Details for: RHOH

Gene ID: 399

Symbol: RHOH

Ensembl ID: ENSG00000168421

Description: ras homolog family member H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.2473
    Cell Significance Index: -10.4600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 23.4520
    Cell Significance Index: 54.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4188
    Cell Significance Index: -10.3800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 5.3660
    Cell Significance Index: 14.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9340
    Cell Significance Index: -8.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8028
    Cell Significance Index: -11.6800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.7880
    Cell Significance Index: 16.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 3.6271
    Cell Significance Index: -0.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.2756
    Cell Significance Index: 386.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9168
    Cell Significance Index: -11.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3477
    Cell Significance Index: 68.9500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.0556
    Cell Significance Index: 6.2700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.9398
    Cell Significance Index: 19.4500
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.8974
    Cell Significance Index: 5.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2815
    Cell Significance Index: 58.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1570
    Cell Significance Index: 74.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9091
    Cell Significance Index: 173.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7005
    Cell Significance Index: 69.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.6517
    Cell Significance Index: 5.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5788
    Cell Significance Index: 522.5700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.3868
    Cell Significance Index: 4.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3348
    Cell Significance Index: 54.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2733
    Cell Significance Index: 1.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2545
    Cell Significance Index: 4.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2492
    Cell Significance Index: 6.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2096
    Cell Significance Index: 22.8000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1192
    Cell Significance Index: 1.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1084
    Cell Significance Index: 21.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0852
    Cell Significance Index: 5.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0786
    Cell Significance Index: 5.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0540
    Cell Significance Index: 33.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0344
    Cell Significance Index: 0.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0268
    Cell Significance Index: 0.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0003
    Cell Significance Index: 0.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0022
    Cell Significance Index: -1.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0120
    Cell Significance Index: -4.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0174
    Cell Significance Index: -0.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0205
    Cell Significance Index: -11.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0239
    Cell Significance Index: -0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0246
    Cell Significance Index: -4.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0259
    Cell Significance Index: -16.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0261
    Cell Significance Index: -19.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0266
    Cell Significance Index: -5.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0268
    Cell Significance Index: -0.5800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0280
    Cell Significance Index: -0.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0289
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0298
    Cell Significance Index: -5.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0337
    Cell Significance Index: -15.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0431
    Cell Significance Index: -12.4200
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.0447
    Cell Significance Index: -0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0689
    Cell Significance Index: -12.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0757
    Cell Significance Index: -8.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0800
    Cell Significance Index: -10.9800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0801
    Cell Significance Index: -1.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0827
    Cell Significance Index: -8.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0831
    Cell Significance Index: -4.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0842
    Cell Significance Index: -10.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1008
    Cell Significance Index: -2.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1049
    Cell Significance Index: -10.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1060
    Cell Significance Index: -15.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1066
    Cell Significance Index: -12.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1069
    Cell Significance Index: -13.1400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1132
    Cell Significance Index: -1.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1193
    Cell Significance Index: -6.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1246
    Cell Significance Index: -5.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1252
    Cell Significance Index: -4.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1255
    Cell Significance Index: -16.2100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1283
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1392
    Cell Significance Index: -6.5400
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1499
    Cell Significance Index: -0.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1512
    Cell Significance Index: -11.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1606
    Cell Significance Index: -3.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1691
    Cell Significance Index: -11.3700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1820
    Cell Significance Index: -1.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1852
    Cell Significance Index: -1.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1934
    Cell Significance Index: -12.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2288
    Cell Significance Index: -12.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2339
    Cell Significance Index: -9.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2370
    Cell Significance Index: -12.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2393
    Cell Significance Index: -2.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2448
    Cell Significance Index: -10.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2526
    Cell Significance Index: -7.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2537
    Cell Significance Index: -11.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2560
    Cell Significance Index: -13.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2592
    Cell Significance Index: -15.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2915
    Cell Significance Index: -11.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2953
    Cell Significance Index: -2.8000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3030
    Cell Significance Index: -2.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3037
    Cell Significance Index: -10.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3095
    Cell Significance Index: -3.2100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3379
    Cell Significance Index: -3.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3467
    Cell Significance Index: -11.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTP-binding protein**: RhoH is a member of the Rho GTPase superfamily, characterized by its ability to bind and hydrolyze GTP. 2. **Regulation of actin filament organization**: RhoH plays a crucial role in regulating actin filament organization, which is essential for cell migration, adhesion, and signaling. 3. **Protein-protein interactions**: RhoH interacts with various proteins, including GTPase activators, GTPase inhibitors, and effector proteins, to regulate its activity and downstream signaling pathways. 4. **Signaling by Rho GTPases**: RhoH is involved in signaling by Rho GTPases, which is essential for regulating various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Rho GTPase cycle**: RhoH is part of the Rho GTPase cycle, which involves the continuous cycling between GTP-bound and GDP-bound states. 2. **Signaling by Rho GTPases**: RhoH is involved in signaling by Rho GTPases, which regulates various cellular processes, including cell proliferation, differentiation, and survival. 3. **Immunological synapse**: RhoH plays a crucial role in regulating the immunological synapse, which is essential for T cell activation and B cell maturation. 4. **Mast cell activation**: RhoH is involved in regulating mast cell activation, which is essential for allergic responses and anaphylaxis. 5. **T cell differentiation**: RhoH is required for T cell differentiation, which is essential for the development of functional T cells. **Clinical Significance:** 1. **Immunodeficiency disorders**: Mutations in the RHOH gene have been associated with immunodeficiency disorders, such as X-linked leukocyte adhesion deficiency (XLAD). 2. **Cancer**: RhoH is overexpressed in various cancers, including breast cancer, lung cancer, and colon cancer, and is associated with poor prognosis. 3. **Autoimmune diseases**: RhoH is involved in regulating immune responses and has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Infectious diseases**: RhoH is involved in regulating immune responses to infections and has been implicated in diseases such as HIV and tuberculosis. In conclusion, the RHOH gene plays a crucial role in regulating various cellular processes, including actin filament organization, cell signaling, and protein-protein interactions. Its dysregulation has been implicated in immunodeficiency disorders, cancer, autoimmune diseases, and infectious diseases, highlighting the importance of RhoH in maintaining immune homeostasis.

Genular Protein ID: 2352740373

Symbol: RHOH_HUMAN

Name: Rho-related GTP-binding protein RhoH

UniProtKB Accession Codes:

Q15669

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 14 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 15 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7784061

Title: TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.

PubMed ID: 7784061

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11809807

Title: The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.

PubMed ID: 11809807

DOI: 10.1128/mcb.22.4.1158-1171.2002

PubMed ID: 17064668

Title: Multiple Rho proteins regulate the subcellular targeting of PAK5.

PubMed ID: 17064668

DOI: 10.1016/j.bbrc.2006.09.172

PubMed ID: 19414807

Title: RhoH/TTF negatively regulates leukotriene production in neutrophils.

PubMed ID: 19414807

DOI: 10.4049/jimmunol.0803846

PubMed ID: 22850876

Title: Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.

PubMed ID: 22850876

DOI: 10.1172/jci62949

Sequence Information:

  • Length: 191
  • Mass: 21331
  • Checksum: C5BF8929AD1E59D0
  • Sequence:
    • MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA 
GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVATQTDQ 
REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR 
RLFSINECKI F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.