * It is involved in cell migration, adhesion, and signaling pathways. * It interacts with various signaling molecules, including those involved in cell migration, growth, and differentiation. ## Pathways and functions * **Cell migration:** LCP1 is crucial for the migration of immune cells, including gamma-delta T cells, macrophages, and dendritic cells. * **Tissue remodeling:** It is involved in the remodeling of tissues by promoting cell migration and tissue repair. * **Immune responses:** LCP1 plays a role in the regulation of immune responses by interacting with various signaling molecules. * **Extracellular matrix disassembly:** It is involved in the disassembly of the extracellular matrix, which is essential for cell migration and tissue remodeling. * **Cytokine signaling:** LCP1 is involved in the regulation of cytokine signaling pathways, which are crucial for immune responses. ## Clinical significance LCP1 has been implicated in various human diseases, including cancer, autoimmune diseases, and inflammation. Studies have shown that mutations in LCP1 can lead to immune deficiencies and various diseases. * **Cancer:** LCP1 is highly expressed in tumor cells and is a target for cancer immunotherapy. * **Autoimmune diseases:** Mutations in LCP1 are associated with the development of autoimmune diseases such as rheumatoid arthritis, psoriasis, and lupus. * **Inflammation:** LCP1 is involved in the regulation of inflammation, and mutations can lead to chronic inflammation. Overall, LCP1 is a critical protein involved in various cellular and physiological processes. Its involvement in cell migration, tissue remodeling, immune responses, and extracellular matrix disassembly makes it a potential therapeutic target for various diseases.

Genular Protein ID: 4064599807

Symbol: PLSL_HUMAN

Name: Plastin-2

UniProtKB Accession Codes:

P13796 B2R613 B4DUA0 Q5TBN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EMDB 1 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRIDE 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2252891

Title: 65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites.

PubMed ID: 2252891

DOI: 10.1021/bi00488a017

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3211125

Title: Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.

PubMed ID: 3211125

DOI: 10.1128/mcb.8.11.4659-4668.1988

PubMed ID: 2378651

Title: Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.

PubMed ID: 2378651

DOI: 10.1128/mcb.10.4.1818-1821.1990

PubMed ID: 8428952

Title: Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.

PubMed ID: 8428952

DOI: 10.1016/s0021-9258(18)53842-4

PubMed ID: 2111166

Title: Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells.

PubMed ID: 2111166

DOI: 10.1021/bi00456a030

PubMed ID: 3261603

Title: Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1.

PubMed ID: 3261603

DOI: 10.1021/bi00410a037

PubMed ID: 10469447

Title: Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma.

PubMed ID: 10469447

DOI: 10.1002/(sici)1098-2264(199910)26:2<97::aid-gcc1>3.3.co;2-0

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16636079

Title: Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells.

PubMed ID: 16636079

DOI: 10.1242/jcs.02874

PubMed ID: 17294403

Title: Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25.

PubMed ID: 17294403

DOI: 10.1002/eji.200636320

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28493397

Title: A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.

PubMed ID: 28493397

DOI: 10.1002/humu.23246

Sequence Information:

  • Length: 627
  • Mass: 70288
  • Checksum: 668E4AA6A3FC7B58
  • Sequence:
    • MARGSVSDEE MMELREAFAK VDTDGNGYIS FNELNDLFKA ACLPLPGYRV REITENLMAT 
GDLDQDGRIS FDEFIKIFHG LKSTDVAKTF RKAINKKEGI CAIGGTSEQS SVGTQHSYSE 
EEKYAFVNWI NKALENDPDC RHVIPMNPNT NDLFNAVGDG IVLCKMINLS VPDTIDERTI 
NKKKLTPFTI QENLNLALNS ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI 
ELSRNEALIA LLREGESLED LMKLSPEELL LRWANYHLEN AGCNKIGNFS TDIKDSKAYY 
HLLEQVAPKG DEEGVPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV TATDVVRGNP 
KLNLAFIANL FNRYPALHKP ENQDIDWGAL EGETREERTF RNWMNSLGVN PRVNHLYSDL 
SDALVIFQLY EKIKVPVDWN RVNKPPYPKL GGNMKKLENC NYAVELGKNQ AKFSLVGIGG 
QDLNEGNRTL TLALIWQLMR RYTLNILEEI GGGQKVNDDI IVNWVNETLR EAKKSSSISS 
FKDPKISTSL PVLDLIDAIQ PGSINYDLLK TENLNDDEKL NNAKYAISMA RKIGARVYAL 
PEDLVEVNPK MVMTVFACLM GKGMKRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.