Details for: CL0000051

Cell ID: CL0000051

Cell Name: common lymphoid progenitor

Marker Score Threshold: 681
(Derived using integrated single-cell and genomic data)

Description: A oligopotent progenitor cell committed to the lymphoid lineage.

Synonyms: common lymphocyte precursor, common lymphocyte progenitor, common lymphoid precursor, CLP, ELP, committed lymphopoietic stem cell, early lymphocyte progenitor, lymphoid stem cell, lymphopoietic stem cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.25
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.97
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.59
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.57
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.55
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.54
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.53
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.29
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.22
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.18
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.18
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.15
    Ensembl ID: ENSG00000143933
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.14
    Ensembl ID: ENSG00000119138
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.99
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.91
    Ensembl ID: ENSG00000185650
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.89
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.88
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.82
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.82
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.8
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.74
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.72
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.72
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.71
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.68
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.67
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.67
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.66
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.63
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.6
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.56
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.56
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.55
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.55
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.54
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.53
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.52
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.51
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: 1.48
    Ensembl ID: ENSG00000196839
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.48
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.47
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.47
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.46
    Ensembl ID: ENSG00000164111
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143799
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.45
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143727
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.41
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.4
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.4
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.39
    Ensembl ID: ENSG00000141522
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.37
    Ensembl ID: ENSG00000173020
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.33
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.33
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.33
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.32
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.3
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.3
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.25
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.25
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.25
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.24
    Ensembl ID: ENSG00000197894
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.22
    Ensembl ID: ENSG00000110987
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.22
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.2
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.2
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.2
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.19
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117054
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.19
    Ensembl ID: ENSG00000042493
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.18
    Ensembl ID: ENSG00000198356
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.17
    Ensembl ID: ENSG00000159199
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.16
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.15
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.13
    Ensembl ID: ENSG00000140299
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168675
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.1
    Ensembl ID: ENSG00000171791
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.1
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.09
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.06
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.04
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.03
    Ensembl ID: ENSG00000141480
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.03
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.01
    Ensembl ID: ENSG00000035687
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Oligopotent Progenitor**: The CLP is an oligopotent progenitor cell, meaning it has the ability to differentiate into multiple cell types, but not all possible cell types. 2. **Lymphoid Lineage**: The CLP is committed to the lymphoid lineage, giving rise to various lymphoid cells, including T cells, B cells, and natural killer cells. 3. **Actin Cytoskeleton**: The CLP has a well-developed actin cytoskeleton, which is essential for its migration, adhesion, and signaling functions. 4. **Adherens Junctions**: The CLP forms adherens junctions, which are essential for its adhesion to the extracellular matrix and other cells. 5. **Regulation by Signaling Pathways**: The CLP's function is regulated by a complex interplay of signaling pathways, including the MAPK/ERK pathway, the PI3K/AKT pathway, and the Wnt/β-catenin pathway. 6. **Transcription Factors**: The CLP is regulated by a set of transcription factors, including Pax5, Ikaros, and E2A, which control its differentiation into lymphoid cell types. **Clinical Significance** 1. **Immunodeficiency Disorders**: The CLP plays a critical role in the development of the immune system, and its dysfunction can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: The CLP can also give rise to cancer cells, including T cell acute lymphoblastic leukemia (T-ALL) and B cell acute lymphoblastic leukemia (B-ALL). 3. **Autoimmune Diseases**: The CLP can also contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by producing autoreactive T cells and B cells. 4. **Immunotherapy**: Understanding the biology of the CLP can lead to the development of novel immunotherapies, such as checkpoint inhibitors and CAR-T cell therapy. 5. **Regenerative Medicine**: The CLP can also be used as a model system for regenerative medicine, allowing researchers to study the development and function of the immune system in vitro. In conclusion, the Common Lymphoid Progenitor is a critical cell type in the development of the immune system, and its dysfunction can lead to a range of immunodeficiency disorders, cancers, and autoimmune diseases. Understanding its biology is essential for the development of novel immunotherapies and treatments for immune-related disorders.