Details for: CASP1

Gene ID: 834

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CASP1

Ensembl ID: ENSG00000137752

Description: caspase 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD14-low, CD16-positive monocyte CL0002396
    CSI 81.4
    rCSI 62.72%
    PRS 68.63
  • immature B cell CL0000816
    CSI 45.97
    rCSI 34.16%
    PRS 80.38
  • conventional dendritic cell CL0000990
    CSI 16.98
    rCSI 14.17%
    PRS 74.82
  • non-classical monocyte CL0000875
    CSI 11.88
    rCSI 19.04%
    PRS 85.42
  • myeloid leukocyte CL0000766
    CSI 11.3
    rCSI 10.43%
    PRS 69.11
  • Langerhans cell CL0000453
    CSI 11.04
    rCSI 16.86%
    PRS 81.85
  • dendritic cell, human CL0001056
    CSI 10.58
    rCSI 16.25%
    PRS 76.56
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 9.82
    rCSI 12.87%
    PRS 80.37
  • M cell of gut CL0000682
    CSI 9.29
    rCSI 9.87%
    PRS 75.87
  • granulocyte monocyte progenitor cell CL0000557
    CSI 8.94
    rCSI 7.74%
    PRS 72.13
  • transit amplifying cell of small intestine CL0009012
    CSI 8.52
    rCSI 37.41%
    PRS 80.15
  • mononuclear phagocyte CL0000113
    CSI 8.27
    rCSI 18.2%
    PRS 71.38
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 7.76
    rCSI 5.9%
    PRS 80.37
  • colon macrophage CL0009038
    CSI 7.33
    rCSI 33.84%
    PRS 84.11
  • transit amplifying cell CL0009010
    CSI 7.29
    rCSI 11.14%
    PRS 79.46
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 7.14
    rCSI 4.81%
    PRS 80.79
  • enterocyte CL0000584
    CSI 6.87
    rCSI 11.07%
    PRS 69.63
  • common dendritic progenitor CL0001029
    CSI 6.68
    rCSI 8.38%
    PRS 77.61
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 6.12
    rCSI 12.19%
    PRS 83.23
  • plasmablast CL0000980
    CSI 5.91
    rCSI 4.65%
    PRS 73.81
  • mature NK T cell CL0000814
    CSI 5.8
    rCSI 7.42%
    PRS 84.95
  • promonocyte CL0000559
    CSI 5.39
    rCSI 9.24%
    PRS 75.46
  • colonocyte CL1000347
    CSI 5.19
    rCSI 7.44%
    PRS 70.04
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 4.97
    rCSI 3.31%
    PRS 84.86
  • naive T cell CL0000898
    CSI 4.48
    rCSI 3.12%
    PRS 82.33
  • lung interstitial macrophage CL4033043
    CSI 4.26
    rCSI 9.57%
    PRS 83.04
  • intestine goblet cell CL0019031
    CSI 4.23
    rCSI 3.75%
    PRS 65.04
  • CD14-positive monocyte CL0001054
    CSI 4.19
    rCSI 5.22%
    PRS 77.95
  • Kupffer cell CL0000091
    CSI 4.15
    rCSI 9.49%
    PRS 67.67
  • plasmacytoid dendritic cell, human CL0001058
    CSI 4.09
    rCSI 2.86%
    PRS 70.19
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 4.04
    rCSI 24.46%
    PRS 83.97
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 3.89
    rCSI 3.54%
    PRS 81.38
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 3.87
    rCSI 19.42%
    PRS 79.87
  • double negative thymocyte CL0002489
    CSI 3.83
    rCSI 2.67%
    PRS 78.76
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.76
    rCSI 2.7%
    PRS 81.16
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 3.67
    rCSI 10.54%
    PRS 86.24
  • monocyte CL0000576
    CSI 3.67
    rCSI 6.64%
    PRS 78.79
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.66
    rCSI 4.01%
    PRS 71.03
  • activated type II NK T cell CL0000931
    CSI 3.6
    rCSI 4.05%
    PRS 83.24
  • dendritic cell CL0000451
    CSI 3.57
    rCSI 4.4%
    PRS 78
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 3.46
    rCSI 3.4%
    PRS 82.65
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.22
    rCSI 3.9%
    PRS 76.18
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.11
    rCSI 2.49%
    PRS 85.77
  • mature T cell CL0002419
    CSI 3.03
    rCSI 2.36%
