Details for: PTPRCAP

Gene ID: 5790

Symbol: PTPRCAP

Ensembl ID: ENSG00000213402

Description: protein tyrosine phosphatase receptor type C associated protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.9220
    Cell Significance Index: -24.7500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 26.2616
    Cell Significance Index: 61.2700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 11.7572
    Cell Significance Index: 64.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 11.0859
    Cell Significance Index: 325.5800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 5.7288
    Cell Significance Index: 17.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.4876
    Cell Significance Index: 529.2300
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.6885
    Cell Significance Index: 21.9100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 1.4531
    Cell Significance Index: 3.7200
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.2098
    Cell Significance Index: 3.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7114
    Cell Significance Index: 8.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0210
    Cell Significance Index: -15.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0503
    Cell Significance Index: -0.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0583
    Cell Significance Index: -1.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0683
    Cell Significance Index: -19.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0816
    Cell Significance Index: -17.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0875
    Cell Significance Index: -17.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1017
    Cell Significance Index: -17.3600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1411
    Cell Significance Index: -1.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1419
    Cell Significance Index: -14.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1429
    Cell Significance Index: -19.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1546
    Cell Significance Index: -17.7100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1799
    Cell Significance Index: -3.0600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2198
    Cell Significance Index: -2.2800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.2314
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2527
    Cell Significance Index: -2.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3175
    Cell Significance Index: -2.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3486
    Cell Significance Index: -3.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3554
    Cell Significance Index: -21.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4438
    Cell Significance Index: -28.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4721
    Cell Significance Index: -12.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4765
    Cell Significance Index: -24.8200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4844
    Cell Significance Index: -4.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5064
    Cell Significance Index: -23.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.5129
    Cell Significance Index: -4.9300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5226
    Cell Significance Index: -6.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5245
    Cell Significance Index: -24.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5331
    Cell Significance Index: -18.6800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5403
    Cell Significance Index: -4.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5651
    Cell Significance Index: -18.1000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5805
    Cell Significance Index: -5.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5981
    Cell Significance Index: -19.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6071
    Cell Significance Index: -6.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6121
    Cell Significance Index: -20.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6412
    Cell Significance Index: -16.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6468
    Cell Significance Index: -13.1600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.6717
    Cell Significance Index: -4.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6866
    Cell Significance Index: -17.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7046
    Cell Significance Index: -20.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7048
    Cell Significance Index: -17.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7432
    Cell Significance Index: -12.5200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.7531
    Cell Significance Index: -7.1400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7632
    Cell Significance Index: -6.3000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.7901
    Cell Significance Index: -6.7300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.8008
    Cell Significance Index: -8.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8057
    Cell Significance Index: -13.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8229
    Cell Significance Index: -20.9700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.8352
    Cell Significance Index: -8.4200
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.8486
    Cell Significance Index: -5.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8523
    Cell Significance Index: -18.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8526
    Cell Significance Index: -18.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8609
    Cell Significance Index: -14.4800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.8656
    Cell Significance Index: -6.4400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.8743
    Cell Significance Index: -9.2700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.8836
    Cell Significance Index: -13.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9019
    Cell Significance Index: -17.9900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9140
    Cell Significance Index: -19.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9163
    Cell Significance Index: -18.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9192
    Cell Significance Index: -18.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9249
    Cell Significance Index: -23.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9294
    Cell Significance Index: -13.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9377
    Cell Significance Index: -27.6200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.9503
    Cell Significance Index: -10.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9532
    Cell Significance Index: -23.7700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.9635
    Cell Significance Index: -4.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.9735
    Cell Significance Index: -10.2500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.9768
    Cell Significance Index: -12.7800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.9875
    Cell Significance Index: -11.4600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.9895
    Cell Significance Index: -8.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9903
    Cell Significance Index: -14.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -1.0143
    Cell Significance Index: -9.8900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0202
    Cell Significance Index: -20.0800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -1.0416
    Cell Significance Index: -14.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.0420
    Cell Significance Index: -17.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0531
    Cell Significance Index: -23.0600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -1.0620
    Cell Significance Index: -8.6000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.0631
    Cell Significance Index: -12.0100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -1.0664
    Cell Significance Index: -9.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0690
    Cell Significance Index: -17.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0961
    Cell Significance Index: -21.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1020
    Cell Significance Index: -16.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.1327
    Cell Significance Index: -13.3900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -1.1346
    Cell Significance Index: -10.5000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -1.1361
    Cell Significance Index: -9.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.1479
    Cell Significance Index: -27.8100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.1523
    Cell Significance Index: -16.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1531
    Cell Significance Index: -16.4200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -1.1565
    Cell Significance Index: -13.9600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.1627
    Cell Significance Index: -15.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTPRCAP is a protein-coupled tyrosine phosphatase receptor type C-associated protein, implying its involvement in the regulation of tyrosine phosphorylation events. Its expression is significantly observed in various immune cells, including T cells (CD8+ and CD4+) and B cells (unswitched memory B cells and T follicular helper cells), suggesting a role in immune system modulation. Additionally, PTPRCAP is expressed in retinal cells, including amacrine, bipolar, and horizontal cells, indicating its involvement in retinal function and development. **Pathways and Functions:** The expression of PTPRCAP is associated with several key signaling pathways, including the defense response and plasma membrane signaling. Its protein-coupled nature suggests that PTPRCAP might be involved in the regulation of tyrosine phosphorylation events, influencing cell signaling and membrane trafficking. The association of PTPRCAP with immune cells suggests that it may play a role in modulating immune responses, potentially affecting the regulation of T cell activation, proliferation, and differentiation. In the context of retinal cells, PTPRCAP may be involved in regulating cellular processes such as synaptic transmission, neurotransmitter release, and photoreceptor development. **Clinical Significance:** The identification of PTPRCAP as a protein associated with immune response and retinal function raises several potential clinical implications. Abnormal expression or function of PTPRCAP in immune cells may contribute to immune-related disorders, such as autoimmune diseases or immunodeficiency syndromes. Similarly, alterations in PTPRCAP expression in retinal cells may be linked to retinal degenerative diseases, such as age-related macular degeneration or retinitis pigmentosa. Further research is necessary to fully elucidate the clinical significance of PTPRCAP and its potential as a therapeutic target for immune-related and retinal disorders. In conclusion, PTPRCAP represents a novel gene with significant implications for our understanding of immune response and retinal function. Further studies are needed to fully elucidate the mechanisms by which PTPRCAP regulates cellular processes and to explore its potential as a therapeutic target for a range of immune-related and retinal disorders.

Genular Protein ID: 3398791778

Symbol: PTCA_HUMAN

Name: Protein tyrosine phosphatase receptor type C-associated protein

UniProtKB Accession Codes:

Q14761 B2R512 O00643 Q6I9S6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7961877

Title: LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes.

PubMed ID: 7961877

DOI: 10.1016/s0021-9258(19)62018-1

PubMed ID: 8954783

Title: Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.

PubMed ID: 8954783

DOI: 10.1006/geno.1996.0595

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8537410

Title: Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45.

PubMed ID: 8537410

DOI: 10.1074/jbc.270.52.31372

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 206
  • Mass: 21196
  • Checksum: 26A9F96699BD34D5
  • Sequence:
    • MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL ALAWRRLSRD 
SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST DNDLERQEDE QDTDYDHVAD 
GGLQADPGEG EQQCGEASSP EQVPVRAEEA RDSDTEGDLV LGSPGPASAG GSAEALLSDL 
HAFAGSAAWD DSARAAGGQG LHVTAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.