Details for: CASP1

Gene ID: 834

Symbol: CASP1

Ensembl ID: ENSG00000137752

Description: caspase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.4145
    Cell Significance Index: -17.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.2263
    Cell Significance Index: -11.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.9561
    Cell Significance Index: -18.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.7866
    Cell Significance Index: -20.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.4344
    Cell Significance Index: -19.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.5684
    Cell Significance Index: -19.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0719
    Cell Significance Index: -17.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.4045
    Cell Significance Index: 99.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2320
    Cell Significance Index: -16.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.6373
    Cell Significance Index: 320.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4551
    Cell Significance Index: -17.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6485
    Cell Significance Index: -7.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.8807
    Cell Significance Index: 172.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6403
    Cell Significance Index: 85.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3835
    Cell Significance Index: 1249.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2551
    Cell Significance Index: 36.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6671
    Cell Significance Index: 294.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6221
    Cell Significance Index: 16.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5790
    Cell Significance Index: 94.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4745
    Cell Significance Index: 11.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4739
    Cell Significance Index: 46.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4213
    Cell Significance Index: 3.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3997
    Cell Significance Index: 8.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3332
    Cell Significance Index: 9.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2774
    Cell Significance Index: 14.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2347
    Cell Significance Index: 16.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2230
    Cell Significance Index: 14.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1856
    Cell Significance Index: 22.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1781
    Cell Significance Index: 2.4300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1765
    Cell Significance Index: 1.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1716
    Cell Significance Index: 3.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1417
    Cell Significance Index: 25.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1113
    Cell Significance Index: 5.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1092
    Cell Significance Index: 20.7800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1001
    Cell Significance Index: 1.0100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0815
    Cell Significance Index: 1.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0643
    Cell Significance Index: 0.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0415
    Cell Significance Index: 5.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0234
    Cell Significance Index: 0.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0226
    Cell Significance Index: 2.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0192
    Cell Significance Index: 2.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0163
    Cell Significance Index: 0.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0071
    Cell Significance Index: -0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0092
    Cell Significance Index: -17.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0113
    Cell Significance Index: -0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0129
    Cell Significance Index: -19.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0154
    Cell Significance Index: -10.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0157
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0260
    Cell Significance Index: -19.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0310
    Cell Significance Index: -19.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0316
    Cell Significance Index: -17.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0347
    Cell Significance Index: -19.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0437
    Cell Significance Index: -19.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0461
    Cell Significance Index: -5.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0522
    Cell Significance Index: -18.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0579
    Cell Significance Index: -2.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0618
    Cell Significance Index: -2.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0626
    Cell Significance Index: -18.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0665
    Cell Significance Index: -3.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0715
    Cell Significance Index: -14.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0841
    Cell Significance Index: -2.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0863
    Cell Significance Index: -17.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0894
    Cell Significance Index: -1.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1032
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1123
