Details for: CASP4

Gene ID: 837

Symbol: CASP4

Ensembl ID: ENSG00000196954

Description: caspase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.23
    Marker Score: 22040
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.11
    Marker Score: 118226
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.05
    Marker Score: 23829
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.05
    Marker Score: 3989
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.01
    Marker Score: 2235
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.99
    Marker Score: 5486
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.96
    Marker Score: 2364
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.94
    Marker Score: 3375
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.9
    Marker Score: 7763
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.86
    Marker Score: 5882
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.71
    Marker Score: 6714
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.67
    Marker Score: 4023
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.65
    Marker Score: 1390
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.65
    Marker Score: 1473
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.64
    Marker Score: 3730
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.61
    Marker Score: 4703
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.58
    Marker Score: 2327
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.57
    Marker Score: 1521
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.56
    Marker Score: 1533
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.54
    Marker Score: 1051
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.54
    Marker Score: 848
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.54
    Marker Score: 4307
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.51
    Marker Score: 653
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.51
    Marker Score: 498
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.51
    Marker Score: 2748
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.5
    Marker Score: 38532
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.49
    Marker Score: 15096
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.49
    Marker Score: 526
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.49
    Marker Score: 2632
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.48
    Marker Score: 9456
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.48
    Marker Score: 891
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.46
    Marker Score: 730
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.46
    Marker Score: 2346
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.46
    Marker Score: 1365
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166059
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.44
    Marker Score: 1454
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.44
    Marker Score: 1089
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.44
    Marker Score: 12387
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.44
    Marker Score: 1511
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.43
    Marker Score: 443
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.43
    Marker Score: 1428
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.43
    Marker Score: 2414.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.42
    Marker Score: 3537.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.38
    Marker Score: 5966
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.37
    Marker Score: 919
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.36
    Marker Score: 2665
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.34
    Marker Score: 3511
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.34
    Marker Score: 764
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.34
    Marker Score: 969
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.34
    Marker Score: 435
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.33
    Marker Score: 768
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.33
    Marker Score: 319
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.31
    Marker Score: 347
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.29
    Marker Score: 1865
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.27
    Marker Score: 820
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.27
    Marker Score: 758
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.27
    Marker Score: 1126
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.26
    Marker Score: 8204
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.26
    Marker Score: 1466
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.25
    Marker Score: 66184
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.25
    Marker Score: 659
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.24
    Marker Score: 848
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.24
    Marker Score: 1103.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.23
    Marker Score: 1104
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.23
    Marker Score: 1688
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.22
    Marker Score: 716
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.22
    Marker Score: 286
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.22
    Marker Score: 433
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.22
    Marker Score: 5222
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.22
    Marker Score: 1308
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.21
    Marker Score: 1230
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2
    Marker Score: 2402
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.2
    Marker Score: 9357
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.2
    Marker Score: 296
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.2
    Marker Score: 3097
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.19
    Marker Score: 1078
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.19
    Marker Score: 1287
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.19
    Marker Score: 726
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.19
    Marker Score: 344
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.18
    Marker Score: 1574
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.18
    Marker Score: 552
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.18
    Marker Score: 861
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.18
    Marker Score: 281
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.17
    Marker Score: 507
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.16
    Marker Score: 642
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.16
    Marker Score: 779
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.16
    Marker Score: 328
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.15
    Marker Score: 285
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.14
    Marker Score: 257
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.14
    Marker Score: 1659
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.14
    Marker Score: 1240.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.14
    Marker Score: 1216
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.14
    Marker Score: 4723
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.14
    Marker Score: 290
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.14
    Marker Score: 1466
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.13
    Marker Score: 927
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.13
    Marker Score: 9787
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.13
    Marker Score: 1004
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.12
    Marker Score: 17947
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 1.12
    Marker Score: 292.5

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Other Information

**Key characteristics:** * CASP4 is a transmembrane protein with a conserved cysteine-rich catalytic domain. * It is a key regulator of apoptosis, promoting the death of cells through various pathways. * CASP4 is involved in both intrinsic and extrinsic apoptotic pathways. **Pathways and functions:** * CASP4 is a key initiator of the intrinsic pathway of apoptosis. * It directly cleaves the Bid protein, leading to mitochondrial outer membrane permeabilization and cell death. * It also plays a role in the extrinsic pathway of apoptosis, where it is activated by various stimuli, including cytokines and the binding of its ligands to cell surface receptors. * CASP4 is also involved in the regulation of programmed cell death, senescence, and other forms of cell death. **Clinical significance:** * Mutations in CASP4 have been linked to several human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. * Caspase-4 inhibitors are being investigated as potential therapeutics for these diseases, as they can prevent cell death and promote tumor growth. **Additional notes:** * CASP4 is a highly conserved protein with homologs in other species. * It is a ubiquitin-dependent protein that is targeted for degradation by the proteasome. * It is a key regulator of inflammation, as it is expressed in immune cells and is involved in the regulation of immune responses.

