Details for: KLRB1

Gene ID: 3820

Symbol: KLRB1

Ensembl ID: ENSG00000111796

Description: killer cell lectin like receptor B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.7985
    Cell Significance Index: -13.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.0790
    Cell Significance Index: -14.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.9776
    Cell Significance Index: -20.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.5168
    Cell Significance Index: -21.8700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 41.0059
    Cell Significance Index: 109.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.9742
    Cell Significance Index: -16.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.0380
    Cell Significance Index: -16.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3816
    Cell Significance Index: -12.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.5176
    Cell Significance Index: 69.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9330
    Cell Significance Index: -12.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8190
    Cell Significance Index: -15.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.1932
    Cell Significance Index: 102.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7107
    Cell Significance Index: 79.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6398
    Cell Significance Index: 74.3300
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 1.3554
    Cell Significance Index: 3.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2066
    Cell Significance Index: 229.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9970
    Cell Significance Index: 98.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.8660
    Cell Significance Index: -2.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8024
    Cell Significance Index: 724.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7419
    Cell Significance Index: 19.8500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5835
    Cell Significance Index: 6.0500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.5226
    Cell Significance Index: 5.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4458
    Cell Significance Index: 72.5100
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.3158
    Cell Significance Index: 0.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3081
    Cell Significance Index: 33.5200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.3038
    Cell Significance Index: 2.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0945
    Cell Significance Index: 6.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0838
    Cell Significance Index: 16.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0543
    Cell Significance Index: 1.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0354
    Cell Significance Index: 0.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0083
    Cell Significance Index: -5.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0217
    Cell Significance Index: -9.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0237
    Cell Significance Index: -4.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0268
    Cell Significance Index: -9.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0280
    Cell Significance Index: -20.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0298
    Cell Significance Index: -16.8300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0312
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0314
    Cell Significance Index: -19.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0410
    Cell Significance Index: -18.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0460
    Cell Significance Index: -2.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0603
    Cell Significance Index: -2.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0604
    Cell Significance Index: -17.3900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0609
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0706
    Cell Significance Index: -0.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0781
    Cell Significance Index: -10.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0864
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0928
    Cell Significance Index: -15.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0933
    Cell Significance Index: -16.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1051
    Cell Significance Index: -4.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1110
    Cell Significance Index: -13.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1207
    Cell Significance Index: -16.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1209
    Cell Significance Index: -8.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1361
    Cell Significance Index: -19.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1371
    Cell Significance Index: -15.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1385
    Cell Significance Index: -8.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1403
    Cell Significance Index: -8.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1421
    Cell Significance Index: -14.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1426
    Cell Significance Index: -16.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1444
    Cell Significance Index: -14.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1490
    Cell Significance Index: -18.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1544
    Cell Significance Index: -19.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1589
    Cell Significance Index: -7.4700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1602
    Cell Significance Index: -2.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1660
    Cell Significance Index: -2.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1702
    Cell Significance Index: -10.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2018
    Cell Significance Index: -13.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2049
    Cell Significance Index: -4.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2344
    Cell Significance Index: -17.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2516
    Cell Significance Index: -7.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2554
    Cell Significance Index: -16.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2563
    Cell Significance Index: -14.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2659
    Cell Significance Index: -19.8200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2673
    Cell Significance Index: -2.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2792
    Cell Significance Index: -12.3500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2849
    Cell Significance Index: -2.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2891
    Cell Significance Index: -7.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2960
    Cell Significance Index: -4.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3129
    Cell Significance Index: -11.8500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3396
    Cell Significance Index: -4.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3675
    Cell Significance Index: -19.0900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3714
    Cell Significance Index: -3.6200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3808
    Cell Significance Index: -3.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3813
    Cell Significance Index: -19.8600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3954
    Cell Significance Index: -3.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4139
    Cell Significance Index: -19.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4202
    Cell Significance Index: -14.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4529
    Cell Significance Index: -14.8300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4712
    Cell Significance Index: -4.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4760
    Cell Significance Index: -15.1600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4764
    Cell Significance Index: -6.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4803
    Cell Significance Index: -12.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface receptor:** KLRB1 is a transmembrane receptor that interacts with specific ligands, influencing immune cell behavior. 2. **Lectin-like receptor:** KLRB1 belongs to the killer cell lectin-like receptor subfamily B, characterized by its carbohydrate-binding properties. 3. **Regulation of NK cell-mediated cytotoxicity:** KLRB1 is known to modulate NK cell activity, influencing their ability to recognize and destroy target cells. 4. **Expression in various immune cells:** KLRB1 is expressed in multiple immune cell types, including NKp46-positive innate lymphoid cells, T-regulatory cells, and mucosal invariant T cells. **Pathways and Functions:** 1. **Adaptive immune system:** KLRB1 is involved in regulating immune responses, particularly in the context of adaptive immunity. 2. **Carbohydrate binding:** KLRB1 interacts with specific carbohydrate ligands, influencing its signaling properties. 3. **Cell surface receptor signaling pathway:** KLRB1 activates downstream signaling pathways, modulating immune cell behavior. 4. **Immune system:** KLRB1 is essential for maintaining immune homeostasis and regulating immune responses. 5. **Immunoregulatory interactions:** KLRB1 interacts with non-lymphoid cells, influencing immune responses and immune homeostasis. **Signaling Mechanisms:** 1. **CD28-B7 interaction:** KLRB1 interacts with CD28, a co-stimulatory molecule, enhancing immune cell activation. 2. **BD-1 interaction:** KLRB1 interacts with BD-1, a co-stimulatory molecule, modulating immune cell behavior. 3. **Ligand-dependent signaling:** KLRB1 activates downstream signaling pathways in response to specific ligand binding. **Clinical Significance:** KLRB1's involvement in regulating immune responses has significant implications for the treatment of various immune-related disorders, including: 1. **Autoimmune diseases:** KLRB1's role in regulating immune homeostasis may influence the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Infectious diseases:** KLRB1's interaction with immune cells may influence the progression of infectious diseases, such as HIV and tuberculosis. 3. **Cancer:** KLRB1's involvement in regulating immune responses may influence cancer progression and treatment outcomes. In conclusion, KLRB1 is a critical component of the adaptive immune system, regulating immune responses and maintaining immune homeostasis. Further research on KLRB1's signaling mechanisms and clinical significance will provide valuable insights into the development of novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 2712804400