    Cell Significance Index: -19.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1148
    Cell Significance Index: -13.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1166
    Cell Significance Index: -13.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1342
    Cell Significance Index: -19.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1593
    Cell Significance Index: -2.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1687
    Cell Significance Index: -17.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2231
    Cell Significance Index: -13.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2374
    Cell Significance Index: -18.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2420
    Cell Significance Index: -18.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2463
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2571
    Cell Significance Index: -20.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2896
    Cell Significance Index: -19.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3096
    Cell Significance Index: -19.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3348
    Cell Significance Index: -2.7300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3417
    Cell Significance Index: -5.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3452
    Cell Significance Index: -6.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3725
    Cell Significance Index: -19.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3832
    Cell Significance Index: -9.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3908
    Cell Significance Index: -7.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4051
    Cell Significance Index: -17.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4123
    Cell Significance Index: -17.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4134
    Cell Significance Index: -10.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4143
    Cell Significance Index: -6.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4181
    Cell Significance Index: -9.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4211
    Cell Significance Index: -15.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4340
    Cell Significance Index: -12.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4487
    Cell Significance Index: -7.5100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4511
    Cell Significance Index: -2.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.4513
    Cell Significance Index: -2.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4700
    Cell Significance Index: -11.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4709
    Cell Significance Index: -17.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -0.4965
    Cell Significance Index: 1.3300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5012
    Cell Significance Index: -7.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Inflammasome activation**: CASP1 is activated by the inflammasome complex, which recognizes and responds to pathogens, toxins, and other danger signals. 2. **Cytokine processing**: CASP1 cleaves and activates pro-inflammatory cytokines, such as IL-1β and IL-18, which are essential for the initiation and resolution of inflammatory responses. 3. **Pyroptosis**: CASP1 is involved in the regulation of pyroptosis, a form of programmed cell death that involves the formation of pores in the cell membrane, leading to cell lysis and the release of pro-inflammatory cytokines. 4. **Cellular localization**: CASP1 is primarily localized to the cytosol, where it interacts with the inflammasome complex and other signaling molecules. 5. **Regulation**: CASP1 is regulated by various cellular processes, including transcriptional regulation by TP53, a tumor suppressor protein, and post-translational modifications, such as ubiquitination and acetylation. **Pathways and Functions** 1. **Inflammasome complex assembly**: CASP1 is activated by the assembly of the inflammasome complex, which recognizes and responds to pathogens, toxins, and other danger signals. 2. **Cytokine signaling**: CASP1 cleaves and activates pro-inflammatory cytokines, such as IL-1β and IL-18, which are essential for the initiation and resolution of inflammatory responses. 3. **Pyroptosis**: CASP1 is involved in the regulation of pyroptosis, a form of programmed cell death that involves the formation of pores in the cell membrane, leading to cell lysis and the release of pro-inflammatory cytokines. 4. **Apoptotic process**: CASP1 is also involved in the regulation of apoptosis, a form of programmed cell death that involves the activation of caspase enzymes, leading to cell death. 5. **Immune system regulation**: CASP1 plays a crucial role in regulating the immune system, including the activation of immune cells, such as macrophages and dendritic cells, and the production of pro-inflammatory cytokines. **Clinical Significance** 1. **Inflammatory diseases**: CASP1 is implicated in various inflammatory diseases, including rheumatoid arthritis, lupus, and Crohn's disease. 2. **Infectious diseases**: CASP1 is involved in the regulation of immune responses to infectious diseases, such as bacterial and viral infections. 3. **Cancer**: CASP1 is also involved in the regulation of cancer, including the activation of cancer cells and the promotion of metastasis. 4. **Neurological disorders**: CASP1 is implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 5. **Immunodeficiency disorders**: CASP1 is involved in the regulation of immune responses in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, CASP1 is a crucial enzyme involved in the regulation of inflammatory responses and programmed cell death, and its dysregulation is implicated in various diseases, including inflammatory diseases, infectious diseases, cancer, and neurological disorders.