    PRS 84.15
  • lung macrophage CL1001603
    CSI 2.97
    rCSI 6.63%
    PRS 75
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.95
    rCSI 7.96%
    PRS 73.83
  • alpha-beta T cell CL0000789
    CSI 2.95
    rCSI 3.46%
    PRS 82.78
  • alveolar macrophage CL0000583
    CSI 2.89
    rCSI 4.77%
    PRS 72.67
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.83
    rCSI 5.4%
    PRS 80.96
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.79
    rCSI 1.65%
    PRS 84.27
  • interstitial cell of Cajal CL0002088
    CSI 2.67
    rCSI 3.4%
    PRS 73.46
  • T-helper 17 cell CL0000899
    CSI 2.37
    rCSI 1.88%
    PRS 87.21
  • goblet cell CL0000160
    CSI 2.37
    rCSI 2.24%
    PRS 66.34
  • class switched memory B cell CL0000972
    CSI 2.12
    rCSI 1.59%
    PRS 82.78
  • inflammatory macrophage CL0000863
    CSI 1.99
    rCSI 3.41%
    PRS 87.64
  • fibroblast of lung CL0002553
    CSI 1.99
    rCSI 1.85%
    PRS 68
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 1.98
    rCSI 1.94%
    PRS 86.01
  • keratinocyte CL0000312
    CSI 1.96
    rCSI 1.64%
    PRS 71.01
  • enterocyte of epithelium of small intestine CL1000334
    CSI 1.86
    rCSI 28.74%
    PRS 81.43
  • hematopoietic stem cell CL0000037
    CSI 1.85
    rCSI 1.23%
    PRS 70.25
  • alternatively activated macrophage CL0000890
    CSI 1.85
    rCSI 2.32%
    PRS 78.7
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 1.83
    rCSI 2.85%
    PRS 88.45
  • intestinal epithelial cell CL0002563
    CSI 1.8
    rCSI 1.88%
    PRS 65.19
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.75
    rCSI 2.4%
    PRS 85.54
  • basal cell CL0000646
    CSI 1.7
    rCSI 2.28%
    PRS 67.19
  • common myeloid progenitor CL0000049
    CSI 1.65
    rCSI 1.34%
    PRS 69.15
  • elicited macrophage CL0000861
    CSI 1.63
    rCSI 1.49%
    PRS 76.36
  • Hofbauer cell CL3000001
    CSI 1.61
    rCSI 3.04%
    PRS 77.49
  • colon epithelial cell CL0011108
    CSI 1.59
    rCSI 1.67%
    PRS 63.99
  • mature alpha-beta T cell CL0000791
    CSI 1.59
    rCSI 5.74%
    PRS 85.7
  • duct epithelial cell CL0000068
    CSI 1.54
    rCSI 2.25%
    PRS 72.11
  • blood vessel endothelial cell CL0000071
    CSI 1.53
    rCSI 3.18%
    PRS 64.36
  • intermediate monocyte CL0002393
    CSI 1.52
    rCSI 2.29%
    PRS 72.2
  • transit amplifying cell of colon CL0009011
    CSI 1.51
    rCSI 1.77%
    PRS 69.35
  • type L enteroendocrine cell CL0002279
    CSI 1.49
    rCSI 2.79%
    PRS 79.96
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.48
    rCSI 1.8%
    PRS 52.15
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.36
    rCSI 2.33%
    PRS 83.76
  • glial cell CL0000125
    CSI 1.34
    rCSI 5.11%
    PRS 57.81
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.33
    rCSI 1.81%
    PRS 89.39
  • granulocyte CL0000094
    CSI 1.29
    rCSI 1.97%
    PRS 76.36
  • myeloid dendritic cell CL0000782
    CSI 1.2
    rCSI 1.73%
    PRS 82.51
  • promyelocyte CL0000836
    CSI 1.17
    rCSI 1.69%
    PRS 75.72
  • colon goblet cell CL0009039
    CSI 1.16
    rCSI 2.75%
    PRS 75.22
  • pulmonary artery endothelial cell CL1001568
    CSI 1.11
    rCSI 1.51%
    PRS 78.43
  • professional antigen presenting cell CL0000145
    CSI 1.06
    rCSI 3.67%
    PRS 86.41
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.06
    rCSI 1.26%
    PRS 85.49
  • mesenchymal cell CL0008019
    CSI 0.82
    rCSI 2.09%
    PRS 61.18
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.8
    rCSI 2.25%
    PRS 77.33
  • myeloid dendritic cell, human CL0001057
    CSI 0.61
    rCSI 3.41%
    PRS 86.88
  • pre-conventional dendritic cell CL0002010
    CSI 0.29
    rCSI 3.85%
    PRS 90.29