Symbol: KLRB1_HUMAN

Name: Killer cell lectin-like receptor subfamily B member 1

UniProtKB Accession Codes:

Q12918 Q24K24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8077657

Title: Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.

PubMed ID: 8077657

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9603467

Title: IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation.

PubMed ID: 9603467

DOI: 10.1002/(sici)1521-4141(199805)28:05<1611::aid-immu1611>3.0.co;2-6

PubMed ID: 12100027

Title: CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver.

PubMed ID: 12100027

DOI: 10.1046/j.1365-2249.2002.01886.x

PubMed ID: 16339512

Title: Lectin-like transcript 1 is a ligand for the CD161 receptor.

PubMed ID: 16339512

DOI: 10.4049/jimmunol.175.12.7791

PubMed ID: 16339513

Title: Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.

PubMed ID: 16339513

DOI: 10.4049/jimmunol.175.12.7796

PubMed ID: 16455998

Title: CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase.

PubMed ID: 16455998

DOI: 10.4049/jimmunol.176.4.2397

PubMed ID: 16925668

Title: Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161).

PubMed ID: 16925668

DOI: 10.1111/j.1399-3089.2006.00332.x

PubMed ID: 20843815

Title: Characterization of alternatively spliced transcript variants of CLEC2D gene.

PubMed ID: 20843815

DOI: 10.1074/jbc.m110.179622

Sequence Information:

  • Length: 225
  • Mass: 25415
  • Checksum: 01BFA925445B83B0
  • Sequence:
    • MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL LVLVVTGLSV 
SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ LREKCLLFSH TVNPWNNSLA 
DCSTKESSLL LIRDKDELIH TQNLIRDKAI LFWIGLNFSL SEKNWKWING SFLNSNDLEI 
RGDAKENSCI SISQTSVYSE YCSTEIRWIC QKELTPVRNK VYPDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.