Details for: CASP1

Gene ID: 834

Symbol: CASP1

Ensembl ID: ENSG00000137752

Description: caspase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.43
    Marker Score: 4147
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.69
    Marker Score: 150674
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.65
    Marker Score: 5156
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.33
    Marker Score: 1867
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.21
    Marker Score: 25673
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.12
    Marker Score: 5117
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.04
    Marker Score: 5088
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.84
    Marker Score: 1870
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.83
    Marker Score: 18172
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.78
    Marker Score: 45533
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.65
    Marker Score: 5222
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.61
    Marker Score: 1607.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.42
    Marker Score: 1371
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.39
    Marker Score: 524
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.39
    Marker Score: 763
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.27
    Marker Score: 11187
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.25
    Marker Score: 1109
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2
    Marker Score: 7688
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.16
    Marker Score: 2267
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.15
    Marker Score: 1014
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.15
    Marker Score: 1696
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.12
    Marker Score: 2895
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.12
    Marker Score: 5358
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.11
    Marker Score: 3066
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.1
    Marker Score: 249
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.08
    Marker Score: 2566
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.07
    Marker Score: 1941
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.06
    Marker Score: 2981
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.05
    Marker Score: 278
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.01
    Marker Score: 1159.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71701
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47931
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.97
    Marker Score: 819
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.97
    Marker Score: 235
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.97
    Marker Score: 1284
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.95
    Marker Score: 523
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.94
    Marker Score: 549
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.93
    Marker Score: 2723
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.93
    Marker Score: 534
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.93
    Marker Score: 1342
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.92
    Marker Score: 1610
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.91
    Marker Score: 1401
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.91
    Marker Score: 5518
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.91
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2707
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9
    Marker Score: 3694
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5114
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.9
    Marker Score: 990
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.89
    Marker Score: 3832
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.89
    Marker Score: 990
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.89
    Marker Score: 289
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.88
    Marker Score: 640
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.87
    Marker Score: 3631.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.87
    Marker Score: 45883
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5235
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.85
    Marker Score: 7289
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.84
    Marker Score: 787
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.84
    Marker Score: 290
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.83
    Marker Score: 2036
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.82
    Marker Score: 343
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.82
    Marker Score: 1065
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.82
    Marker Score: 1338
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8
    Marker Score: 1175
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.8
    Marker Score: 485
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.79
    Marker Score: 525
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.77
    Marker Score: 529
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.77
    Marker Score: 450
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.77
    Marker Score: 562
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.75
    Marker Score: 834
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.74
    Marker Score: 458
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.74
    Marker Score: 516
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.72
    Marker Score: 635
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.71
    Marker Score: 607
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.71
    Marker Score: 560
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.71
    Marker Score: 1806
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.71
    Marker Score: 976
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.7
    Marker Score: 315
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.7
    Marker Score: 216
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.69
    Marker Score: 242
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2892.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.69
    Marker Score: 248
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.68
    Marker Score: 295
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.68
    Marker Score: 1170
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.68
    Marker Score: 470
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.68
    Marker Score: 499
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.68
    Marker Score: 239
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.67
    Marker Score: 451
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.67
    Marker Score: 352
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.66
    Marker Score: 229

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Other Information

**Key characteristics:** * CASP1 is a serine protease that is expressed in high levels in myeloid and lymphoid cells. * It is a key regulator of inflammation and cell death. * It is activated by a variety of stimuli, including cytokines, growth factors, and cellular stress. * Activation of CASP1 leads to the cleavage of various substrates, including Bid, resulting in the activation of pro-apoptotic pathways. **Pathways and functions:** * CASP1 is involved in the regulation of innate immunity. It is expressed in myeloid and lymphoid cells, where it plays a key role in the activation of pro-inflammatory pathways. * It is also expressed in epithelial cells, where it is involved in the regulation of cell migration and inflammation. * CASP1 is a key regulator of cell death. It is activated by a variety of stimuli, including cytokines, growth factors, and cellular stress, and it leads to the cleavage of Bid, resulting in the activation of pro-apoptotic pathways. * CASP1 is also involved in the regulation of apoptosis in neurons. **Clinical significance:** * CASP1 mutations have been linked to a number of human diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. * Inhibition of CASP1 has been shown to be effective in protecting cells from death, and it is therefore being investigated as a potential therapeutic agent for cancer and other diseases. * CASP1 is a promising target for the development of new cancer therapies.

