Details for: CASP4

Gene ID: 837

Symbol: CASP4

Ensembl ID: ENSG00000196954

Description: caspase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.7420
    Cell Significance Index: -31.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.7343
    Cell Significance Index: -35.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.1494
    Cell Significance Index: -32.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.7187
    Cell Significance Index: -33.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.4895
    Cell Significance Index: -35.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.5050
    Cell Significance Index: -33.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.1278
    Cell Significance Index: -11.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9411
    Cell Significance Index: -32.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.7511
    Cell Significance Index: -31.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0343
    Cell Significance Index: -30.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2526
    Cell Significance Index: -32.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.9628
    Cell Significance Index: 54.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.6131
    Cell Significance Index: -7.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.3114
    Cell Significance Index: 40.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9081
    Cell Significance Index: 114.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5076
    Cell Significance Index: 163.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3397
    Cell Significance Index: 39.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3391
    Cell Significance Index: 86.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2729
    Cell Significance Index: 207.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2649
    Cell Significance Index: 59.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0464
    Cell Significance Index: 27.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9583
    Cell Significance Index: 44.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8418
    Cell Significance Index: 372.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8306
    Cell Significance Index: 57.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8276
    Cell Significance Index: 101.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8213
    Cell Significance Index: 81.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7517
    Cell Significance Index: 39.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7171
    Cell Significance Index: 129.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6084
    Cell Significance Index: 83.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6083
    Cell Significance Index: 6.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5903
    Cell Significance Index: 76.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5338
    Cell Significance Index: 14.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4443
    Cell Significance Index: 52.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4423
    Cell Significance Index: 31.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4377
    Cell Significance Index: 22.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4152
    Cell Significance Index: 226.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3968
    Cell Significance Index: 5.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3903
    Cell Significance Index: 11.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3499
    Cell Significance Index: 6.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3164
    Cell Significance Index: 54.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2356
    Cell Significance Index: 46.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2353
    Cell Significance Index: 30.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2152
    Cell Significance Index: 6.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1958
    Cell Significance Index: 14.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1827
    Cell Significance Index: 1.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1571
    Cell Significance Index: 3.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1397
    Cell Significance Index: 126.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1327
    Cell Significance Index: 6.9100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1294
    Cell Significance Index: 2.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1274
    Cell Significance Index: 2.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0843
    Cell Significance Index: 16.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0576
    Cell Significance Index: 43.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0547
    Cell Significance Index: 2.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0344
    Cell Significance Index: 21.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0187
    Cell Significance Index: 2.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0071
    Cell Significance Index: -13.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0201
    Cell Significance Index: -30.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0260
    Cell Significance Index: -14.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0268
    Cell Significance Index: -36.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0279
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0378
    Cell Significance Index: -27.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0640
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0686
    Cell Significance Index: -31.1200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0885
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0924
    Cell Significance Index: -19.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0925
    Cell Significance Index: -33.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0979
    Cell Significance Index: -28.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0985
    Cell Significance Index: -3.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1135
    Cell Significance Index: -2.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1238
    Cell Significance Index: -18.0000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1245
    Cell Significance Index: -1.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1651
    Cell Significance Index: -19.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1667
    Cell Significance Index: -33.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1733
    Cell Significance Index: -5.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1766
    Cell Significance Index: -2.4100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1829
    Cell Significance Index: -0.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2072
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2656
    Cell Significance Index: -30.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2682
    Cell Significance Index: -20.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2770
    Cell Significance Index: -7.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3042
    Cell Significance Index: -4.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3100
    Cell Significance Index: -32.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4078
    Cell Significance Index: -32.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4991
    Cell Significance Index: -33.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5109
    Cell Significance Index: -10.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5531
    Cell Significance Index: -34.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5546
    Cell Significance Index: -34.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5608
    Cell Significance Index: -9.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5781
    Cell Significance Index: -35.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5852
    Cell Significance Index: -8.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6335
    Cell Significance Index: -16.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6607
    Cell Significance Index: -6.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6655
    Cell Significance Index: -37.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7348
    Cell Significance Index: -23.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7413
    Cell Significance Index: -12.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CASP4 is a caspase enzyme that belongs to the family of cysteine proteases. It is a homodimeric protein, consisting of two identical subunits, each with an active site that is responsible for cleaving specific peptide substrates. CASP4 is characterized by its ability to activate inflammasomes, which are complex assemblies of proteins that recognize and respond to cellular stress signals. This activation leads to the cleavage of pro-inflammatory cytokines, such as IL-1β and IL-18, and the induction of pyroptosis, a form of programmed cell death that is characterized by the release of pro-inflammatory cytokines. **Pathways and Functions** CASP4 is involved in several key pathways, including: 1. **Apoptotic process**: CASP4 is involved in the regulation of apoptosis, particularly in response to endoplasmic reticulum stress and amyloid-beta. It cleaves specific substrates that regulate the activation of caspase-8, a critical enzyme in the intrinsic apoptotic pathway. 2. **Inflammatory response**: CASP4 is a key component of the inflammasome complex, which is activated in response to cellular stress signals, such as bacterial infection and tissue damage. The activation of CASP4 leads to the cleavage of pro-inflammatory cytokines, such as IL-1β and IL-18. 3. **Innate immune response**: CASP4 is involved in the regulation of the innate immune response, particularly in the activation of immune cells, such as macrophages and dendritic cells. 4. **Cytosolic proteolysis**: CASP4 is involved in the regulation of cytosolic proteolysis, particularly in the cleavage of specific substrates that regulate cellular signaling pathways. **Clinical Significance** CASP4 has significant clinical implications, particularly in the diagnosis and treatment of autoimmune and inflammatory diseases, such as: 1. **Inflammatory bowel disease**: CASP4 is involved in the regulation of inflammation in the gut, and its dysregulation is thought to contribute to the development of inflammatory bowel disease. 2. **Rheumatoid arthritis**: CASP4 is involved in the regulation of inflammation and immune responses in rheumatoid arthritis, and its dysregulation is thought to contribute to the development of the disease. 3. **Cancer**: CASP4 is involved in the regulation of apoptosis and inflammation in cancer, and its dysregulation is thought to contribute to the development and progression of cancer. 4. **Neurodegenerative diseases**: CASP4 is involved in the regulation of apoptosis and inflammation in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CASP4 is a critical enzyme that regulates apoptosis, inflammation, and immune responses. Its dysregulation is thought to contribute to the development of various diseases, including inflammatory bowel disease, rheumatoid arthritis, cancer, and neurodegenerative diseases. Further research is needed to fully understand the role of CASP4 in these diseases and to develop therapeutic strategies that target this enzyme.

