Gene H3 3A - ENSG00000163041 | NCBI Gene ID: 3020

Details for: H3 3A

Gene ID: 3020

Symbol: H3 3A

Ensembl ID: ENSG00000163041

Description: H3.3 histone A

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromosome maintenance
(R-HSA-73886)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hemostasis
(R-HSA-109582)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Chromosome, telomeric region
(GO:0000781)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Nucleoplasm
(GO:0005654)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Positive regulation of cell growth
(GO:0030307)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Structural constituent of chromatin
(GO:0030527)
Telomere organization
(GO:0032200)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: follicular B cell (CL0000843)
Fold Change: 7.3
Marker Score: 7915
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 6.2
Marker Score: 4151
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 5.74
Marker Score: 4202
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 5.59
Marker Score: 11800.5
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.34
Marker Score: 4272
Cell Name: secretory cell (CL0000151)
Fold Change: 5.19
Marker Score: 9472
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.89
Marker Score: 12420
Cell Name: mature T cell (CL0002419)
Fold Change: 4.84
Marker Score: 47908
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.72
Marker Score: 13777
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.67
Marker Score: 1720
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.58
Marker Score: 256076
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 4.58
Marker Score: 2683
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.47
Marker Score: 14116.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.47
Marker Score: 58983
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.45
Marker Score: 9320
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.35
Marker Score: 5666
Cell Name: naive T cell (CL0000898)
Fold Change: 4.29
Marker Score: 2765
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.29
Marker Score: 4764.5
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.28
Marker Score: 2606
Cell Name: blood cell (CL0000081)
Fold Change: 4.25
Marker Score: 49446
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.17
Marker Score: 220637
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 4.16
Marker Score: 1622
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.09
Marker Score: 11307
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.09
Marker Score: 21477
Cell Name: malignant cell (CL0001064)
Fold Change: 4.07
Marker Score: 54682
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.07
Marker Score: 3466
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.06
Marker Score: 9916
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.03
Marker Score: 137276
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.99
Marker Score: 5772
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.98
Marker Score: 3917
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.97
Marker Score: 29586
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.84
Marker Score: 3715
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.84
Marker Score: 2787.5
Cell Name: myelocyte (CL0002193)
Fold Change: 3.82
Marker Score: 1651
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.8
Marker Score: 10661
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.76
Marker Score: 3358
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.75
Marker Score: 4007
Cell Name: supporting cell (CL0000630)
Fold Change: 3.75
Marker Score: 7041
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.71
Marker Score: 24107
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.7
Marker Score: 4232
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.7
Marker Score: 5444
Cell Name: Mueller cell (CL0000636)
Fold Change: 3.7
Marker Score: 5125
Cell Name: theca cell (CL0000503)
Fold Change: 3.69
Marker Score: 2646
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.69
Marker Score: 1895
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.66
Marker Score: 23348
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.64
Marker Score: 3431.5
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.62
Marker Score: 4377.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.62
Marker Score: 3895
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.6
Marker Score: 1186
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.59
Marker Score: 3094
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.58
Marker Score: 27974.5
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.55
Marker Score: 2984
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.54
Marker Score: 30746
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.53
Marker Score: 23021
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.53
Marker Score: 1828
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.52
Marker Score: 1145
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.5
Marker Score: 2329
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 3.5
Marker Score: 1026
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.49
Marker Score: 4123.5
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.49
Marker Score: 2736.5
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.48
Marker Score: 3790
Cell Name: naive B cell (CL0000788)
Fold Change: 3.48
Marker Score: 3110
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.46
Marker Score: 3089.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.44
Marker Score: 10813
Cell Name: granulocyte (CL0000094)
Fold Change: 3.44
Marker Score: 1542
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.44
Marker Score: 1432
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.44
Marker Score: 3569
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.43
Marker Score: 2442
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.43
Marker Score: 2911
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.43
Marker Score: 3475
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.42
Marker Score: 3425
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.41
Marker Score: 2466
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.41
Marker Score: 855
Cell Name: centroblast (CL0009112)
Fold Change: 3.39
Marker Score: 1670
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.39
Marker Score: 9080
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.39
Marker Score: 2127
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.38
Marker Score: 5549
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.38
Marker Score: 1166
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.37
Marker Score: 116753.5
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.36
Marker Score: 6720
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.35
Marker Score: 7609
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.33
Marker Score: 8050
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.33
Marker Score: 19746
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.33
Marker Score: 6479
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 3.32
Marker Score: 1157
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.32
Marker Score: 2614
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.3
Marker Score: 11714
Cell Name: memory B cell (CL0000787)
Fold Change: 3.3
Marker Score: 2496
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.29
Marker Score: 12684
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.29
Marker Score: 1641
Cell Name: ciliated cell (CL0000064)
Fold Change: 3.28
Marker Score: 11268
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.27
Marker Score: 4623
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.26
Marker Score: 3123
Cell Name: motor neuron (CL0000100)
Fold Change: 3.25
Marker Score: 1930
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.25
Marker Score: 1133
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.24
Marker Score: 2883
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.23
Marker Score: 3572
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.22
Marker Score: 2746
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.22
Marker Score: 9562
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.22
Marker Score: 2839

