Details for: SCN2B

Gene ID: 6327

Symbol: SCN2B

Ensembl ID: ENSG00000149575

Description: sodium voltage-gated channel beta subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5935
    Cell Significance Index: 119.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5134
    Cell Significance Index: 184.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2857
    Cell Significance Index: 19.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1894
    Cell Significance Index: 131.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1756
    Cell Significance Index: 9.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1268
    Cell Significance Index: 5.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0621
    Cell Significance Index: 2.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0076
    Cell Significance Index: -3.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0122
    Cell Significance Index: -2.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0130
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0227
    Cell Significance Index: -16.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0242
    Cell Significance Index: -15.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0243
    Cell Significance Index: -44.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0287
    Cell Significance Index: -21.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0295
    Cell Significance Index: -45.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0316
    Cell Significance Index: -23.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0342
    Cell Significance Index: -46.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0362
    Cell Significance Index: -19.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0455
    Cell Significance Index: -2.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0500
    Cell Significance Index: -0.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0526
    Cell Significance Index: -15.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0529
    Cell Significance Index: -2.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0538
    Cell Significance Index: -24.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0661
    Cell Significance Index: -8.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0763
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0946
    Cell Significance Index: -16.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1013
    Cell Significance Index: -21.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1023
    Cell Significance Index: -12.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1050
    Cell Significance Index: -15.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1170
    Cell Significance Index: -23.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1178
    Cell Significance Index: -8.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1199
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1427
    Cell Significance Index: -16.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1533
    Cell Significance Index: -17.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1535
    Cell Significance Index: -21.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1540
    Cell Significance Index: -3.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1569
    Cell Significance Index: -4.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1593
    Cell Significance Index: -3.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1692
    Cell Significance Index: -2.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1699
    Cell Significance Index: -17.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1739
    Cell Significance Index: -4.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1863
    Cell Significance Index: -3.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1897
    Cell Significance Index: -11.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2054
    Cell Significance Index: -15.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2114
    Cell Significance Index: -16.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2131
    Cell Significance Index: -2.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2261
    Cell Significance Index: -23.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2341
    Cell Significance Index: -4.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3022
    Cell Significance Index: -5.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3070
    Cell Significance Index: -39.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3102
    Cell Significance Index: -7.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3228
    Cell Significance Index: -10.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3241
    Cell Significance Index: -15.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3329
    Cell Significance Index: -20.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3545
    Cell Significance Index: -3.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3697
    Cell Significance Index: -12.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3752
    Cell Significance Index: -6.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4015
    Cell Significance Index: -6.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4025
    Cell Significance Index: -14.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4291
    Cell Significance Index: -24.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4366
    Cell Significance Index: -10.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4430
    Cell Significance Index: -5.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4567
    Cell Significance Index: -11.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4613
    Cell Significance Index: -16.0300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4640
    Cell Significance Index: -3.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4719
    Cell Significance Index: -22.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4729
    Cell Significance Index: -9.2300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4733
    Cell Significance Index: -6.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4779
    Cell Significance Index: -9.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5125
    Cell Significance Index: -7.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5256
    Cell Significance Index: -15.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5335
    Cell Significance Index: -39.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5342
    Cell Significance Index: -27.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5663
    Cell Significance Index: -6.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5845
    Cell Significance Index: -6.9900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5846
    Cell Significance Index: -8.5200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.6310
    Cell Significance Index: -8.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6487
    Cell Significance Index: -17.3200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.6527
    Cell Significance Index: -6.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6569
    Cell Significance Index: -8.2900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.6569
    Cell Significance Index: -7.1700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.6582
    Cell Significance Index: -7.2700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.6686
    Cell Significance Index: -9.5100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6693
    Cell Significance Index: -8.6800
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.6694
    Cell Significance Index: -7.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6696
    Cell Significance Index: -10.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6743
    Cell Significance Index: -7.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6788
    Cell Significance Index: -17.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6828
    Cell Significance Index: -14.6000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.6920
    Cell Significance Index: -9.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6971
    Cell Significance Index: -17.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6991
    Cell Significance Index: -13.7600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.7037
    Cell Significance Index: -7.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7125
    Cell Significance Index: -29.1900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7149
    Cell Significance Index: -10.0200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7200
    Cell Significance Index: -8.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7332
    Cell Significance Index: -17.7600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7412
    Cell Significance Index: -5.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit structure**: SCN2B is a beta subunit of the voltage-gated sodium channel, which consists of several subunits (α, β, δ, and γ). The β subunits, including SCN2B, are responsible for modulating the channel's properties and regulating its activity. 2. **Expression pattern**: SCN2B is widely expressed in various cell types, including blood vessel endothelial cells, granulocyte monocyte progenitor cells, and neurons. This broad expression pattern suggests that SCN2B plays a critical role in multiple physiological processes. 3. **Functional significance**: SCN2B modulates the activity of voltage-gated sodium channels, which are essential for the initiation and propagation of action potentials in neurons and muscle cells. Abnormalities in SCN2B function have been implicated in various neurological and cardiac disorders. **Pathways and Functions** 1. **Neuronal excitability**: SCN2B modulates the activity of voltage-gated sodium channels, which are essential for the initiation and propagation of action potentials in neurons. Abnormalities in SCN2B function can lead to altered neuronal excitability, contributing to neurological disorders. 2. **Muscle contraction**: SCN2B regulates the activity of voltage-gated sodium channels, which are essential for muscle contraction. Disruptions in SCN2B function can lead to muscle weakness or paralysis. 3. **Cardiac conduction**: SCN2B modulates the activity of voltage-gated sodium channels, which are essential for cardiac conduction. Abnormalities in SCN2B function can lead to cardiac arrhythmias and conduction disorders. 4. **Sensory perception**: SCN2B is involved in the regulation of sensory perception, particularly in the detection of sweet, bitter, and umami (glutamate) tastes. **Clinical Significance** 1. **Neurological disorders**: SCN2B has been implicated in various neurological disorders, including epilepsy, myoclonic seizures, and developmental disorders. Mutations in the SCN2B gene have been associated with an increased risk of developing these conditions. 2. **Cardiac arrhythmias**: SCN2B has been linked to cardiac arrhythmias, including long QT syndrome and Brugada syndrome. Mutations in the SCN2B gene can disrupt cardiac conduction, leading to arrhythmias and potentially life-threatening complications. 3. **Muscle disorders**: SCN2B has been implicated in muscle disorders, including muscle weakness and paralysis. Mutations in the SCN2B gene can disrupt muscle contraction, leading to muscle weakness and wasting. 4. **Developmental disorders**: SCN2B has been linked to developmental disorders, including intellectual disability and autism spectrum disorder. Mutations in the SCN2B gene can disrupt normal neuronal development and function, leading to developmental delays and cognitive impairments. In conclusion, the SCN2B gene plays a critical role in regulating various cellular processes, including neuronal excitability, muscle contraction, and cardiac conduction. Its dysregulation has been implicated in various neurological, cardiac, and muscle disorders, highlighting the importance of SCN2B in maintaining normal physiological function.

