Details for: TRAV39

Gene ID: 28642

Symbol: TRAV39

Ensembl ID: ENSG00000211818

Description: T cell receptor alpha variable 39

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 4.54
    Marker Score: 5,052
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.63
    Marker Score: 483
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 353
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.26
    Marker Score: 442
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.23
    Marker Score: 187
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.19
    Marker Score: 343
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.15
    Marker Score: 134
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 396
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.08
    Marker Score: 115
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.07
    Marker Score: 301
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 129
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.05
    Marker Score: 2,769
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.05
    Marker Score: 448
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.04
    Marker Score: 104
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 484
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.03
    Marker Score: 76
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 104
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 59
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 10

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV39 belongs to the T cell receptor alpha (TRAV) family, which is responsible for encoding the variable region of the T cell receptor alpha chain. This gene is part of the larger TRAV family, which consists of 24 distinct members, each with unique amino acid sequences. TRAV39 is significantly expressed in various immune cells, including macrophages, granulocytes, neutrophils, and early T lineage precursors, highlighting its broad immunological importance. **Pathways and Functions:** TRAV39 is involved in the adaptive immune response, particularly in recognizing bacterial pathogens. The gene is part of the T cell receptor complex, which is essential for recognizing and responding to antigens. The T cell receptor complex is composed of the T cell receptor alpha (TCRα) chain, which is encoded by the TRAV family, including TRAV39. The TCRα chain recognizes and binds to specific antigens, triggering a signaling cascade that leads to T cell activation and proliferation. In addition to its role in the adaptive immune response, TRAV39 is also involved in the response to bacterium, highlighting its importance in the innate immune response. The gene's expression in various immune cells suggests that it plays a crucial role in the coordination of immune responses, particularly in the context of bacterial infections. **Clinical Significance:** The clinical significance of TRAV39 lies in its role in recognizing and responding to bacterial infections. Variations in the TRAV39 gene have been associated with an increased susceptibility to certain bacterial infections, such as tuberculosis and pneumonia. Moreover, TRAV39 has been implicated in the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where the immune system mistakenly targets self-antigens. Furthermore, TRAV39 has been studied as a potential target for immunotherapy in cancer treatment. The gene's expression in tumor-infiltrating T cells suggests that it may play a role in the recognition and targeting of cancer cells. Additionally, TRAV39 has been investigated as a potential biomarker for diagnosing and monitoring immune-related disorders. In conclusion, TRAV39 is a critical component of the adaptive immune system, playing a vital role in recognizing and responding to bacterial infections. Its clinical significance lies in its association with increased susceptibility to certain bacterial infections and autoimmune diseases, as well as its potential as a target for immunotherapy and biomarker for immune-related disorders. Further research is needed to fully elucidate the immunological significance of TRAV39 and its potential applications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.