Hover over a box to see details here...

**Key characteristics:** * H3.3 is a large protein with a molecular weight of approximately 140 kDa. * It is one of the most abundant histones in the nucleus. * It is found in all eukaryotic cells. * It is a highly conserved protein, with similar sequences found in organisms from yeast to humans. **Pathways and functions:** * H3.3 is involved in the activation of hox genes during differentiation. * It is a key regulator of cell cycle progression and cell cycle checkpoints. * It is involved in the regulation of transcription and translation. * It is also involved in the regulation of apoptosis (programmed cell death). * It is a key regulator of immune responses. **Clinical significance:** * Mutations in H3.3 have been linked to a number of human diseases, including cancer, developmental disorders, and autoimmune diseases. * H3.3 is a promising target for cancer therapy. * Targeting H3.3 has been shown to be effective in inhibiting cancer cell growth and metastasis. **Additional information:** * H3.3 is a highly dynamic protein that undergoes different post-translational modifications that can alter its function. * It is a major component of the nucleosome, a protein complex that is responsible for packaging and delivering genetic information to the site of transcription. * It is a key regulator of gene expression, and its mutations can lead to a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H3.3

Genular Protein ID: 3685484018

Symbol: H33_HUMAN

Name: Histone H3.3

UniProtKB Accession Codes:

P84243 P06351 P33155 Q5VV55 Q5VV56 Q66I33 Q9V3W4

Database IDs:

Citations:

PubMed ID: 2859593

Title: Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.

PubMed ID: 2859593

DOI: 10.1073/pnas.82.9.2834

PubMed ID: 3031613

Title: Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family.

PubMed ID: 3031613

DOI: 10.1093/nar/15.7.2871

PubMed ID: 8586426

Title: The human replacement histone H3.3B gene (H3F3B).

PubMed ID: 8586426

DOI: 10.1006/geno.1995.9878

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7309716

Title: Human spleen histone H3. Isolation and amino acid sequence.

PubMed ID: 7309716

DOI: 10.1093/oxfordjournals.jbchem.a133573

PubMed ID: 16185088

Title: Modifications of human histone H3 variants during mitosis.

PubMed ID: 16185088

DOI: 10.1021/bi050906n

PubMed ID: 10464286

Title: Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.

PubMed ID: 10464286

DOI: 10.1074/jbc.274.36.25543

PubMed ID: 11242053

Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

PubMed ID: 11242053

DOI: 10.1038/35065132

PubMed ID: 11856369

Title: Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.

PubMed ID: 11856369

DOI: 10.1046/j.1356-9597.2001.00498.x

PubMed ID: 12560483

Title: Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.

PubMed ID: 12560483

DOI: 10.1093/nar/gkg176

PubMed ID: 14718166

Title: Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.

PubMed ID: 14718166

DOI: 10.1016/s0092-8674(03)01064-x

PubMed ID: 15471871

Title: Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.

PubMed ID: 15471871

DOI: 10.1074/jbc.m410021200

PubMed ID: 15525939

Title: Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

PubMed ID: 15525939

DOI: 10.1038/nature03114

PubMed ID: 15345777

Title: Human PAD4 regulates histone arginine methylation levels via demethylimination.

