Details for: STEAP1B AS1

Gene ID: 100506178

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: STEAP1B AS1

Ensembl ID: ENSG00000232759

Description: STEAP1B antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • conventional dendritic cell CL0000990
    CSI 79.12
    rCSI 66.05%
    PRS 0.66
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 72.79
    rCSI 88.2%
    PRS 0.31
  • regulatory T cell CL0000815
    CSI 62.34
    rCSI 72.26%
    PRS 0.72
  • helper T cell CL0000912
    CSI 45.51
    rCSI 64.35%
    PRS 0.3
  • basal cell of epidermis CL0002187
    CSI 42.27
    rCSI 74.91%
    PRS 0.25
  • suprabasal keratinocyte CL4033013
    CSI 37.33
    rCSI 60.93%
    PRS 0.35
  • melanocyte of skin CL1000458
    CSI 33.08
    rCSI 45.08%
    PRS 0.28
  • cytotoxic T cell CL0000910
    CSI 8.77
    rCSI 50.25%
    PRS 0.32
  • chondrocyte CL0000138
    CSI -38.59
    rCSI -61.37%
    PRS 0.17
  • innate lymphoid cell CL0001065
    CSI -43.26
    rCSI -89.31%
    PRS 0.33
  • pericyte CL0000669
    CSI -72.87
    rCSI -100%
    PRS 1.93

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [STEAP1B AS1](/details-gene/100506178) is a long non-coding antisense RNA located on chromosome 7. The expression profile of this gene suggests a specialized role within the immune system and epithelial tissues. **Overall**, it demonstrates particularly high significance in professional antigen-presenting cells, such as [conventional dendritic cells](/details-cell/CL0000990), as well as in multiple subsets of T lymphocytes, including [CD8-positive, alpha-beta memory T cells](/details-cell/CL0001203) and [regulatory T cells](/details-cell/CL0000815). Additionally, its notable expression in skin cells like [basal cells of the epidermis](/details-cell/CL0002187) points towards a potential function in skin homeostasis or cutaneous immunity. ## Cellular Roles and Expression Landscape The expression pattern of [STEAP1B AS1](/details-gene/100506178) indicates a focused biological role at the interface of immunity and barrier tissues. **Overall**, the gene is most significant in cell types critical for adaptive immunity. It is a top marker for [conventional dendritic cells](/details-cell/CL0000990) (CSI: 79.12), which are pivotal for initiating T cell responses. This is complemented by its high significance in various T cell populations, including [CD8-positive, alpha-beta memory T cells](/details-cell/CL0001203) (CSI: 72.79), [regulatory T cells](/details-cell/CL0000815) (CSI: 62.34), and [helper T cells](/details-cell/CL0000912) (CSI: 45.51). This co-expression pattern suggests its involvement in the regulation of T cell activation, differentiation, or memory formation. A secondary but distinct expression signature is observed in the skin. The gene shows significant expression in [basal cells of the epidermis](/details-cell/CL0002187) (CSI: 42.27), [suprabasal keratinocytes](/details-cell/CL4033013) (CSI: 37.33), and [melanocytes](/details-cell/CL1000458) (CSI: 33.08), implying a role in epidermal maintenance, differentiation, or local immune surveillance within this barrier organ. Conversely, the gene's low to negligible significance in mesenchymal lineages such as [pericytes](/details-cell/CL0000669) (CSI: -72.87) and [chondrocytes](/details-cell/CL0000138) (CSI: -38.59) highlights its specificity. Notably, its low significance in [innate lymphoid cells](/details-cell/CL0001065) (CSI: -43.26), despite high levels in T cells, suggests a more specialized function within the adaptive, rather than the broader innate, lymphoid system. ## Pathways and Molecular Function Detailed functional annotations for [STEAP1B AS1](/details-gene/100506178) were not available in the provided dataset. As an antisense non-coding RNA, it is mechanistically predicted to regulate the expression of its sense gene, STEAP1B, or other genes in *cis* or *trans*. Such regulation can occur through transcriptional interference, chromatin modification, or by altering the stability of target mRNAs. Its high expression in dendritic cells and T cells suggests a potential role in molecular pathways governing antigen presentation, T cell receptor signaling, or cytokine production, though direct evidence is currently lacking. ## Research Directions The specific expression profile of [STEAP1B AS1](/details-gene/100506178) in immune and epithelial cells warrants further investigation into its precise molecular functions and therapeutic potential. **Proposed Hypotheses:** 1. Given its high significance in both [conventional dendritic cells](/details-cell/CL0000990) and multiple T cell subsets, [STEAP1B AS1](/details-gene/100506178) may act as a critical modulator of the immunological synapse, influencing the efficiency of antigen presentation by DCs and the subsequent activation and polarization of T cells. 2. The co-expression in [basal cells of the epidermis](/details-cell/CL0002187) and [keratinocytes](/details-cell/CL4033013) suggests that [STEAP1B AS1](/details-gene/100506178) could regulate epidermal stratification and barrier integrity, potentially by controlling the expression of genes involved in keratinocyte differentiation. **Suggested Experimental Approach:** To test the hypothesis that [STEAP1B AS1](/details-gene/100506178) regulates T cell activation, one could perform a loss-of-function study. Specifically, antisense oligonucleotides (ASOs) could be used to knock down [STEAP1B AS1](/details-gene/100506178) in primary human monocyte-derived dendritic cells. These knockdown DCs would then be loaded with a known peptide antigen and co-cultured with naive CD4+ T cells. The impact of the knockdown could be assessed by quantifying T cell proliferation (e.g., via CFSE dilution), cytokine secretion (e.g., IL-2, IFN-gamma, IL-4 via ELISA or Luminex), and master transcription factor expression (e.g., T-bet, GATA3, Foxp3 via flow cytometry) to determine its role in T cell priming and differentiation. **Therapeutic Potential:** As a non-coding RNA with a specific expression pattern in key immune cells, [STEAP1B AS1](/details-gene/100506178) represents a potential therapeutic target for modulating immune responses. Its role in both activating ([helper T cell](/details-cell/CL0000912)) and suppressive ([regulatory T cell](/details-cell/CL0000815)) lineages makes it an intriguing candidate for intervention in autoimmune diseases or cancer. Therapeutic modulation, likely via targeted delivery of antisense oligonucleotides or siRNAs for inhibition, could offer a way to fine-tune immune cell function. However, a deeper understanding of its precise molecular mechanism is required to predict whether inhibition or overexpression would be therapeutically beneficial in specific disease contexts.