Genular Protein ID: 1683427698

Symbol: CASP4_HUMAN

Name: Caspase-4 subunit p10

UniProtKB Accession Codes:

P49662 A2NHL8 A2NHL9 A2NHM0 B3KPZ9 B4DJH5 B4E2D2 O95601 Q7KYX7 Q9UG96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 19 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7743998

Title: A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

PubMed ID: 7743998

DOI: 10.1002/j.1460-2075.1995.tb07183.x

PubMed ID: 7797592

Title: Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.

PubMed ID: 7797592

DOI: 10.1074/jbc.270.26.15870

PubMed ID: 7797510

Title: Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.

PubMed ID: 7797510

DOI: 10.1074/jbc.270.25.15250

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 10986288

Title: Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.

PubMed ID: 10986288

DOI: 10.1074/jbc.m007255200

PubMed ID: 15123740

Title: Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.

PubMed ID: 15123740

DOI: 10.1083/jcb.200310015

PubMed ID: 15326478

Title: A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

PubMed ID: 15326478

DOI: 10.1038/sj.onc.1208036

PubMed ID: 16893518

Title: Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants.

PubMed ID: 16893518

DOI: 10.1016/j.bbrc.2006.07.104

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18511561

Title: A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.

PubMed ID: 18511561

DOI: 10.1073/pnas.0802726105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22246630

Title: Caspase-4 is required for activation of inflammasomes.

PubMed ID: 22246630

DOI: 10.4049/jimmunol.1101620

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23661706

Title: Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis.

PubMed ID: 23661706

DOI: 10.1074/jbc.m113.458836

PubMed ID: 23516580

Title: The E. coli effector protein NleF is a caspase inhibitor.

PubMed ID: 23516580

DOI: 10.1371/journal.pone.0058937

PubMed ID: 25121752

Title: Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.

PubMed ID: 25121752

DOI: 10.1016/j.chom.2014.07.002

PubMed ID: 24879791

Title: A critical role for human caspase-4 in endotoxin sensitivity.

PubMed ID: 24879791

DOI: 10.4049/jimmunol.1303424

PubMed ID: 25119034

Title: Inflammatory caspases are innate immune receptors for intracellular LPS.

PubMed ID: 25119034

DOI: 10.1038/nature13683

PubMed ID: 26174085

Title: Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.

PubMed ID: 26174085

DOI: 10.1002/eji.201545523

PubMed ID: 26173988

Title: NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

PubMed ID: 26173988

DOI: 10.1002/eji.201545655

PubMed ID: 26508369

Title: Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.

PubMed ID: 26508369

DOI: 10.1038/ncomms9761

PubMed ID: 26375003

Title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

PubMed ID: 26375003

DOI: 10.1038/nature15514

PubMed ID: 25695505

Title: NF-kappaB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.

PubMed ID: 25695505

DOI: 10.1371/journal.pone.0117953

PubMed ID: 25964352

Title: Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.

PubMed ID: 25964352

DOI: 10.1073/pnas.1421699112

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 29077095

Title: Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.

PubMed ID: 29077095

DOI: 10.1038/cdd.2017.167

PubMed ID: 29520027

Title: The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

PubMed ID: 29520027

DOI: 10.1038/s41467-018-03409-3

PubMed ID: 31268602

Title: Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.

PubMed ID: 31268602

DOI: 10.15252/embj.2018100926

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 33377178

Title: NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.

PubMed ID: 33377178

DOI: 10.1111/iej.13469

PubMed ID: 34671164

Title: Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.

PubMed ID: 34671164

DOI: 10.1038/s41586-021-04020-1

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 37001519

Title: The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.

PubMed ID: 37001519

DOI: 10.1016/j.immuni.2023.03.003

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

Sequence Information:

  • Length: 377
  • Mass: 43262
  • Checksum: DC7CCEC6E9D483EB
  • Sequence:
    • MAEGNHRKKP LKVLESLGKD FLTGVLDNLV EQNVLNWKEE EKKKYYDAKT EDKVRVMADS 
MQEKQRMAGQ MLLQTFFNID QISPNKKAHP NMEAGPPESG ESTDALKLCP HEEFLRLCKE 
RAEEIYPIKE RNNRTRLALI ICNTEFDHLP PRNGADFDIT GMKELLEGLD YSVDVEENLT 
ARDMESALRA FATRPEHKSS DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN 
RNCLSLKDKP KVIIVQACRG ANRGELWVRD SPASLEVASS QSSENLEEDA VYKTHVEKDF 
IAFCSSTPHN VSWRDSTMGS IFITQLITCF QKYSWCCHLE EVFRKVQQSF ETPRAKAQMP 
TIERLSMTRY FYLFPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.