PubMed ID: 15345777

DOI: 10.1126/science.1101400

PubMed ID: 15776021

Title: Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division.

PubMed ID: 15776021

DOI: 10.1038/sj.embor.7400366

PubMed ID: 15681610

Title: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

PubMed ID: 15681610

DOI: 10.1101/gad.1267105

PubMed ID: 15684425

Title: Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

PubMed ID: 15684425

DOI: 10.1074/jbc.m410521200

PubMed ID: 15851689

Title: Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes.

PubMed ID: 15851689

DOI: 10.1073/pnas.0502413102

PubMed ID: 16258499

Title: Histone H3.3 deposition at E2F-regulated genes is linked to transcription.

PubMed ID: 16258499

DOI: 10.1038/sj.embor.7400561

PubMed ID: 16267050

Title: Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

PubMed ID: 16267050

DOI: 10.1074/jbc.m509266200

PubMed ID: 16457588

Title: Mass spectrometric characterization of human histone H3: a bird's eye view.

PubMed ID: 16457588

DOI: 10.1021/pr050266a

PubMed ID: 16497732

Title: Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.

PubMed ID: 16497732

DOI: 10.1210/me.2005-0365

PubMed ID: 18079182

Title: PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation.

PubMed ID: 18079182

DOI: 10.1101/gad.447007

PubMed ID: 16567635

Title: Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4.

PubMed ID: 16567635

DOI: 10.1073/pnas.0509639103

PubMed ID: 17194708

Title: Organismal differences in post-translational modifications in histones H3 and H4.

PubMed ID: 17194708

DOI: 10.1074/jbc.m607900200

PubMed ID: 17189264

Title: Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.

PubMed ID: 17189264

DOI: 10.1074/jbc.m607909200

PubMed ID: 17898714

Title: Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.

PubMed ID: 17898714

DOI: 10.1038/nature06166

PubMed ID: 18077460

Title: Arginine methylation of the histone H3 tail impedes effector binding.

PubMed ID: 18077460

DOI: 10.1074/jbc.c700192200

PubMed ID: 18066052

Title: Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.

PubMed ID: 18066052

DOI: 10.1038/ncb1668

PubMed ID: 19520870

Title: Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding.

PubMed ID: 19520870

DOI: 10.1074/jbc.m109.003202

PubMed ID: 19783980

Title: JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.

PubMed ID: 19783980

DOI: 10.1038/nature08448

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20850016

Title: Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

PubMed ID: 20850016

DOI: 10.1016/j.cell.2010.08.020

PubMed ID: 20504901

Title: The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.

PubMed ID: 20504901

DOI: 10.1101/gad.566910

PubMed ID: 20228790

Title: Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

PubMed ID: 20228790

DOI: 10.1038/nature08839

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22901803

Title: PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

PubMed ID: 22901803

DOI: 10.1016/j.cell.2012.07.018

PubMed ID: 22387026

Title: Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.

PubMed ID: 22387026

DOI: 10.1016/j.molcel.2012.01.019

PubMed ID: 22483618

Title: Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.

PubMed ID: 22483618

DOI: 10.1016/j.molcel.2012.03.002

PubMed ID: 27392148

Title:

PubMed ID: 27392148

DOI: 10.1016/j.molcel.2016.06.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23415232

Title: Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.

PubMed ID: 23415232

DOI: 10.1016/j.cell.2013.01.032

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27735137

Title: Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

PubMed ID: 27735137

DOI: 10.1111/febs.13922

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27436229

Title: SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.

PubMed ID: 27436229

DOI: 10.1038/ncomms12235

PubMed ID: 27016736

Title: Structure and function of human histone H3.Y nucleosome.

PubMed ID: 27016736

DOI: 10.1093/nar/gkw202

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 30257210

Title: Interplay of histone marks with serine ADP-ribosylation.

PubMed ID: 30257210

DOI: 10.1016/j.celrep.2018.08.092

PubMed ID: 29480802

Title: Serine is the major residue for ADP-ribosylation upon DNA damage.

PubMed ID: 29480802

DOI: 10.7554/elife.34334

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 30867594

Title: Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

PubMed ID: 30867594

DOI: 10.1038/s41586-019-1024-7

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 32273471

Title: Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.

