Details for: CL0000814

Cell ID: CL0000814

Cell Name: mature NK T cell

Marker Score Threshold: 463
(Derived using integrated single-cell and genomic data)

Description: A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response.

Synonyms: mature NK T lymphocyte, mature NK T-cell, mature NK T-lymphocyte, mature NKT cell, mature natural killer T cell, mature natural killer T lymphocyte, mature natural killer T-cell, mature natural killer T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.77
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.14
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.1
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.04
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.02
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.89
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.76
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.69
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.59
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.58
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.34
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.31
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.27
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.26
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.2
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.2
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.18
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.12
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.12
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.1
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.07
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.97
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.95
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.93
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.89
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.87
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.85
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.81
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.77
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.76
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.74
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.73
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.72
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.71
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.68
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.63
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.62
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.61
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.56
    Ensembl ID: ENSG00000104964
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.56
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.55
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.54
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.52
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.49
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.41
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.41
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.41
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.41
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.4
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.4
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.4
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.39
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.38
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.36
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.35
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.32
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.32
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087088
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.27
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.27
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.27
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.27
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.22
    Ensembl ID: ENSG00000126247
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.22
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.22
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.21
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.21
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.18
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.16
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.15
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.13
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.09
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197043
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.06
    Ensembl ID: ENSG00000177105
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.04
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131100
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.01
    Ensembl ID: ENSG00000096401
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110848
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183255
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1
    Ensembl ID: ENSG00000149823
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: N/A
    Ensembl ID: ENSG00000006125
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Alpha-beta T cell lineage**: The mature NK T cell is a member of the alpha-beta T cell lineage, which is distinct from the gamma delta T cell lineage. 2. **Natural killer markers**: NK T cells express natural killer markers, such as CD56 and CD16, which are characteristic of natural killer cells. 3. **T cell receptor specificity**: NK T cells have a T cell receptor specific for a limited set of ligands, which allows them to recognize and respond to specific pathogens. 4. **Early activation and regulation**: NK T cells play a crucial role in the early stages of the immune response, particularly in the activation and regulation of the immune system. 5. **Unique expression of surface receptors**: NK T cells have a unique expression of surface receptors, including CD94/NKG2A and CD94/NKG2C, which are involved in the regulation of NK cell activity. **Clinical Significance** 1. **Immune system regulation**: NK T cells play a crucial role in the regulation of the immune system, particularly in the early stages of the immune response. 2. **Cancer immunotherapy**: NK T cells have been used as a therapeutic approach in cancer immunotherapy, where they are engineered to recognize and kill cancer cells. 3. **Infectious diseases**: NK T cells have been shown to play a role in the immune response to infectious diseases, such as tuberculosis and HIV. 4. **Autoimmune diseases**: NK T cells have been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 5. **Immunodeficiency disorders**: NK T cells have been used as a marker for immunodeficiency disorders, such as severe combined immunodeficiency (SCID). **Pathways and Ontology** The mature NK T cell is involved in various signaling pathways, including: 1. **Actin cytoskeleton**: The mature NK T cell is involved in the regulation of the actin cytoskeleton, which is essential for cell migration and adhesion. 2. **Adherens junction**: The mature NK T cell is involved in the formation and regulation of adherens junctions, which are essential for cell-cell adhesion and signaling. 3. **Apoptosis**: The mature NK T cell is involved in the regulation of apoptosis, which is essential for the elimination of infected cells and tumor cells. 4. **Cytokine signaling**: The mature NK T cell is involved in the regulation of cytokine signaling, which is essential for the coordination of the immune response. Overall, the mature NK T cell is a unique and critical component of the immune system, playing a crucial role in the regulation of the immune response and the elimination of pathogens and tumor cells.