Details for: CL0001065

Cell ID: CL0001065

Cell Name: innate lymphoid cell

Marker Score Threshold: 359
(Derived using integrated single-cell and genomic data)

Description: A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.46
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.32
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.07
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.85
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.81
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.73
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.72
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.63
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.58
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.57
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.42
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.39
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.33
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 2.28
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.23
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.19
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.14
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 2.06
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.05
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.93
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.93
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.91
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.86
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.85
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.85
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.83
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.81
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.79
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.77
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.74
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.74
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.74
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.66
    Ensembl ID: ENSG00000173762
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.66
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.66
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.61
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.6
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.56
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.55
    Ensembl ID: ENSG00000109321
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.52
    Ensembl ID: ENSG00000143119
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.51
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.49
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.48
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.46
    Ensembl ID: ENSG00000116459
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.45
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.43
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.43
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.41
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.41
    Ensembl ID: ENSG00000020633
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.4
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198898
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.36
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.35
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.34
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.34
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.34
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.33
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.3
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.26
    Ensembl ID: ENSG00000159199
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.24
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.23
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.22
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.21
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.2
    Ensembl ID: ENSG00000006125
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.2
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.15
    Ensembl ID: ENSG00000130303
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.13
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.11
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.08
    Ensembl ID: ENSG00000171791
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.05
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.04
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.03
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164615
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.01
    Ensembl ID: ENSG00000168675
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Lack of specific markers**: ILCs do not express specific markers for T cells, B cells, myeloid cells, and dendritic cells. 2. **Production of cytokines**: ILCs are capable of producing cytokines, which are essential for initiating the immune response. 3. **Innate immune response**: ILCs are involved in the innate immune response, which is the first line of defense against pathogens. 4. **Actin cytoskeleton organization**: ILCs have a complex actin cytoskeleton that is essential for their function and morphology. 5. **Adherens junctions**: ILCs have adherens junctions, which are critical for maintaining cell-cell interactions and tissue architecture. **Clinical Significance** 1. **Immune system disorders**: ILCs play a crucial role in maintaining immune homeostasis, and dysregulation of ILCs has been implicated in various immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Cancer immunotherapy**: ILCs have been explored as a potential target for cancer immunotherapy, as they can produce cytokines that stimulate anti-tumor immune responses. 3. **Infectious diseases**: ILCs are essential for responding to infectious diseases, and dysregulation of ILCs can contribute to the development of severe infections. 4. **Allergic reactions**: ILCs can also contribute to allergic reactions, and understanding the mechanisms of ILC function can provide insights into the development of novel therapeutic strategies for allergic diseases. **Pathways and Ontology** ILCs are involved in various cellular processes, including: 1. **Actin cytoskeleton organization**: ILCs have a complex actin cytoskeleton that is essential for their function and morphology. 2. **Adherens junctions**: ILCs have adherens junctions, which are critical for maintaining cell-cell interactions and tissue architecture. 3. **Cytokine signaling**: ILCs produce cytokines, which are essential for initiating the immune response. 4. **Apoptosis regulation**: ILCs can regulate apoptosis, which is essential for maintaining immune homeostasis. The Ensembl ID for this cell is ENSG00000075624, and its gene symbol is ACTB. The pathways and ontology associated with this cell include: 1. **Actin cytoskeleton**: ILCs have a complex actin cytoskeleton that is essential for their function and morphology. 2. **Adherens junctions**: ILCs have adherens junctions, which are critical for maintaining cell-cell interactions and tissue architecture. 3. **Cytokine signaling**: ILCs produce cytokines, which are essential for initiating the immune response. 4. **Apoptosis regulation**: ILCs can regulate apoptosis, which is essential for maintaining immune homeostasis.