H3 3A | ENSG00000163041 | NCBI 3020

Details for: H3 3A

Gene ID: 3020

Symbol: H3 3A

Ensembl ID: ENSG00000163041

Description: H3.3 histone A

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromosome maintenance
(R-HSA-73886)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hemostasis
(R-HSA-109582)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Cell population proliferation
(GO:0008283)
Embryo implantation
(GO:0007566)
Male gonad development
(GO:0008584)
Multicellular organism growth
(GO:0035264)
Muscle cell differentiation
(GO:0042692)
Nucleosomal dna binding
(GO:0031492)
Nucleosome assembly
(GO:0006334)
Nucleus organization
(GO:0006997)
Oocyte maturation
(GO:0001556)
Osteoblast differentiation
(GO:0001649)
Pericentric heterochromatin formation
(GO:0031508)
Positive regulation of cell growth
(GO:0030307)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Single fertilization
(GO:0007338)
Spermatid development
(GO:0007286)
Structural constituent of chromatin
(GO:0030527)
Subtelomeric heterochromatin formation
(GO:0031509)
Telomere organization
(GO:0032200)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 4.34
Cell Significance Index: 7
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.61
Cell Significance Index: 4
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.66
Cell Significance Index: 2
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.64
Cell Significance Index: 2
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.46
Cell Significance Index: 2
Cell Name: lactocyte (CL0002325)
Fold Change: 1.38
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.34
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.34
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 1.27
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.27
Cell Significance Index: 1
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.25
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: theca cell (CL0000503)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.95
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** H3.3 histone A is a member of the histone H3 family, which is essential for chromatin structure and gene regulation. This gene is characterized by its ability to regulate gene expression through various mechanisms, including histone modification, chromatin assembly, and DNA replication. Notably, H3.3 histone A is involved in the assembly of the pre-replicative complex and the origin of replication, highlighting its critical role in DNA replication and cell cycle progression. **Pathways and Functions:** H3.3 histone A is implicated in numerous cellular processes, including: 1. **Gene Expression Regulation**: H3.3 histone A regulates gene expression through histone modification, chromatin assembly, and DNA replication. 2. **DNA Replication**: H3.3 histone A is involved in the assembly of the pre-replicative complex and the origin of replication, ensuring accurate DNA replication. 3. **Cell Cycle Regulation**: H3.3 histone A regulates cell cycle progression, including mitotic prophase and the G2/M checkpoint. 4. **Immune Cell Development and Differentiation**: H3.3 histone A is expressed in follicular B cells, skeletal muscle satellite cells, and effector memory CD4-positive T cells, highlighting its role in immune cell development and differentiation. 5. **Epigenetic Regulation**: H3.3 histone A is involved in epigenetic regulation, including DNA methylation and histone modification, which shape gene expression and cellular behavior. **Clinical Significance:** The dysregulation of H3.3 histone A has been implicated in various immunological disorders, including: 1. **Autoimmune Diseases**: H3.3 histone A dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where chromatin structure and gene regulation are disrupted. 2. **Cancer**: H3.3 histone A alterations have been observed in various cancers, including leukemia and lymphoma, where chromatin structure and gene expression are dysregulated. 3. **Immunodeficiency Disorders**: H3.3 histone A dysfunction has been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where chromatin structure and gene regulation are impaired. In conclusion, H3.3 histone A is a multifaceted gene that plays a critical role in various cellular processes, including gene expression regulation, DNA replication, and immune cell development and differentiation. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of understanding its mechanisms and functions in the context of immunology and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.