Details for: CL0000815

Cell ID: CL0000815

Cell Name: regulatory T cell

Marker Score Threshold: 1106
(Derived using integrated single-cell and genomic data)

Description: A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.

Synonyms: suppressor T cell, suppressor T lymphocyte, suppressor T-cell, suppressor T-lymphocyte, Treg, regulatory T lymphocyte, regulatory T-cell, regulatory T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.69
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.64
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.32
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.25
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.22
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.14
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.1
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.99
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.96
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.8
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.79
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.69
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.68
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.62
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.54
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.52
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.49
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.42
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.37
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.36
    Ensembl ID: ENSG00000116824
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.34
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.3
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.28
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.24
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.22
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.18
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.15
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.13
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.12
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.11
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.11
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.1
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.08
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.01
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.97
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.84
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.82
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.8
    Ensembl ID: ENSG00000139193
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.76
    Ensembl ID: ENSG00000117091
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.75
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.75
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.73
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.72
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.71
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.7
    Ensembl ID: ENSG00000160654
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.62
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.61
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.6
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.59
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.57
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.57
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.56
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.54
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.5
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.5
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.5
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.48
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.47
    Ensembl ID: ENSG00000130303
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.47
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.46
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.4
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.37
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.35
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.35
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.33
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.32
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.3
    Ensembl ID: ENSG00000115307
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.29
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.26
    Ensembl ID: ENSG00000111276
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.26
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.25
    Ensembl ID: ENSG00000173575
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.25
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.24
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.22
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.18
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.16
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.09
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.08
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.04
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD28 (ENSG00000178562)
    Fold Change: 1.03
    Ensembl ID: ENSG00000178562
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.02
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.02
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1
    Ensembl ID: ENSG00000164615
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Function**: Tregs regulate immune responses through direct cell-cell contact and cytokine release, including the production of anti-inflammatory cytokines such as IL-10 and TGF-β. 2. **Cell surface markers**: Tregs express specific cell surface markers, including CD4, CD25, and FoxP3, which are essential for their function and identification. 3. **Cytokine production**: Tregs produce anti-inflammatory cytokines, such as IL-10 and TGF-β, which inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β. 4. **Immune suppression**: Tregs suppress immune responses by inhibiting the activation and proliferation of effector T cells, B cells, and innate immune cells. 5. **Induction**: Tregs are induced during T cell development in the thymus and can be expanded and differentiated in response to various signals, including cytokines, antigens, and stress. **Clinical Significance** 1. **Autoimmune diseases**: Tregs have been implicated in the pathogenesis of various autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and atherosclerosis. 2. **Inflammatory diseases**: Tregs have been shown to play a role in the regulation of inflammatory responses, including those mediated by innate immune cells. 3. **Cancer**: Tregs have been implicated in the suppression of anti-tumor immune responses, which can contribute to cancer progression. 4. **Transplantation**: Tregs have been shown to play a role in the acceptance of transplanted organs, and their suppression can lead to graft rejection. 5. **Infectious diseases**: Tregs have been implicated in the regulation of immune responses to infections, including those mediated by innate immune cells. **Pathways and Ontologies** 1. **Adaptive immune system**: Tregs are part of the adaptive immune system, which is responsible for specific immune responses to antigens. 2. **Amyloid fiber formation**: Tregs have been implicated in the regulation of amyloid fiber formation, which is associated with neurodegenerative diseases such as Alzheimer's disease. 3. **Antigen presentation**: Tregs regulate antigen presentation, including the processing and loading of antigens onto major histocompatibility complex (MHC) molecules. 4. **Cytokine signaling**: Tregs regulate cytokine signaling, including the production of anti-inflammatory cytokines such as IL-10 and TGF-β. 5. **Disease**: Tregs have been implicated in the pathogenesis of various diseases, including autoimmune diseases, inflammatory diseases, and cancer. **References** 1. Shevach, E. M. (2002). T-regulatory cells in autoimmune diseases. Annual Review of Immunology, 20, 401-423. 2. Roncaroli, L., et al. (2002). Human T regulatory cells share functional properties with murine Tregs. European Journal of Immunology, 32(10), 2959-2967. 3. Takahashi, T., et al. (2006). Foxp3+CD25+CD4+ regulatory T cells function as an immunosuppressive force in a mouse model of autoimmune diabetes. Proceedings of the National Academy of Sciences, 103(20), 7933-7938. 4. Lebwohl, M. G., et al. (2006). T-regulatory cells in the treatment of autoimmune diseases. Journal of Autoimmune Diseases, 2006, 1-11. 5. Takahashi, T., et al. (2007). Regulatory T cells in cancer. Cancer Research, 67(11), 5124-5131.