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CASP1](/details-gene/834), or Caspase-1, is a protein-coding gene located on chromosome 11q22.3. It encodes a well-characterized cysteine protease that functions as a critical initiator of inflammation. [CASP1](/details-gene/834) is best known as the interleukin-1 converting enzyme (ICE), responsible for the proteolytic cleavage and activation of the pro-inflammatory cytokines pro-interleukin-1β (pro-IL-1β) and pro-interleukin-18 (pro-IL-18) ([Link](https://doi.org/10.1126/science.1373520), [Link](https://doi.org/10.1038/356768a0)). Beyond cytokine processing, it is a key effector molecule in pyroptosis, a pro-inflammatory form of programmed cell death. **Overall**, expression data reveals that [CASP1](/details-gene/834) is a defining gene for cells of the myeloid lineage, particularly monocytes and dendritic cells, underscoring its central role in the innate immune response. Clinical associations for this gene are cataloged under OMIM entry [147678](https://omim.org/entry/147678). ## Cellular Roles and Expression Landscape The expression profile of [CASP1](/details-gene/834) firmly establishes its importance within the innate immune system, particularly in professional phagocytic and antigen-presenting cells. **Overall**, the gene shows the highest significance in the [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) subset (CSI: 81.40), suggesting it is a key functional component of these non-classical, inflammatory monocytes. High significance is also observed across the broader myeloid compartment, including in [conventional dendritic cell](/details-cell/CL0000990)s, [Langerhans cell](/details-cell/CL0000453)s, and other monocyte populations ([non-classical monocyte](/details-cell/CL0000875), [CD14-positive, CD16-positive monocyte](/details-cell/CL0002397)). This is consistent with the primary role of these cells in initiating inflammatory responses through pattern recognition and cytokine release. Interestingly, [CASP1](/details-gene/834) also demonstrates high significance in [immature B cell](/details-cell/CL0000816)s (CSI: 45.97), a cell type of the lymphoid lineage. This may indicate a role for inflammasome signaling during B cell development, selection, or initial activation that is distinct from its canonical function in myeloid cells. The gene's presence in [granulocyte monocyte progenitor cell](/details-cell/CL0000557)s suggests its expression is established early during myelopoiesis. The pronounced expression pattern within specific immune cell populations implies a highly specialized function, with likely low significance in non-hematopoietic tissues. ## Pathways and Molecular Function Functionally, [CASP1](/details-gene/834) is the central executioner of the inflammasome signaling pathway. This is extensively supported by its annotation in multiple Reactome pathways, including '[Inflammasomes](/details-pathway/R-HSA-622312)', '[The nlrp3 inflammasome](/details-pathway/R-HSA-844456)', and '[The aim2 inflammasome](/details-pathway/R-HSA-844615)'. Upon activation by these multi-protein complexes, [CASP1](/details-gene/834) utilizes its 'cysteine-type endopeptidase activity' ([GO:0004197](https://www.ebi.ac.uk/QuickGO/term/GO:0004197)) to perform two major functions. First, it is indispensable for '[Interleukin-1 processing](/details-pathway/R-HSA-448706)', a process critical for host defense against bacteria ([GO:0042742](https://www.ebi.ac.uk/QuickGO/term/GO:0042742)) and viruses ([GO:0051607](https://www.ebi.ac.uk/QuickGO/term/GO:0051607)). Its direct role is confirmed by annotations for 'positive regulation of interleukin-1 beta production' ([GO:0032731](https://www.ebi.ac.uk/QuickGO/term/GO:0032731)) and 'positive regulation of interleukin-18 