Genular Protein ID: 752667597

Symbol: CASP1_HUMAN

Name: Caspase-1

UniProtKB Accession Codes:

P29466 B5MDZ1 Q53EY6 Q6DMQ1 Q6GSS3 Q6PI75 Q9UCN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 1 EMBL 11 EMDB 1 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 38 PIR 5 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 10 RefSeq 7 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1574116

Title: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

PubMed ID: 1574116

DOI: 10.1038/356768a0

PubMed ID: 1373520

Title: Molecular cloning of the interleukin-1 beta converting enzyme.

PubMed ID: 1373520

DOI: 10.1126/science.1373520

PubMed ID: 7876192

Title: Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.

PubMed ID: 7876192

DOI: 10.1074/jbc.270.9.4312

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15498465

Title: Caspase-1 zeta, a new splice variant of caspase-1 gene.

PubMed ID: 15498465

DOI: 10.1016/j.ygeno.2004.06.005

PubMed ID: 1321594

Title: Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor.

PubMed ID: 1321594

DOI: 10.1016/0003-9861(92)90629-b

PubMed ID: 1339309

Title: Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.

PubMed ID: 1339309

DOI: 10.1016/0092-8674(92)90223-y

PubMed ID: 11051551

Title: ICEBERG: a novel inhibitor of interleukin-1beta generation.

PubMed ID: 11051551

DOI: 10.1016/s0092-8674(00)00108-2

PubMed ID: 15030775

Title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

PubMed ID: 15030775

DOI: 10.1016/s1074-7613(04)00046-9

PubMed ID: 15383541

Title: INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.

PubMed ID: 15383541

DOI: 10.1074/jbc.m407891200

PubMed ID: 15326478

Title: A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

PubMed ID: 15326478

DOI: 10.1038/sj.onc.1208036

PubMed ID: 16785446

Title: The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

PubMed ID: 16785446

DOI: 10.1073/pnas.0602081103

PubMed ID: 20197547

Title: Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

PubMed ID: 20197547

DOI: 10.1182/blood-2009-10-243444

PubMed ID: 20148899

Title: Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.

PubMed ID: 20148899

DOI: 10.1111/j.1462-5822.2010.01450.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 26375003

Title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

PubMed ID: 26375003

DOI: 10.1038/nature15514

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30065070

Title: Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.

PubMed ID: 30065070

DOI: 10.15252/embj.201899347

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 32051255

Title: Caspase-1 interdomain linker cleavage is required for pyroptosis.

PubMed ID: 32051255

DOI: 10.26508/lsa.202000664

PubMed ID: 8044845

Title: Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.

PubMed ID: 8044845

DOI: 10.1016/0092-8674(94)90303-4

PubMed ID: 9190289

Title: A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).

PubMed ID: 9190289

DOI: 10.1016/s1074-5521(97)90258-1

PubMed ID: 9987822

Title: Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.

PubMed ID: 9987822

DOI: 10.1248/cpb.47.11

PubMed ID: 15296730

Title: Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.

PubMed ID: 15296730

DOI: 10.1016/j.str.2004.05.010

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

PubMed ID: 32553275

Title: Caspase-1 engages full-length Gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage.

PubMed ID: 32553275

DOI: 10.1016/j.immuni.2020.06.007

PubMed ID: 33420033

Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.

PubMed ID: 33420033

DOI: 10.1038/s41467-020-20320-y

Sequence Information:

  • Length: 404
  • Mass: 45159
  • Checksum: ABF33CF33CC71584
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN 
PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT 
GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 
EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG 
VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY 
ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH

Genular Protein ID: 2793292085

Symbol: A8K249_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K249

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 10 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 404
  • Mass: 45099
  • Checksum: B6584CE779D344C1
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN 
PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT 
GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 
EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG 
VSGNLSLPTT EESEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY 
ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH

Genular Protein ID: 2653271366

Symbol: A8K257_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K257

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 10 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 383
  • Mass: 42860
  • Checksum: 59F188110BEA1571
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS AAPQAVQDNP AMPTSSGSEG NVKLCSLEEA 
QRIWKQKSAE IYPIMDKSSR TRLALIICNE EFDSIPRRTG AEVDITGMTM LLQNLGYSVD 
VKKNLTASDM TTELEAFAHR PEHKTSDSTF LVFMSHGIRE GICGKKHSEQ VPDILQLNAI 
FNMLNTKNCP SLKDKPKVII IQACRGDSPG VVWFKDSVGA SGNLSLPTTE EFEDDAIKKA 
HIEKDFIAFC SSTPDNVSWR HPTMGSVFIG RLIEHMQEYA CSCDVEEIFR KVRFSFEQPD 
GRAQMPTTER VTLTRCFYLF PGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.