Details for: HPR

Gene ID: 3250

Symbol: HPR

Ensembl ID: ENSG00000261701

Description: haptoglobin-related protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 6.8922
    Cell Significance Index: -2.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 6.0398
    Cell Significance Index: 193.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.6512
    Cell Significance Index: 61.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.6499
    Cell Significance Index: -2.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9310
    Cell Significance Index: 41.8400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.4633
    Cell Significance Index: 13.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9260
    Cell Significance Index: 22.4300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.9215
    Cell Significance Index: 10.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8056
    Cell Significance Index: 13.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7973
    Cell Significance Index: 158.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6789
    Cell Significance Index: 10.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.4589
    Cell Significance Index: 6.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4354
    Cell Significance Index: 82.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2897
    Cell Significance Index: 13.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2598
    Cell Significance Index: 25.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2321
    Cell Significance Index: 25.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2217
    Cell Significance Index: 17.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2167
    Cell Significance Index: 13.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2008
    Cell Significance Index: 181.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1882
    Cell Significance Index: 30.6100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1576
    Cell Significance Index: 2.5000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1353
    Cell Significance Index: 1.4000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.1311
    Cell Significance Index: 0.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1059
    Cell Significance Index: 7.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0930
    Cell Significance Index: 1.9300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.0761
    Cell Significance Index: 0.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0615
    Cell Significance Index: 2.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0222
    Cell Significance Index: 2.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0212
    Cell Significance Index: 0.3500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0200
    Cell Significance Index: 0.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0157
    Cell Significance Index: 0.6800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0117
    Cell Significance Index: 0.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0002
    Cell Significance Index: 0.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0034
    Cell Significance Index: -1.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0050
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0054
    Cell Significance Index: -0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0090
    Cell Significance Index: -1.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0096
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0129
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0140
    Cell Significance Index: -1.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0149
    Cell Significance Index: -2.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0150
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0168
    Cell Significance Index: -2.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0192
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0199
    Cell Significance Index: -2.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0201
    Cell Significance Index: -1.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0213
    Cell Significance Index: -2.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0233
    Cell Significance Index: -0.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0260
    Cell Significance Index: -1.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0263
    Cell Significance Index: -2.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0278
    Cell Significance Index: -0.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0293
    Cell Significance Index: -0.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0299
    Cell Significance Index: -0.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0342
    Cell Significance Index: -2.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0356
    Cell Significance Index: -1.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0378
    Cell Significance Index: -2.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0397
    Cell Significance Index: -2.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0405
    Cell Significance Index: -2.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0461
    Cell Significance Index: -0.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0521
    Cell Significance Index: -1.3700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0530
    Cell Significance Index: -0.6800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0541
    Cell Significance Index: -1.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0541
    Cell Significance Index: -1.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0548
    Cell Significance Index: -0.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0549
    Cell Significance Index: -0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0559
    Cell Significance Index: -2.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0571
    Cell Significance Index: -2.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0600
    Cell Significance Index: -1.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0606
    Cell Significance Index: -2.6800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0617
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0628
    Cell Significance Index: -1.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0646
    Cell Significance Index: -0.6700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0649
    Cell Significance Index: -0.9000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0669
    Cell Significance Index: -0.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0689
    Cell Significance Index: -1.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0691
    Cell Significance Index: -2.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0693
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0707
    Cell Significance Index: -0.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0721
    Cell Significance Index: -2.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0804
    Cell Significance Index: -2.9500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0836
    Cell Significance Index: -0.3200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0838
    Cell Significance Index: -0.8200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0842
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0894
    Cell Significance Index: -2.5500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0897
    Cell Significance Index: -1.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HPR is a small, secreted protein that is structurally similar to haptoglobin, a well-studied protein involved in heme removal and antioxidant defense. The HPR protein shares a common domain with haptoglobin and exhibits similar binding properties to heme. However, the specific characteristics of HPR, such as its expression pattern and subcellular localization, are distinct from those of haptoglobin. HPR is primarily expressed in cells of the immune system, including conventional dendritic cells, and cells of the epithelium, such as enterocytes and goblet cells. Its expression is also detected in other cell types, including cardiac myocytes and proximal convoluted tubule epithelial cells. The protein's expression pattern and cell-specific localization suggest its potential role in regulating immune responses and maintaining tissue homeostasis. **Pathways and Functions** The pathways and functions of HPR are not yet fully understood, but several key processes are implicated: 1. **Scavenging of heme from plasma**: HPR's binding properties to heme suggest its potential role in removing excess heme from plasma, which could help regulate oxidative stress and inflammation. 2. **Vesicle-mediated transport**: HPR's expression in cells of the immune system and epithelium suggests its involvement in vesicle-mediated transport, which could facilitate the transfer of heme and other molecules between cells. 3. **Binding and uptake of ligands by scavenger receptors**: HPR's structure and function suggest its potential role in binding and uptake of ligands by scavenger receptors, which could regulate immune responses and inflammation. 4. **Serine-type endopeptidase activity**: HPR's expression in cardiac myocytes and other cell types suggests its potential role in regulating serine-type endopeptidase activity, which could influence cellular signaling and homeostasis. **Clinical Significance** The clinical significance of HPR is not yet fully understood, but its expression in various cell types and its involvement in several cellular processes suggest its potential role in: 1. **Regulating inflammation**: HPR's expression in immune cells and its potential role in scavenging heme and regulating oxidative stress suggest its potential role in regulating inflammation. 2. **Maintaining tissue homeostasis**: HPR's expression in epithelial cells and its potential role in regulating vesicle-mediated transport and serine-type endopeptidase activity suggest its potential role in maintaining tissue homeostasis. 3. **Cardiovascular disease**: HPR's expression in cardiac myocytes and its potential role in regulating serine-type endopeptidase activity suggest its potential role in cardiovascular disease. 4. **Cancer**: HPR's expression in cancer cells and its potential role in regulating vesicle-mediated transport and serine-type endopeptidase activity suggest its potential role in cancer development and progression. Further research is needed to fully understand the function and clinical significance of HPR, but its expression in various cell types and its involvement in several cellular processes suggest its potential importance in maintaining cellular homeostasis and regulating inflammation.

