Details for: HPR

Gene ID: 3250

Symbol: HPR

Ensembl ID: ENSG00000261701

Description: haptoglobin-related protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.5
    Marker Score: 2393.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1515
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169568
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1459
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.1
    Marker Score: 24599
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.08
    Marker Score: 2241
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1
    Marker Score: 4302
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 628
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.92
    Marker Score: 5926
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13632
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8
    Marker Score: 4303
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.56
    Marker Score: 383
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 396
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.37
    Marker Score: 570
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 206
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.33
    Marker Score: 632
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3
    Marker Score: 319.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.29
    Marker Score: 110
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.27
    Marker Score: 1780
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 621
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.26
    Marker Score: 929
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.25
    Marker Score: 317
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.24
    Marker Score: 481
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 224
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.23
    Marker Score: 1919
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1209
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.19
    Marker Score: 194
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.18
    Marker Score: 586
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.17
    Marker Score: 268
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.16
    Marker Score: 103
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 140
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.15
    Marker Score: 127
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 347
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1
    Marker Score: 287
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.09
    Marker Score: 226
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 116
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 36

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Other Information

## Summary HPR is a protein that plays a crucial role in the body by binding and transporting heme from the plasma to various tissues. It is expressed in several cell types, including retinal horizontal cells, dendritic cells, goblet cells, and enterocytes. ## Key characteristics - HPR is a glycoprotein with a molecular weight of approximately 60 kDa. - It is a scavenger receptor that is expressed on cells throughout the body. - It is involved in the uptake of iron from the plasma and the transportation of this iron to various tissues. - It is also involved in the clearance of oxidized hemoglobin from the plasma. ## Pathways and functions HPR is involved in several pathways and functions, including: - Binding and uptake of ligands by scavenger receptors: HPR binds to oxidized hemoglobin and other ligands and is then internalized into the cell. - Blood microparticle: HPR is also expressed on blood microparticles, which are small particles that are released into the plasma by damaged cells. HPR is thought to play a role in the uptake of these microparticles by cells. - Extracellular exosome: HPR is also expressed on extracellular exosomes, which are small vesicles that are released by cells. HPR is thought to be involved in the uptake of exosomes by cells. - Extracellular region: HPR is also expressed on the surface of endothelial cells and macrophages. It is thought to be involved in the uptake of ligands by these cells. - Extracellular space: HPR is also expressed on the surface of immune cells, such as macrophages and dendritic cells. It is thought to be involved in the uptake of ligands by these cells. - Hemoglobin binding: HPR is a ligand for hemoglobin, which is an oxygen-binding protein. HPR is expressed in the red blood cells, and it is thought to be involved in the transport of oxygen from the lungs to the tissues. - Scavenging of heme from plasma: HPR is also involved in the scavenging of heme from the plasma. This is important for maintaining the oxygen supply to tissues, and it is thought to be a mechanism for preventing the accumulation of oxidized hemoglobin in the body. - Serine-type endopeptidase activity: HPR is also a serine-type endopeptidase, which means that it can break down proteins into smaller peptides. This activity is important for the processing of other proteins, and it is also involved in the degradation of hemoglobin. - Spherical high-density lipoprotein particle: HPR is also expressed on the surface of spherical high-density lipoprotein particles, which are large particles that are released by cells into the plasma. HPR is thought to be involved in the uptake of these particles by cells. - Vesicle-mediated transport: HPR is also involved in the vesicular transport of proteins between cells. This is important for the exchange of proteins between cells, and it is thought to be a mechanism for regulating the flow of molecules in and out of cells. ## Clinical significance HPR is a key protein in the body that plays a crucial role in the transport of heme from the plasma to various tissues. Mutations in the HPR gene have been linked to several human diseases, including sickle cell anemia and thalassemia. These diseases are caused by mutations in the HBB gene, which encodes for the HPR protein. When the HBB gene is mutated, it can produce a protein that is unable to bind to heme, which can lead to the accumulation of oxidized hemoglobin in the blood and tissues. This can eventually lead to the development of anemia.

Genular Protein ID: 2363720509

Symbol: HPTR_HUMAN

Name: Haptoglobin-related protein

UniProtKB Accession Codes:

P00739 Q7LE20 Q92658 Q92659 Q9ULB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4018023

Title: Structure and expression of the human haptoglobin locus.

PubMed ID: 4018023

DOI: 10.1002/j.1460-2075.1985.tb02325.x

PubMed ID: 2987228

Title: Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.

PubMed ID: 2987228

DOI: 10.1016/s0021-9258(18)88836-6

PubMed ID: 1478675

Title: Junctions between genes in the haptoglobin gene cluster of primates.

PubMed ID: 1478675

DOI: 10.1016/s0888-7543(05)80116-8

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 8945641

Title: Transcriptionally active haptoglobin-related (Hpr) gene in Hepatoma G2 and leukamia molt-4 cells.

PubMed ID: 8945641

DOI: 10.1089/dna.1996.15.1001

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 16778136

Title: Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.

PubMed ID: 16778136

DOI: 10.1182/blood-2006-05-022327

PubMed ID: 25037218

Title: A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein.

PubMed ID: 25037218

DOI: 10.1074/jbc.m114.567578

Sequence Information:

  • Length: 348
  • Mass: 39030
  • Checksum: CF9EC3352B8182FA
  • Sequence:
    • MSDLGAVISL LLWGRQLFAL YSGNDVTDIS DDRFPKPPEI ANGYVEHLFR YQCKNYYRLR 
TEGDGVYTLN DKKQWINKAV GDKLPECEAV CGKPKNPANP VQRILGGHLD AKGSFPWQAK 
MVSHHNLTTG ATLINEQWLL TTAKNLFLNH SENATAKDIA PTLTLYVGKK QLVEIEKVVL 
HPNYHQVDIG LIKLKQKVLV NERVMPICLP SKNYAEVGRV GYVSGWGQSD NFKLTDHLKY 
VMLPVADQYD CITHYEGSTC PKWKAPKSPV GVQPILNEHT FCVGMSKYQE DTCYGDAGSA 
FAVHDLEEDT WYAAGILSFD KSCAVAEYGV YVKVTSIQHW VQKTIAEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.