Genular Protein ID: 752667597

Symbol: CASP1_HUMAN

Name: Caspase-1

UniProtKB Accession Codes:

P29466 B5MDZ1 Q53EY6 Q6DMQ1 Q6GSS3 Q6PI75 Q9UCN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 1 EMBL 11 EMDB 2 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 5 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 10 RefSeq 7 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1574116

Title: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

PubMed ID: 1574116

DOI: 10.1038/356768a0

PubMed ID: 1373520

Title: Molecular cloning of the interleukin-1 beta converting enzyme.

PubMed ID: 1373520

DOI: 10.1126/science.1373520

PubMed ID: 7876192

Title: Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.

PubMed ID: 7876192

DOI: 10.1074/jbc.270.9.4312

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15498465

Title: Caspase-1 zeta, a new splice variant of caspase-1 gene.

PubMed ID: 15498465

DOI: 10.1016/j.ygeno.2004.06.005

PubMed ID: 1321594

Title: Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor.

PubMed ID: 1321594

DOI: 10.1016/0003-9861(92)90629-b

PubMed ID: 1339309

Title: Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.

PubMed ID: 1339309

DOI: 10.1016/0092-8674(92)90223-y

PubMed ID: 9334240

Title: Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.

PubMed ID: 9334240

DOI: 10.1074/jbc.272.42.26595

PubMed ID: 11051551

Title: ICEBERG: a novel inhibitor of interleukin-1beta generation.

PubMed ID: 11051551

DOI: 10.1016/s0092-8674(00)00108-2

PubMed ID: 15030775

Title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

PubMed ID: 15030775

DOI: 10.1016/s1074-7613(04)00046-9

PubMed ID: 15383541

Title: INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.

PubMed ID: 15383541

DOI: 10.1074/jbc.m407891200

PubMed ID: 15326478

Title: A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

PubMed ID: 15326478

DOI: 10.1038/sj.onc.1208036

PubMed ID: 16785446

Title: The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

PubMed ID: 16785446

DOI: 10.1073/pnas.0602081103

PubMed ID: 20197547

Title: Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

PubMed ID: 20197547

DOI: 10.1182/blood-2009-10-243444

PubMed ID: 20148899

Title: Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.

PubMed ID: 20148899

DOI: 10.1111/j.1462-5822.2010.01450.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 26375003

Title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

PubMed ID: 26375003

DOI: 10.1038/nature15514

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30065070

Title: Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.

PubMed ID: 30065070

DOI: 10.15252/embj.201899347

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 32051255

Title: Caspase-1 interdomain linker cleavage is required for pyroptosis.

PubMed ID: 32051255

DOI: 10.26508/lsa.202000664

PubMed ID: 37993714

Title: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

PubMed ID: 37993714

DOI: 10.1038/s41586-023-06742-w

PubMed ID: 8044845

Title: Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.

PubMed ID: 8044845

DOI: 10.1016/0092-8674(94)90303-4

PubMed ID: 9190289

Title: A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).

PubMed ID: 9190289

DOI: 10.1016/s1074-5521(97)90258-1

PubMed ID: 9987822

Title: Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.

PubMed ID: 9987822

DOI: 10.1248/cpb.47.11

PubMed ID: 15296730

Title: Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.

PubMed ID: 15296730

DOI: 10.1016/j.str.2004.05.010

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

PubMed ID: 32553275

Title: Caspase-1 engages full-length Gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage.

PubMed ID: 32553275

DOI: 10.1016/j.immuni.2020.06.007

PubMed ID: 33420033

Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.

PubMed ID: 33420033

DOI: 10.1038/s41467-020-20320-y

Sequence Information:

  • Length: 404
  • Mass: 45159
  • Checksum: ABF33CF33CC71584
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN 
PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT 
GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 
EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG 
VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY 
ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH

Genular Protein ID: 2653271366

Symbol: A8K257_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K257

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 9 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 383
  • Mass: 42860
  • Checksum: 59F188110BEA1571
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS AAPQAVQDNP AMPTSSGSEG NVKLCSLEEA 
QRIWKQKSAE IYPIMDKSSR TRLALIICNE EFDSIPRRTG AEVDITGMTM LLQNLGYSVD 
VKKNLTASDM TTELEAFAHR PEHKTSDSTF LVFMSHGIRE GICGKKHSEQ VPDILQLNAI 
FNMLNTKNCP SLKDKPKVII IQACRGDSPG VVWFKDSVGA SGNLSLPTTE EFEDDAIKKA 
HIEKDFIAFC SSTPDNVSWR HPTMGSVFIG RLIEHMQEYA CSCDVEEIFR KVRFSFEQPD 
GRAQMPTTER VTLTRCFYLF PGH

Genular Protein ID: 2793292085

Symbol: A8K249_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K249

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 9 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 404
  • Mass: 45099
  • Checksum: B6584CE779D344C1
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN 
PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT 
GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 
EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG 
VSGNLSLPTT EESEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY 
ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.