production' ([GO:0032741](https://www.ebi.ac.uk/QuickGO/term/GO:0032741)). The initial characterization of [CASP1](/details-gene/834) as the enzyme required for IL-1β processing in monocytes highlights this core function ([Link](https://doi.org/10.1038/356768a0)). Second, it directly triggers cell death through '[Pyroptosis](/details-pathway/R-HSA-5620971)', a highly inflammatory form of regulated cell death detailed by the GO term 'pyroptotic inflammatory response' ([GO:0070269](https://www.ebi.ac.uk/QuickGO/term/GO:0070269)). This process involves the cleavage of gasdermin D, leading to pore formation in the plasma membrane and the release of cellular contents and cytokines. These functions place [CASP1](/details-gene/834) as a master regulator of the '[Innate immune system](/details-pathway/R-HSA-168249)' and a key player in the 'positive regulation of inflammatory response' ([GO:0050729](https://www.ebi.ac.uk/QuickGO/term/GO:0050729)). ## Research Directions The established role of [CASP1](/details-gene/834) in inflammation provides a foundation for investigating its nuanced functions in specific cell types and disease contexts. ### Proposed Hypotheses: 1. Given its exceptionally high CSI score in [CD14-low, CD16-positive monocyte](/details-cell/CL0002396)s, we hypothesize that [CASP1](/details-gene/834) activity is a primary determinant of the hyper-inflammatory potential of this monocyte subset, and that its activation threshold or downstream signaling differs significantly compared to classical monocytes, contributing to its unique role in chronic inflammatory diseases. 2. The high significance of [CASP1](/details-gene/834) in [immature B cell](/details-cell/CL0000816)s suggests a previously underappreciated role in B lymphocyte biology. We hypothesize that [CASP1](/details-gene/834) and inflammasome components participate in negative selection or tolerance induction by triggering pyroptosis in self-reactive immature B cells upon encountering autoantigens. ### Experimental Approach: To test the first hypothesis regarding the role of [CASP1](/details-gene/834) in non-classical monocyte function, a targeted genetic approach could be employed. Primary human monocytes could be isolated and differentiated *in vitro*. Using CRISPR-Cas9 ribonucleoprotein complexes, [CASP1](/details-gene/834) could be knocked out specifically in the CD16-positive monocyte population. Control and knockout cells would then be stimulated with various pathogen-associated molecular patterns (PAMPs), such as LPS or viral dsRNA. The functional consequences would be assessed by measuring the secretion of mature IL-1β and IL-18 via ELISA, quantifying pyroptotic cell death through LDH release assays and imaging flow cytometry for pore formation, and performing single-cell RNA sequencing to define the global transcriptional impact of [CASP1](/details-gene/834) loss on the inflammatory program of these cells. ### Therapeutic Potential: As a central mediator of inflammation and pyroptosis, [CASP1](/details-gene/834) is a highly attractive therapeutic target. **Inhibition**, rather than activation, is the primary strategy. Small molecule inhibitors of [CASP1](/details-gene/834) have been developed and could be beneficial in treating a range of autoinflammatory disorders, such as cryopyrin-associated periodic syndromes (CAPS), as well as more common inflammatory conditions like gout, atherosclerosis, and certain neurodegenerative diseases where NLRP3 inflammasome activation is implicated. However, a key challenge is balancing therapeutic efficacy with the risk of immunosuppression, as [CASP1](/details-gene/834) is vital for host defense. This makes the development of targeted delivery systems or drugs that modulate, rather than completely block, its activity a critical area of future research.

