Details for: RHOG

Gene ID: 391

Symbol: RHOG

Ensembl ID: ENSG00000177105

Description: ras homolog family member G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.4117
    Cell Significance Index: -27.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.4446
    Cell Significance Index: -37.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.2906
    Cell Significance Index: -37.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.6509
    Cell Significance Index: -37.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.1236
    Cell Significance Index: -40.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.2989
    Cell Significance Index: -19.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.1260
    Cell Significance Index: -38.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.0569
    Cell Significance Index: -33.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3490
    Cell Significance Index: -28.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9761
    Cell Significance Index: -35.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.3059
    Cell Significance Index: 116.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.1474
    Cell Significance Index: 101.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1364
    Cell Significance Index: -13.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6815
    Cell Significance Index: -15.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.2262
    Cell Significance Index: 124.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8299
    Cell Significance Index: 215.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8137
    Cell Significance Index: 211.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7970
    Cell Significance Index: 1622.6000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.3785
    Cell Significance Index: 9.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2298
    Cell Significance Index: 133.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0012
    Cell Significance Index: 64.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7800
    Cell Significance Index: 36.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6731
    Cell Significance Index: 18.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5825
    Cell Significance Index: 80.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5150
    Cell Significance Index: 66.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5077
    Cell Significance Index: 37.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4942
    Cell Significance Index: 25.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4409
    Cell Significance Index: 54.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3521
    Cell Significance Index: 34.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3049
    Cell Significance Index: 134.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2897
    Cell Significance Index: 158.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2629
    Cell Significance Index: 7.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2557
    Cell Significance Index: 6.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2556
    Cell Significance Index: 46.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2016
    Cell Significance Index: 5.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1860
    Cell Significance Index: 23.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1422
    Cell Significance Index: 3.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1111
    Cell Significance Index: 2.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0879
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0693
    Cell Significance Index: 13.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0599
    Cell Significance Index: 0.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0528
    Cell Significance Index: 9.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0425
    Cell Significance Index: 3.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0401
    Cell Significance Index: 7.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0213
    Cell Significance Index: 2.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0182
    Cell Significance Index: 12.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0082
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0155
    Cell Significance Index: -28.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0237
    Cell Significance Index: -32.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0274
    Cell Significance Index: -5.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0305
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0457
    Cell Significance Index: -33.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0565
    Cell Significance Index: -35.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0578
    Cell Significance Index: -20.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0809
    Cell Significance Index: -36.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0917
    Cell Significance Index: -19.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0988
    Cell Significance Index: -5.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1018
    Cell Significance Index: -29.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1027
    Cell Significance Index: -4.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1092
    Cell Significance Index: -0.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1135
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1334
    Cell Significance Index: -15.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1336
    Cell Significance Index: -3.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2140
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2157
    Cell Significance Index: -24.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2398
    Cell Significance Index: -34.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2541
    Cell Significance Index: -4.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2831
    Cell Significance Index: -4.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3318
    Cell Significance Index: -34.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3335
    Cell Significance Index: -9.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4053
    Cell Significance Index: -12.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4070
    Cell Significance Index: -20.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4184
    Cell Significance Index: -8.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4325
    Cell Significance Index: -6.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4336
    Cell Significance Index: -33.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4441
    Cell Significance Index: -18.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4908
    Cell Significance Index: -38.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4976
    Cell Significance Index: -4.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5321
    Cell Significance Index: -35.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5564
    Cell Significance Index: -35.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5633
    Cell Significance Index: -34.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6034
    Cell Significance Index: -33.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6048
    Cell Significance Index: -12.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6195
    Cell Significance Index: -37.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6481
    Cell Significance Index: -22.5200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.6885
    Cell Significance Index: -4.4000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.6932
    Cell Significance Index: -3.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6956
    Cell Significance Index: -36.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7923
    Cell Significance Index: -10.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8077
    Cell Significance Index: -23.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8082
    Cell Significance Index: -35.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8100
    Cell Significance Index: -8.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8425
    Cell Significance Index: -6.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RHOG is a small GTPase that belongs to the Rho family of GTPases, which are known to regulate actin cytoskeleton organization, cell migration, and cell cycle progression. RHOG is specifically involved in regulating the actin cytoskeleton organization and cell shape, which are crucial for immune cell function and migration. RHOG is also a key regulator of the PI3K/Akt signaling pathway, which is involved in cell survival, proliferation, and differentiation. **Pathways and Functions:** RHOG is involved in several signaling pathways that regulate immune cell function and disease. These include: 1. **Actin cytoskeleton organization**: RHOG regulates the organization of the actin cytoskeleton, which is essential for cell shape, migration, and cell cycle progression. 2. **PI3K/Akt signaling pathway**: RHOG is a key regulator of the PI3K/Akt signaling pathway, which is involved in cell survival, proliferation, and differentiation. 3. **Cell chemotaxis**: RHOG is involved in regulating cell chemotaxis, which is the movement of cells in response to chemical signals. 4. **Immune system**: RHOG is significantly expressed in immune cells, such as monocytes, macrophages, and T cells, and is involved in regulating immune cell function and signaling pathways. 5. **Cancer**: RHOG has been implicated in various cancers, including breast, lung, and colon cancer, where it regulates cell proliferation, invasion, and metastasis. **Clinical Significance:** RHOG has significant clinical implications in various diseases, including: 1. **Cancer**: RHOG is a potential therapeutic target for cancer treatment, as it regulates cell proliferation, invasion, and metastasis. 2. **Inflammatory disorders**: RHOG is involved in regulating immune cell function and signaling pathways, which are crucial for inflammatory disorders, such as rheumatoid arthritis and asthma. 3. **Autoimmune diseases**: RHOG is involved in regulating immune cell function and signaling pathways, which are crucial for autoimmune diseases, such as multiple sclerosis and lupus. 4. **Infectious diseases**: RHOG is involved in regulating immune cell function and signaling pathways, which are crucial for infectious diseases, such as tuberculosis and HIV. In conclusion, RHOG is a key regulator of immune cell function and signaling pathways, and its dysregulation has significant clinical implications in various diseases. Further research is needed to understand the mechanisms by which RHOG regulates immune cell function and signaling pathways, and to develop therapeutic strategies for treating diseases associated with RHOG dysregulation.

