Details for: ADAR

Gene ID: 103

Symbol: ADAR

Ensembl ID: ENSG00000160710

Description: adenosine deaminase RNA specific

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.32
    Marker Score: 20356
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.27
    Marker Score: 627
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.16
    Marker Score: 120923
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.02
    Marker Score: 1989
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.01
    Marker Score: 1209
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.96
    Marker Score: 516
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.96
    Marker Score: 683
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.93
    Marker Score: 6078
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.92
    Marker Score: 101558.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.92
    Marker Score: 1796
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.88
    Marker Score: 813
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.88
    Marker Score: 1254
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.84
    Marker Score: 652
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.82
    Marker Score: 2505
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.77
    Marker Score: 6073
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.75
    Marker Score: 66420
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.74
    Marker Score: 1468
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.74
    Marker Score: 4886
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.72
    Marker Score: 63622
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.71
    Marker Score: 34037
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.7
    Marker Score: 990
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.69
    Marker Score: 16717
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.68
    Marker Score: 1322
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.68
    Marker Score: 401
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102710
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.66
    Marker Score: 1409
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.66
    Marker Score: 4576
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.64
    Marker Score: 6349
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.64
    Marker Score: 1196
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.64
    Marker Score: 9733
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.64
    Marker Score: 1769
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.64
    Marker Score: 1115
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.63
    Marker Score: 18973
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.62
    Marker Score: 16732
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.62
    Marker Score: 3149
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.59
    Marker Score: 1426
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.59
    Marker Score: 1920
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.59
    Marker Score: 1204
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.59
    Marker Score: 3958
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.59
    Marker Score: 14947
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.56
    Marker Score: 11597
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.56
    Marker Score: 1061
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.55
    Marker Score: 2548.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.55
    Marker Score: 1364.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.55
    Marker Score: 1688
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.55
    Marker Score: 23199
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.55
    Marker Score: 6428
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.55
    Marker Score: 1058
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.55
    Marker Score: 14722
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.55
    Marker Score: 673
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.54
    Marker Score: 622
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.54
    Marker Score: 701
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.53
    Marker Score: 15549
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.53
    Marker Score: 1531
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.53
    Marker Score: 13140
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.53
    Marker Score: 762
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.52
    Marker Score: 1532
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.51
    Marker Score: 11576
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.51
    Marker Score: 2007
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.51
    Marker Score: 615
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.51
    Marker Score: 1140
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.49
    Marker Score: 462
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.49
    Marker Score: 6052
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.47
    Marker Score: 362
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.47
    Marker Score: 386
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.47
    Marker Score: 876
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.47
    Marker Score: 2619
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.46
    Marker Score: 1343.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.46
    Marker Score: 1765
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.46
    Marker Score: 1057
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.46
    Marker Score: 3559
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.46
    Marker Score: 5403
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.46
    Marker Score: 1569
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.46
    Marker Score: 16389
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.45
    Marker Score: 3693
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.45
    Marker Score: 1458
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.44
    Marker Score: 2081
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.43
    Marker Score: 312
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.42
    Marker Score: 1163
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.42
    Marker Score: 367
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.41
    Marker Score: 374
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.41
    Marker Score: 318
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.41
    Marker Score: 1485
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.41
    Marker Score: 12228.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.4
    Marker Score: 322
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.4
    Marker Score: 933
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.4
    Marker Score: 18847
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.4
    Marker Score: 606
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.4
    Marker Score: 567
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.4
    Marker Score: 29837
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2056
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.39
    Marker Score: 1746
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.39
    Marker Score: 422
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.39
    Marker Score: 457
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.39
    Marker Score: 7284
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.38
    Marker Score: 2766
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.38
    Marker Score: 483
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.38
    Marker Score: 478
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.38
    Marker Score: 313
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.38
    Marker Score: 644

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Other Information

**Key characteristics:** - ADAR is a protein with a molecular weight of approximately 150 kDa. - It is a member of the DNA-binding protein family. - ADAR is highly expressed in cells of the immune system, particularly in antigen-presenting cells. - It is involved in the regulation of innate immune responses. **Pathways and functions:** - ADAR is involved in the antiviral mechanism of interferons. - It is a key regulator of the cytokine signaling pathway. - It is involved in the regulation of inflammation and tissue repair. - It is involved in the regulation of the adaptive immune response. **Clinical significance:** - Mutations in the ADAR gene have been linked to several human diseases, including systemic sclerosis, lupus, and cancer. - ADAR inhibitors are being investigated as potential treatments for these diseases. **Additional information:** - ADAR is a highly conserved protein, with similar genes found in other mammals. - It is a key regulator of innate immune responses. - It is a target for cancer immunotherapy.

