Details for: SKAP1

Gene ID: 8631

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SKAP1

Ensembl ID: ENSG00000141293

Description: src kinase associated phosphoprotein 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 18.64
    rCSI 48.2%
    PRS 87.05
  • fallopian tube secretory epithelial cell CL4030006
    CSI 10.25
    rCSI 9.87%
    PRS 88.62
  • basophil CL0000767
    CSI 9.9
    rCSI 20.94%
    PRS 94.98
  • alpha-beta T cell CL0000789
    CSI 9.64
    rCSI 11.3%
    PRS 96.96
  • mucosal invariant T cell CL0000940
    CSI 9.45
    rCSI 7.63%
    PRS 94.91
  • naive B cell CL0000788
    CSI 9.37
    rCSI 8.04%
    PRS 93.53
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 8.82
    rCSI 7.07%
    PRS 95.03
  • group 3 innate lymphoid cell CL0001071
    CSI 8.48
    rCSI 6.37%
    PRS 93.34
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 7.79
    rCSI 11.04%
    PRS 87.7
  • naive T cell CL0000898
    CSI 7.59
    rCSI 5.28%
    PRS 97.66
  • renal principal cell CL0005009
    CSI 7.55
    rCSI 19.61%
    PRS 89.29
  • kidney connecting tubule epithelial cell CL1000768
    CSI 7.52
    rCSI 19.08%
    PRS 83.69
  • double negative thymocyte CL0002489
    CSI 7.43
    rCSI 5.17%
    PRS 97.02
  • ionocyte CL0005006
    CSI 7.16
    rCSI 7.68%
    PRS 91.37
  • IgG plasma cell CL0000985
    CSI 6.86
    rCSI 8.22%
    PRS 94.02
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 6.52
    rCSI 4.68%
    PRS 97.56
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 6.34
    rCSI 4.82%
    PRS 97.6
  • ciliated epithelial cell CL0000067
    CSI 6.04
    rCSI 5.31%
    PRS 81.37
  • gamma-delta T cell CL0000798
    CSI 5.97
    rCSI 7.01%
    PRS 95.28
  • T-helper 1 cell CL0000545
    CSI 5.63
    rCSI 10.16%
    PRS 96.58
  • natural T-regulatory cell CL0000903
    CSI 5.43
    rCSI 10.29%
    PRS 98.19
  • CD4-positive helper T cell CL0000492
    CSI 5.38
    rCSI 4.07%
    PRS 96.56
  • mature NK T cell CL0000814
    CSI 4.62
    rCSI 5.91%
    PRS 94.14
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 4.55
    rCSI 4.76%
    PRS 95.72
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 4.53
    rCSI 3.02%
    PRS 95.44
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 4.52
    rCSI 3.39%
    PRS 97.5
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 4.44
    rCSI 3.12%
    PRS 96.36
  • T follicular helper cell CL0002038
    CSI 4.32
    rCSI 3.23%
    PRS 96.71
  • mononuclear phagocyte CL0000113
    CSI 4.27
    rCSI 9.4%
    PRS 92.35
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 4.15
    rCSI 3.78%
    PRS 96.92
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 4.15
    rCSI 4.07%
    PRS 97.43
  • kidney collecting duct principal cell CL1001431
    CSI 3.99
    rCSI 20.06%
    PRS 85.17
  • renal alpha-intercalated cell CL0005011
    CSI 3.93
    rCSI 5.26%
    PRS 93.29
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 3.91
    rCSI 2.31%
    PRS 98.38
  • hematopoietic stem cell CL0000037
    CSI 3.88
    rCSI 2.58%
    PRS 91.43
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 3.86
    rCSI 3.56%
    PRS 97.48
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 3.57
    rCSI 3.64%
    PRS 94.94
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 3.47
    rCSI 4.36%
    PRS 96.62
  • immature B cell CL0000816
    CSI 3.39
    rCSI 2.52%
    PRS 95.77
  • epithelial cell CL0000066
    CSI 3.38
    rCSI 5.19%
    PRS 78.6
  • unswitched memory B cell CL0000970
    CSI 3.38
    rCSI 2.84%
    PRS 96.99
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 3.37
    rCSI 3.31%
    PRS 96.43
  • regulatory T cell CL0000815
