Details for: ND4L

Gene ID: 4539

Symbol: ND4L

Ensembl ID: ENSG00000212907

Description: NADH dehydrogenase subunit 4L

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 347.1523
    Cell Significance Index: -178.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 314.5369
    Cell Significance Index: -148.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 221.7960
    Cell Significance Index: -148.8300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 64.2536
    Cell Significance Index: 901.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 54.2955
    Cell Significance Index: -145.4500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 47.7251
    Cell Significance Index: 127.8500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 31.4705
    Cell Significance Index: 250.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 19.7873
    Cell Significance Index: 253.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 15.2721
    Cell Significance Index: 225.4200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 14.1466
    Cell Significance Index: 109.0400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 9.8243
    Cell Significance Index: 74.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 9.5795
    Cell Significance Index: 281.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 8.2115
    Cell Significance Index: 372.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 8.1170
    Cell Significance Index: 2335.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.0319
    Cell Significance Index: 201.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 6.5923
    Cell Significance Index: 242.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 6.4090
    Cell Significance Index: 96.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.1010
    Cell Significance Index: 239.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.9978
    Cell Significance Index: 144.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.9511
    Cell Significance Index: 91.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.6219
    Cell Significance Index: 2524.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.2193
    Cell Significance Index: 579.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 3.9105
    Cell Significance Index: 399.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.3984
    Cell Significance Index: 89.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.3215
    Cell Significance Index: 172.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.2183
    Cell Significance Index: 87.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2019
    Cell Significance Index: 29.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.8566
    Cell Significance Index: 24.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.6897
    Cell Significance Index: 292.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4937
    Cell Significance Index: 28.3300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.4128
    Cell Significance Index: 11.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3652
    Cell Significance Index: 110.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.2142
    Cell Significance Index: 1623.4100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.7904
    Cell Significance Index: 37.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7361
    Cell Significance Index: 282.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5681
    Cell Significance Index: 192.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5552
    Cell Significance Index: 199.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5187
    Cell Significance Index: 79.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3674
    Cell Significance Index: 135.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2565
    Cell Significance Index: 29.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1360
    Cell Significance Index: 204.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9512
    Cell Significance Index: 25.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.9232
    Cell Significance Index: 73.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9160
    Cell Significance Index: 59.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9100
    Cell Significance Index: 54.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9071
    Cell Significance Index: 117.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7495
    Cell Significance Index: 12.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7399
    Cell Significance Index: 26.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5212
    Cell Significance Index: 103.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4380
    Cell Significance Index: 157.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3043
    Cell Significance Index: 274.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2684
    Cell Significance Index: 51.0900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.2318
    Cell Significance Index: 1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1500
    Cell Significance Index: 113.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1308
    Cell Significance Index: 9.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0713
    Cell Significance Index: 14.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0532
    Cell Significance Index: -1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0729
    Cell Significance Index: -137.2900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.0822
    Cell Significance Index: -0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0988
    Cell Significance Index: -182.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0999
    Cell Significance Index: -17.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1183
    Cell Significance Index: -182.1900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1338
    Cell Significance Index: -0.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1350
    Cell Significance Index: -183.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1721
    Cell Significance Index: -127.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2286
    Cell Significance Index: -128.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2676
    Cell Significance Index: -169.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2694
    Cell Significance Index: -168.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3502
    Cell Significance Index: -158.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4780
    Cell Significance Index: -54.7600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.6150
    Cell Significance Index: -4.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6151
    Cell Significance Index: -15.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7386
    Cell Significance Index: -155.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7756
    Cell Significance Index: -52.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8477
    Cell Significance Index: -42.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8566
    Cell Significance Index: -35.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9245
    Cell Significance Index: -20.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9734
    Cell Significance Index: -67.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1722
    Cell Significance Index: -73.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1839
    Cell Significance Index: -172.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2162
    Cell Significance Index: -12.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2271
    Cell Significance Index: -23.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3598
    Cell Significance Index: -141.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.5761
    Cell Significance Index: -32.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.7766
    Cell Significance Index: -136.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.9710
    Cell Significance Index: -110.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9978
    Cell Significance Index: -63.9900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -2.0192
    Cell Significance Index: -34.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1788
    Cell Significance Index: -133.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.1793
    Cell Significance Index: -62.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.2618
    Cell Significance Index: -139.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.2643
    Cell Significance Index: -13.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2682
    Cell Significance Index: -37.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.3357
    Cell Significance Index: -59.6700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -2.6675
    Cell Significance Index: -26.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.6708
    Cell Significance Index: -56.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.0774
    Cell Significance Index: -136.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.1126
    Cell Significance Index: -46.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.7279
    Cell Significance Index: -141.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -3.7461
    Cell Significance Index: -77.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial Localization:** The ND4L gene is specifically localized to the mitochondrial inner membrane, where it plays a critical role in the electron transport chain. 2. **Aerobic Respiration:** The ND4L gene is involved in the process of aerobic respiration, which generates energy for cells through the transfer of electrons. 3. **NADH to Ubiquinone:** The ND4L gene is part of the NADH dehydrogenase complex, which converts NADH into ubiquinone, a crucial step in the electron transport chain. 4. **Proton Motive Force-Driven ATP Synthesis:** The ND4L gene contributes to the production of ATP, the primary energy currency of cells, through the proton motive force-driven process. **Pathways and Functions:** 1. **Aerobic Respiration:** The ND4L gene is involved in the aerobic respiration pathway, which is responsible for generating energy for cells. 2. **Mitochondrial Electron Transport:** The ND4L gene is part of the mitochondrial electron transport chain, which is responsible for transferring electrons from NADH to ubiquinone. 3. **NADH to Ubiquinone:** The ND4L gene plays a critical role in the conversion of NADH into ubiquinone, a key step in the electron transport chain. 4. **Proton Motive Force-Driven ATP Synthesis:** The ND4L gene contributes to the production of ATP through the proton motive force-driven process. **Clinical Significance:** 1. **Mitochondrial Diseases:** Abnormalities in the ND4L gene have been implicated in several mitochondrial diseases, including Leber's hereditary optic neuropathy (LHON) and MELAS syndrome. 2. **Neurodegenerative Diseases:** The ND4L gene has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by mitochondrial dysfunction. 3. **Cancer:** The ND4L gene has been implicated in cancer development and progression, particularly in cells with high energy demands, such as skeletal muscle and pancreatic cells. 4. **Infectious Diseases:** The ND4L gene has been shown to play a role in the immune system, with abnormalities in the gene contributing to susceptibility to infections. In conclusion, the ND4L gene plays a critical role in maintaining mitochondrial function and overall cellular health. Abnormalities in the gene have been implicated in several diseases, highlighting its importance in understanding the molecular mechanisms underlying human disease. Further research is needed to fully elucidate the functions of the ND4L gene and its role in human disease.

