Details for: FANCB

Gene ID: 2187

Symbol: FANCB

Ensembl ID: ENSG00000181544

Description: FA complementation group B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169584
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.24
    Marker Score: 2173.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.06
    Marker Score: 772
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5195
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.86
    Marker Score: 582
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1588
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 546
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2847
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 459
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1274
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.66
    Marker Score: 1360
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.55
    Marker Score: 412
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.54
    Marker Score: 672
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 334
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.5
    Marker Score: 723
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5
    Marker Score: 1482
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 293
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.48
    Marker Score: 300
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.48
    Marker Score: 172
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.47
    Marker Score: 1287
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.47
    Marker Score: 620
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.43
    Marker Score: 664
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.4
    Marker Score: 3775
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.37
    Marker Score: 891
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.37
    Marker Score: 22496
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 347
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 835
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 160
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 220
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.32
    Marker Score: 304
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.32
    Marker Score: 2757
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 139
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.31
    Marker Score: 226
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.28
    Marker Score: 205
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.28
    Marker Score: 289
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.27
    Marker Score: 338
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.27
    Marker Score: 174
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.26
    Marker Score: 316
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.26
    Marker Score: 129
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.25
    Marker Score: 982
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.24
    Marker Score: 123
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.24
    Marker Score: 2211
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.23
    Marker Score: 8849
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.23
    Marker Score: 114
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.23
    Marker Score: 116
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 287
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.23
    Marker Score: 1755
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 194
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.22
    Marker Score: 141
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.22
    Marker Score: 123
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.22
    Marker Score: 141
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.21
    Marker Score: 226
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 384
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.21
    Marker Score: 252
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.21
    Marker Score: 87
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.2
    Marker Score: 50
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 320
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.2
    Marker Score: 96
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2
    Marker Score: 175
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 180
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.19
    Marker Score: 133
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.19
    Marker Score: 251
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 167
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.19
    Marker Score: 757
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.18
    Marker Score: 40
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.18
    Marker Score: 236
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.18
    Marker Score: 2715
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.18
    Marker Score: 45

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Other Information

**Key characteristics:** * FANCB is a serine/threonine kinase. * It is a key component of the Fanconi anemia pathway. * It is expressed in a variety of cell types, including mural cell, germ cell, colon goblet cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, tuft cell of colon, and BEST4+ intestinal epithelial cell. **Pathways and functions:** * FANCB is involved in the repair of DNA damage caused by exposure to carcinogens. * It is a key component of the Fanconi anemia pathway, a cellular mechanism that is responsible for repairing DNA damage caused by exposure to carcinogens. * It is involved in the regulation of cell cycle progression and DNA repair. * It is involved in the regulation of stem cell differentiation. **Clinical significance:** * Mutations in the FANCB gene have been linked to the development of Fanconi anemia, a genetic disorder that causes severe blood cancer and other cancers. * FANCB inhibitors are being investigated as a treatment for Fanconi anemia.

Genular Protein ID: 875977352

Symbol: FANCB_HUMAN

Name: Fanconi anemia group B protein

UniProtKB Accession Codes:

Q8NB91 B2RMZ4 Q7Z2U2 Q86XG1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 6 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 8 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15502827

Title: X-linked inheritance of Fanconi anemia complementation group B.

PubMed ID: 15502827

DOI: 10.1038/ng1458

PubMed ID: 16116422

Title: A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

PubMed ID: 16116422

DOI: 10.1038/ng1626

PubMed ID: 16679491

Title: Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome.

