Details for: RGS5

Gene ID: 8490

Symbol: RGS5

Ensembl ID: ENSG00000143248

Description: regulator of G protein signaling 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.6046
    Cell Significance Index: -27.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.7748
    Cell Significance Index: -27.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.8221
    Cell Significance Index: -23.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3203
    Cell Significance Index: -27.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9012
    Cell Significance Index: -20.9100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 10.2470
    Cell Significance Index: 53.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0070
    Cell Significance Index: -27.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4575
    Cell Significance Index: 22.5500
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.9143
    Cell Significance Index: 6.8500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7904
    Cell Significance Index: 12.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6846
    Cell Significance Index: 35.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4102
    Cell Significance Index: 52.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2875
    Cell Significance Index: 57.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2435
    Cell Significance Index: 110.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2262
    Cell Significance Index: 43.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1361
    Cell Significance Index: 10.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1152
    Cell Significance Index: 22.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0747
    Cell Significance Index: 1.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0615
    Cell Significance Index: 2.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0555
    Cell Significance Index: 50.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0457
    Cell Significance Index: 16.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0170
    Cell Significance Index: 32.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0117
    Cell Significance Index: -2.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0137
    Cell Significance Index: -21.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0162
    Cell Significance Index: -10.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0229
    Cell Significance Index: -31.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0257
    Cell Significance Index: -11.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0310
    Cell Significance Index: -5.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0313
    Cell Significance Index: -5.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0370
    Cell Significance Index: -20.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0397
    Cell Significance Index: -30.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0554
    Cell Significance Index: -7.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0605
    Cell Significance Index: -6.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0627
    Cell Significance Index: -1.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0657
    Cell Significance Index: -18.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0659
    Cell Significance Index: -13.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0795
    Cell Significance Index: -9.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0836
    Cell Significance Index: -8.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0838
    Cell Significance Index: -9.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0859
    Cell Significance Index: -12.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0888
    Cell Significance Index: -4.0300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0897
    Cell Significance Index: -1.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0918
    Cell Significance Index: -5.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0969
    Cell Significance Index: -10.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1154
    Cell Significance Index: -1.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1520
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1613
    Cell Significance Index: -18.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1799
    Cell Significance Index: -12.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1805
    Cell Significance Index: -2.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1904
    Cell Significance Index: -11.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2133
    Cell Significance Index: -24.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2135
    Cell Significance Index: -22.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2187
    Cell Significance Index: -15.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2339
    Cell Significance Index: -7.4900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2489
    Cell Significance Index: -3.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2657
    Cell Significance Index: -14.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2714
    Cell Significance Index: -18.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3209
    Cell Significance Index: -14.9600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.3222
    Cell Significance Index: -1.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3411
    Cell Significance Index: -7.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3460
    Cell Significance Index: -9.6700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3681
    Cell Significance Index: -5.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3726
    Cell Significance Index: -19.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3836
    Cell Significance Index: -23.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3886
    Cell Significance Index: -24.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4140
    Cell Significance Index: -10.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4161
    Cell Significance Index: -11.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4556
    Cell Significance Index: -9.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4841
    Cell Significance Index: -22.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4992
    Cell Significance Index: -22.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5070
    Cell Significance Index: -25.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5121
    Cell Significance Index: -8.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5364
    Cell Significance Index: -18.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5777
    Cell Significance Index: -14.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5966
    Cell Significance Index: -19.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6071
    Cell Significance Index: -22.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6073
    Cell Significance Index: -16.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6206
    Cell Significance Index: -20.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6279
    Cell Significance Index: -9.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6489
    Cell Significance Index: -18.6000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6580
    Cell Significance Index: -4.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6633
    Cell Significance Index: -23.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6825
    Cell Significance Index: -13.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6923
    Cell Significance Index: -11.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7095
    Cell Significance Index: -14.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7613
    Cell Significance Index: -15.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7746
    Cell Significance Index: -19.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7776
    Cell Significance Index: -22.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7839
    Cell Significance Index: -32.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7972
    Cell Significance Index: -17.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7999
    Cell Significance Index: -16.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.8006
    Cell Significance Index: -9.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8086
    Cell Significance Index: -17.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8281
    Cell Significance Index: -24.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8352
    Cell Significance Index: -17.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS5 is a protein that belongs to the regulator of G protein signaling (RGS) family, which consists of nine members that share a common structure and function. RGS5 is predominantly expressed in the nervous system, where it is highly expressed in chromaffin cells, sympathetic neurons, and GABAergic cortical interneurons. The protein is also found in other tissues, including the prostate, smooth muscle cells, and corneal endothelial cells. RGS5 is a GTPase-activating protein (GAP) for the Gαq subunit of heterotrimeric G proteins, which are involved in various signaling pathways, including those mediated by GPCRs. **Pathways and Functions:** RGS5 modulates GPCR signaling pathways through its interaction with GRKs, which are enzymes that phosphorylate and desensitize GPCRs. By binding to GRKs, RGS5 enhances their GTPase activity, leading to the degradation of Gαq subunits and the termination of GPCR signaling. RGS5 also regulates the activity of other GPCRs, including those involved in cardiovascular function, neurotransmission, and inflammation. The protein's ability to modulate GPCR signaling is essential for maintaining homeostasis and regulating various physiological processes. **Clinical Significance:** Dysregulation of RGS5 has been implicated in various diseases, including cardiovascular disorders, neurological disorders, and cancer. For example, RGS5 has been shown to play a role in the regulation of blood pressure and cardiovascular function, and its dysregulation has been linked to hypertension and cardiac arrhythmias. Additionally, RGS5 has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease, where it may contribute to the regulation of neurotransmission and synaptic plasticity. Further research is needed to fully understand the role of RGS5 in human disease and to explore its potential as a therapeutic target. In conclusion, RGS5 is a critical regulator of GPCR signaling pathways, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of RGS5 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1216815569

Symbol: RGS5_HUMAN

Name: Regulator of G-protein signaling 5

UniProtKB Accession Codes:

O15539 E9PMP5 Q53XA9 Q599J0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9747037

Title: Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene.

PubMed ID: 9747037

DOI: 10.1007/s100380050071

PubMed ID: 10471929

Title: Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.

PubMed ID: 10471929

DOI: 10.1038/12867

PubMed ID: 15670159

Title: Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues.

PubMed ID: 15670159

DOI: 10.1111/j.1742-4658.2004.04516.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 181
  • Mass: 20946
  • Checksum: 2E08CB0179DE7687
  • Sequence:
    • MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT QKTSLDEALQ 
WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY KKIKSPAKMA EKAKQIYEEF 
IQTEAPKEVN IDHFTKDITM KNLVEPSLSS FDMAQKRIHA LMEKDSLPRF VRSEFYQELI 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.