    CSI 3.23
    rCSI 3.75%
    PRS 85.19
  • erythrocyte CL0000232
    CSI 3
    rCSI 6.81%
    PRS 88.43
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 2.95
    rCSI 4.6%
    PRS 96.53
  • mast cell CL0000097
    CSI 2.94
    rCSI 6.34%
    PRS 89.05
  • pulmonary ionocyte CL0017000
    CSI 2.93
    rCSI 3.56%
    PRS 93.5
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.86
    rCSI 1.93%
    PRS 97.48
  • T-helper 17 cell CL0000899
    CSI 2.77
    rCSI 2.2%
    PRS 97.91
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.72
    rCSI 7.1%
    PRS 91.44
  • mature T cell CL0002419
    CSI 2.61
    rCSI 2.03%
    PRS 97.07
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 2.59
    rCSI 7.42%
    PRS 98.33
  • mature B cell CL0000785
    CSI 2.58
    rCSI 2.24%
    PRS 95.72
  • intraepithelial lymphocyte CL0002496
    CSI 2.52
    rCSI 6.87%
    PRS 97.09
  • group 2 innate lymphoid cell CL0001069
    CSI 2.52
    rCSI 13.62%
    PRS 97.6
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 2.48
    rCSI 2.96%
    PRS 97.38
  • activated type II NK T cell CL0000931
    CSI 2.45
    rCSI 2.75%
    PRS 96.74
  • neural progenitor cell CL0011020
    CSI 2.36
    rCSI 10.4%
    PRS 79.67
  • plasmablast CL0000980
    CSI 2.31
    rCSI 1.82%
    PRS 92.41
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 2.16
    rCSI 3.7%
    PRS 95.93
  • parietal epithelial cell CL1000452
    CSI 2.14
    rCSI 5.71%
    PRS 84.56
  • epithelial cell of proximal tubule CL0002306
    CSI 2.13
    rCSI 5.21%
    PRS 83.37
  • BEST4+ enteroycte CL4030026
    CSI 2.1
    rCSI 2.61%
    PRS 89.87
  • granulocyte CL0000094
    CSI 2.08
    rCSI 3.18%
    PRS 94.06
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.04
    rCSI 1.84%
    PRS 88.76
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 1.98
    rCSI 3.94%
    PRS 96.29
  • lung neuroendocrine cell CL1000223
    CSI 1.98
    rCSI 2.93%
    PRS 91.71
  • renal beta-intercalated cell CL0002201
    CSI 1.97
    rCSI 4.7%
    PRS 90.04
  • podocyte CL0000653
    CSI 1.92
    rCSI 8.53%
    PRS 90.61
  • renal interstitial pericyte CL1001318
    CSI 1.86
    rCSI 5.12%
    PRS 87.18
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.84
    rCSI 2.53%
    PRS 97.68
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 1.83
    rCSI 4.73%
    PRS 97.48
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.75
    rCSI 2.38%
    PRS 97.88
  • kidney collecting duct intercalated cell CL1001432
    CSI 1.72
    rCSI 12.32%
    PRS 86.03
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.51
    rCSI 1.83%
    PRS 70.88
  • helper T cell CL0000912
    CSI 1.44
    rCSI 2.03%
    PRS 86.14
  • innate lymphoid cell CL0001065
    CSI 1.38
    rCSI 2.85%
    PRS 84.59
  • memory T cell CL0000813
    CSI 1.37
    rCSI 2.64%
    PRS 97.64
  • exhausted T cell CL0011025
    CSI 1.17
    rCSI 19.81%
    PRS 93.2
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.01
    rCSI 10.65%
    PRS 86.23
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.92
    rCSI 7.98%
    PRS 84.72
  • mature alpha-beta T cell CL0000791
    CSI 0.92
    rCSI 3.33%
    PRS 98.13
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 0.62
    rCSI 2.83%
    PRS 97.08
  • hepatic pit cell CL2000054
    CSI 0.56
    rCSI 7.73%
    PRS 95.18
  • central nervous system neuron CL2000029
    CSI 0.38
    rCSI 2.79%
    PRS 81.45
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.37
    rCSI 1.86%
    PRS 96.73
  • double negative T regulatory cell CL0011024
    CSI 0.33
    rCSI 6.24%
    PRS 97.04
  • cytotoxic T cell CL0000910
    CSI 0.31
    rCSI 1.79%
    PRS 89.38