PubMed ID: 16679491

DOI: 10.1136/jmg.2006.041673

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 859
  • Mass: 97726
  • Checksum: 6CECD725B63C3901
  • Sequence:
    • MTSKQAMSSN EQERLLCYNG EVLVFQLSKG NFADKEPTKT PILHVRRMVF DRGTKVFVQK 
STGFFTIKEE NSHLKIMCCN CVSDFRTGIN LPYIVIEKNK KNNVFEYFLL ILHSTNKFEM 
RLSFKLGYEM KDGLRVLNGP LILWRHVKAF FFISSQTGKV VSVSGNFSSI QWAGEIENLG 
MVLLGLKECC LSEEECTQEP SKSDYAIWNT KFCVYSLESQ EVLSDIYIIP PAYSSVVTYV 
HICATEIIKN QLRISLIALT RKNQLISFQN GTPKNVCQLP FGDPCAVQLM DSGGGNLFFV 
VSFISNNACA VWKESFQVAA KWEKLSLVLI DDFIGSGTEQ VLLLFKDSLN SDCLTSFKIT 
DLGKINYSSE PSDCNEDDLF EDKQENRYLV VPPLETGLKV CFSSFRELRQ HLLLKEKIIS 
KSYKALINLV QGKDDNTSSA EEKECLVPLC GEEENSVHIL DEKLSDNFQD SEQLVEKIWY 
RVIDDSLVVG VKTTSSLKLS LNDVTLSLLM DQAHDSRFRL LKCQNRVIKL STNPFPAPYL 
MPCEIGLEAK RVTLTPDSKK EESFVCEHPS KKECVQIITA VTSLSPLLTF SKFCCTVLLQ 
IMERESGNCP KDRYVVCGRV FLSLEDLSTG KYLLTFPKKK PIEHMEDLFA LLAAFHKSCF 
QITSPGYALN SMKVWLLEHM KCEIIKEFPE VYFCERPGSF YGTLFTWKQR TPFEGILIIY 
SRNQTVMFQC LHNLIRILPI NCFLKNLKSG SENFLIDNMA FTLEKELVTL SSLSSAIAKH 
ESNFMQRCEV SKGKSSVVAA ALSDRRENIH PYRKELQREK KKMLQTNLKV SGALYREITL 
KVAEVQLKSD FAAQKLSNL

Genular Protein ID: 2000015413

Symbol: C9J5X9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J5X9

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 832
  • Mass: 94822
  • Checksum: AF04B8BA52351553
  • Sequence:
    • MTSKQAMSSN EQERLLCYNG EVLVFQLSKG NFADKEPTKT PILHVRRMVF DRGTKVFVQK 
STGFFTIKEE NSHLKIMCCN CVSDFRTGIN LPYIVIEKNK KNNVFEYFLL ILHSTNKFEM 
RLSFKLGYEM KDGLRVLNGP LILWRHVKAF FFISSQTGKV VSVSGNFSSI QWAGEIENLG 
MVLLGLKECC LSEEECTQEP SKSDYAIWNT KFCVYSLESQ EVLSDIYIIP PAYSSVVTYV 
HICATEIIKN QLRISLIALT RKNQLISFQN GTPKNVCQLP FGDPCAVQLM DSGGGNLFFV 
VSFISNNACA VWKESFQVAA KWEKLSLVLI DDFIGSGTEQ VLLLFKDSLN SDCLTSFKIT 
DLGKINYSSE PSDCNEDDLF EDKQENRYLV VPPLETGLKV CFSSFRELRQ HLLLKEKIIS 
KSYKALINLV QGKDDNTSSA EEKECLVPLC GEEENSVHIL DEKLSDNFQD SEQLVEKIWY 
RVIDDSLVVG VKTTSSLKLS LNDVTLSLLM DQAHDSRFRL LKCQNRVIKL STNPFPAPYL 
MPCEIGLEAK RVTLTPDSKK EESFVCEHPS KKECVQIITA VTSLSPLLTF SKFCCTVLLQ 
IMERESGNCP KDRYVVCGRV FLSLEDLSTG KYLLTFPKKK PIEHMEDLFA LLAAFHKSCF 
QITSPGYALN SMKVWLLEHM KCEIIKEFPE VYFCERPGSF YGTLFTWKQR TPFEGILIIY 
SRNQTVMFQC LHNLIRILPI NCFLKNLKSG SENFLIDNMA FTLEKELVTL SSLSSAIAKH 
ESNFMQRCEV SKGKSSVVAA ALSDRRENIH PYRKELQREK KKMLQTNLKW PS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.