Details for: ND4L

Gene ID: 4539

Symbol: ND4L

Ensembl ID: ENSG00000212907

Description: NADH dehydrogenase subunit 4L

Associated with

  • Aerobic respiration
    (GO:0009060)
  • Mitochondrial electron transport, nadh to ubiquinone
    (GO:0006120)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial respiratory chain complex i
    (GO:0005747)
  • Nadh dehydrogenase (ubiquinone) activity
    (GO:0008137)
  • Proton motive force-driven mitochondrial atp synthesis
    (GO:0042776)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 7.79
    Marker Score: 5214
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.97
    Marker Score: 29308
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 5.96
    Marker Score: 35368
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 5.7
    Marker Score: 7109
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 5.49
    Marker Score: 5699
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 5.29
    Marker Score: 4557
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.22
    Marker Score: 10942
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 5.18
    Marker Score: 18410
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.05
    Marker Score: 3566
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.96
    Marker Score: 10475.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.86
    Marker Score: 2949
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 4.8
    Marker Score: 11787
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.78
    Marker Score: 15078.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.66
    Marker Score: 11368
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.63
    Marker Score: 157700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.51
    Marker Score: 238579
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.3
    Marker Score: 3059.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 4.23
    Marker Score: 3464
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.22
    Marker Score: 11316
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.15
    Marker Score: 7118
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.11
    Marker Score: 17626
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.09
    Marker Score: 47564
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.06
    Marker Score: 3927
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.02
    Marker Score: 4298
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.99
    Marker Score: 1169
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.98
    Marker Score: 11165
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.94
    Marker Score: 5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.93
    Marker Score: 219569
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.91
    Marker Score: 29106
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.89
    Marker Score: 7089
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.86
    Marker Score: 3275
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.79
    Marker Score: 3375
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.79
    Marker Score: 2330
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.79
    Marker Score: 3559
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.74
    Marker Score: 24332
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.7
    Marker Score: 4371
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.7
    Marker Score: 2902
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.67
    Marker Score: 3459
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.66
    Marker Score: 2431
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.59
    Marker Score: 21835
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 3.54
    Marker Score: 4256
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.53
    Marker Score: 4864
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.51
    Marker Score: 3083
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.48
    Marker Score: 2004
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.48
    Marker Score: 3532
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.47
    Marker Score: 2363
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.41
    Marker Score: 5647
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.41
    Marker Score: 5585
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.39
    Marker Score: 26492
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.37
    Marker Score: 10592
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.34
    Marker Score: 1524
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.34
    Marker Score: 115523.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.31
    Marker Score: 2390
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.3
    Marker Score: 2738.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.29
    Marker Score: 21009
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.26
    Marker Score: 2390
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.24
    Marker Score: 32107
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.22
    Marker Score: 4564
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.22
    Marker Score: 6058
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.2
    Marker Score: 27773
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 3.14
    Marker Score: 8534
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.14
    Marker Score: 7120
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.13
    Marker Score: 2793
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.11
    Marker Score: 3459
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.11
    Marker Score: 2350
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.08
    Marker Score: 2952
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.07
    Marker Score: 1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.07
    Marker Score: 1711
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.04
    Marker Score: 14589
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.03
    Marker Score: 5415
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.03
    Marker Score: 30472
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 3.02
    Marker Score: 5928
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.01
    Marker Score: 3196.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.97
    Marker Score: 1965
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.96
    Marker Score: 1979
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.94
    Marker Score: 1109
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.94
    Marker Score: 2006.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.93
    Marker Score: 2890
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.93
    Marker Score: 18747.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.92
    Marker Score: 2454
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.88
    Marker Score: 38003
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.88
    Marker Score: 3372
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.87
    Marker Score: 4127
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.86
    Marker Score: 3459
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.85
    Marker Score: 6488
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.81
    Marker Score: 1846
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.8
    Marker Score: 1173
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 2.79
    Marker Score: 1800
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.79
    Marker Score: 2022
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.79
    Marker Score: 707
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.78
    Marker Score: 2106
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.78
    Marker Score: 1868.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.78
    Marker Score: 2366
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.77
    Marker Score: 6990
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.77
    Marker Score: 2019
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.76
    Marker Score: 1360
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.75
    Marker Score: 1188
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.75
    Marker Score: 656
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 2.73
    Marker Score: 1096
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.72
    Marker Score: 4745

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Other Information

**Key characteristics:** * ND4L is a large protein with a molecular weight of approximately 160 kDa. * It is found in the mitochondrial inner membrane. * It is involved in the regulation of mitochondrial respiration. **Pathways and functions:** * ND4L is a key enzyme in the citric acid cycle, where it transfers electrons from NADH to the electron acceptor, flavin adenine dinucleotide (FADH2). * This electron transfer chain allows the production of ATP through oxidative phosphorylation. * ND4L is also involved in the regulation of fatty acid oxidation and cholesterol synthesis. **Clinical significance:** * Mutations in ND4L have been linked to several human diseases, including mitochondrial disorders and cancer. * These diseases are characterized by impaired mitochondrial function and energy production. * Targeting ND4L has been explored as a potential therapeutic strategy for these diseases. **Additional notes:** * ND4L is a multi-functional protein that also plays a role in the regulation of calcium homeostasis, apoptosis, and inflammation. * It is a highly conserved protein with homologs in other organisms. * The expression of ND4L is regulated by a variety of factors, including glucose availability, oxygen tension, and the activity of other mitochondrial proteins.

Genular Protein ID: 2837036511

Symbol: NU4LM_HUMAN

Name: NADH-ubiquinone oxidoreductase chain 4L

UniProtKB Accession Codes:

P03901

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 100 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7219534

Title: Sequence and organization of the human mitochondrial genome.

PubMed ID: 7219534

DOI: 10.1038/290457a0

PubMed ID: 7530363

Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.

PubMed ID: 7530363

DOI: 10.1073/pnas.92.2.532

PubMed ID: 8919866

Title: Comparison between the complete mitochondrial DNA sequences of Homo and the common chimpanzee based on nonchimeric sequences.

PubMed ID: 8919866

DOI: 10.1007/bf02198840

PubMed ID: 12949126

Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.

PubMed ID: 12949126

DOI: 10.1093/molbev/msg230

PubMed ID: 11130070

Title: Mitochondrial genome variation and the origin of modern humans.

PubMed ID: 11130070

DOI: 10.1038/35047064

PubMed ID: 12840039

Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.

PubMed ID: 12840039

DOI: 10.1101/gr.686603

PubMed ID: 14760490

Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.

PubMed ID: 14760490

DOI: 10.1007/s00414-004-0427-6

PubMed ID: 3921850

Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

PubMed ID: 3921850

DOI: 10.1038/314592a0

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 1757091

Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.

PubMed ID: 1757091

DOI: 10.1007/bf00206061

PubMed ID: 8680405

Title: Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial DNA's indicates multiple independent occurrences of the common mutations.

PubMed ID: 8680405

DOI: 10.1002/humu.1380060405

PubMed ID: 9806551

Title: Somatic mutations of the mitochondrial genome in human colorectal tumours.

PubMed ID: 9806551

DOI: 10.1038/3108

Sequence Information:

  • Length: 98
  • Mass: 10741
  • Checksum: 24B91F1DCDB0BE22
  • Sequence:
    • MPLIYMNIML AFTISLLGML VYRSHLMSSL LCLEGMMLSL FIMATLMTLN THSLLANIVP 
IAMLVFAACE AAVGLALLVS ISNTYGLDYV HNLNLLQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.