Genular Protein ID: 1683427698

Symbol: CASP4_HUMAN

Name: Caspase-4 subunit p10

UniProtKB Accession Codes:

P49662 A2NHL8 A2NHL9 A2NHM0 B3KPZ9 B4DJH5 B4E2D2 O95601 Q7KYX7 Q9UG96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 19 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7743998

Title: A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

PubMed ID: 7743998

DOI: 10.1002/j.1460-2075.1995.tb07183.x

PubMed ID: 7797592

Title: Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.

PubMed ID: 7797592

DOI: 10.1074/jbc.270.26.15870

PubMed ID: 7797510

Title: Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.

PubMed ID: 7797510

DOI: 10.1074/jbc.270.25.15250

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 10986288

Title: Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.

PubMed ID: 10986288

DOI: 10.1074/jbc.m007255200

PubMed ID: 15123740

Title: Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.

PubMed ID: 15123740

DOI: 10.1083/jcb.200310015

PubMed ID: 15326478

Title: A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

PubMed ID: 15326478

DOI: 10.1038/sj.onc.1208036

PubMed ID: 16893518

Title: Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants.

PubMed ID: 16893518

DOI: 10.1016/j.bbrc.2006.07.104

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18511561

Title: A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.

PubMed ID: 18511561

DOI: 10.1073/pnas.0802726105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22246630

Title: Caspase-4 is required for activation of inflammasomes.

