Details for: TRAV39

Gene ID: 28642

Symbol: TRAV39

Ensembl ID: ENSG00000211818

Description: T cell receptor alpha variable 39

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: helper T cell (CL0000912)
    Fold Change: 3.4041
    Cell Significance Index: 48.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0043
    Cell Significance Index: -1.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0082
    Cell Significance Index: -1.6400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0257
    Cell Significance Index: -0.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0404
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0413
    Cell Significance Index: -0.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0473
    Cell Significance Index: -1.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0490
    Cell Significance Index: -1.5600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0607
    Cell Significance Index: -0.6400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0650
    Cell Significance Index: -0.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0665
    Cell Significance Index: -1.6600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0705
    Cell Significance Index: -0.6900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0748
    Cell Significance Index: -0.8000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0924
    Cell Significance Index: -0.8800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1048
    Cell Significance Index: -0.6800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1172
    Cell Significance Index: -0.6700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1478
    Cell Significance Index: -0.9100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.2311
    Cell Significance Index: -0.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -2.5918
    Cell Significance Index: -62.7800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -2.6811
    Cell Significance Index: -22.6600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -3.7955
    Cell Significance Index: -45.5100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -4.4758
    Cell Significance Index: -52.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -4.8387
    Cell Significance Index: -80.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -4.9623
    Cell Significance Index: -126.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -5.0359
    Cell Significance Index: -98.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -5.3093
    Cell Significance Index: -142.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -5.3261
    Cell Significance Index: -98.4400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -5.5993
    Cell Significance Index: -66.5600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -6.0467
    Cell Significance Index: -66.6700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -6.1095
    Cell Significance Index: -83.9000
  • Cell Name: club cell (CL0000158)
    Fold Change: -6.1423
    Cell Significance Index: -66.9200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -6.2288
    Cell Significance Index: -60.2600
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -6.9224
    Cell Significance Index: -68.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -7.0745
    Cell Significance Index: -60.1300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -7.1448
    Cell Significance Index: -78.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -7.1983
    Cell Significance Index: -73.4900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -7.5227
    Cell Significance Index: -96.6400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -7.5569
    Cell Significance Index: -121.5100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -7.5934
    Cell Significance Index: -68.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -7.7516
    Cell Significance Index: -117.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -7.9719
    Cell Significance Index: -129.1200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -8.3668
    Cell Significance Index: -78.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -8.4294
    Cell Significance Index: -88.9200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -8.5323
    Cell Significance Index: -88.4900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -8.7024
    Cell Significance Index: -66.5300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -8.8121
    Cell Significance Index: -80.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -8.9969
    Cell Significance Index: -152.8100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -9.2032
    Cell Significance Index: -97.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -9.2456
    Cell Significance Index: -129.5900
  • Cell Name: B cell (CL0000236)
    Fold Change: -9.2748
    Cell Significance Index: -109.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -9.3348
    Cell Significance Index: -122.5000
  • Cell Name: platelet (CL0000233)
    Fold Change: -9.4188
    Cell Significance Index: -96.9000
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -9.6527
    Cell Significance Index: -73.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -9.6994
    Cell Significance Index: -141.3700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -9.8853
    Cell Significance Index: -131.3600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -9.9038
    Cell Significance Index: -109.6900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -9.9131
    Cell Significance Index: -96.6300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -9.9439
    Cell Significance Index: -115.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -9.9773
    Cell Significance Index: -170.5500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -10.0537
    Cell Significance Index: -95.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -10.0771
    Cell Significance Index: -122.6800
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -10.1485
    Cell Significance Index: -82.8400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -10.2273
    Cell Significance Index: -113.2300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -10.3081
    Cell Significance Index: -177.7000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -10.3128
    Cell Significance Index: -122.7200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -10.5116
    Cell Significance Index: -129.2100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -10.5233
    Cell Significance Index: -98.0400
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -10.6187
    Cell Significance Index: -95.1200
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -10.6326
    Cell Significance Index: -98.0600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -10.8070
    Cell Significance Index: -142.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -10.9220
    Cell Significance Index: -142.5800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -10.9561
    Cell Significance Index: -96.5300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -10.9610
    Cell Significance Index: -126.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -11.0047
    Cell Significance Index: -150.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -11.1333
    Cell Significance Index: -142.5800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -11.1658
    Cell Significance Index: -112.5000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -11.1808
    Cell Significance Index: -150.8800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -11.2127
    Cell Significance Index: -129.0200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -11.2251
    Cell Significance Index: -98.1800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -11.2858
    Cell Significance Index: -137.3000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -11.3355
    Cell Significance Index: -141.6100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -11.3713
    Cell Significance Index: -96.9200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -11.4911
    Cell Significance Index: -142.1400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -11.5376
    Cell Significance Index: -128.9000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -11.5548
    Cell Significance Index: -109.5500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -11.6459
    Cell Significance Index: -117.6500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -11.6572
    Cell Significance Index: -95.6600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -11.6705
    Cell Significance Index: -96.5300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -11.7010
    Cell Significance Index: -142.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -11.8221
    Cell Significance Index: -171.6400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -11.8422
    Cell Significance Index: -109.5400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -11.8549
    Cell Significance Index: -109.5300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -11.8558
    Cell Significance Index: -139.4900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -11.8995
    Cell Significance Index: -118.7700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -11.9562
    Cell Significance Index: -141.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -11.9780
    Cell Significance Index: -151.1500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -12.0838
    Cell Significance Index: -122.5300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -12.2160
    Cell Significance Index: -126.5900
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -12.2573
    Cell Significance Index: -73.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV39 belongs to the T cell receptor alpha (TRAV) family, which is responsible for encoding the variable region of the T cell receptor alpha chain. This gene is part of the larger TRAV family, which consists of 24 distinct members, each with unique amino acid sequences. TRAV39 is significantly expressed in various immune cells, including macrophages, granulocytes, neutrophils, and early T lineage precursors, highlighting its broad immunological importance. **Pathways and Functions:** TRAV39 is involved in the adaptive immune response, particularly in recognizing bacterial pathogens. The gene is part of the T cell receptor complex, which is essential for recognizing and responding to antigens. The T cell receptor complex is composed of the T cell receptor alpha (TCRα) chain, which is encoded by the TRAV family, including TRAV39. The TCRα chain recognizes and binds to specific antigens, triggering a signaling cascade that leads to T cell activation and proliferation. In addition to its role in the adaptive immune response, TRAV39 is also involved in the response to bacterium, highlighting its importance in the innate immune response. The gene's expression in various immune cells suggests that it plays a crucial role in the coordination of immune responses, particularly in the context of bacterial infections. **Clinical Significance:** The clinical significance of TRAV39 lies in its role in recognizing and responding to bacterial infections. Variations in the TRAV39 gene have been associated with an increased susceptibility to certain bacterial infections, such as tuberculosis and pneumonia. Moreover, TRAV39 has been implicated in the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where the immune system mistakenly targets self-antigens. Furthermore, TRAV39 has been studied as a potential target for immunotherapy in cancer treatment. The gene's expression in tumor-infiltrating T cells suggests that it may play a role in the recognition and targeting of cancer cells. Additionally, TRAV39 has been investigated as a potential biomarker for diagnosing and monitoring immune-related disorders. In conclusion, TRAV39 is a critical component of the adaptive immune system, playing a vital role in recognizing and responding to bacterial infections. Its clinical significance lies in its association with increased susceptibility to certain bacterial infections and autoimmune diseases, as well as its potential as a target for immunotherapy and biomarker for immune-related disorders. Further research is needed to fully elucidate the immunological significance of TRAV39 and its potential applications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.