PubMed ID: 32273471

DOI: 10.1126/science.aaw8806

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

PubMed ID: 35939806

Title: Potent Activation of NAD+-Dependent Deacetylase Sirt7 by Nucleosome Binding.

PubMed ID: 35939806

DOI: 10.1021/acschembio.2c00348

PubMed ID: 24590075

Title: ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.

PubMed ID: 24590075

DOI: 10.1038/nature13045

PubMed ID: 33857403

Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.

PubMed ID: 33857403

DOI: 10.1016/j.molcel.2021.03.041

PubMed ID: 32911480

Title: Structural basis for sequestration and autoinhibition of cGAS by chromatin.

PubMed ID: 32911480

DOI: 10.1038/s41586-020-2748-0

PubMed ID: 22286216

Title: Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

PubMed ID: 22286216

DOI: 10.1038/ng.1102

PubMed ID: 22286061

Title: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

PubMed ID: 22286061

DOI: 10.1038/nature10833

PubMed ID: 23539269

Title: Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

PubMed ID: 23539269

DOI: 10.1158/2159-8290.cd-12-0426

PubMed ID: 23603901

Title: The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

PubMed ID: 23603901

DOI: 10.1101/gad.217778.113

PubMed ID: 24162739

Title: Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

PubMed ID: 24162739

DOI: 10.1038/ng.2814

PubMed ID: 23539183

Title: Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

PubMed ID: 23539183

DOI: 10.1126/science.1232245

PubMed ID: 27174990

Title: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.

PubMed ID: 27174990

DOI: 10.1126/science.aac7272

PubMed ID: 28067913

Title: Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

PubMed ID: 28067913

DOI: 10.1038/ng.3757

PubMed ID: 33268356

Title: Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients.

PubMed ID: 33268356

DOI: 10.1126/sciadv.abc9207

PubMed ID: 34876591

Title: De novo variants in H3-3A and H3-3B are associated with neurodevelopmental delay, dysmorphic features, and structural brain abnormalities.

PubMed ID: 34876591

DOI: 10.1038/s41525-021-00268-8

Sequence Information:

Length: 136
Mass: 15328
Checksum: 5158ED279E6F9E1C
Sequence:

MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR EIRRYQKSTE 
LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI 
MPKDIQLARR IRGERA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: H3 3A

Associated with

Cells (max top 100)

Other Information

Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs. PubMed ID: 2859593

Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family. PubMed ID: 3031613

The human replacement histone H3.3B gene (H3F3B). PubMed ID: 8586426

Large-scale cDNA transfection screening for genes related to cancer development and progression. PubMed ID: 15498874

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human spleen histone H3. Isolation and amino acid sequence. PubMed ID: 7309716

Modifications of human histone H3 variants during mitosis. PubMed ID: 16185088

Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. PubMed ID: 10464286

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. PubMed ID: 11242053

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. PubMed ID: 11856369

Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. PubMed ID: 12560483

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. PubMed ID: 14718166

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. PubMed ID: 15471871

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. PubMed ID: 15525939

Human PAD4 regulates histone arginine methylation levels via demethylimination. PubMed ID: 15345777

Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division. PubMed ID: 15776021

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. PubMed ID: 15681610

Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. PubMed ID: 15684425

Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. PubMed ID: 15851689

Histone H3.3 deposition at E2F-regulated genes is linked to transcription. PubMed ID: 16258499

Expression patterns and post-translational modifications associated with mammalian histone H3 variants. PubMed ID: 16267050

Mass spectrometric characterization of human histone H3: a bird's eye view. PubMed ID: 16457588

Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. PubMed ID: 16497732

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. PubMed ID: 18079182

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. PubMed ID: 16567635

Organismal differences in post-translational modifications in histones H3 and H4. PubMed ID: 17194708

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. PubMed ID: 17189264

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. PubMed ID: 17898714

Arginine methylation of the histone H3 tail impedes effector binding. PubMed ID: 18077460

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. PubMed ID: 18066052

Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding. PubMed ID: 19520870

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. PubMed ID: 19783980

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. PubMed ID: 20850016

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. PubMed ID: 20504901

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. PubMed ID: 20228790

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. PubMed ID: 22901803

Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. PubMed ID: 22387026

Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. PubMed ID: 22483618