Details for: P2RX3

Gene ID: 5024

Symbol: P2RX3

Ensembl ID: ENSG00000109991

Description: purinergic receptor P2X 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 15.3625
    Cell Significance Index: 262.6100
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.0540
    Cell Significance Index: 16.8200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.4496
    Cell Significance Index: 15.1000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.2267
    Cell Significance Index: 17.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0086
    Cell Significance Index: 24.4300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.8804
    Cell Significance Index: 9.7000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5690
    Cell Significance Index: 9.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3598
    Cell Significance Index: 11.3800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2636
    Cell Significance Index: 3.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0234
    Cell Significance Index: 4.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0206
    Cell Significance Index: 0.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0172
    Cell Significance Index: 0.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0168
    Cell Significance Index: 0.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0052
    Cell Significance Index: 1.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0007
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0016
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0022
    Cell Significance Index: -1.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0024
    Cell Significance Index: -0.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0034
    Cell Significance Index: -0.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0041
    Cell Significance Index: -0.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0054
    Cell Significance Index: -0.7800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0077
    Cell Significance Index: -0.0500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0080
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0086
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0086
    Cell Significance Index: -1.1800
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0088
    Cell Significance Index: -0.1100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0107
    Cell Significance Index: -0.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0112
    Cell Significance Index: -1.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0149
    Cell Significance Index: -1.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0162
    Cell Significance Index: -1.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0168
    Cell Significance Index: -0.6900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0182
    Cell Significance Index: -0.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0216
    Cell Significance Index: -0.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0225
    Cell Significance Index: -1.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0228
    Cell Significance Index: -0.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0231
    Cell Significance Index: -0.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0231
    Cell Significance Index: -1.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0242
    Cell Significance Index: -1.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0248
    Cell Significance Index: -0.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0257
    Cell Significance Index: -0.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0271
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0274
    Cell Significance Index: -1.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0281
    Cell Significance Index: -0.9200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0290
    Cell Significance Index: -0.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0291
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0291
    Cell Significance Index: -0.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0314
    Cell Significance Index: -1.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0317
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0363
    Cell Significance Index: -0.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0367
    Cell Significance Index: -0.9200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0376
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0396
    Cell Significance Index: -1.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0404
    Cell Significance Index: -0.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0414
    Cell Significance Index: -1.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0438
    Cell Significance Index: -0.9300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0439
    Cell Significance Index: -0.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0467
    Cell Significance Index: -1.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0468
    Cell Significance Index: -1.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0475
    Cell Significance Index: -1.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0481
    Cell Significance Index: -0.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0482
    Cell Significance Index: -0.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0483
    Cell Significance Index: -1.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0484
    Cell Significance Index: -0.5300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0488
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0492
    Cell Significance Index: -1.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0496
    Cell Significance Index: -0.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0498
    Cell Significance Index: -1.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0504
    Cell Significance Index: -1.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0513
    Cell Significance Index: -1.0700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0515
    Cell Significance Index: -0.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0516
    Cell Significance Index: -1.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0517
    Cell Significance Index: -1.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0534
    Cell Significance Index: -0.7400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0536
    Cell Significance Index: -0.5400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0539
    Cell Significance Index: -1.0600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0544
    Cell Significance Index: -0.6700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0562
    Cell Significance Index: -0.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0563
    Cell Significance Index: -1.3000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0564
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0570
    Cell Significance Index: -0.6200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0580
    Cell Significance Index: -0.6000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0586
    Cell Significance Index: -0.7500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0600
    Cell Significance Index: -0.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0600
    Cell Significance Index: -1.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The P2RX3 receptor is a homotrimeric purinergic receptor composed of three identical subunits. 2. **Binding:** It binds to extracellular ATP (adenosine triphosphate), a key energy molecule in cells, and facilitates the influx of cations (positively charged ions) into the cell. 3. **Signaling:** The binding of ATP to the P2RX3 receptor triggers a signaling cascade that regulates various cellular processes, including calcium ion transport, excitatory postsynaptic potentials, and synaptic plasticity. 4. **Expression:** The P2RX3 receptor is expressed in multiple cell types, including hematopoietic stem cells, plasma cells, and GABAergic interneurons in the cerebral cortex. **Pathways and Functions:** 1. **Calcium Ion Transport:** The P2RX3 receptor regulates the influx of calcium ions into cells, which is crucial for various cellular processes, including muscle contraction, neurotransmission, and immune response. 2. **Neurotransmission:** The P2RX3 receptor plays a role in excitatory neurotransmission, particularly in the hippocampus and cerebral cortex, where it mediates the release of glutamate and other neurotransmitters. 3. **Synaptic Plasticity:** The P2RX3 receptor is involved in synaptic plasticity, the ability of synapses to adapt and change in response to experience or learning. 4. **Immune Response:** The P2RX3 receptor is expressed in immune cells, including plasma cells and hematopoietic stem cells, and regulates immune responses, including antibody production and immune cell activation. 5. **Pain Signaling:** The P2RX3 receptor is involved in pain signaling, particularly in the transmission of nociceptive information from sensory neurons to the central nervous system. **Clinical Significance:** 1. **Immune System Disorders:** Alterations in P2RX3 receptor expression or function may contribute to immune system disorders, such as autoimmune diseases and immunodeficiencies. 2. **Neurological Disorders:** The P2RX3 receptor's involvement in synaptic plasticity and neurotransmission makes it a potential target for the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression. 3. **Pain Management:** The P2RX3 receptor's role in pain signaling makes it a potential target for the development of novel pain therapies. 4. **Cancer:** The P2RX3 receptor's expression in cancer cells may contribute to cancer progression and metastasis, highlighting its potential as a therapeutic target. In conclusion, the P2RX3 purinergic receptor plays a complex and multifaceted role in various physiological processes, including immune response, neurotransmission, and cellular homeostasis. Its involvement in pain signaling, synaptic plasticity, and sensory perception further underscores its significance in human health and disease. Further research is needed to fully elucidate the P2RX3 receptor's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4278112055

Symbol: P2RX3_HUMAN

Name: P2X purinoceptor 3

UniProtKB Accession Codes:

P56373 Q6DK37 Q9UQB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 3 SMR 1 STRING 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9016352

Title: Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.

PubMed ID: 9016352

DOI: 10.1124/mol.51.1.109

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27626375

Title: X-ray structures define human P2X(3) receptor gating cycle and antagonist action.

PubMed ID: 27626375

DOI: 10.1038/nature19367

Sequence Information:

  • Length: 397
  • Mass: 44289
  • Checksum: 3CB0081E65748EED
  • Sequence:
    • MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ VRDTAIESSV 
VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE NQMQGFCPES EEKYRCVSDS 
QCGPERLPGG GILTGRCVNY SSVLRTCEIQ GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR 
FPLFNFEKGN LLPNLTARDM KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG 
IKIGWVCDLD KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA DQYKAKKFEE 
VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.