Genular Protein ID: 2364671782

Symbol: RHOG_HUMAN

Name: Rho-related GTP-binding protein RhoG

UniProtKB Accession Codes:

P84095 P35238 Q8NI04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1620121

Title: Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

PubMed ID: 1620121

DOI: 10.1128/mcb.12.7.3138-3148.1992

PubMed ID: 8464478

Title: Oncogene ect2 is related to regulators of small GTP-binding proteins.

PubMed ID: 8464478

DOI: 10.1038/362462a0

PubMed ID: 8810274

Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.

PubMed ID: 8810274

DOI: 10.1074/jbc.271.41.25173

PubMed ID: 15133129

Title: SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.

PubMed ID: 15133129

DOI: 10.1091/mbc.e04-02-0146

PubMed ID: 17074883

Title: Differential activation and function of Rho GTPases during Salmonella-host cell interactions.

PubMed ID: 17074883

DOI: 10.1083/jcb.200605144

PubMed ID: 17875742

Title: RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.

PubMed ID: 17875742

DOI: 10.1083/jcb.200612053

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33513601

Title: RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis.

PubMed ID: 33513601

DOI: 10.1182/blood.2020008738

Sequence Information:

  • Length: 191
  • Mass: 21309
  • Checksum: 0C4FE9C54140F499
  • Sequence:
    • MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT VNLNLWDTAG 
QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE VCHHCPDVPI LLVGTKKDLR 
AQPDTLRRLK EQGQAPITPQ QGQALAKQIH AVRYLECSAL QQDGVKEVFA EAVRAVLNPT 
PIKRGRSCIL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.