Details for: ADAR

Gene ID: 103

Symbol: ADAR

Ensembl ID: ENSG00000160710

Description: adenosine deaminase RNA specific

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 387.6043
    Cell Significance Index: -60.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 221.0190
    Cell Significance Index: -56.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.4283
    Cell Significance Index: -57.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.8895
    Cell Significance Index: -66.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 124.9841
    Cell Significance Index: -64.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.7002
    Cell Significance Index: -66.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.3304
    Cell Significance Index: -57.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.3076
    Cell Significance Index: -63.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.2520
    Cell Significance Index: -59.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2441
    Cell Significance Index: -64.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.2334
    Cell Significance Index: -49.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.7669
    Cell Significance Index: -30.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.8104
    Cell Significance Index: 146.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8082
    Cell Significance Index: 33.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7238
    Cell Significance Index: 342.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6851
    Cell Significance Index: 183.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6753
    Cell Significance Index: 336.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3598
    Cell Significance Index: 1227.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1925
    Cell Significance Index: 163.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1155
    Cell Significance Index: 400.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0259
    Cell Significance Index: 66.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9961
    Cell Significance Index: 179.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9036
    Cell Significance Index: 111.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8716
    Cell Significance Index: 141.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7448
    Cell Significance Index: 406.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6383
    Cell Significance Index: 35.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6310
    Cell Significance Index: 436.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5584
    Cell Significance Index: 246.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4912
    Cell Significance Index: 62.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4272
    Cell Significance Index: 12.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4136
    Cell Significance Index: 48.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4005
    Cell Significance Index: 39.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3199
    Cell Significance Index: 22.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2517
    Cell Significance Index: 6.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2167
    Cell Significance Index: 16.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2009
    Cell Significance Index: 5.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1967
    Cell Significance Index: 8.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1749
    Cell Significance Index: 33.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1723
    Cell Significance Index: 13.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1716
    Cell Significance Index: 9.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1629
    Cell Significance Index: 10.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1279
    Cell Significance Index: 2.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0967
    Cell Significance Index: 16.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0845
    Cell Significance Index: 3.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0822
    Cell Significance Index: 5.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0759
    Cell Significance Index: 142.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0700
    Cell Significance Index: 4.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0641
    Cell Significance Index: 2.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0504
    Cell Significance Index: 2.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0309
    Cell Significance Index: 47.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0255
    Cell Significance Index: 47.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0202
    Cell Significance Index: 0.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0103
    Cell Significance Index: 6.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0206
    Cell Significance Index: -1.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0212
    Cell Significance Index: -15.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0327
    Cell Significance Index: -24.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0329
    Cell Significance Index: -24.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0411
    Cell Significance Index: -25.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0572
    Cell Significance Index: -2.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0579
    Cell Significance Index: -7.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0607
    Cell Significance Index: -1.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0717
    Cell Significance Index: -40.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0749
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1458
    Cell Significance Index: -30.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1578
    Cell Significance Index: -4.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1927
    Cell Significance Index: -55.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1974
    Cell Significance Index: -12.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2162
    Cell Significance Index: -6.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2339
    Cell Significance Index: -34.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2641
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3160
    Cell Significance Index: -36.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3414
    Cell Significance Index: -38.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3426
    Cell Significance Index: -39.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4833
    Cell Significance Index: -12.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5146
    Cell Significance Index: -11.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5419
    Cell Significance Index: -11.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5475
    Cell Significance Index: -57.0100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6288
    Cell Significance Index: -9.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6750
    Cell Significance Index: -19.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6856
    Cell Significance Index: -41.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7023
    Cell Significance Index: -55.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7667
    Cell Significance Index: -20.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8426
    Cell Significance Index: -51.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8523
    Cell Significance Index: -17.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8710
    Cell Significance Index: -22.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8736
    Cell Significance Index: -20.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8933
    Cell Significance Index: -15.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9077
    Cell Significance Index: -10.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9361
    Cell Significance Index: -32.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9653
    Cell Significance Index: -13.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9774
    Cell Significance Index: -16.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0064
    Cell Significance Index: -28.7200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.0673
    Cell Significance Index: -14.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0727
    Cell Significance Index: -28.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2958
    Cell Significance Index: -25.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3765
    Cell Significance Index: -43.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3812
    Cell Significance Index: -45.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3843
    Cell Significance Index: -29.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADAR is a unique gene that possesses several distinct characteristics: 1. **RNA editing**: ADAR's primary function is to edit RNA molecules by converting adenosine to inosine, a process that affects the structure and function of RNA. 2. **Specificity**: ADAR's specificity for double-stranded RNA is a hallmark of its activity, allowing it to target specific RNA sequences. 3. **Multiple expression patterns**: ADAR is expressed in various cell types, including immune cells, endothelial cells, and hematopoietic cells, highlighting its diverse roles in different tissues. 4. **Regulation of gene expression**: ADAR's activity influences gene expression by regulating RNA editing, splicing, and the translation of RNA into protein. **Pathways and Functions** ADAR's functions can be categorized into several pathways: 1. **Adenosine to inosine editing**: ADAR's primary function is to convert adenosine to inosine in double-stranded RNA, a process that affects RNA structure and function. 2. **Antiviral mechanism**: ADAR's activity can interfere with viral replication by editing viral RNA, thereby inhibiting viral gene expression. 3. **Cytokine signaling**: ADAR's expression in immune cells suggests its involvement in cytokine signaling, which regulates immune responses. 4. **Hematopoiesis**: ADAR's expression in hematopoietic cells implies its role in the regulation of blood cell development and function. 5. **Apoptosis regulation**: ADAR's activity can influence apoptosis (programmed cell death) by regulating the expression of pro-apoptotic and anti-apoptotic genes. **Clinical Significance** ADAR's dysregulation has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in ADAR have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune diseases**: ADAR's dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: ADAR's activity can influence cancer development and progression by regulating gene expression and apoptosis. 4. **Neurological disorders**: ADAR's expression in neurons suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ADAR is a critical gene that plays a pivotal role in RNA editing, immune response, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding ADAR's functions and mechanisms. Further research is necessary to elucidate the complex relationships between ADAR and disease, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 2994240667