Genular Protein ID: 2994240667

Symbol: DSRAD_HUMAN

Name: Double-stranded RNA-specific adenosine deaminase

UniProtKB Accession Codes:

P55265 B1AQQ9 B1AQR0 D3DV76 O15223 O43859 O43860 Q9BYM3 Q9BYM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 59 EPD 1 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 18 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 8 Rhea 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7972084

Title: Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

PubMed ID: 7972084

DOI: 10.1073/pnas.91.24.11457

PubMed ID: 7565688

Title: Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.

PubMed ID: 7565688

DOI: 10.1128/mcb.15.10.5376

PubMed ID: 9020165

Title: Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase.

PubMed ID: 9020165

DOI: 10.1074/jbc.272.7.4419

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10200312

Title: Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible.

PubMed ID: 10200312

DOI: 10.1073/pnas.96.8.4621

PubMed ID: 12618436

Title: Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA.

PubMed ID: 12618436

DOI: 10.1074/jbc.m213127200

PubMed ID: 12665561

Title: Dynamic association of RNA-editing enzymes with the nucleolus.

PubMed ID: 12665561

DOI: 10.1242/jcs.00371

PubMed ID: 15556947

Title: ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.

PubMed ID: 15556947

DOI: 10.1074/jbc.m407876200

PubMed ID: 15858013

Title: New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1.

PubMed ID: 15858013

DOI: 10.1128/jvi.79.10.6291-6298.2005

PubMed ID: 16120648

Title: SUMO-1 modification alters ADAR1 editing activity.

PubMed ID: 16120648

DOI: 10.1091/mbc.e05-06-0536

PubMed ID: 16055709

Title: ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing.

PubMed ID: 16055709

DOI: 10.1128/mcb.25.16.6956-6963.2005

PubMed ID: 16475990

Title: The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-alpha-stimulated host cells.

PubMed ID: 16475990

DOI: 10.1111/j.1365-2893.2005.00663.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17079286

Title: Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.

PubMed ID: 17079286

DOI: 10.1128/jvi.01527-06

PubMed ID: 18178553

Title: Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.

PubMed ID: 18178553

DOI: 10.1074/jbc.m708316200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18362360

Title: The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.

PubMed ID: 18362360

DOI: 10.1073/pnas.0710576105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19710021

Title: RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.

PubMed ID: 19710021

DOI: 10.1074/jbc.m109.045146

PubMed ID: 19605474

Title: ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.

PubMed ID: 19605474

DOI: 10.1128/jvi.02457-08

PubMed ID: 19124606

Title: RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

PubMed ID: 19124606

DOI: 10.1128/mcb.01519-08

PubMed ID: 19651874

Title: Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection.

PubMed ID: 19651874

DOI: 10.1093/nar/gkp604

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20192758

Title: Functions and regulation of RNA editing by ADAR deaminases.

PubMed ID: 20192758

DOI: 10.1146/annurev-biochem-060208-105251

PubMed ID: 19908260

Title: Human BLCAP transcript: new editing events in normal and cancerous tissues.

PubMed ID: 19908260

DOI: 10.1002/ijc.25022

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22022963

Title: RNA editing catalyzed by ADAR1 and its function in mammalian cells.

PubMed ID: 22022963

DOI: 10.1134/s0006297911080050

PubMed ID: 21289159

Title: ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor.

PubMed ID: 21289159

DOI: 10.1099/vir.0.028043-0

PubMed ID: 21182352

Title: Adenosine deaminases acting on RNA, RNA editing, and interferon action.

PubMed ID: 21182352

DOI: 10.1089/jir.2010.0097

PubMed ID: 21490091

Title: Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase.

PubMed ID: 21490091

DOI: 10.1128/jvi.00240-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21211811

Title: Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.