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SKAP1](/details-gene/8631) (Src kinase associated phosphoprotein 1) encodes an intracellular adaptor protein critical for immune cell signaling. Originally identified as a protein associated with the tyrosine kinase Fyn in T-lymphocytes ([Link](https://doi.org/10.1074/jbc.272.26.16077)), [SKAP1](/details-gene/8631) plays a pivotal role in the `[T cell receptor signaling pathway](/details-cell/GO:0050852)` and the regulation of integrin-mediated cell adhesion. Its function is essential for the formation of the immunological synapse and the activation of downstream signaling cascades ([Link](https://doi.org/10.1038/ni913)). Expression data reveals its high significance not only in various lymphoid populations, including `[alpha-beta T cell](/details-cell/CL0000789)` and `[naive B cell](/details-cell/CL0000788)`, but also, unexpectedly, in specialized epithelial cells of the kidney, suggesting functions beyond adaptive immunity. ## Cellular Roles and Expression Landscape The expression profile of [SKAP1](/details-gene/8631) underscores its deep involvement in the immune system, particularly within the lymphoid lineage. **Overall**, it shows high significance in multiple T cell subsets, such as `[alpha-beta T cell](/details-cell/CL0000789)` (CSI: 9.64), `[mucosal invariant T cell](/details-cell/CL0000940)` (CSI: 9.45), `[naive T cell](/details-cell/CL0000898)` (CSI: 7.59), and developing thymocytes like `[CD4-positive, alpha-beta thymocyte](/details-cell/CL0000810)` (CSI: 8.82) and `[double negative thymocyte](/details-cell/CL0002489)` (CSI: 7.43). Its importance extends to other lymphocytes, including `[naive B cell](/details-cell/CL0000788)` (CSI: 9.37), `[group 3 innate lymphoid cell](/details-cell/CL0001071)` (CSI: 8.48), and terminally differentiated `[IgG plasma cell](/details-cell/CL0000985)` (CSI: 6.86). This pattern is consistent with its established role as a key signaling scaffold in lymphocytes. Intriguingly, the highest significance score for [SKAP1](/details-gene/8631) is observed in a non-immune cell type: the `[kidney loop of Henle thin ascending limb epithelial cell](/details-cell/CL1001107)` (CSI: 18.64), with high scores also seen in other renal and epithelial cells like `[kidney loop of Henle thin descending limb epithelial cell](/details-cell/CL1001111)` (CSI: 7.79) and `[fallopian tube secretory epithelial cell](/details-cell/CL4030006)` (CSI: 10.25). This suggests that the molecular machinery involving [SKAP1](/details-gene/8631), particularly its function in regulating cell adhesion, may be co-opted for specialized roles in epithelial tissues involved in transport and barrier function. The high CSI in `[basophil](/details-cell/CL0000767)` (CSI: 9.90) further broadens its relevance within the hematopoietic system beyond the adaptive immune response. ## Pathways and Molecular Function The functions of [SKAP1](/details-gene/8631) are centered on its role as a molecular scaffold that orchestrates signaling complexes. Its annotation for `[protein binding](/details-cell/GO:0005515)`, specifically `[protein kinase binding](/details-cell/GO:0019901)` and `[SH3 domain binding](/details-cell/GO:0017124)`, reflects its mechanism of action, where it links upstream receptor signals to downstream effector pathways. This is central to its involvement in the `[T cell receptor signaling pathway](/details-cell/GO:0050852)`, where it is known to associate with other adaptors and kinases to propagate the signal ([Link](https://doi.org/10.1074/jbc.273.40.25789)). A major consequence of [SKAP1](/details-gene/8631)-mediated signaling is the regulation of cellular adhesion. This is highlighted by its involvement in the `[positive regulation of cell-cell adhesion mediated by integrin](/details-cell/GO:0033634)` and the `[positive regulation of leukocyte cell-cell adhesion](/details-cell/GO:1903039)`. In T cells, [SKAP1](/details-gene/8631) is crucial for converting T-cell receptor signals into the activation of LFA-1 integrin, a key step for forming stable conjugates with antigen-presenting cells ([Link](https://doi.org/10.1084/jem.20042577), [Link](https://doi.org/10.1128/mcb.00331-06)). Its localization to the `[immunological synapse](/details-cell/GO:0001772)` and `[T cell receptor complex](/details-cell/GO:0042101)` places it at the physical hub of these activities. These functions are consistent with its contribution to the broader `[adaptive immune response](/details-cell/GO:0002250)`. ## Research Directions The expression and functional data for [SKAP1](/details-gene/8631) suggest several avenues for future investigation, particularly concerning its roles outside of T cells. **Proposed Hypotheses:** 1. Given its fundamental role in regulating integrin-mediated adhesion in T cells and its exceptionally high significance in kidney epithelial cells, [SKAP1](/details-gene/8631) may function as a key regulator of cell-matrix and cell-cell junctions essential for maintaining the architecture and transport functions of the nephron's loop of Henle. 2. The high significance of [SKAP1](/details-gene/8631) in `[group 3 innate lymphoid cell](/details-cell/CL0001071)` (ILC3s) suggests it is a critical signaling node downstream of activating receptors (e.g., NKp44/NKp46) in these cells, regulating their effector functions such as IL-22 production, which is vital for mucosal immunity. **Key Experimental Approach:** To test the first hypothesis regarding its role in kidney epithelium, a compelling experiment would involve the use of human kidney organoids derived from induced pluripotent stem cells (iPSCs). 1. Generate isogenic iPSC lines with a homozygous knockout of [SKAP1](/details-gene/8631) using CRISPR-Cas9 editing. 2. Differentiate both wild-type and [SKAP1](/details-gene/8631)-knockout iPSCs into kidney organoids containing segmented nephron-like structures. 3. Assess the structural integrity and cell adhesion properties of the loop of Henle-like tubules using advanced imaging techniques (e.g., confocal or light-sheet microscopy) to visualize cell junctions (staining for E-cadherin, ZO-1) and cell-matrix interactions (staining for integrins and vinculin). 4. Functional consequences could be measured by assessing the organoids' response to osmotic stress or their ability to perform specific transport functions, which rely on intact epithelial adhesion and polarity. **Therapeutic Potential:** As an intracellular adaptor protein, [SKAP1](/details-gene/8631) presents a challenging but potentially valuable therapeutic target. Its critical role in T cell activation suggests that its **inhibition** could be a strategy for treating autoimmune diseases or preventing transplant rejection by dampening T cell responses. However, its lack of enzymatic activity makes it difficult to target with conventional small-molecule inhibitors. Novel therapeutic modalities, such as proteolysis-targeting chimeras (PROTACs) designed to induce the targeted degradation of [SKAP1](/details-gene/8631), could offer a viable path forward. The high expression in specific kidney cells warrants caution, as systemic inhibition could lead to unforeseen renal toxicity, necessitating targeted delivery strategies for any potential immunomodulatory therapy.