Genular Protein ID: 2837036511

Symbol: NU4LM_HUMAN

Name: NADH-ubiquinone oxidoreductase chain 4L

UniProtKB Accession Codes:

P03901

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 100 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7219534

Title: Sequence and organization of the human mitochondrial genome.

PubMed ID: 7219534

DOI: 10.1038/290457a0

PubMed ID: 7530363

Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.

PubMed ID: 7530363

DOI: 10.1073/pnas.92.2.532

PubMed ID: 8919866

Title: Comparison between the complete mitochondrial DNA sequences of Homo and the common chimpanzee based on nonchimeric sequences.

PubMed ID: 8919866

DOI: 10.1007/bf02198840

PubMed ID: 12949126

Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.

PubMed ID: 12949126

DOI: 10.1093/molbev/msg230

PubMed ID: 11130070

Title: Mitochondrial genome variation and the origin of modern humans.

PubMed ID: 11130070

DOI: 10.1038/35047064

PubMed ID: 12840039

Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.

PubMed ID: 12840039

DOI: 10.1101/gr.686603

PubMed ID: 14760490

Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.

PubMed ID: 14760490

DOI: 10.1007/s00414-004-0427-6

PubMed ID: 3921850

Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

PubMed ID: 3921850

DOI: 10.1038/314592a0

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 1757091

Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.

PubMed ID: 1757091

DOI: 10.1007/bf00206061

PubMed ID: 8680405

Title: Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial DNA's indicates multiple independent occurrences of the common mutations.

PubMed ID: 8680405

DOI: 10.1002/humu.1380060405

PubMed ID: 9806551

Title: Somatic mutations of the mitochondrial genome in human colorectal tumours.

PubMed ID: 9806551

DOI: 10.1038/3108

Sequence Information:

  • Length: 98
  • Mass: 10741
  • Checksum: 24B91F1DCDB0BE22
  • Sequence:
    • MPLIYMNIML AFTISLLGML VYRSHLMSSL LCLEGMMLSL FIMATLMTLN THSLLANIVP 
IAMLVFAACE AAVGLALLVS ISNTYGLDYV HNLNLLQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.