Genular Protein ID: 752667597

Symbol: CASP1_HUMAN

Name: Caspase-1

UniProtKB Accession Codes:

P29466 B5MDZ1 Q53EY6 Q6DMQ1 Q6GSS3 Q6PI75 Q9UCN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 1 EMBL 11 EMDB 2 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 5 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 10 RefSeq 7 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1574116

Title: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

PubMed ID: 1574116

DOI: 10.1038/356768a0

PubMed ID: 1373520

Title: Molecular cloning of the interleukin-1 beta converting enzyme.

PubMed ID: 1373520

DOI: 10.1126/science.1373520

PubMed ID: 7876192

Title: Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.

PubMed ID: 7876192

DOI: 10.1074/jbc.270.9.4312

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15498465

Title: Caspase-1 zeta, a new splice variant of caspase-1 gene.

PubMed ID: 15498465

DOI: 10.1016/j.ygeno.2004.06.005

PubMed ID: 1321594

Title: Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor.

PubMed ID: 1321594

DOI: 10.1016/0003-9861(92)90629-b

PubMed ID: 1339309

Title: Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.

PubMed ID: 1339309

DOI: 10.1016/0092-8674(92)90223-y

PubMed ID: 9334240

Title: Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.

PubMed ID: 9334240

DOI: 10.1074/jbc.272.42.26595

PubMed ID: 11051551

Title: ICEBERG: a novel inhibitor of interleukin-1beta generation.

PubMed ID: 11051551

DOI: 10.1016/s0092-8674(00)00108-2

PubMed ID: 15030775

Title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

PubMed ID: 15030775

DOI: 10.1016/s1074-7613(04)00046-9

PubMed ID: 15383541

Title: INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.

PubMed ID: 15383541

DOI: 10.1074/jbc.m407891200

PubMed ID: 15326478

Title: A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

PubMed ID: 15326478

DOI: 10.1038/sj.onc.1208036

PubMed ID: 16785446

Title: The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

PubMed ID: 16785446

DOI: 10.1073/pnas.0602081103

PubMed ID: 20197547

Title: Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

PubMed ID: 20197547

DOI: 10.1182/blood-2009-10-243444

PubMed ID: 20148899

Title: Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.

PubMed ID: 20148899

DOI: 10.1111/j.1462-5822.2010.01450.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 26375003

Title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

PubMed ID: 26375003

DOI: 10.1038/nature15514

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30065070

Title: Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.

PubMed ID: 30065070

DOI: 10.15252/embj.201899347

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 32051255

Title: Caspase-1 interdomain linker cleavage is required for pyroptosis.

PubMed ID: 32051255

DOI: 10.26508/lsa.202000664

PubMed ID: 37993714

Title: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

PubMed ID: 37993714

DOI: 10.1038/s41586-023-06742-w

PubMed ID: 8044845

Title: Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.

PubMed ID: 8044845

DOI: 10.1016/0092-8674(94)90303-4

PubMed ID: 9190289

Title: A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).

PubMed ID: 9190289

DOI: 10.1016/s1074-5521(97)90258-1

PubMed ID: 9987822

Title: Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.

PubMed ID: 9987822

DOI: 10.1248/cpb.47.11

PubMed ID: 15296730

Title: Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.

PubMed ID: 15296730

DOI: 10.1016/j.str.2004.05.010

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

PubMed ID: 32553275

Title: Caspase-1 engages full-length Gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage.

PubMed ID: 32553275

DOI: 10.1016/j.immuni.2020.06.007

PubMed ID: 33420033

Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.

PubMed ID: 33420033

DOI: 10.1038/s41467-020-20320-y

Sequence Information:

  • Length: 404
  • Mass: 45159
  • Checksum: ABF33CF33CC71584
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN 
PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT 
GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 
EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG 
VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY 
ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH

Genular Protein ID: 2653271366

Symbol: A8K257_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K257

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 9 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 383
  • Mass: 42860
  • Checksum: 59F188110BEA1571
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS AAPQAVQDNP AMPTSSGSEG NVKLCSLEEA 
QRIWKQKSAE IYPIMDKSSR TRLALIICNE EFDSIPRRTG AEVDITGMTM LLQNLGYSVD 
VKKNLTASDM TTELEAFAHR PEHKTSDSTF LVFMSHGIRE GICGKKHSEQ VPDILQLNAI 
FNMLNTKNCP SLKDKPKVII IQACRGDSPG VVWFKDSVGA SGNLSLPTTE EFEDDAIKKA 
HIEKDFIAFC SSTPDNVSWR HPTMGSVFIG RLIEHMQEYA CSCDVEEIFR KVRFSFEQPD 
GRAQMPTTER VTLTRCFYLF PGH

Genular Protein ID: 2793292085

Symbol: A8K249_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K249

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 9 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 404
  • Mass: 45099
  • Checksum: B6584CE779D344C1
  • Sequence:
    • MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS 
VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN 
PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT 
GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 
EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG 
VSGNLSLPTT EESEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY 
ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH