Details for: CL0000669

Cell ID: CL0000669

Cell Name: pericyte

Marker Score Threshold: 584
(Derived using integrated single-cell and genomic data)

Description: An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.

Synonyms: ARC, adventitial reticular cell, cell of Rouget, pericyte cell, pericyte of Rouget, adventitial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.83
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.72
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.01
    Ensembl ID: ENSG00000122786
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.86
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.73
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.67
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.51
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.49
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.34
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.32
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.25
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.2
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.18
    Ensembl ID: ENSG00000110955
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.15
    Ensembl ID: ENSG00000175899
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.95
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.95
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.88
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.88
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.88
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.85
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.8
    Ensembl ID: ENSG00000155366
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.8
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.79
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.78
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.75
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.72
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.68
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ALPP (ENSG00000163283)
    Fold Change: 1.66
    Ensembl ID: ENSG00000163283
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.66
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.65
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.64
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104763
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.62
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.62
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.6
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.58
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.56
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.56
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.54
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.53
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.51
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.49
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.49
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.48
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.47
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.46
    Ensembl ID: ENSG00000162772
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.45
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.41
    Ensembl ID: ENSG00000163286
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.41
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 1.36
    Ensembl ID: ENSG00000179477
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.34
    Ensembl ID: ENSG00000197894
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.34
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.29
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.28
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.27
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.25
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.24
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.23
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.23
    Ensembl ID: ENSG00000182492
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APOC4 (ENSG00000267467)
    Fold Change: 1.21
    Ensembl ID: ENSG00000267467
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.2
    Ensembl ID: ENSG00000100823
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.2
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.2
    Ensembl ID: ENSG00000163399
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.18
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.12
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138175
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.11
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.11
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.1
    Ensembl ID: ENSG00000058668
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 1.1
    Ensembl ID: ENSG00000172482
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.08
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.04
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AQP6 (ENSG00000086159)
    Fold Change: 1.04
    Ensembl ID: ENSG00000086159
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.03
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ERC2 IT1 (ENSG00000281708)
    Fold Change: 1.02
    Ensembl ID: ENSG00000281708
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1
    Ensembl ID: ENSG00000204217
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Pericytes are found wrapped around precapillary arterioles outside the basement membrane. 2. **Structure**: Elongated, contractile cells with a characteristic "ring-like" shape. 3. **Function**: Regulate blood flow, maintain vascular homeostasis, and interact with endothelial cells and other components of the vascular wall. 4. **Differentiation**: Can differentiate into various cell types, including fibroblasts, macrophages, and smooth muscle cells. 5. **Gene expression**: Actin cytoskeleton, adherens junctions, and other cellular processes are regulated by genes involved in cell signaling, cytoskeleton organization, and protein localization. **Clinical Significance** 1. **Vascular diseases**: Pericytes play a crucial role in maintaining vascular homeostasis, and their dysfunction has been implicated in various vascular diseases, including atherosclerosis, hypertension, and diabetes. 2. **Inflammation**: Pericytes interact with endothelial cells and other components of the vascular wall to modulate inflammation, and their dysfunction can contribute to inflammatory disorders. 3. **Immune responses**: Pericytes can differentiate into immune cells, such as macrophages, and play a role in regulating immune responses. 4. **Neurological disorders**: Pericytes have been implicated in the pathogenesis of neurological disorders, including multiple sclerosis and Alzheimer's disease. 5. **Cancer**: Pericytes can contribute to cancer progression by regulating angiogenesis, immune responses, and metastasis. **Pathways/Ontology** 1. **Actin cytoskeleton**: Regulated by genes involved in actin filament formation, actin filament dynamics, and actin-binding proteins. 2. **Adherens junctions**: Regulated by genes involved in adherens junction assembly, adherens junction interactions, and adherens junction organization. 3. **Apical junction complex**: Regulated by genes involved in apical protein localization and apical junction complex organization. 4. **Blood microparticle**: Regulated by genes involved in blood microparticle formation and blood microparticle trafficking. 5. **Chromatin remodeling**: Regulated by genes involved in chromatin organization, chromatin remodeling, and histone acetylation. **Gene Symbol**: ACTB (Ensembl ID: ENSG00000075624) **Gene Symbol**: B2M (Ensembl ID: ENSG00000166710) These genes are involved in various cellular processes, including cell signaling, cytoskeleton organization, and protein localization.