Details for: RHOH

Gene ID: 399

Symbol: RHOH

Ensembl ID: ENSG00000168421

Description: ras homolog family member H

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3
    Marker Score: 2954
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.92
    Marker Score: 6123
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.86
    Marker Score: 2165
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.77
    Marker Score: 1686
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.76
    Marker Score: 1359
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.65
    Marker Score: 7428
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.59
    Marker Score: 25660
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.56
    Marker Score: 135196
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.44
    Marker Score: 7233
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.3
    Marker Score: 6354
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.28
    Marker Score: 2744
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.28
    Marker Score: 1084
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.26
    Marker Score: 1361
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.24
    Marker Score: 794
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.22
    Marker Score: 1109
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.21
    Marker Score: 2070
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.21
    Marker Score: 5393
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.21
    Marker Score: 9475
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.18
    Marker Score: 3795
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.14
    Marker Score: 1257
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.06
    Marker Score: 3686
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.04
    Marker Score: 1175
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.03
    Marker Score: 1711
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.96
    Marker Score: 8031
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.94
    Marker Score: 998
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.94
    Marker Score: 3805
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.94
    Marker Score: 1732
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.86
    Marker Score: 2012
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.84
    Marker Score: 1774
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.82
    Marker Score: 783
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.81
    Marker Score: 1891
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.81
    Marker Score: 1304.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.8
    Marker Score: 4055
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.79
    Marker Score: 1314
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.79
    Marker Score: 3070
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.79
    Marker Score: 1296
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.78
    Marker Score: 553
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.78
    Marker Score: 424
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.78
    Marker Score: 541
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.78
    Marker Score: 410
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.77
    Marker Score: 5574
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.75
    Marker Score: 1940
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.75
    Marker Score: 4748
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.73
    Marker Score: 1631
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.7
    Marker Score: 19756.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.69
    Marker Score: 1279.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.67
    Marker Score: 1806
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.66
    Marker Score: 1413
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.65
    Marker Score: 10568
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.55
    Marker Score: 412
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.5
    Marker Score: 963
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.49
    Marker Score: 2115
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.49
    Marker Score: 1168
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169406.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.42
    Marker Score: 1960
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.42
    Marker Score: 1427
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.4
    Marker Score: 505
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.37
    Marker Score: 1518
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.36
    Marker Score: 1211
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.36
    Marker Score: 667
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.35
    Marker Score: 830
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.34
    Marker Score: 678
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.34
    Marker Score: 466
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.31
    Marker Score: 1084
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.3
    Marker Score: 864
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.3
    Marker Score: 783
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.26
    Marker Score: 917.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.26
    Marker Score: 322
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.25
    Marker Score: 437
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.24
    Marker Score: 3606
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.22
    Marker Score: 829
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.22
    Marker Score: 1075
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.21
    Marker Score: 1027
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.17
    Marker Score: 856
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.15
    Marker Score: 1877
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.15
    Marker Score: 1098
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.15
    Marker Score: 840
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.14
    Marker Score: 668
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2148
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.13
    Marker Score: 820
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4746
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.12
    Marker Score: 247
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.12
    Marker Score: 11381
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.11
    Marker Score: 979
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.1
    Marker Score: 905
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.09
    Marker Score: 1600
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.05
    Marker Score: 342
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.04
    Marker Score: 1135
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.04
    Marker Score: 363
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.03
    Marker Score: 701.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.03
    Marker Score: 692
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1
    Marker Score: 448
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71721
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1
    Marker Score: 2583
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47946
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.97
    Marker Score: 300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.95
    Marker Score: 1230

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Other Information

**Key characteristics:** * RHOH is a member of the Rho GTPase family, which are a large family of GTPases that regulate various cellular processes. * It is expressed in a wide range of cell types, including immune cells, endothelial cells, and cancer cells. * RHOH is a key regulator of cell migration, as it is required for the assembly and stability of cell adhesion complexes. * It is also involved in the regulation of cell signaling, as it regulates the activation of various signaling pathways. **Pathways and functions:** * RHOH is involved in the organization of the actin filament network, which is a complex network of actin filaments that plays a critical role in cell migration, adhesion, and signaling. * It is a key regulator of cell migration, as it is required for the assembly and stability of cell adhesion complexes. * It is also involved in the regulation of cell signaling, as it regulates the activation of various signaling pathways. * RHOH is also involved in the regulation of immune responses, as it is expressed in immune cells and is required for the activation of immune responses. **Clinical significance:** * Mutations in the RHOH gene have been linked to several human diseases, including cancer and autoimmune disorders. * RHOH is a potential target for cancer therapy, as it can be used to inhibit the growth of cancer cells. * Inhibition of RHOH has been shown to inhibit cancer cell growth and metastasis.

Genular Protein ID: 2352740373

Symbol: RHOH_HUMAN

Name: Rho-related GTP-binding protein RhoH

UniProtKB Accession Codes:

Q15669

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 14 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 15 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7784061

Title: TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.

PubMed ID: 7784061

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11809807

Title: The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.

PubMed ID: 11809807

DOI: 10.1128/mcb.22.4.1158-1171.2002

PubMed ID: 17064668

Title: Multiple Rho proteins regulate the subcellular targeting of PAK5.

PubMed ID: 17064668

DOI: 10.1016/j.bbrc.2006.09.172

PubMed ID: 19414807

Title: RhoH/TTF negatively regulates leukotriene production in neutrophils.

PubMed ID: 19414807

DOI: 10.4049/jimmunol.0803846

PubMed ID: 22850876

Title: Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.

PubMed ID: 22850876

DOI: 10.1172/jci62949

Sequence Information:

  • Length: 191
  • Mass: 21331
  • Checksum: C5BF8929AD1E59D0
  • Sequence:
    • MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA 
GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVATQTDQ 
REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR 
RLFSINECKI F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.