Details for: RGS5

Gene ID: 8490

Symbol: RGS5

Ensembl ID: ENSG00000143248

Description: regulator of G protein signaling 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 10.85
    Marker Score: 15263
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 6.88
    Marker Score: 2274
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 3.2
    Marker Score: 815
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 3.05
    Marker Score: 7176
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.02
    Marker Score: 1638
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.74
    Marker Score: 6019
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.42
    Marker Score: 4540
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.89
    Marker Score: 1102.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.87
    Marker Score: 2153
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.67
    Marker Score: 61721
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.47
    Marker Score: 1910.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.46
    Marker Score: 3717
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.45
    Marker Score: 565
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 497
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.05
    Marker Score: 908
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.05
    Marker Score: 614
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.01
    Marker Score: 488.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.01
    Marker Score: 115484.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.97
    Marker Score: 638
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.93
    Marker Score: 419
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322.5
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.88
    Marker Score: 258
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.83
    Marker Score: 762
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.82
    Marker Score: 1929
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.79
    Marker Score: 272
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.77
    Marker Score: 6748
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.74
    Marker Score: 243
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.73
    Marker Score: 2200
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.73
    Marker Score: 1646
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.68
    Marker Score: 219
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.68
    Marker Score: 283
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.64
    Marker Score: 182
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.62
    Marker Score: 660
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.61
    Marker Score: 594
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.58
    Marker Score: 170
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.56
    Marker Score: 153
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 178
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 168
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.52
    Marker Score: 2180
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.52
    Marker Score: 11008
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5125
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.51
    Marker Score: 5243
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.5
    Marker Score: 189
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5
    Marker Score: 433
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.49
    Marker Score: 2974
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.47
    Marker Score: 852
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.47
    Marker Score: 417
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.46
    Marker Score: 490
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 699
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 443
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.44
    Marker Score: 1242
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.43
    Marker Score: 238
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.43
    Marker Score: 389.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.43
    Marker Score: 860
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.43
    Marker Score: 254
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.42
    Marker Score: 358
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.42
    Marker Score: 1726
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.41
    Marker Score: 384
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.41
    Marker Score: 3857
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.41
    Marker Score: 168
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.4
    Marker Score: 185
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4
    Marker Score: 1664
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.4
    Marker Score: 949
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.39
    Marker Score: 218
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.39
    Marker Score: 3307
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.37
    Marker Score: 14008
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.37
    Marker Score: 22673
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.36
    Marker Score: 450
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.36
    Marker Score: 4775
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.35
    Marker Score: 179
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 152.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.34
    Marker Score: 933
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.34
    Marker Score: 6778
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.34
    Marker Score: 93
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.34
    Marker Score: 1402
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.33
    Marker Score: 391
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.33
    Marker Score: 320
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.33
    Marker Score: 2090
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.33
    Marker Score: 2120
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.32
    Marker Score: 199

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Other Information

**Key Characteristics:** RGS5 is a protein that belongs to the regulator of G protein signaling (RGS) family, which consists of nine members that share a common structure and function. RGS5 is predominantly expressed in the nervous system, where it is highly expressed in chromaffin cells, sympathetic neurons, and GABAergic cortical interneurons. The protein is also found in other tissues, including the prostate, smooth muscle cells, and corneal endothelial cells. RGS5 is a GTPase-activating protein (GAP) for the Gαq subunit of heterotrimeric G proteins, which are involved in various signaling pathways, including those mediated by GPCRs. **Pathways and Functions:** RGS5 modulates GPCR signaling pathways through its interaction with GRKs, which are enzymes that phosphorylate and desensitize GPCRs. By binding to GRKs, RGS5 enhances their GTPase activity, leading to the degradation of Gαq subunits and the termination of GPCR signaling. RGS5 also regulates the activity of other GPCRs, including those involved in cardiovascular function, neurotransmission, and inflammation. The protein's ability to modulate GPCR signaling is essential for maintaining homeostasis and regulating various physiological processes. **Clinical Significance:** Dysregulation of RGS5 has been implicated in various diseases, including cardiovascular disorders, neurological disorders, and cancer. For example, RGS5 has been shown to play a role in the regulation of blood pressure and cardiovascular function, and its dysregulation has been linked to hypertension and cardiac arrhythmias. Additionally, RGS5 has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease, where it may contribute to the regulation of neurotransmission and synaptic plasticity. Further research is needed to fully understand the role of RGS5 in human disease and to explore its potential as a therapeutic target. In conclusion, RGS5 is a critical regulator of GPCR signaling pathways, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of RGS5 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1216815569

Symbol: RGS5_HUMAN

Name: Regulator of G-protein signaling 5

UniProtKB Accession Codes:

O15539 E9PMP5 Q53XA9 Q599J0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9747037

Title: Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene.

PubMed ID: 9747037

DOI: 10.1007/s100380050071

PubMed ID: 10471929

Title: Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.

PubMed ID: 10471929

DOI: 10.1038/12867

PubMed ID: 15670159

Title: Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues.

PubMed ID: 15670159

DOI: 10.1111/j.1742-4658.2004.04516.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 181
  • Mass: 20946
  • Checksum: 2E08CB0179DE7687
  • Sequence:
    • MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT QKTSLDEALQ 
WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY KKIKSPAKMA EKAKQIYEEF 
IQTEAPKEVN IDHFTKDITM KNLVEPSLSS FDMAQKRIHA LMEKDSLPRF VRSEFYQELI 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.