Gene ARHGDIB - ENSG00000111348 | NCBI Gene ID: 397

Details for: ARHGDIB

Gene ID: 397

Symbol: ARHGDIB

Ensembl ID: ENSG00000111348

Description: Rho GDP dissociation inhibitor beta

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac3 gtpase cycle
(R-HSA-9013423)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rhoh gtpase cycle
(R-HSA-9013407)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cellular response to redox state
(GO:0071461)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Gtpase activator activity
(GO:0005096)
Gtpase activity
(GO:0003924)
Membrane
(GO:0016020)
Negative regulation of trophoblast cell migration
(GO:1901164)
Protein binding
(GO:0005515)
Regulation of rho protein signal transduction
(GO:0035023)
Rho gdp-dissociation inhibitor activity
(GO:0005094)
Rho protein signal transduction
(GO:0007266)
Small gtpase binding
(GO:0031267)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.71
Marker Score: 5062
Cell Name: mature T cell (CL0002419)
Fold Change: 5.17
Marker Score: 51156
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.76
Marker Score: 13887
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.72
Marker Score: 14882
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.49
Marker Score: 237200
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.25
Marker Score: 11730
Cell Name: blood cell (CL0000081)
Fold Change: 4.19
Marker Score: 48691
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.17
Marker Score: 4030
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.11
Marker Score: 11519
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.08
Marker Score: 6997
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.04
Marker Score: 17328
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.01
Marker Score: 224283
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.93
Marker Score: 9577
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.89
Marker Score: 4319
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.86
Marker Score: 2799
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.86
Marker Score: 5681
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.74
Marker Score: 2190
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.66
Marker Score: 3081
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.64
Marker Score: 3425
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.62
Marker Score: 3216
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.6
Marker Score: 1852
Cell Name: naive T cell (CL0000898)
Fold Change: 3.59
Marker Score: 2315
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.58
Marker Score: 2176
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.55
Marker Score: 6351
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.52
Marker Score: 3471
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.4
Marker Score: 1874
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.39
Marker Score: 2974
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.37
Marker Score: 3981.5
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.35
Marker Score: 8093
Cell Name: basophil (CL0000767)
Fold Change: 3.34
Marker Score: 1588
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.31
Marker Score: 3099
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.3
Marker Score: 6911
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.29
Marker Score: 1645
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.29
Marker Score: 3765.5
Cell Name: centroblast (CL0009112)
Fold Change: 3.28
Marker Score: 1618
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.26
Marker Score: 6355
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.26
Marker Score: 4500
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.25
Marker Score: 2549
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.19
Marker Score: 4515
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.16
Marker Score: 9374
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.15
Marker Score: 1360
Cell Name: naive B cell (CL0000788)
Fold Change: 3.11
Marker Score: 2775
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.1
Marker Score: 2242
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 3.09
Marker Score: 6053
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.06
Marker Score: 1068
Cell Name: B-1 B cell (CL0000819)
Fold Change: 3.03
Marker Score: 5290
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3
Marker Score: 924
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3
Marker Score: 30368
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3
Marker Score: 974
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.99
Marker Score: 2193
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.98
Marker Score: 1832
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.96
Marker Score: 18940
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.95
Marker Score: 784
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.95
Marker Score: 1776
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.93
Marker Score: 909
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.93
Marker Score: 1685
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.9
Marker Score: 2903.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.88
Marker Score: 11796
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.88
Marker Score: 947
Cell Name: memory B cell (CL0000787)
Fold Change: 2.88
Marker Score: 2175.5
Cell Name: memory T cell (CL0000813)
Fold Change: 2.87
Marker Score: 1232
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.84
Marker Score: 1189
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.84
Marker Score: 7061.5
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.82
Marker Score: 999
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.81
Marker Score: 2036
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.8
Marker Score: 3101
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.77
Marker Score: 6245
Cell Name: ILC1, human (CL0001077)
Fold Change: 2.73
Marker Score: 691
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.72
Marker Score: 1109
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.71
Marker Score: 595
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.68
Marker Score: 6957.5
Cell Name: immature B cell (CL0000816)
Fold Change: 2.68
Marker Score: 1772
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.61
Marker Score: 2137.5
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.55
Marker Score: 2758
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.55
Marker Score: 2120
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.54
Marker Score: 65177
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.54
Marker Score: 2558
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.51
Marker Score: 1472
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.48
Marker Score: 2103
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 2.45
Marker Score: 854
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.45
Marker Score: 1853
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.44
Marker Score: 741
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 2.38
Marker Score: 1168
Cell Name: Unknown (CL0000548)
Fold Change: 2.36
Marker Score: 1717
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.34
Marker Score: 6359
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 2.32
Marker Score: 813
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.3
Marker Score: 1264
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.29
Marker Score: 5826
Cell Name: B-1b B cell (CL0000821)
Fold Change: 2.27
Marker Score: 523
Cell Name: granulocyte (CL0000094)
Fold Change: 2.27
Marker Score: 1017
Cell Name: centrocyte (CL0009111)
Fold Change: 2.24
Marker Score: 534
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 2.22
Marker Score: 712
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 2.19
Marker Score: 3558
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.19
Marker Score: 2281
Cell Name: pro-B cell (CL0000826)
Fold Change: 2.19
Marker Score: 2109
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 2.18
Marker Score: 494
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.18
Marker Score: 1923
Cell Name: promyelocyte (CL0000836)
Fold Change: 2.17
Marker Score: 1074
Cell Name: myelocyte (CL0002193)
Fold Change: 2.17
Marker Score: 937
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.15
Marker Score: 11316

