Details for: CL0000625

Cell ID: CL0000625

Cell Name: CD8-positive, alpha-beta T cell

Marker Score Threshold: 1627
(Derived using integrated single-cell and genomic data)

Description: A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor.

Synonyms: CD8-positive, alpha-beta T lymphocyte, CD8-positive, alpha-beta T-cell, CD8-positive, alpha-beta T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DLX5 (ENSG00000105880)
    Fold Change: 17.65
    Ensembl ID: ENSG00000105880
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.7
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.26
    Ensembl ID: ENSG00000156508
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.26
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.92
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.83
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.52
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.51
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 2.46
    Ensembl ID: ENSG00000051523
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.42
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.41
    Ensembl ID: ENSG00000169100
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.41
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.31
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.3
    Ensembl ID: ENSG00000152518
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.3
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.29
    Ensembl ID: ENSG00000167286
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.22
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.19
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.11
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.1
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.07
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2
    Ensembl ID: ENSG00000198851
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.99
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.97
    Ensembl ID: ENSG00000110848
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.94
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.91
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.91
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.88
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169442
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.85
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.82
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.79
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.78
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.76
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.7
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.67
    Ensembl ID: ENSG00000104894
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.67
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.66
    Ensembl ID: ENSG00000026508
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.65
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.63
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.63
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.63
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.6
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.59
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.57
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.56
    Ensembl ID: ENSG00000143761
  • Gene Symbol: DUSP2 (ENSG00000158050)
    Fold Change: 1.54
    Ensembl ID: ENSG00000158050
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.53
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.5
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.46
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CREM (ENSG00000095794)
    Fold Change: 1.46
    Ensembl ID: ENSG00000095794
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.45
    Ensembl ID: ENSG00000176340
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.45
    Ensembl ID: ENSG00000134825
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.41
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 1.41
    Ensembl ID: ENSG00000153563
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.39
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.39
    Ensembl ID: ENSG00000160213
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.37
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.36
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.35
    Ensembl ID: ENSG00000154518
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.34
    Ensembl ID: ENSG00000155368
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.34
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.33
    Ensembl ID: ENSG00000112576
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.32
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.32
    Ensembl ID: ENSG00000160654
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.29
    Ensembl ID: ENSG00000182718
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.29
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.28
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.23
    Ensembl ID: ENSG00000132965
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.23
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.22
    Ensembl ID: ENSG00000165527
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.22
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.21
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.2
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 1.19
    Ensembl ID: ENSG00000172116
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.18
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172270
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.15
    Ensembl ID: ENSG00000116489
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.15
    Ensembl ID: ENSG00000215301
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.15
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.13
    Ensembl ID: ENSG00000113712
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.09
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.09
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CTSW (ENSG00000172543)
    Fold Change: 1.09
    Ensembl ID: ENSG00000172543
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.08
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.07
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198821
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.04
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.04
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.04
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.04
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.01
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1
    Ensembl ID: ENSG00000134480
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * CD8-positive, alpha-beta T cell receptor * CD8 coreceptor * Expression of DLX5 gene * Involved in morphogenesis, cell differentiation, and immune responses * Involvement in antigen presentation, immune system development, and response to viral infections * Expression of EEF1A1 and ACTB genes, which are involved in translation and actin cytoskeleton regulation * Involvement in autophagy, cellular responses to stress, and cellular responses to stimuli **Clinical Significance** CD8-positive, alpha-beta T cells play a crucial role in the adaptive immune system, particularly in the context of viral infections and cancer. These cells are involved in the recognition and elimination of infected cells or tumor cells, and their dysregulation can lead to immunodeficiency or autoimmune diseases. The cell's genes, including DLX5, are also involved in various diseases, such as developmental disorders, and the cell's expression of EEF1A1 and ACTB genes can be altered in various diseases, including cancer and neurological disorders. In the context of viral infections, CD8-positive, alpha-beta T cells are essential for the control of viral replication and the elimination of infected cells. The cell's expression of DLX5 and EEF1A1 genes is involved in the regulation of gene expression and translation, which is critical for the cell's ability to recognize and respond to viral antigens. Additionally, the cell's involvement in antigen presentation and immune system development makes it an important target for the development of immunotherapies for viral infections. Overall, the CD8-positive, alpha-beta T cell is a critical component of the adaptive immune system, and its dysregulation can have significant clinical implications. Understanding the cell's biology and its involvement in various diseases can provide insights into the development of novel therapeutic strategies for viral infections and other diseases.