PubMed ID: 21211811

DOI: 10.1016/j.virol.2010.12.004

PubMed ID: 22988838

Title: A-to-I editing of protein coding and noncoding RNAs.

PubMed ID: 22988838

DOI: 10.3109/10409238.2012.714350

PubMed ID: 21769729

Title: ADAR proteins: structure and catalytic mechanism.

PubMed ID: 21769729

DOI: 10.1007/82_2011_144

PubMed ID: 22278222

Title: Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus.

PubMed ID: 22278222

DOI: 10.1128/jvi.06307-11

PubMed ID: 22113393

Title: Activity regulation of adenosine deaminases acting on RNA (ADARs).

PubMed ID: 22113393

DOI: 10.1007/s12035-011-8220-2

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10364558

Title: Crystal structure of the Z alpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.

PubMed ID: 10364558

DOI: 10.1126/science.284.5421.1841

PubMed ID: 10535945

Title: The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.

PubMed ID: 10535945

DOI: 10.1073/pnas.96.22.12465

PubMed ID: 16237447

Title: Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases.

PubMed ID: 16237447

DOI: 10.1038/nature04088

PubMed ID: 24753571

Title: A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.

PubMed ID: 24753571

DOI: 10.1073/pnas.1323698111

PubMed ID: 12916015

Title: Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria.

PubMed ID: 12916015

DOI: 10.1086/378209

PubMed ID: 15146470

Title: Seven novel mutations of the ADAR gene in Chinese families and sporadic patients with dyschromatosis symmetrica hereditaria (DSH).

PubMed ID: 15146470

DOI: 10.1002/humu.9246

PubMed ID: 15659327

Title: A new arginine substitution mutation of DSRAD gene in a Chinese family with dyschromatosis symmetrica hereditaria.

PubMed ID: 15659327

DOI: 10.1016/j.jdermsci.2004.11.004

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23001123

Title: Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature.

PubMed ID: 23001123

DOI: 10.1038/ng.2414

Sequence Information:

  • Length: 1226
  • Mass: 136066
  • Checksum: 9CE095D6F9C1BC79
  • Sequence:
    • MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ LPEAPVIGKQ 
TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLR SQGLQRGFQH PSPRGRSLPQ 
RGVDCLSSHF QELSIYQDQE QRILKFLEEL GEGKATTAHD LSGKLGTPKK EINRVLYSLA 
KKGKLQKEAG TPPLWKIAVS TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED 
LLEPFIAVSA QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 
EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP PIWHLTDKKR 
ERMQIKRNTN SVPETAPAAI PETKRNAEFL TCNIPTSNAS NNMVTTEKVE NGQEPVIKLE 
NRQEARPEPA RLKPPVHYNG PSKAGYVDFE NGQWATDDIP DDLNSIRAAP GEFRAIMEMP 
SFYSHGLPRC SPYKKLTECQ LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV 
INGREFPPAE AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 
TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV AVGAQTFPSV 
SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE SLDNLESMMP NKVRKIGELV 
RYLNTNPVGG LLEYARSHGF AAEFKLVDQS GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG 
KQEAADAALR VLIGENEKAE RMGFTEVTPV TGASLRRTML LLSRSPEAQP KTLPLTGSTF 
HDQIAMLSHR CFNTLTNSFQ PSLLGRKILA AIIMKKDSED MGVVVSLGTG NRCVKGDSLS 
LKGETVNDCH AEIISRRGFI RFLYSELMKY NSQTAKDSIF EPAKGGEKLQ IKKTVSFHLY 
ISTAPCGDGA LFDKSCSDRA MESTESRHYP VFENPKQGKL RTKVENGEGT IPVESSDIVP 
TWDGIRLGER LRTMSCSDKI LRWNVLGLQG ALLTHFLQPI YLKSVTLGYL FSQGHLTRAI 
CCRVTRDGSA FEDGLRHPFI VNHPKVGRVS IYDSKRQSGK TKETSVNWCL ADGYDLEILD 
GTRGTVDGPR NELSRVSKKN IFLLFKKLCS FRYRRDLLRL SYGEAKKAAR DYETAKNYFK 
KGLKDMGYGN WISKPQEEKN FYLCPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.