Genular Protein ID: 1644032186

Symbol: SCN2B_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60939 O75302 Q9UNN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 20 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 8 EMDB 27 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 33 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9295116

Title: Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel.

PubMed ID: 9295116

DOI: 10.1097/00001756-199708180-00025

PubMed ID: 9887383

Title: Exclusion of the SCN2B gene as candidate for CMT4B.

PubMed ID: 9887383

DOI: 10.1038/sj.ejhg.5200220

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22992729

Title: Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits.

PubMed ID: 22992729

DOI: 10.1074/jbc.m112.397646

PubMed ID: 26894959

Title: Binary architecture of the Nav1.2-beta2 signaling complex.

PubMed ID: 26894959

DOI: 10.7554/elife.10960

PubMed ID: 30765606

Title: Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.

PubMed ID: 30765606

DOI: 10.1126/science.aaw2493

PubMed ID: 30765605

Title: Molecular basis for pore blockade of human Na+ channel Nav1.2 by the mu-conotoxin KIIIA.

PubMed ID: 30765605

DOI: 10.1126/science.aaw2999

PubMed ID: 35277491

Title: Structural basis for modulation of human NaV1.3 by clinical drug and selective antagonist.

PubMed ID: 35277491

DOI: 10.1038/s41467-022-28808-5

PubMed ID: 36823201

Title: Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.

PubMed ID: 36823201

DOI: 10.1038/s41467-023-36766-9

PubMed ID: 19808477

Title: Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.

PubMed ID: 19808477

DOI: 10.1161/circep.108.779181

PubMed ID: 23559163

Title: A missense mutation in the sodium channel beta2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome.

PubMed ID: 23559163

DOI: 10.1002/humu.22328

Sequence Information:

  • Length: 215
  • Mass: 24326
  • Checksum: 94A30A60A32683F3
  • Sequence:
    • MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH 
KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE 
DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE PPERDSTVAV IVGASVGGFL AVVILVLMVV 
KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.