Details for: WNT11

Gene ID: 7481

Symbol: WNT11

Ensembl ID: ENSG00000085741

Description: Wnt family member 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.6589
    Cell Significance Index: -5.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.3308
    Cell Significance Index: 62.4600
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 2.1022
    Cell Significance Index: 2.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3279
    Cell Significance Index: -5.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0982
    Cell Significance Index: 209.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8012
    Cell Significance Index: 16.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7991
    Cell Significance Index: 79.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6282
    Cell Significance Index: 12.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6213
    Cell Significance Index: 561.0100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5730
    Cell Significance Index: 3.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5191
    Cell Significance Index: 14.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4213
    Cell Significance Index: 45.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4167
    Cell Significance Index: 21.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4144
    Cell Significance Index: 67.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3245
    Cell Significance Index: 19.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2727
    Cell Significance Index: 3.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2153
    Cell Significance Index: 14.8900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.2151
    Cell Significance Index: 1.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2136
    Cell Significance Index: 3.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1944
    Cell Significance Index: 8.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1317
    Cell Significance Index: 2.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1315
    Cell Significance Index: 26.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0701
    Cell Significance Index: 2.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0481
    Cell Significance Index: 6.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0448
    Cell Significance Index: 19.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0140
    Cell Significance Index: 26.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0106
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0091
    Cell Significance Index: 1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0088
    Cell Significance Index: 1.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0085
    Cell Significance Index: 0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0055
    Cell Significance Index: 0.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0048
    Cell Significance Index: 0.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0007
    Cell Significance Index: 0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0048
    Cell Significance Index: -0.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0077
    Cell Significance Index: -1.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0082
    Cell Significance Index: -5.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0089
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0098
    Cell Significance Index: -4.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0104
    Cell Significance Index: -3.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0117
    Cell Significance Index: -4.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0137
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0139
    Cell Significance Index: -2.3700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0171
    Cell Significance Index: -0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0194
    Cell Significance Index: -3.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0209
    Cell Significance Index: -0.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0255
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0266
    Cell Significance Index: -3.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0275
    Cell Significance Index: -0.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0351
    Cell Significance Index: -1.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0395
    Cell Significance Index: -5.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0412
    Cell Significance Index: -1.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0456
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0491
    Cell Significance Index: -5.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0515
    Cell Significance Index: -2.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0581
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0584
    Cell Significance Index: -3.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0614
    Cell Significance Index: -4.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0614
    Cell Significance Index: -1.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0622
    Cell Significance Index: -1.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0639
    Cell Significance Index: -1.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0719
    Cell Significance Index: -5.3600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0767
    Cell Significance Index: -0.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0781
    Cell Significance Index: -5.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0791
    Cell Significance Index: -4.8600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0869
    Cell Significance Index: -0.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0871
    Cell Significance Index: -2.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0894
    Cell Significance Index: -4.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0901
    Cell Significance Index: -0.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0951
    Cell Significance Index: -3.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0959
    Cell Significance Index: -0.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1009
    Cell Significance Index: -5.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1039
    Cell Significance Index: -5.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1066
    Cell Significance Index: -3.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1205
    Cell Significance Index: -6.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1219
    Cell Significance Index: -3.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1246
    Cell Significance Index: -5.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1297
    Cell Significance Index: -3.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1361
    Cell Significance Index: -4.7300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1411
    Cell Significance Index: -0.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1411
    Cell Significance Index: -3.7100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1465
    Cell Significance Index: -1.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1487
    Cell Significance Index: -5.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1560
    Cell Significance Index: -4.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1592
    Cell Significance Index: -2.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1607
    Cell Significance Index: -3.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1679
    Cell Significance Index: -4.7900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1682
    Cell Significance Index: -1.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Wnt family member**: WNT11 belongs to the Wnt family, a group of signaling molecules involved in various developmental and physiological processes. 2. **Significant expression**: WNT11 is expressed in multiple cell types, including blood vessel endothelial cells, cardiac muscle cells, and lymphoid lineage-restricted progenitor cells. 3. **Canonical Wnt pathway involvement**: WNT11 is involved in the canonical Wnt signaling pathway, which regulates cell fate commitment, cellular response to mechanical stimulus, and other cellular processes. 4. **Planar cell polarity pathway involvement**: WNT11 is also involved in the planar cell polarity pathway, which regulates axis elongation, gastrula mediolateral intercalation, and other developmental processes. 5. **Calcium modulating pathway involvement**: WNT11 is involved in the calcium modulating pathway, which regulates cellular responses to calcium levels. **Pathways and Functions:** 1. **Canonical Wnt signaling pathway**: WNT11 regulates cell fate commitment, cellular response to mechanical stimulus, and other cellular processes through the canonical Wnt signaling pathway. 2. **Planar cell polarity pathway**: WNT11 regulates axis elongation, gastrula mediolateral intercalation, and other developmental processes through the planar cell polarity pathway. 3. **Calcium modulating pathway**: WNT11 regulates cellular responses to calcium levels through the calcium modulating pathway. 4. **Adrenal gland development**: WNT11 is involved in adrenal gland development, a process that requires precise regulation of cellular responses to mechanical stimuli and other signaling molecules. 5. **Bone mineralization**: WNT11 is involved in bone mineralization, a process that requires precise regulation of cellular responses to mechanical stimuli and other signaling molecules. 6. **Cellular response to mechanical stimulus**: WNT11 regulates cellular responses to mechanical stimulus, including cell fate commitment and cellular migration. 7. **Epithelial to mesenchymal transition**: WNT11 regulates epithelial to mesenchymal transition, a process that involves changes in cellular morphology and gene expression. **Clinical Significance:** Dysregulation of WNT11 has been implicated in various diseases, including: 1. **Adrenal gland disorders**: WNT11 dysregulation has been implicated in adrenal gland disorders, such as congenital adrenal hyperplasia. 2. **Bone disorders**: WNT11 dysregulation has been implicated in bone disorders, such as osteoporosis and bone cancer. 3. **Immune system disorders**: WNT11 dysregulation has been implicated in immune system disorders, such as autoimmune diseases and lymphoid lineage-restricted progenitor cell disorders. 4. **Neurological disorders**: WNT11 dysregulation has been implicated in neurological disorders, such as autism and schizophrenia. In conclusion, WNT11 plays a crucial role in various developmental processes and immunological responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of WNT11 signaling in normal and pathological conditions.

Genular Protein ID: 1778851615

Symbol: WNT11_HUMAN

Name: Protein Wnt-11

UniProtKB Accession Codes:

O96014 B2R8Z6 Q14DE8 Q8WZ98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 61 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9757009

Title: Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung.

PubMed ID: 9757009

DOI: 10.1016/s0378-1119(98)00393-x

PubMed ID: 11712081

Title: Molecular cloning and characterization of human WNT11.

PubMed ID: 11712081

DOI: 10.3892/ijmm.8.6.651

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 354
  • Mass: 39179
  • Checksum: 0E29717C98541DBB
  • Sequence:
    • MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG LVSAQVQLCR 
SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 
AISHAIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 
TGSQANKLMR LHNSEVGRQA LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR 
YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.