Genular Protein ID: 4009097982

Symbol: SKAP1_HUMAN

Name: Src kinase-associated phosphoprotein 1

UniProtKB Accession Codes:

Q86WV1 D3DTV1 O15268

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9195899

Title: Molecular cloning of SKAP55, a novel protein that associates with p59fyn in human T-lymphocytes.

PubMed ID: 9195899

DOI: 10.1074/jbc.272.26.16077

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9748251

Title: Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.

PubMed ID: 9748251

DOI: 10.1074/jbc.273.40.25789

PubMed ID: 9671755

Title: FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.

PubMed ID: 9671755

DOI: 10.1073/pnas.95.15.8779

PubMed ID: 10856234

Title: SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.

PubMed ID: 10856234

DOI: 10.1093/emboj/19.12.2889

PubMed ID: 12171928

Title: SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation.

PubMed ID: 12171928

DOI: 10.1074/jbc.m206023200

PubMed ID: 11909961

Title: SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.

PubMed ID: 11909961

DOI: 10.1128/mcb.22.8.2673-2686.2002

PubMed ID: 12652296

Title: SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.

PubMed ID: 12652296

DOI: 10.1038/ni913

PubMed ID: 15849195

Title: Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.

PubMed ID: 15849195

DOI: 10.1074/jbc.m413201200

PubMed ID: 15939789

Title: An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R.

PubMed ID: 15939789

DOI: 10.1084/jem.20042577

PubMed ID: 16461356

Title: Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.

PubMed ID: 16461356

DOI: 10.1074/jbc.m508774200

PubMed ID: 16980616

Title: The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.

PubMed ID: 16980616

DOI: 10.1128/mcb.00331-06

PubMed ID: 17658605

Title: SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.

PubMed ID: 17658605

DOI: 10.1016/j.molimm.2007.05.024

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

Sequence Information:

  • Length: 359
  • Mass: 41432
  • Checksum: 630FE4C17295BD6D
  • Sequence:
    • MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG 
GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD 
HSFFGSEWQK RWCVVSRGLF YYYANEKSKQ PKGTFLIKGY GVRMAPHLRR DSKKESCFEL 
TSQDRRSYEF TATSPAEARD WVDQISFLLK DLSSLTIPYE EDEEEEEKEE TYDDIDGFDS 
PSCGSQCRPT ILPGSVGIKE PTEEKEEEDI YEVLPDEEHD LEEDESGTRR KGVDYASYYQ 
GLWDCHGDQP DELSFQRGDL IRILSKEYNM YGWWVGELNS LVGIVPKEYL TTAFEVEER

Genular Protein ID: 2741902162

Symbol: V9HW03_HUMAN

Name: N/A

UniProtKB Accession Codes:

V9HW03

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 Gene3D 3 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 358
  • Mass: 41333
  • Checksum: 158BBE1D48539DAC
  • Sequence:
    • MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG 
GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD 
HSFFGSEWQK RWCVVSRGLF YYYANEKSKQ PKGTFLIKGY GVRMAPHLRR DSKKESCFEL 
TSQDRRSYEF TATSPAEARD WVDQISFLLK DLSSLTIPYE EDEEEEEKEE TYDDIDGFDS 
PSCGSQCRPT ILPGSVGIKE PTEEKEEEDI YEVLPDEEHD LEEDESGTRR KGDYASYYQG 
LWDCHGDQPD ELSFQRGDLI RILSKEYNMY GWWVGELNSL VGIVPKEYLT TAFEVEER