Symbol: DSRAD_HUMAN

Name: Double-stranded RNA-specific adenosine deaminase

UniProtKB Accession Codes:

P55265 B1AQQ9 B1AQR0 D3DV76 O15223 O43859 O43860 Q9BYM3 Q9BYM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 59 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 8 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7972084

Title: Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

PubMed ID: 7972084

DOI: 10.1073/pnas.91.24.11457

PubMed ID: 7565688

Title: Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.

PubMed ID: 7565688

DOI: 10.1128/mcb.15.10.5376

PubMed ID: 9020165

Title: Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase.

PubMed ID: 9020165

DOI: 10.1074/jbc.272.7.4419

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10200312

Title: Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible.

PubMed ID: 10200312

DOI: 10.1073/pnas.96.8.4621

PubMed ID: 12618436

Title: Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA.

PubMed ID: 12618436

DOI: 10.1074/jbc.m213127200

PubMed ID: 12665561

Title: Dynamic association of RNA-editing enzymes with the nucleolus.

PubMed ID: 12665561

DOI: 10.1242/jcs.00371

PubMed ID: 15556947

Title: ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.

PubMed ID: 15556947

DOI: 10.1074/jbc.m407876200

PubMed ID: 15858013

Title: New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1.

PubMed ID: 15858013

DOI: 10.1128/jvi.79.10.6291-6298.2005

PubMed ID: 16120648

Title: SUMO-1 modification alters ADAR1 editing activity.

PubMed ID: 16120648

DOI: 10.1091/mbc.e05-06-0536

PubMed ID: 16055709

Title: ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing.

PubMed ID: 16055709

DOI: 10.1128/mcb.25.16.6956-6963.2005

PubMed ID: 16475990

Title: The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-alpha-stimulated host cells.

PubMed ID: 16475990

DOI: 10.1111/j.1365-2893.2005.00663.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17079286

Title: Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.

PubMed ID: 17079286

DOI: 10.1128/jvi.01527-06

PubMed ID: 18178553

Title: Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.

PubMed ID: 18178553

DOI: 10.1074/jbc.m708316200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18362360

Title: The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.

PubMed ID: 18362360

DOI: 10.1073/pnas.0710576105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19710021

Title: RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.

PubMed ID: 19710021

DOI: 10.1074/jbc.m109.045146

PubMed ID: 19605474

Title: ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.

PubMed ID: 19605474

DOI: 10.1128/jvi.02457-08

PubMed ID: 19124606

Title: RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

PubMed ID: 19124606

DOI: 10.1128/mcb.01519-08

PubMed ID: 19651874

Title: Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection.

PubMed ID: 19651874

DOI: 10.1093/nar/gkp604

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20192758

Title: Functions and regulation of RNA editing by ADAR deaminases.

PubMed ID: 20192758

DOI: 10.1146/annurev-biochem-060208-105251

PubMed ID: 19908260

Title: Human BLCAP transcript: new editing events in normal and cancerous tissues.

PubMed ID: 19908260

DOI: 10.1002/ijc.25022

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22022963

Title: RNA editing catalyzed by ADAR1 and its function in mammalian cells.

