Details for: ARHGDIB

Gene ID: 397

Symbol: ARHGDIB

Ensembl ID: ENSG00000111348

Description: Rho GDP dissociation inhibitor beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.7362
    Cell Significance Index: -43.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 165.4215
    Cell Significance Index: -68.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 136.8138
    Cell Significance Index: -70.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.5587
    Cell Significance Index: -55.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.2775
    Cell Significance Index: -55.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.6177
    Cell Significance Index: -43.9200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 27.8530
    Cell Significance Index: 74.6200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 25.4065
    Cell Significance Index: 59.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.1315
    Cell Significance Index: -55.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5345
    Cell Significance Index: -31.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8990
    Cell Significance Index: -50.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 10.7464
    Cell Significance Index: 315.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.2077
    Cell Significance Index: 151.7000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 6.6489
    Cell Significance Index: 44.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.5465
    Cell Significance Index: 422.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.3853
    Cell Significance Index: 753.0200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.5517
    Cell Significance Index: 35.4400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 5.4301
    Cell Significance Index: 22.6000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.9849
    Cell Significance Index: 12.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.8064
    Cell Significance Index: 95.1500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.9747
    Cell Significance Index: 12.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7212
    Cell Significance Index: 128.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6979
    Cell Significance Index: 36.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6674
    Cell Significance Index: 15.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3450
    Cell Significance Index: 15.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0472
    Cell Significance Index: 199.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9416
    Cell Significance Index: 121.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7548
    Cell Significance Index: 92.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5948
    Cell Significance Index: 58.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5904
    Cell Significance Index: 533.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4445
    Cell Significance Index: 80.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3064
    Cell Significance Index: 5.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2933
    Cell Significance Index: 47.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2170
    Cell Significance Index: 11.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2115
    Cell Significance Index: 9.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1940
    Cell Significance Index: 22.6100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1339
    Cell Significance Index: 0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1022
    Cell Significance Index: 77.3400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0652
    Cell Significance Index: 0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0607
    Cell Significance Index: 26.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0388
    Cell Significance Index: 3.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0172
    Cell Significance Index: 0.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0023
    Cell Significance Index: -0.2500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.0123
    Cell Significance Index: -0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0242
    Cell Significance Index: -0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0248
    Cell Significance Index: -46.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0334
    Cell Significance Index: -61.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0343
    Cell Significance Index: -25.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0365
    Cell Significance Index: -19.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0398
    Cell Significance Index: -1.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0398
    Cell Significance Index: -61.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0453
    Cell Significance Index: -61.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0549
    Cell Significance Index: -34.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0551
    Cell Significance Index: -2.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0632
    Cell Significance Index: -35.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0978
    Cell Significance Index: -71.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1014
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1035
    Cell Significance Index: -17.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1113
    Cell Significance Index: -70.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1423
    Cell Significance Index: -51.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1456
    Cell Significance Index: -66.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1563
    Cell Significance Index: -44.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1572
    Cell Significance Index: -7.9400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1618
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1623
    Cell Significance Index: -34.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1666
    Cell Significance Index: -22.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1869
    Cell Significance Index: -5.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1964
    Cell Significance Index: -38.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2169
    Cell Significance Index: -15.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2305
    Cell Significance Index: -46.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2361
    Cell Significance Index: -10.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2420
    Cell Significance Index: -9.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3131
    Cell Significance Index: -40.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3319
    Cell Significance Index: -22.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4025
    Cell Significance Index: -45.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4829
    Cell Significance Index: -50.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4835
    Cell Significance Index: -55.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4860
    Cell Significance Index: -70.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5905
    Cell Significance Index: -12.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6059
    Cell Significance Index: -37.1500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.6193
    Cell Significance Index: -6.2100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6420
    Cell Significance Index: -9.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6802
    Cell Significance Index: -52.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7468
    Cell Significance Index: -23.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8141
    Cell Significance Index: -54.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9137
    Cell Significance Index: -72.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9212
    Cell Significance Index: -58.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9708
    Cell Significance Index: -59.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9987
    Cell Significance Index: -56.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0206
    Cell Significance Index: -27.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0361
    Cell Significance Index: -54.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1102
    Cell Significance Index: -25.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1333
    Cell Significance Index: -24.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.1613
    Cell Significance Index: -50.5000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -1.2179
    Cell Significance Index: -8.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2310
    Cell Significance Index: -54.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2584
    Cell Significance Index: -10.5700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -1.2645
    Cell Significance Index: -9.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2775
    Cell Significance Index: -17.4300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.2777
    Cell Significance Index: -21.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARHGDIB is a small GTPase-binding protein that specifically interacts with Rho GTPases, including RhoA, RhoB, RhoC, and Rac1. It functions as a GDP-dissociation inhibitor, which means it promotes the dissociation of GDP from the Rho GTPases, allowing them to interact with downstream effectors. This interaction is crucial for regulating the activity of Rho GTPases, which are involved in various cellular processes, including cytoskeleton reorganization, cell migration, and signaling. ARHGDIB is also involved in the regulation of trophoblast cell migration and has been implicated in the pathogenesis of certain diseases, including cancer and autoimmune disorders. **Pathways and Functions** ARHGDIB is involved in several signaling pathways, including: 1. **Cdc42 GTPase Cycle**: ARHGDIB regulates the activity of Cdc42, a member of the Rho GTPase family, which is involved in cell migration, cytoskeleton reorganization, and cell cycle progression. 2. **Rac1 GTPase Cycle**: ARHGDIB modulates the activity of Rac1, which is involved in cell signaling, cytoskeleton reorganization, and cell migration. 3. **Rho GTPase Cycle**: ARHGDIB regulates the activity of Rho GTPases, which are involved in cell migration, cytoskeleton reorganization, and cell signaling. 4. **Regulation of Rho Protein Signal Transduction**: ARHGDIB modulates the activity of Rho GTPases, which are involved in the regulation of various cellular processes, including cell migration, cytoskeleton reorganization, and cell signaling. **Clinical Significance** Dysregulation of ARHGDIB has been implicated in various diseases, including: 1. **Cancer**: ARHGDIB has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. Its dysregulation may contribute to cancer progression and metastasis. 2. **Autoimmune Disorders**: ARHGDIB has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. Its dysregulation may contribute to the development of these diseases. 3. **Immune System Development**: ARHGDIB is highly expressed in hematopoietic stem cells and other immune cells, suggesting its importance in immune system development and function. In conclusion, ARHGDIB is a critical gene involved in various cellular processes, including cytoskeleton regulation, cell migration, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders. Further research is needed to fully understand the role of ARHGDIB in human disease and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 2665148150

Symbol: GDIR2_HUMAN

Name: Rho GDP-dissociation inhibitor 2

UniProtKB Accession Codes:

P52566 B5BU79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8356058

Title: Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

PubMed ID: 8356058

DOI: 10.1073/pnas.90.16.7568

PubMed ID: 8262133

Title: Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.

PubMed ID: 8262133

DOI: 10.1006/excr.1993.1298

PubMed ID: 8434008

Title: cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.

PubMed ID: 8434008

DOI: 10.1073/pnas.90.4.1479

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2226408

Title: Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database.

PubMed ID: 2226408

DOI: 10.1002/elps.1150110702

PubMed ID: 7512369

Title: Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.

PubMed ID: 7512369

DOI: 10.1002/gcc.2870080408

PubMed ID: 10802295

Title: Cloning of bovine low molecular weight GTPases (Rac1 and Rac2) and Rho GDP-dissociation inhibitor 2 (D4-GDI).

PubMed ID: 10802295

DOI: 10.1016/s0165-2427(00)00176-8

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10655614

Title: The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

PubMed ID: 10655614

DOI: 10.1038/72392

Sequence Information:

  • Length: 201
  • Mass: 22988
  • Checksum: F1E840134F643E5F
  • Sequence:
    • MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT 
DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV 
SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPVE EAPKGMLARG TYHNKSFFTD 
DDKQDHLSWE WNLSIKKEWT E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.