Details for: CL0000940

Cell ID: CL0000940

Cell Name: mucosal invariant T cell

Marker Score Threshold: 889
(Derived using integrated single-cell and genomic data)

Description: An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule.

Synonyms: mucosal invariant T lymphocyte, mucosal invariant T-cell, mucosal invariant T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.02
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.88
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.83
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.82
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.62
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.57
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.53
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.49
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.49
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.46
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.38
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.24
    Ensembl ID: ENSG00000019582
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.23
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.13
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.04
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 2.99
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.98
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.89
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.89
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.84
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.84
    Ensembl ID: ENSG00000070831
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.75
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.69
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.55
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.52
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.49
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.47
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.45
    Ensembl ID: ENSG00000132965
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.42
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.41
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.36
    Ensembl ID: ENSG00000160654
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.34
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.32
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.3
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.21
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.2
    Ensembl ID: ENSG00000026508
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.19
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.17
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.17
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.14
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.08
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.06
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.03
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.95
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.87
    Ensembl ID: ENSG00000197043
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.87
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.84
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.82
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.81
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.78
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.77
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 1.75
    Ensembl ID: ENSG00000153563
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.73
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.7
    Ensembl ID: ENSG00000123146
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.64
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.64
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.61
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.61
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.61
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.6
    Ensembl ID: ENSG00000085224
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.58
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.56
    Ensembl ID: ENSG00000111276
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.55
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.53
    Ensembl ID: ENSG00000135404
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.51
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.48
    Ensembl ID: ENSG00000152495
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.47
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.47
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.46
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.45
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.44
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.4
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.38
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.37
    Ensembl ID: ENSG00000136717
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.35
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.33
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.33
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.28
    Ensembl ID: ENSG00000163631
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.26
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 1.25
    Ensembl ID: ENSG00000137752
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.21
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.18
    Ensembl ID: ENSG00000139193
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.15
    Ensembl ID: ENSG00000057657
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.08
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.07
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.05
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164615
Hovered Details

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Hovered Details

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**Key Characteristics** * **Alpha-beta T cell**: MucI cells are a type of alpha-beta T cell, which are a subset of T cells that recognize antigens presented by MHC I and II molecules. * **Mucosal tissue**: MucI cells are found in the lamina propria of mucosal tissues, including the gut, respiratory tract, and genitourinary tract. * **MR-1 restricted**: MucI cells are restricted by the MR-1 molecule, which presents non-peptide antigens to these cells. * **Non-peptide antigen recognition**: MucI cells recognize non-peptide antigens presented by MHC I, which is distinct from the recognition of peptide antigens by conventional T cells. * **Regulation of inflammation**: MucI cells play a role in regulating inflammation and immune homeostasis in mucosal tissues. * **Implicated in disease**: MucI cells are implicated in various diseases, including autoimmune disorders, cancer, and infectious diseases. **Clinical Significance** * **Autoimmune disorders**: MucI cells have been implicated in the pathogenesis of autoimmune disorders, such as inflammatory bowel disease and Crohn's disease. * **Cancer**: MucI cells have been shown to play a role in the development and progression of cancer, including colorectal and breast cancer. * **Infectious diseases**: MucI cells are involved in the immune response to infectious diseases, including HIV and tuberculosis. * **Vaccine development**: MucI cells have been identified as a potential target for vaccine development, particularly for mucosal vaccines. * **Therapeutic applications**: MucI cells have been explored as a potential therapeutic target for the treatment of autoimmune disorders and cancer. Overall, the mucosal invariant T cell is a unique and important component of the immune system, playing a crucial role in the regulation of inflammation and immune homeostasis in mucosal tissues. Further research is needed to fully understand the mechanisms of mucI cell function and to explore their potential therapeutic applications.