Details for: RHOG

Gene ID: 391

Symbol: RHOG

Ensembl ID: ENSG00000177105

Description: ras homolog family member G

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.47
    Marker Score: 194112
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.1
    Marker Score: 6049
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.09
    Marker Score: 35884.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.04
    Marker Score: 3668
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.7
    Marker Score: 6737
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.68
    Marker Score: 6461
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.49
    Marker Score: 24666
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.48
    Marker Score: 2841
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.41
    Marker Score: 15433
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.29
    Marker Score: 936
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.2
    Marker Score: 2129
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.19
    Marker Score: 8950
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.18
    Marker Score: 55777
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.16
    Marker Score: 2165
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.08
    Marker Score: 6573
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.07
    Marker Score: 1245
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.07
    Marker Score: 6028
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.05
    Marker Score: 5304
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.01
    Marker Score: 8610
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.01
    Marker Score: 953
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.96
    Marker Score: 103899
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.95
    Marker Score: 875.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.95
    Marker Score: 1413
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.94
    Marker Score: 623
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.94
    Marker Score: 5750
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.93
    Marker Score: 5412
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.91
    Marker Score: 3325
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.9
    Marker Score: 1046
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.87
    Marker Score: 3342
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.86
    Marker Score: 3642
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.85
    Marker Score: 1734
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.83
    Marker Score: 764
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.82
    Marker Score: 1318
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.79
    Marker Score: 1684
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.75
    Marker Score: 755
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.75
    Marker Score: 2472
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.74
    Marker Score: 10581
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.73
    Marker Score: 1519
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.7
    Marker Score: 2496
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.69
    Marker Score: 1233
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.67
    Marker Score: 591
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.65
    Marker Score: 965
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.64
    Marker Score: 1668
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.64
    Marker Score: 3431
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.63
    Marker Score: 2800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.62
    Marker Score: 1120
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.62
    Marker Score: 934
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.62
    Marker Score: 808
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.62
    Marker Score: 6348
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.61
    Marker Score: 565
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.61
    Marker Score: 4447
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.6
    Marker Score: 1731
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.6
    Marker Score: 3902
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.6
    Marker Score: 1327
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.6
    Marker Score: 1572
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.59
    Marker Score: 1168
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.59
    Marker Score: 2188
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.58
    Marker Score: 1195
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.58
    Marker Score: 778
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.57
    Marker Score: 1741
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.57
    Marker Score: 1581
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.57
    Marker Score: 1320
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.54
    Marker Score: 366
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.53
    Marker Score: 1591
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.51
    Marker Score: 1339
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.5
    Marker Score: 879
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.49
    Marker Score: 738
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.46
    Marker Score: 980
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.46
    Marker Score: 885.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.45
    Marker Score: 997
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.44
    Marker Score: 11282.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.44
    Marker Score: 1132.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.43
    Marker Score: 615
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.4
    Marker Score: 426
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.4
    Marker Score: 12068
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.4
    Marker Score: 850
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.39
    Marker Score: 5778
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.39
    Marker Score: 1138
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.38
    Marker Score: 918
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.37
    Marker Score: 473
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.36
    Marker Score: 714
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.34
    Marker Score: 464
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.34
    Marker Score: 1780
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.33
    Marker Score: 13506
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.32
    Marker Score: 1183
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.31
    Marker Score: 5668
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.31
    Marker Score: 407
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.31
    Marker Score: 288
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.31
    Marker Score: 1029
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.29
    Marker Score: 261
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.29
    Marker Score: 1402
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.28
    Marker Score: 1072
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.28
    Marker Score: 707
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.28
    Marker Score: 305
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.27
    Marker Score: 319
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.27
    Marker Score: 337
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.26
    Marker Score: 320
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.26
    Marker Score: 794
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.25
    Marker Score: 885

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Other Information

**Key characteristics:** * RHOG is a transmembrane protein with a conserved catalytic domain and a cytoplasmic domain. * It is expressed in a variety of cells, including monocyte, macrophage, and endothelial cells. * It is a key regulator of the PI3K/AKT pathway in cancer cells. * It is involved in cell migration, invasion, and metastasis. **Pathways and functions:** * Activation of RHOG by PI3K/AKT pathway leads to the phosphorylation of AKT, which is a key regulator of cell growth, proliferation, and survival. * Phosphorylation of AKT by RHOG inhibits its interaction with BAD, a pro-apoptotic protein, leading to cell survival. * RHOG also regulates the expression of anti-apoptotic genes, such as Bcl-2, which can lead to cell death. **Clinical significance:** * Mutations in the RHOG gene have been linked to several human cancers, including breast cancer, lung cancer, and prostate cancer. * Targeting RHOG with small molecule inhibitors has shown promise in preclinical models of cancer. * Therefore, RHOG is a promising target for cancer therapy. **Additional information:** * The RHOG gene is also involved in inflammation, immune response, and angiogenesis. * It is a key regulator of the balance between cell growth and apoptosis. * Mutations in the RHOG gene have been linked to impaired immune responses, which can contribute to the development of autoimmune diseases.

Genular Protein ID: 2364671782

Symbol: RHOG_HUMAN

Name: Rho-related GTP-binding protein RhoG

UniProtKB Accession Codes:

P84095 P35238 Q8NI04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1620121

Title: Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

PubMed ID: 1620121

DOI: 10.1128/mcb.12.7.3138-3148.1992

PubMed ID: 8464478

Title: Oncogene ect2 is related to regulators of small GTP-binding proteins.

PubMed ID: 8464478

DOI: 10.1038/362462a0

PubMed ID: 8810274

Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.

PubMed ID: 8810274

DOI: 10.1074/jbc.271.41.25173

PubMed ID: 15133129

Title: SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.

PubMed ID: 15133129

DOI: 10.1091/mbc.e04-02-0146

PubMed ID: 17074883

Title: Differential activation and function of Rho GTPases during Salmonella-host cell interactions.

PubMed ID: 17074883

DOI: 10.1083/jcb.200605144

PubMed ID: 17875742

Title: RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.

PubMed ID: 17875742

DOI: 10.1083/jcb.200612053

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33513601

Title: RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis.

PubMed ID: 33513601

DOI: 10.1182/blood.2020008738

Sequence Information:

  • Length: 191
  • Mass: 21309
  • Checksum: 0C4FE9C54140F499
  • Sequence:
    • MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT VNLNLWDTAG 
QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE VCHHCPDVPI LLVGTKKDLR 
AQPDTLRRLK EQGQAPITPQ QGQALAKQIH AVRYLECSAL QQDGVKEVFA EAVRAVLNPT 
PIKRGRSCIL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.