Hover over a box to see details here...

**Key characteristics:** * ARHGDIB is a protein with a molecular weight of approximately 150 kDa. * It is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of the Cdc42 gtpase cycle, a signaling pathway that is involved in cell cycle progression. * It also regulates the activity of other GTPases, including Rac1, Rac3, and Rhoa gtases. **Pathways and functions:** * ARHGDIB inhibits the activity of Rho GTPases by binding to their GTP-bound form and blocking their interaction with the GTP. * This prevents the activation of downstream signaling pathways that are dependent on Rho GTPases. * By inhibiting Rho GTPases, ARHGDIB promotes cell cycle progression and prevents cell cycle arrest or apoptosis. * It is involved in the regulation of cell growth, differentiation, and apoptosis. **Clinical significance:** * Mutations in ARHGDIB have been linked to several human diseases, including cancer and autoimmune disorders. * As an anti-cancer drug, ARHGDIB is being investigated as a potential therapeutic agent. * By targeting ARHGDIB, it is possible to inhibit Rho GTPase activity and potentially inhibit cancer cell growth. **Additional information:** * ARHGDIB is a member of the Rho GDP dissociation inhibitor (RGD) family of proteins. * It is expressed in a variety of cell types, including hematopoietic stem cells, immune cells, and cancer cells. * It is a highly conserved protein that is found in mammals.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Rho GDP-dissociation inhibitor 2

Genular Protein ID: 2665148150

Symbol: GDIR2_HUMAN

Name: Rho GDP-dissociation inhibitor 2

UniProtKB Accession Codes:

P52566 B5BU79

Database IDs:

Citations:

PubMed ID: 8356058

Title: Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

PubMed ID: 8356058

DOI: 10.1073/pnas.90.16.7568

PubMed ID: 8262133

Title: Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.

PubMed ID: 8262133

DOI: 10.1006/excr.1993.1298

PubMed ID: 8434008

Title: cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.

PubMed ID: 8434008

DOI: 10.1073/pnas.90.4.1479

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2226408

Title: Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database.

PubMed ID: 2226408

DOI: 10.1002/elps.1150110702

PubMed ID: 7512369

Title: Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.

PubMed ID: 7512369

DOI: 10.1002/gcc.2870080408

PubMed ID: 10802295

Title: Cloning of bovine low molecular weight GTPases (Rac1 and Rac2) and Rho GDP-dissociation inhibitor 2 (D4-GDI).

PubMed ID: 10802295

DOI: 10.1016/s0165-2427(00)00176-8

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10655614

Title: The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

PubMed ID: 10655614

DOI: 10.1038/72392

Sequence Information:

Length: 201
Mass: 22988
Checksum: F1E840134F643E5F
Sequence:

MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT 
DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV 
SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPVE EAPKGMLARG TYHNKSFFTD 
DDKQDHLSWE WNLSIKKEWT E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ARHGDIB

Associated with

Cells (max top 100)

Other Information

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. PubMed ID: 8356058

Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. PubMed ID: 8262133

cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. PubMed ID: 8434008

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database. PubMed ID: 2226408

Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. PubMed ID: 7512369

Cloning of bovine low molecular weight GTPases (Rac1 and Rac2) and Rho GDP-dissociation inhibitor 2 (D4-GDI). PubMed ID: 10802295

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. PubMed ID: 20400958

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. PubMed ID: 10655614