Genular Protein ID: 2363720509

Symbol: HPTR_HUMAN

Name: Haptoglobin-related protein

UniProtKB Accession Codes:

P00739 Q7LE20 Q92658 Q92659 Q9ULB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4018023

Title: Structure and expression of the human haptoglobin locus.

PubMed ID: 4018023

DOI: 10.1002/j.1460-2075.1985.tb02325.x

PubMed ID: 2987228

Title: Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.

PubMed ID: 2987228

DOI: 10.1016/s0021-9258(18)88836-6

PubMed ID: 1478675

Title: Junctions between genes in the haptoglobin gene cluster of primates.

PubMed ID: 1478675

DOI: 10.1016/s0888-7543(05)80116-8

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 8945641

Title: Transcriptionally active haptoglobin-related (Hpr) gene in Hepatoma G2 and leukamia molt-4 cells.

PubMed ID: 8945641

DOI: 10.1089/dna.1996.15.1001

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 16778136

Title: Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.

PubMed ID: 16778136

DOI: 10.1182/blood-2006-05-022327

PubMed ID: 25037218

Title: A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein.

PubMed ID: 25037218

DOI: 10.1074/jbc.m114.567578

Sequence Information:

  • Length: 348
  • Mass: 39030
  • Checksum: CF9EC3352B8182FA
  • Sequence:
    • MSDLGAVISL LLWGRQLFAL YSGNDVTDIS DDRFPKPPEI ANGYVEHLFR YQCKNYYRLR 
TEGDGVYTLN DKKQWINKAV GDKLPECEAV CGKPKNPANP VQRILGGHLD AKGSFPWQAK 
MVSHHNLTTG ATLINEQWLL TTAKNLFLNH SENATAKDIA PTLTLYVGKK QLVEIEKVVL 
HPNYHQVDIG LIKLKQKVLV NERVMPICLP SKNYAEVGRV GYVSGWGQSD NFKLTDHLKY 
VMLPVADQYD CITHYEGSTC PKWKAPKSPV GVQPILNEHT FCVGMSKYQE DTCYGDAGSA 
FAVHDLEEDT WYAAGILSFD KSCAVAEYGV YVKVTSIQHW VQKTIAEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.