PubMed ID: 22246630

DOI: 10.4049/jimmunol.1101620

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23661706

Title: Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis.

PubMed ID: 23661706

DOI: 10.1074/jbc.m113.458836

PubMed ID: 23516580

Title: The E. coli effector protein NleF is a caspase inhibitor.

PubMed ID: 23516580

DOI: 10.1371/journal.pone.0058937

PubMed ID: 25121752

Title: Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.

PubMed ID: 25121752

DOI: 10.1016/j.chom.2014.07.002

PubMed ID: 24879791

Title: A critical role for human caspase-4 in endotoxin sensitivity.

PubMed ID: 24879791

DOI: 10.4049/jimmunol.1303424

PubMed ID: 25119034

Title: Inflammatory caspases are innate immune receptors for intracellular LPS.

PubMed ID: 25119034

DOI: 10.1038/nature13683

PubMed ID: 26174085

Title: Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.

PubMed ID: 26174085

DOI: 10.1002/eji.201545523

PubMed ID: 26173988

Title: NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

PubMed ID: 26173988

DOI: 10.1002/eji.201545655

PubMed ID: 26508369

Title: Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.

PubMed ID: 26508369

DOI: 10.1038/ncomms9761

PubMed ID: 26375003

Title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

PubMed ID: 26375003

DOI: 10.1038/nature15514

PubMed ID: 25695505

Title: NF-kappaB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.

PubMed ID: 25695505

DOI: 10.1371/journal.pone.0117953

PubMed ID: 25964352

Title: Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.

PubMed ID: 25964352

DOI: 10.1073/pnas.1421699112

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 29077095

Title: Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.

PubMed ID: 29077095

DOI: 10.1038/cdd.2017.167

PubMed ID: 29520027

Title: The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

PubMed ID: 29520027

DOI: 10.1038/s41467-018-03409-3

PubMed ID: 31268602

Title: Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.

PubMed ID: 31268602

DOI: 10.15252/embj.2018100926

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 32510692

Title: Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.

PubMed ID: 32510692

DOI: 10.15252/embj.2020104926

PubMed ID: 32581219

Title: Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.

PubMed ID: 32581219

DOI: 10.1038/s41467-020-16889-z

PubMed ID: 33377178

Title: NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.

PubMed ID: 33377178

DOI: 10.1111/iej.13469

PubMed ID: 34671164

Title: Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.

PubMed ID: 34671164

DOI: 10.1038/s41586-021-04020-1

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 37001519

Title: The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.

PubMed ID: 37001519

DOI: 10.1016/j.immuni.2023.03.003

PubMed ID: 37014865

Title: Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation.

PubMed ID: 37014865

DOI: 10.1073/pnas.2218469120

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

PubMed ID: 36624349

Title: Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.

PubMed ID: 36624349

DOI: 10.1038/s41594-022-00888-3

PubMed ID: 37993712

Title: Structural insights into cytokine cleavage by inflammatory caspase-4.

PubMed ID: 37993712

DOI: 10.1038/s41586-023-06751-9

PubMed ID: 37993714

Title: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

PubMed ID: 37993714

DOI: 10.1038/s41586-023-06742-w

Sequence Information:

  • Length: 377
  • Mass: 43262
  • Checksum: DC7CCEC6E9D483EB
  • Sequence:
    • MAEGNHRKKP LKVLESLGKD FLTGVLDNLV EQNVLNWKEE EKKKYYDAKT EDKVRVMADS 
MQEKQRMAGQ MLLQTFFNID QISPNKKAHP NMEAGPPESG ESTDALKLCP HEEFLRLCKE 
RAEEIYPIKE RNNRTRLALI ICNTEFDHLP PRNGADFDIT GMKELLEGLD YSVDVEENLT 
ARDMESALRA FATRPEHKSS DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN 
RNCLSLKDKP KVIIVQACRG ANRGELWVRD SPASLEVASS QSSENLEEDA VYKTHVEKDF 
IAFCSSTPHN VSWRDSTMGS IFITQLITCF QKYSWCCHLE EVFRKVQQSF ETPRAKAQMP 
TIERLSMTRY FYLFPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.