PubMed ID: 22022963

DOI: 10.1134/s0006297911080050

PubMed ID: 21289159

Title: ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor.

PubMed ID: 21289159

DOI: 10.1099/vir.0.028043-0

PubMed ID: 21182352

Title: Adenosine deaminases acting on RNA, RNA editing, and interferon action.

PubMed ID: 21182352

DOI: 10.1089/jir.2010.0097

PubMed ID: 21490091

Title: Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase.

PubMed ID: 21490091

DOI: 10.1128/jvi.00240-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21211811

Title: Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.

PubMed ID: 21211811

DOI: 10.1016/j.virol.2010.12.004

PubMed ID: 22988838

Title: A-to-I editing of protein coding and noncoding RNAs.

PubMed ID: 22988838

DOI: 10.3109/10409238.2012.714350

PubMed ID: 21769729

Title: ADAR proteins: structure and catalytic mechanism.

PubMed ID: 21769729

DOI: 10.1007/82_2011_144

PubMed ID: 22278222

Title: Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus.

PubMed ID: 22278222

DOI: 10.1128/jvi.06307-11

PubMed ID: 22113393

Title: Activity regulation of adenosine deaminases acting on RNA (ADARs).

PubMed ID: 22113393

DOI: 10.1007/s12035-011-8220-2

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10364558

Title: Crystal structure of the Z alpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.

PubMed ID: 10364558

DOI: 10.1126/science.284.5421.1841

PubMed ID: 10535945

Title: The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.

PubMed ID: 10535945

DOI: 10.1073/pnas.96.22.12465

PubMed ID: 16237447

Title: Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases.

PubMed ID: 16237447

DOI: 10.1038/nature04088

PubMed ID: 24753571

Title: A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.

PubMed ID: 24753571

DOI: 10.1073/pnas.1323698111

PubMed ID: 12916015

Title: Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria.

PubMed ID: 12916015

DOI: 10.1086/378209

PubMed ID: 15146470

Title: Seven novel mutations of the ADAR gene in Chinese families and sporadic patients with dyschromatosis symmetrica hereditaria (DSH).

PubMed ID: 15146470

DOI: 10.1002/humu.9246

PubMed ID: 15659327

Title: A new arginine substitution mutation of DSRAD gene in a Chinese family with dyschromatosis symmetrica hereditaria.

PubMed ID: 15659327

DOI: 10.1016/j.jdermsci.2004.11.004

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23001123

Title: Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature.

PubMed ID: 23001123

DOI: 10.1038/ng.2414

Sequence Information:

  • Length: 1226
  • Mass: 136066
  • Checksum: 9CE095D6F9C1BC79
  • Sequence:
    • MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ LPEAPVIGKQ 
TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLR SQGLQRGFQH PSPRGRSLPQ 
RGVDCLSSHF QELSIYQDQE QRILKFLEEL GEGKATTAHD LSGKLGTPKK EINRVLYSLA 
KKGKLQKEAG TPPLWKIAVS TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED 
LLEPFIAVSA QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 
EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP PIWHLTDKKR 
ERMQIKRNTN SVPETAPAAI PETKRNAEFL TCNIPTSNAS NNMVTTEKVE NGQEPVIKLE 
NRQEARPEPA RLKPPVHYNG PSKAGYVDFE NGQWATDDIP DDLNSIRAAP GEFRAIMEMP 
SFYSHGLPRC SPYKKLTECQ LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV 
INGREFPPAE AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 
TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV AVGAQTFPSV 
SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE SLDNLESMMP NKVRKIGELV 
RYLNTNPVGG LLEYARSHGF AAEFKLVDQS GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG 
KQEAADAALR VLIGENEKAE RMGFTEVTPV TGASLRRTML LLSRSPEAQP KTLPLTGSTF 
HDQIAMLSHR CFNTLTNSFQ PSLLGRKILA AIIMKKDSED MGVVVSLGTG NRCVKGDSLS 
LKGETVNDCH AEIISRRGFI RFLYSELMKY NSQTAKDSIF EPAKGGEKLQ IKKTVSFHLY 
ISTAPCGDGA LFDKSCSDRA MESTESRHYP VFENPKQGKL RTKVENGEGT IPVESSDIVP 
TWDGIRLGER LRTMSCSDKI LRWNVLGLQG ALLTHFLQPI YLKSVTLGYL FSQGHLTRAI 
CCRVTRDGSA FEDGLRHPFI VNHPKVGRVS IYDSKRQSGK TKETSVNWCL ADGYDLEILD 
GTRGTVDGPR NELSRVSKKN IFLLFKKLCS FRYRRDLLRL SYGEAKKAAR DYETAKNYFK 
KGLKDMGYGN WISKPQEEKN FYLCPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.