Details for: LRRC52 AS1

Gene ID: 400794

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LRRC52 AS1

Ensembl ID: ENSG00000237463

Description: LRRC52 antisense RNA 1

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • conventional dendritic cell CL0000990
    CSI 75.27
    rCSI 62.83%
    PRS 99.48
  • regulatory T cell CL0000815
    CSI 34.95
    rCSI 40.52%
    PRS 99.49
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 28.52
    rCSI 34.56%
    PRS 98.01
  • helper T cell CL0000912
    CSI 21.07
    rCSI 29.8%
    PRS 99.61
  • innate lymphoid cell CL0001065
    CSI 15.48
    rCSI 31.96%
    PRS 99.55
  • melanocyte of skin CL1000458
    CSI 8.46
    rCSI 11.53%
    PRS 98.18
  • basal cell of epidermis CL0002187
    CSI 7.48
    rCSI 13.25%
    PRS 97.16
  • cytotoxic T cell CL0000910
    CSI 6.35
    rCSI 36.42%
    PRS 99.7
  • cardiac muscle cell CL0000746
    CSI 4.21
    rCSI 6.04%
    PRS 99.68
  • retinal ganglion cell CL0000740
    CSI 4.06
    rCSI 8.97%
    PRS 99.8
  • suprabasal keratinocyte CL4033013
    CSI 3.28
    rCSI 5.35%
    PRS 98.59

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
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  • Node Color (Target Cell CSI, relative to current network):
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    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LRRC52 AS1](/details-gene/400794) is a non-coding RNA located on chromosome 1. **Overall**, expression data reveals that [LRRC52 AS1](/details-gene/400794) is a highly significant gene within the immune system, exhibiting its most profound and specific expression in [conventional dendritic cells](/details-cell/CL0000990). It is also consistently expressed across various T lymphocyte populations, including [regulatory T cells](/details-cell/CL0000815) and memory T cells, suggesting a broad role in adaptive immunity. Its presence in several non-immune cell types, such as those in the skin and heart, indicates potential pleiotropic functions beyond the hematopoietic lineage. ## Cellular Roles and Expression Landscape The expression profile of [LRRC52 AS1](/details-gene/400794) strongly implicates it as a key player in immune cell biology. Its highest significance score by a large margin is observed in [conventional dendritic cells](/details-cell/CL0000990) (CSI: 75.27), suggesting it may be integral to the identity or specialized functions of these professional antigen-presenting cells. Beyond its dominant role in dendritic cells, [LRRC52 AS1](/details-gene/400794) is also a significant transcript in a spectrum of adaptive and innate lymphocytes. It is notably active in several T cell subsets, including [regulatory T cells](/details-cell/CL0000815) (CSI: 34.95), [CD8-positive, alpha-beta memory T cells](/details-cell/CL0001203) (CSI: 28.52), [helper T cells](/details-cell/CL0000912) (CSI: 21.07), and [cytotoxic T cells](/details-cell/CL0000910) (CSI: 6.35). This pattern suggests a potential role in T cell lineage maintenance, homeostasis, or effector function. Furthermore, its expression in [innate lymphoid cells](/details-cell/CL0001065) (CSI: 15.48) indicates a broader involvement in the lymphoid arm of the immune system. Interestingly, [LRRC52 AS1](/details-gene/400794) also shows modest but consistent expression in several non-immune tissues. These include skin cells like [melanocytes](/details-cell/CL1000458) and epidermal cells ([basal](/details-cell/CL0002187) and [suprabasal](/details-cell/CL4033013)), as well as specialized cells like [cardiac muscle cells](/details-cell/CL0000746) and [retinal ganglion cells](/details-cell/CL0000740). This diverse expression pattern may point to context-dependent functions outside of immunity. ## Pathways and Molecular Function Based on the provided data, the precise molecular function of [LRRC52 AS1](/details-gene/400794) is not characterized, as no GO or Reactome pathway annotations were available. However, its designation as an antisense RNA ("AS1") suggests its primary mechanism may involve the post-transcriptional regulation of its sense-strand counterpart, the `LRRC52` gene. Antisense non-coding RNAs can modulate the stability, splicing, or translation of their target mRNA. Therefore, it is plausible that [LRRC52 AS1](/details-gene/400794) fine-tunes the expression of the LRRC52 protein, which may be critical for the function of the cell types where this non-coding RNA is highly expressed, such as [dendritic cells](/details-cell/CL0000990) and [T cells](/details-cell/CL0000815). ## Research Directions The highly specific expression pattern of [LRRC52 AS1](/details-gene/400794) in key immune cell populations provides a foundation for several testable hypotheses regarding its function in health and disease. **Proposed Hypotheses:** 1. [LRRC52 AS1](/details-gene/400794) is a critical regulator of dendritic cell maturation and antigen presentation. Its expression may modulate the levels of the sense `LRRC52` transcript, thereby controlling the signaling pathways required for [dendritic cell](/details-cell/CL0000990) activation in response to pathogens. 2. In T cells, [LRRC52 AS1](/details-gene/400794) plays a role in maintaining lineage stability and function. For instance, its high expression in [regulatory T cells](/details-cell/CL0000815) may be essential for their suppressive capacity, potentially by stabilizing the expression of key transcription factors. **Proposed Key Experiment:** To test the hypothesis that [LRRC52 AS1](/details-gene/400794) regulates [dendritic cell](/details-cell/CL0000990) function (Hypothesis 1), one could perform a loss-of-function study. Primary human monocytes would be differentiated into dendritic cells in vitro, followed by transfection with either a specific antisense oligonucleotide (ASO) to degrade [LRRC52 AS1](/details-gene/400794) or a non-targeting control ASO. The impact of the knockdown would be assessed by: * **Molecular Analysis:** Quantifying mRNA and protein levels of the sense `LRRC52` gene via qRT-PCR and Western blotting to confirm the regulatory relationship. * **Functional Analysis:** Stimulating the dendritic cells with a Toll-like receptor agonist (e.g., LPS) and measuring the expression of co-stimulatory molecules (CD80, CD86) and MHC Class II by flow cytometry. Cytokine secretion (e.g., IL-12, IL-10) could be measured by ELISA. * **T Cell Stimulation Assay:** Co-culturing the knockdown and control dendritic cells with allogeneic T cells in a mixed lymphocyte reaction (MLR) to determine if the absence of [LRRC52 AS1](/details-gene/400794) impairs their ability to induce T cell proliferation. **Therapeutic Potential:** As a non-coding RNA with highly specific expression in immune cells, [LRRC52 AS1](/details-gene/400794) presents a promising target for nucleic acid-based therapies. If its dysregulation is linked to autoimmune diseases or cancer, ASOs or siRNAs could be developed to modulate its levels. For example, if [LRRC52 AS1](/details-gene/400794) is found to promote an inflammatory phenotype in [dendritic cells](/details-cell/CL0000990), its inhibition could serve as a novel anti-inflammatory strategy. Conversely, if it enhances the function of [regulatory T cells](/details-cell/CL0000815), agonistic RNA molecules could be explored to treat autoimmune conditions.